Susten SR 300mg Tablet 10'S

Introduction About SUSTEN SR 300MG TABLET

SUSTEN SR 300MG TABLET contains a medicine called progesterone which is a steroid hormone that functions similar to the endogenous female sex hormones.

It is used in the management of female infertility and other progesterone deficiency states such as abnormal uterine bleeding, menopausal disorders and secondary amenorrhea in combination with oestrogen therapy. It supports the early stages of pregnancy and reduces the risk of threatened abortions and pre-term delivery in pregnant women.

Inform your doctor if you have any liver, heart or kidney problems, diabetes, asthma, epilepsy, or depression. Do not take SUSTEN SR 300MG TABLET if you have or previously had breast cancer, uterine cancer, unexplained vaginal bleeding, or blood clots. Your doctor will instruct you to have periodic blood tests and regular physical examination (breast and uterine examination) as a precaution.

SUSTEN SR 300MG TABLET may be prescribed by your doctor during early stages of pregnancy to support the growth of fetus. However, consult your doctor before taking it. SUSTEN SR 300MG TABLET is not recommended for use in breast-feeding women and in children and adolescents (below 18 years of age).

Common side effects of taking SUSTEN SR 300MG TABLET are headache, hair loss, pain in the breast, stomach or abdominal cramps, bloating, nausea, vomiting. Consult your doctor if any of the side effect worsens.

Uses Of SUSTEN SR 300MG TABLET

Manages:

• Female infertility
• Abnormal uterine bleeding
• Menopausal disorders
• Secondary amenorrhea
• Supports early stages of pregnancy
• Threatened abortions and pre-term delivery

Benefits of SUSTEN SR 300MG TABLET

1. Provides Gradual and Steady Release of Progesterone

Its sustained-release formulation allows progesterone to be released slowly over several hours, helping maintain a more consistent hormone level through the day.

2. Supports Hormone Balance in Healthcare-Supervised Plans

Often included in hormone-support regimens where maintaining progesterone levels is essential as guided by healthcare professionals.

3. Designed for Once-Daily Convenience

The sustained-release format may reduce the need for multiple doses per day, making it convenient for routine use.

4. Uses Natural Micronised Progesterone

Contains micronised progesterone, which is a form commonly used to support natural hormonal functions under medical supervision.

5. Useful in Various Progesterone-Support Protocols

Healthcare providers may include this tablet in different hormone-management or supplement plans depending on individual requirements.

6. Helps Align with Body’s Natural Hormonal Rhythm

Its slow-release mechanism can help mimic the body’s natural progesterone fluctuations more smoothly compared to immediate-release options.

7. Patient-Friendly Oral Tablet Format

Easy to take, swallow, and store making it a convenient option for progesterone supplementation.

How SUSTEN SR 300MG TABLET Works

1. Sustained-Release (SR) Technology Controls How the Tablet Dissolves

• The tablet is formulated with a special matrix that slowly breaks down after swallowing.
• This allows progesterone to be released gradually over several hours instead of all at once.
• As a result, the bloodstream receives progesterone in steady and controlled amounts, helping maintain stable hormone levels during the day.

2. Micronised Progesterone Improves Absorption

• The progesterone particles are micronised (reduced in size).
• Smaller particles improve solubility and allow easier absorption through the digestive tract.
• This ensures a more predictable and uniform uptake compared to non-micronised forms.

3. Hormonal Binding and Distribution in the Body

Once absorbed:

• Progesterone enters the bloodstream and binds to progesterone receptors present in various tissues.
• These receptors help the hormone interact with endometrial tissue, reproductive organs, brain, and other hormonal pathways, supporting normal physiological functions.
• This receptor interaction helps maintain the natural cyclical hormonal environment guided by the body.

4. Mimics the Body’s Natural Progesterone Pattern

• Because the tablet delivers progesterone slowly, it more closely resembles how the body naturally releases progesterone in phases.
• This reduces sharp hormonal fluctuations and supports a more consistent hormonal environment through the dosing interval.

