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Introduction About SULTACLIN 375 TABLET
SULTACLIN 375 TABLET contains Sultamicillin which belongs to the group of medicines called Penicillins. SULTACLIN 375 TABLET is used to manage upper respiratory tract infections (such as sinusitis, otitis media, tonsillitis), lower respiratory tract infections (such as bacterial pneumonias, bronchitis), urinary tract infections, pyelonephritis (inflammation of kidney), skin & soft tissue infections, and gonococcal infections (sexually transmitted disease) in affected individuals.
SULTACLIN 375 TABLET is also indicated in patients who require sulbactam/ampicillin therapy (antibacterial therapy) following initial therapy with intramuscular/intravenous sulbactam/ampicillin medicine. SULTACLIN 375 TABLET is not recommended for use in patients allergic to Sultamicillin. It is also not recommended for use in patients with infectious mononucleosis (a viral infection), galactose intolerance, Lapp-lactase deficiency, and/or glucose-galactose malabsorption (rare hereditary problems).
Before taking SULTACLIN 375 TABLET, inform your doctor if you had previously suffered from hypersensitivity reactions (to penicillins, cephalosporins, carbapenems, and/or other beta-lactam antibiotic agents), and/or have kidney problems (such as severe renal impairment), and/or liver problems (such as liver dysfunction).
SULTACLIN 375 TABLET should be used with caution during pregnancy only if it is clearly necessary. It is not recommended for use in breastfeeding women as it may pass through breast milk.
SULTACLIN 375 TABLET should be used with caution in children and adolescents (aged below 18 years) which is also advised to be used with caution in elderly patients (aged 65 years/above) after consulting the doctor.
The most common side effects of taking SULTACLIN 375 TABLET are headache, nausea, vomiting, diarrhea, stomach pain, itching, and/or rashes. Consult your doctor if any of these symptoms worsens.
Uses Of SULTACLIN 375 TABLET
- Manage upper & lower respiratory tract infections, urinary tract infections, pyelonephritis, skin & soft tissue infections, and gonococcal infections. in affected individuals
- Manage bacterial infections in patients who require sulbactam/ampicillin therapy following initial therapy with intramuscular/intravenous sulbactam/ampicillin medicine
How SULTACLIN 375 TABLET Works
SULTACLIN 375 TABLET works by inhibiting penicillin binding proteins (responsible for bacterial cell wall formation) which leads to activation of autolytic enzymes in the bacterial cell wall resulting in its destruction thus managing the spread of infection in affected individuals.
How to use SULTACLIN 375 TABLET
Take SULTACLIN 375 TABLET as advised by your physician. Swallow the medicine with water. Do not crush or chew the medicine. Your doctor will decide an appropriate dose and duration depending upon your age, body weight and disease condition.
Side Effects Of SULTACLIN 375 TABLET
Common
- candida (yeast) infection
- headache
- nausea, vomiting, diarrhea, stomach pain
- rashes, itching
Uncommon
- dizziness
- dark stools
- stomatitis (painful swelling/sores inside the mouth)
- skin inflammation
- joint pain
- fatigue, general discomfort
- swollen tongue
Rare
Stop taking SULTACLIN 375 TABLET and contact your doctor immediately if you experience any of the following side effects:
- signs of allergic reactions such as runny nose, coughing, breathlessness, and/or swollen eyes/lips/mouth/throat
- signs of severe anaphylactic reaction (life threatening allergic reaction) such as wheezing, shallow breathing, feeling faint, and/or losing consciousness
- severe skin reactions such as toxic epidermal necrolysis, Stevens-Johnson syndrome, dermatitis exfoliative, erythema multiforme, acute generalized exanthematous pustulosis associated with symptoms such as blistering skin, redness of skin, itching, sore mouth, and/or fever
How To Manage Side Effects
Headache:
Drink plenty of water and get adequate rest. Try to be relaxed and stress free. Check with your doctor before taking any medicine for headache. If headache does not get better, consult your doctor.
Nausea and Vomiting:
Take SULTACLIN 375 TABLET with or just after a meal. Stick to simple meals. Avoid eating oil rich or spicy foods, sugary snacks and drinks. Avoid drinking too much liquid along with your meals, drink slowly in between meals. Inform your doctor if the condition worsens.
Diarrhoea:
Drink plenty of water and stay hydrated. Try to avoid taking any medicine on your own to manage diarrhea. Consult and inform your doctor if the symptom worsens.
Rash:
Do not scratch the affected area. Wear protective clothing while going outdoors. Regularly moisturize your skin. Consult and inform your doctor if the symptom gets worse.
Dizziness:
Try to rest and get enough sleep. Try to avoid driving or operating any tools or machines while you feel dizzy. Limit consumption of alcohol, as it can aggravate dizziness. Consult and inform your doctor if the symptom worsens.
Warning & Precautions
Pregnancy
SULTACLIN 375 TABLET should be used with caution during pregnancy only if it is clearly necessary. Consult your doctor before taking the medicine.
