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Introduction About STON 1 ORAL SOLUTION

STON 1 ORAL SOLUTION is a combination of Potassium citrate and Magnesium citrate which belongs to the group of medicines called Urinary alkalizers and Saline laxatives respectively. It is used in the management of renal tubular acidosis with calcium stones and kidney stones (hypocitraturic calcium oxalate nephrolithiasis and uric acid lithiasis with or without calcium stones).

Renal tubular acidosis is a condition in which the kidneys do not remove acids from the blood into the urine as they usually should. Before taking STON 1 ORAL SOLUTION, your doctor might want you to take certain blood tests and ECG to understand your existing condition.

STON 1 ORAL SOLUTION is not recommended for use in patients with hyperkalemia (high potassium levels in the blood), gastrointestinal disease, peptic ulcer disease, urinary tract infection and kidney disease.

STON 1 ORAL SOLUTION is not recommended for use in pregnant and breastfeeding women unless it is clearly advised by the doctor. Safety and effectiveness of STON 1 ORAL SOLUTION in children has not been established yet. The most common side effects of taking STON 1 ORAL SOLUTION are abdominal discomfort, nausea, vomiting and diarrhea.

Uses Of STON 1 ORAL SOLUTION

Manages,

renal tubular acidosis (RTA) with calcium stones
hypocitraturic calcium oxalate nephrolithiasis
uric acid lithiasis (with or without calcium stones)

How STON 1 ORAL SOLUTION Works

STON 1 ORAL SOLUTION works by reducing the kidney stone formation. Potassium citrate and magnesium citrate, causes the metabolism of absorbed citrate producing an alkaline load. In addition to raising urinary pH and citrate, this also increases urinary potassium and magnesium. In certain patients, potassium citrate causes a transient reduction in urinary calcium. These changes produce urine that is less helpful to the crystallization of stone-forming salts.

How to use STON 1 ORAL SOLUTION

Take STON 1 ORAL SOLUTION as advised by your physician. Shake well before use. Use a measuring cup or spoon to properly measure a dose. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Side Effects Of STON 1 ORAL SOLUTION

Common

abdominal discomfort
nausea, vomiting
diarrhea
loose bowel movements

Rare

Stop taking STON 1 ORAL SOLUTION and contact your doctor immediately if you experience any of the following side effects:

severe abdominal pain, vomiting or gastrointestinal bleeding

How To Manage Side Effects

Diarrhea

Drink lot of fluids such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for managing diarrhea. Consult your doctor if the symptom does not improve.

Nausea And Vomiting

Try to take STON 1 ORAL SOLUTION with or just after a meal or a snack. Stick to simple meals. Avoid eating oil rich, fried or spicy foods. Consult your doctor if the symptom does not improve.

Stomach Pain

Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. Do not self-manage on your own and consult your doctor if the symptom does not improve.

Warning & Precautions

Pregnancy

Monitoring required

STON 1 ORAL SOLUTION should be used in pregnant woman only if considered clearly necessary. Consult your doctor before taking it.

Breastfeeding

Monitoring required

STON 1 ORAL SOLUTION should be used in breast-feeding woman only if considered clearly necessary. Consult your doctor before taking it.

Kidney

Contraindicated

STON 1 ORAL SOLUTION is not recommended for use in patients with renal insufficiency. Consult your doctor before taking it.

Allergy

Do not take STON 1 ORAL SOLUTION if you are allergic to potassium citrate or magnesium citrate.

Heart Disease

Contraindicated

STON 1 ORAL SOLUTION is not recommended for use in patients with severe myocardial damage or heart failure because it impairs the excretion of potassium. Consult your doctor before taking it.

Use In Pediatrics

Consult your doctor

Safety and effectiveness of STON 1 ORAL SOLUTION have not been established yet in children. Consult your child’s doctor for advice.