5. Longer Duration of Action

• Due to sustained release, progesterone remains available in the bloodstream for a longer period.
• This helps extend the duration of hormonal availability compared to immediate-release formulations, which dissolve faster.

6. Stable Blood Levels Support Routine Hormonal Balance

• Controlled delivery leads to stable plasma concentrations, avoiding sudden peaks or drops.
• This steady profile is beneficial in healthcare-supervised hormonal regimens that rely on predictable progesterone levels.

7. Reduced Need for Frequent Dosing

• The extended-release format typically supports once-daily intake, depending on clinical guidance.
• This improves convenience and supports better adherence to hormone-support plans.

How to use SUSTEN SR 300MG TABLET

Recommended Dosage of SUSTEN SR 300MG TABLET

The dosage of SUSTEN SR 300MG TABLET is based on individual hormonal requirements and is determined by a healthcare professional.
Strength, frequency, and duration may vary depending on the specific hormone-support plan.
Patients should follow the exact dosage instructions provided by their doctor, as sustained-release tablets are designed to work over a fixed duration.

Step-by-Step Directions for Using SUSTEN SR 300MG TABLET

1. Swallow the tablet whole with a glass of water.
2. Do not crush, chew, or split the sustained-release tablet.
3. Take the tablet at the same time every day for consistent hormone levels.
4. Follow the food-related guidance provided by your healthcare professional.
5. If the blister is damaged or tablets appear altered, avoid using them.
6. Store the tablet in a cool, dry place, away from direct sunlight.

Administration Guidelines for SUSTEN SR 300MG TABLET

• Designed for oral administration only.
• Should be taken as instructed to maintain the sustained-release effect.
• Ensure adequate hydration when taking the tablet.
• If multiple medications are being taken, keep a gap between doses as advised by a healthcare provider.
• Do not change timing or frequency without medical guidance.

Best Time to Take SUSTEN SR 300MG TABLET

The ideal time to take SUSTEN SR 300MG TABLET is based on the dosing plan recommended by a healthcare professional.
Many patients are advised to take progesterone formulations during:

• Evening or nighttime, as this aligns with natural hormonal patterns for some regimens.

Your doctor may personalise the timing depending on your routine and hormone-support schedule.

How Often to Take SUSTEN SR 300MG TABLET

The frequency of intake depends on the dosing plan provided by your doctor.
Sustained-release tablets are often designed for once-daily administration, but dosing frequency can vary in some hormone-support protocols.

Never increase or reduce the frequency without medical advice.

Food and Timing Considerations for SUSTEN SR 300MG

• Some individuals may be advised to take the tablet after food to support absorption or reduce stomach discomfort.
• Others may be instructed to take it on an empty stomach, depending on their personalised regimen.
• Maintain a consistent pattern if taken after food, do so at the same mealtime each day.
• Avoid alcohol close to dosing unless cleared with a healthcare provider.
• Follow the specific food-timing instructions given during consultation.

What if I forgot to take SUSTEN SR 300MG TABLET

• If a dose is missed, take it as soon as you remember.
• If it is almost time for the next scheduled dose, skip the missed dose do not double the dose.
• Continue with the regular dosing schedule.
• For repeated missed doses or confusion about timing, consult a healthcare professional for guidance.

Overdose

If you or anyone else accidentally take too much of SUSTEN SR 300MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms include dizziness, tiredness, drowsiness or sleepiness.