Breastfeeding
SULTACLIN 375 TABLET is generally not recommended for use in breastfeeding women as it may pass through breast milk. Consult your doctor before taking the medicine.
Kidney
SULTACLIN 375 TABLET should be used with caution in patients with kidney problems such as severe renal impairment. Consult your doctor before taking the medicine.
Liver
SULTACLIN 375 TABLET should be used with caution in patients with liver disease such as hepatic dysfunction. Consult your doctor before taking the medicine.
Allergy
Do not take SULTACLIN 375 TABLET if you are allergic to Sultamicillin, and/or any other ingredients of this medicine.
Others
SULTACLIN 375 TABLET is not recommended for use if you:
- have infectious mononucleosis (a viral infection)
- have galactose intolerance, Lapp-lactase deficiency, and/or glucose-galactose malabsorption (rare hereditary problems)
Before taking SULTACLIN 375 TABLET, inform your doctor if you:
- previously had hypersensitivity reactions to penicillins, cephalosporins, carbapenems, and/or other beta-lactam agents
Use in Pediatrics:
SULTACLIN 375 TABLET should be used with caution in children and adolescents (aged below 18 years). Consult your doctor before administering the medicine to the child.
Use in Geriatrics:
SULTACLIN 375 TABLET should be used with caution in elderly patients (aged 65 years/above). Consult your doctor before taking the medicine.
Interactions
A. Drug-Drug interactions:
Before taking SULTACLIN 375 TABLET, inform your doctor if you are taking any of the following medicines:
- medicines used to manage gout (Ex. allopurinol, probenecid)
- medicines used for blood thinning (Ex. warfarin, rivaroxaban)
- medicines used to manage bacterial infections (Ex. chloramphenicol, erythromycin, sulfamethoxazole, tetracycline)
- medicines used to manage pregnancy (Ex. ethinyl estradiol)
- methotrexate (used in cancer management)
Overdosage:
If you or anyone else accidentally take too much of SULTACLIN 375 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose includes neurologic effects such as seizures.
Synopsis
| Drug | : | Sultamicillin |
| Pharmacological Category | : | Penicillins |
| Therapeutic Indication | : | Infections caused by susceptible micro-organisms |
| Dosage Forms | : | Tablet |
More Information
- Keep SULTACLIN 375 TABLET out of reach of children
- Do not store SULTACLIN 375 TABLET above 30°C
FAQs About SULTACLIN 375 TABLET
What is SULTACLIN 375 TABLET used for?
SULTACLIN 375 TABLET is used to manage upper and lower respiratory tract infections, urinary tract infections, pyelonephritis (inflammation of kidney), skin & soft tissue infections, and gonococcal infections (sexually transmitted disease) in affected individuals. It is also indicated for use in patients who require sulbactam/ampicillin therapy (antibacterial therapy) following initial therapy with intramuscular/intravenous sulbactam/ampicillin medicine.
What are the side effects of SULTACLIN 375 TABLET?
The most common side effects of taking SULTACLIN 375 TABLET are headache, nausea, vomiting, diarrhea, stomach pain, itching, and/or rashes. Consult your doctor if any of these symptoms worsens.
How SULTACLIN 375 TABLET works?
SULTACLIN 375 TABLET works by inhibiting penicillin binding proteins (responsible for bacterial cell wall formation) which leads to activation of autolytic enzymes in the bacterial cell wall resulting in its destruction thus managing the spread of infection in affected individuals.
How SULTACLIN 375 TABLET is taken?
Take SULTACLIN 375 TABLET as advised by your physician. Swallow the medicine with water. Do not crush or chew the medicine. Your doctor will decide an appropriate dose and duration depending upon your age, body weight and disease condition.
What happens if SULTACLIN 375 TABLET is taken more than its required dosage?
If you or anyone else accidentally take too much of SULTACLIN 375 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose includes neurologic effects such as seizures.
References
1. K.D. Tripathi. Beta-Lactam Antibiotics. Essentials of medical pharmacology. Seventh edition. 2013. Page- 725.
2. Sultamicillin. NIH National Library of Medicine. National center for biotechnology information. PubChem. November 2022. [Accessed on 11th July 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Sultamicillin
3. J Majcher-Peszynska, M Loebermann, S Klammt, S Frimmel, R G Mundkowski, T Welte, E C Reisinger, B Drewelow, CAPNETZ Study Group. Ampicillin/sulbactam in elderly patients with community-acquired pneumonia. NIH National Library of Medicine. National Center for Biotechnology Information. PubMed.gov. February 2014. [Accessed on 11th July 2022] https://pubmed.ncbi.nlm.nih.gov/23904004/
4. Pfizer Global Supply Japan Inc. Unasyn Oral. [Revised in November 2019] [Accessed on 11th July 2022] https://labeling.pfizer.com/ShowLabeling.aspx?id=12271
5. Cathay Drug Company Inc. Silgram. [Accessed on 11th July 2022] https://cathaydrug.com/product/silgram-tablet/
Useful Diagnostic Tests
- Chest X-ray
- Urine analysis
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