Others

STON 1 ORAL SOLUTION is not recommended for use if you:

have hyperkalemia (increased level of potassium in the blood) or pre-disposing factor of hyperkalemia (such as uncontrolled diabetes mellitus, acute dehydration, strenuous physical exercise in unconditioned individuals, adrenal insufficiency, extensive tissue breakdown)
have cause for arrest or delay in passage through the gastrointestinal tract (such as those suffering from delayed gastric emptying, esophageal compression, intestinal obstruction or stricture)
have peptic ulcer disease
have urinary tract infection

Interactions

A. Drug - Drug interactions:

Before taking STON 1 ORAL SOLUTION, inform your doctor if you are taking any of the following medicines:

potassium sparing diuretic Ex. triamterene, spironolactone or amiloride (used to manage high blood pressure and congestive heart failure)
anticholinergics Ex. clozapine, thorazine (used to control schizophrenia)

Overdosage:

If you or anyone else accidentally take too much of STON 1 ORAL SOLUTION, consult your doctor immediately or visit the nearby hospital. Overdosage symptom of STON 1 ORAL SOLUTION is hyperkalemia (increased potassium in the blood).

Synopsis

Drug	:	Potassium citrate, Magnesium citrate
Pharmacological Category	:	Urinary alkalizer , Saline laxative
Therapeutic Indication	:	Renal tubular acidosis (RTA) with calcium stones, Hypocitraturic calcium oxalate nephrolithiasis, Uric acid lithiasis
Dosage Forms	:	Oral solution, Oral suspension, Syrup, Tablet

More Information

Keep STON 1 ORAL SOLUTION out of reach of children
Store at room temperature

FAQs About STON 1 ORAL SOLUTION

Q: What is STON 1 ORAL SOLUTION used for?

A: STON 1 ORAL SOLUTION is used in the management of renal tubular acidosis with calcium stones and kidney stones (hypocitraturic calcium oxalate nephrolithiasis and uric acid lithiasis with or without calcium stones).

Q: Can STON 1 ORAL SOLUTION be used by pregnant women?

A: STON 1 ORAL SOLUTION should be used in pregnant woman only if considered clearly necessary. Consult your doctor before taking this medicine if you are pregnant or planning to get pregnant.

Q: Is STON 1 ORAL SOLUTION safe to use in patients with heart problems?

A: STON 1 ORAL SOLUTION is not recommended for use in patients with severe myocardial damage or heart failure because it impairs the excretion of potassium. Consult your doctor before taking it.

Q: Can STON 1 ORAL SOLUTION be used in children?

A: Safety and effectiveness of STON 1 ORAL SOLUTION have not been established yet in children. Consult your child’s doctor for advice to select a suitable alternative therapy for your child to manage the specific condition.

Q: Does STON 1 ORAL SOLUTION cause diarrhea?

A: Yes, STON 1 ORAL SOLUTION may cause diarrhea in some individuals. To manage this effect, drink lot of fluids such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for managing diarrhea. Consult your doctor if the symptom does not improve.

References

1. Goodman Gilmans. Treatment of disorder of bowl motility and water flux. The Pharmacological Basis of Therapeutics. Twelfth Edition. 2011. Page –1331

2. B Ettinger, C Y Pak, J T Citron, C Thomas, B Adams-Huet, A Vangessel. Potassium-magnesium citrate is an effective prophylaxis against recurrent calcium oxalate nephrolithiasis. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. December 1997. [Accessed on 31st May 2022] https://pubmed.ncbi.nlm.nih.gov/9366314/

3. Cipla Ltd. Ston1 oral solution (Potassium citrate + Magnesium citrate) Ciplamed. [Revised in April 2016] [Accessed on 31st May 2022] https://www.ciplamed.com/content/ston1-oral-solution

Useful Diagnostic Tests

Uric acid test
Abdominal ultrasound

Author Details

Written By Dr. R. Dinesh John Rajkumar - Pharm.D

Reviewed For Accuracy By Dr. Pushpraj Singh - MBBS

Last updated on 23 Feb 2023 | 06:00 PM(IST)

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