Side Effects Of SUSTEN SR 300MG TABLET

Common Side Effects of SUSTEN SR 300MG TABLET:

• headache
• breast pain
• irregular vaginal bleeding or spotting
• stomach or abdominal cramps, bloating, nausea, vomiting, constipation
• hair loss
• fluid retention
• vaginal yeast infection

When to consult a doctor:

• signs of liver disease (such as yellow skin or white of the eyes)
• severely high blood pressure (signs include headache, tiredness and dizziness)
• migraine-like headaches (happening for the first time)
• sudden or gradual, partial, or complete loss of eyesight
• bulging of one or both eyes, double vision
• swelling of the optic nerve
• retinal vascular lesions (eye diseases)
• signs of blood clot (such as painful swelling and redness of the legs, sudden chest pain and trouble breathing)

Warning & Precautions

Pregnancy

Consult your doctor

SUSTEN SR 300MG TABLET can be taken by pregnant women to support the growth of fetus during the early stages of pregnancy. However, consult your doctor before taking it.

Breastfeeding

Contraindicated

SUSTEN SR 300MG TABLET is not advised for use during breast-feeding. Therefore, consult your doctor before taking it.

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if you feel dizzy or drowsy after taking SUSTEN SR 300MG TABLET.

Kidney

Use with Caution

SUSTEN SR 300MG TABLET should be used cautiously in patients with kidney problems.

Liver

Consult your doctor

SUSTEN SR 300MG TABLET is not advised for use in patients who had or have liver disease and with abnormal liver function test. It should be used with caution in patients with benign liver tumor.

Allergy

Contraindicated

Do not take SUSTEN SR 300MG TABLET if you are allergic to Progesterone.

Lungs

Consult your doctor

SUSTEN SR 300MG TABLET is not recommended for use in patients who had or have blood clot in the lungs (pulmonary embolism). It should be used cautiously in patients with asthma.

Heart Disease

Consult your doctor

SUSTEN SR 300MG TABLET is not recommended for use in patients with recent heart attack or chest pain. It should be used cautiously in patients with high blood pressure.

Use In Pediatrics

Contraindicated

SUSTEN SR 300MG TABLET is not recommended for use in children and adolescents (under 18 years of age).

Other Warnings for SUSTEN SR 300MG TABLET

Before taking SUSTEN SR 300MG TABLET, inform your doctor if you:

• have problems in your uterus (such as fibroid growths or endometriosis (womb lining growth outside your womb)
• have a history of excessive womb lining growth (endometrial hyperplasia) 
• have increased risk of blood clot formation (when you are unable to walk for long time after major surgery, injury or illness, obese and older age)
• have a family history of having breast cancer
• have diabetes
• have gallstones
• have migraine or severe headaches
• have systemic lupus erythematosus (an immune system disease that affects many organs of the body)
• have epilepsy (fits)
• have otosclerosis (disease affecting the eardrum and hearing)
• have ever had depression
• have skin sensitivity towards light

Who should not take SUSTEN SR 300MG TABLET

SUSTEN SR 300MG TABLET is not recommended for use if you:

• have known or suspected cancer of the breast or womb lining (endometrium)
• have unusual vaginal bleeding
• had or have blood clots in the legs (deep venous thrombosis) or in the veins (thrombosis)
• have bleeding on the brain (cerebral hemorrhage) or stroke
• have blood clotting disorder (like protein C, protein S, or antithrombin deficiency)
• have porphyria (rare genetic blood disorder)

Drug - Drug interaction

1. Medicines That Affect Hormone Levels

Certain hormonal preparations may interact with progesterone:

• Other progesterone or estrogen-containing medications
• Hormonal support or reproductive health medicines
• Corticosteroids

These may influence overall hormone balance or modify progesterone activity.

2. Medicines Affecting Liver Enzymes

Progesterone is metabolized in the liver, so drugs that induce or inhibit liver enzymes may affect its levels:

• Enzyme inducers (may reduce progesterone levels):
  – Rifampicin
  – Carbamazepine
  – Phenytoin
  – Phenobarbital
• Enzyme inhibitors (may increase progesterone exposure):
  – Ketoconazole
  – Itraconazole
  – Erythromycin
  – Clarithromycin

These interactions may require professional monitoring or adjustment.

3. Sedatives and CNS-Acting Medicines

Progesterone may have mild sedative effects in some individuals. Combining it with other CNS depressants may enhance drowsiness:

• Sleep aids
• Anti-anxiety medicines
• Certain antihistamines
• Alcohol-containing formulations

Caution is advised when combining such products.

4. Medicines Used for Thyroid and Metabolic Conditions

Some studies suggest progesterone may influence thyroid-binding proteins or metabolic pathways.
Patients using thyroid medications, diabetes medicines, or similar metabolic agents should confirm compatibility with their healthcare provider.

5. Herbal and Dietary Interactions

Natural or herbal products may also influence hormone levels or liver metabolism:

• St. John’s Wort
• High-dose supplements affecting hormonal pathways

These may reduce or alter progesterone’s expected exposure.

Drug - Food interaction

1. Effect of Food on Absorption

• Taking progesterone tablets with food, particularly a high-fat meal, can increase the absorption of the hormone.
• This may lead to higher-than-expected blood levels, as food slows gastric emptying and enhances uptake.
• Because sustained-release tablets rely on controlled release, irregular food habits can affect the release profile.

2.  Caffeine-Rich Foods and Beverages

• Caffeine does not directly interact with progesterone metabolism.
• However, it may worsen symptoms like nervousness or sleep disturbance in sensitive individuals.

Synopsis

More Information

Why Sustained-Release Formulations Are Preferred

• Sustained-release (SR) formulations are designed to release the active ingredient slowly and steadily over several hours.
• This controlled delivery helps maintain more stable hormone levels, reducing the sharp peaks and drops that may occur with immediate-release tablets.
• SR tablets also support better convenience, as they often require fewer doses in a day, which can improve routine consistency for individuals following hormone-support plans.
• Additionally, a gradual release mirrors the body’s natural rhythm more closely, offering a smoother hormonal exposure throughout the dosing interval.

Difference Between Natural and Synthetic Progesterone Forms

Natural micronised progesterone is structurally identical to the progesterone produced by the human body. Because its molecular structure matches the body’s own hormone, it interacts with progesterone receptors in a more physiologically familiar way.
Synthetic progesterone forms (progestins), on the other hand, are chemically modified versions used in various hormonal preparations. These may differ in how they bind to receptors, how long they stay in the body, and the kinds of hormonal effects they produce.

Natural progesterone is often chosen in situations where a closer alignment with the body’s own hormone profile is desired, while synthetic forms may be selected for specific clinical goals depending on the healthcare provider’s judgment.

Similar Products

Here are general categories of products similar to SUSTEN SR 300MG TABLET based on formulation type and active ingredient, without brand promotion:

• Micronised Progesterone Sustained-Release Tablets
  Other SR tablets containing natural micronised progesterone in varying strengths.
• Micronised Progesterone Capsules (Immediate-Release)
  Oral capsules with natural progesterone but without sustained-release technology.
• Vaginal Progesterone Preparations
  Such as vaginal gels, suppositories, or pessaries containing progesterone for localized absorption.
• Progesterone Oil Injectables
  Injectable formulations used in certain hormone-support protocols.

These options differ in route, release profile, and absorption characteristics, and are chosen by healthcare professionals based on individual requirements.

FAQs About SUSTEN SR 300MG TABLET

Q. Is SUSTEN SR 300MG TABLET safe to use in patients with liver problems?

A. SUSTEN SR 300MG TABLET is not recommended for use in patients who had or have blood clot in the lungs (pulmonary embolism) and it should be used with caution in patients with asthma. Consult your doctor before taking it

Q. What are the common side effects of SUSTEN SR 300MG TABLET?

A. The most common side effects of taking SUSTEN SR 300MG TABLET are headache, hair loss, pain in the breast, stomach or abdominal cramps, bloating, nausea, vomiting, irregular vaginal bleeding or spotting, fluid retention and vaginal yeast infection. Consult your doctor if any of the side effect worsens.

Q. Why is SUSTEN SR 300MG TABLET necessary for pregnancy?

A. SUSTEN SR 300MG TABLET supplements your body with sufficient levels of progesterone that is required for a successful implantation of fertilized egg in the uterus and for the maintenance of an early pregnancy. It sustains pregnancy among infertile women and in women who face repeated/threatened abortions by increasing the thickness of uterine wall.

Q. When is progesterone produced in the reproductive cycle?

A. The typical menstrual cycle takes approximately 28 to 32 days and is divided into three distinct phases namely the follicular phase, the ovulatory phase, and the luteal phase. The luteal phase is the period when the body produces progesterone, the hormone that makes the uterus prepare its lining to receive the egg.

Q. What precautions need to be followed while taking SUSTEN SR 300MG TABLET?

A. Before taking SUSTEN SR 300MG TABLET inform your doctor if you have or previously had breast cancer, uterine cancer, unexplained vaginal bleeding, heart problems, blood clots, diabetes, or asthma. Take it regularly as instructed by the physician without fail. Do not miss a dose of SUSTEN SR 300MG TABLET to achieve maximum benefits.

Q: What are SUSTEN SR 300MG TABLET used for?

A: SUSTEN SR 300MG TABLET is commonly used in the management of menstrual disorders, support early pregnancy, manage hormone replacement therapy (HRT), and address symptoms of menopause or infertility.

Q: How SUSTEN SR 300MG TABLET works?

A: SUSTEN SR 300MG TABLET is a steroid hormone used to manage progesterone deficiency in the body. It supplements your body with sufficient levels of progesterone that is required for a successful implantation of fertilized egg in the uterus and for the maintenance of an early pregnancy.

It sustains pregnancy among infertile women by increasing the thickness of uterine wall. It also regulates hormonal balance in the body and corrects abnormal uterine bleeding and other menstrual problems caused due to incorrect levels of progesterone in the body.

Q: Can progesterone tablets cause weight gain?

A: Progesterone may cause water retention and bloating, which can lead to temporary weight gain in some individuals.

Q: Can you take progesterone tablets during pregnancy?

A: Yes, in certain cases, progesterone tablets are prescribed during early pregnancy to support the uterine lining and reduce the risk of miscarriage.

Q: Can progesterone tablets affect mood?

A: Yes, mood swings or depression can occur as a side effect of progesterone, particularly when hormone levels fluctuate.

Q: How long does it take for progesterone tablets to work?

A: The effect of progesterone tablets can vary depending on the condition being treated, but some users notice changes within a few days to weeks.

Q: Are there any interactions between progesterone tablets and other medications?

A: Yes, progesterone can interact with certain medications like antifungals, anticonvulsants, and blood thinners. Always inform your doctor about any medications you're taking.

References

1. KD. Tripathi. Estrogens, Progestins, and Contraceptives. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 316.

2. Michaela Jewson, Prashant Purohit, Mary Ann Lumsden. Progesterone and abnormal uterine bleeding/menstrual disorders. ScienceDirect. November 2020. [Accessed on 9th March 2026] 

3. R Erny, A Pigne, C Prouvost, M Gamerre, C Malet, H Serment, J Barrat. The effects of oral administration of progesterone for premature labor. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. March 1986. [Accessed on 9th March 2026] 

4. Cyndea Pharma. Electronic Medicines Compendium (EMC). [Revised in February 2022] [Accessed on 9th March 2026] 

5. Catalent Pharma Solutions. U.S. Food & Drug Administration. [Accessed on 9th March 2026] 

User Feedback

Useful Diagnostic Tests

• 17 Oh Progesterone
• Progesterone
• Early Pregnancy Checkup

Author Details

Written By Srilekha. R - B.Pharm

Reviewed For Accuracy By Dr. M N Himaja - MBBS

Last updated on 23 Nov 2024 | 05:01 PM(IST)