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Introduction About STIMUCART 50MG TABLET
STIMUCART 50MG TABLET contains Diacerein which belongs to the group of medicines called Anthraquinones. It is used for the symptomatic management of functional symptoms of osteoarthritis.
Osteoarthritis is a common progressive disorder affecting primarily weight bearing joints (knee, hip), characterised by progressive destruction of cartilage causing pain, limitation of motion, stiffness, deformity and disability.
Prior to the management, your doctor may want you to take several blood tests to understand your existing condition like liver disease.
Avoid taking alcohol with STIMUCART 50MG TABLET as it may increase the risk of liver damage. STIMUCART 50MG TABLET is not recommended for use in patients having liver or kidney disease, colitis or crohn’s disease, partial or complete intestinal obstruction or abdominal pain with an unknown cause.
Inform your doctor, if you have kidney or urinary problems, history of diarrhea, irritable bowel disease, rare hereditary diseases such as congenital galactosemia, glucose or galactose malabsorption syndrome or lactase deficiency.
STIMUCART 50MG TABLET is not recommended for use in pregnant and breastfeeding women. Contact your doctor before taking.
STIMUCART 50MG TABLET is not recommended for use in children and adolescents under 15 years of age. Contact your doctor before taking.
STIMUCART 50MG TABLET should be used with caution in elderly aged above 65 years. Contact your doctor before taking.
The most common side effects of taking STIMUCART 50MG TABLET are diarrhea, soft stools, pain in abdomen, frequent bowel movements, flatulence, skin rash, itching, and eczema. Contact your doctor if any of the side effects worsen.
Uses Of STIMUCART 50MG TABLET
- Used for the symptomatic management of Osteoarthritis
How STIMUCART 50MG TABLET Works
STIMUCART 50MG TABLET works by blocking the chemicals (interleukin-1) causing inflammation and destruction of cartilage in the body. It also stimulates the production of certain chemicals called transforming growth factor-β (TGF-β) which triggers chondrocyte proliferation and stimulates the production of collagen and proteoglycan, glycosaminoglycans and hyaluronic acid. Therefore STIMUCART 50MG TABLET manages the cartilage destruction and improves symptoms in patients with osteoarthritis.
How to use STIMUCART 50MG TABLET
Take STIMUCART 50MG TABLET as advised by your physician. Swallow the medicines with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of STIMUCART 50MG TABLET
Common
- diarrhea
- soft stools
- pain in abdomen
- frequent bowel movements
- flatulence
- skin rash, itching, eczema
Uncommon
- increased liver enzymes
Rare
- pigmentation of colorectal mucosa (melanosis coli)
Stop taking STIMUCART 50MG TABLET and contact your doctor immediately if you experience any of the following side effects:
- diarrhea (risk of dehydration and hypokalemia)
- signs of liver disease such as increased liver enzyme, tiredness, and loss of appetite, jaundice (yellowish discoloration of skin and white of eyes), abdominal pain, nausea, vomiting, change in stool and urine colour, reduced consciousness, itchy skin
How To Manage Side Effects
Diarrhoea:
Drink lots of fluids, such as water or fruit juices to keep you hydrated. Do not take any medicine on your own for managing diarrhea. Contact your doctor if the symptom did not improve.
Stomach pain:
Rest and relax. Try to have smaller meals but take frequently. Keep a heat pad on your stomach. Do not self-manage and contact your doctor if the symptom did not improve.
Flatulence:
Eat smaller meals but take frequently and exercise regularly. If the symptom does not improve, contact your doctor.
Itchy skin:
Avoid hot showers because hot water can irritate the skin. Do not scratch the affected area. Use sunscreen and protective clothing when outdoors. Regularly use unscented moisturizers to soothe and hydrate the affected area. If the symptom does not improve, contact your doctor.
Warning & Precautions
Pregnancy
STIMUCART 50MG TABLET is generally not recommended for use in pregnant women. Consult your doctor before taking.
Breastfeeding
STIMUCART 50MG TABLET is generally not recommended for use in breastfeeding women as it is not known if this medicine passes into breast milk. Consult your doctor before taking.
Alcohol
Avoid consumption of alcohol while taking STIMUCART 50MG TABLET as it increases the risk of liver damage.
Kidney
STIMUCART 50MG TABLET is not recommended for use in patients with severe kidney disease. Consult your doctor before taking.
Liver
STIMUCART 50MG TABLET is not recommended for use in patients with liver disease. Consult your doctor before taking.
Allergy
Do not take STIMUCART 50MG TABLET if you are allergic to Diacerein or any of the other ingredients of this medicine.
Others
STIMUCART 50MG TABLET is not recommended for use if you have:
- colitis or crohn’s disease
- partial or complete intestinal obstruction
- abdominal pain with an unknown cause
- rapidly progressive (worsening) hip osteoarthritis
Before taking STIMUCART 50MG TABLET, inform your doctor if you have:
- urinary system problems
- irritable bowel disease
- rare hereditary diseases such as congenital galactosemia, glucose or galactose malabsorption syndrome or lactase deficiency
Use in pediatrics:
STIMUCART 50MG TABLET is generally not recommended for use in children and adolescents under 15 years of age. Consult your doctor before taking.
Use in geriatrics:
STIMUCART 50MG TABLET is not recommended for use in elderly patients aged above 65 years. Consult your doctor before taking.
Interactions
A. Drug - Drug interactions:
Before taking STIMUCART 50MG TABLET, inform your doctor if you are taking any of the following medicine:
- laxatives (medicines used to manage constipation)
- antacids (Ex. Aluminium hydroxide, magnesium hydroxide or calcium hydroxide) (medicines used to manage acidity)
- diuretics (medicines used for hypertension)
- digoxin, digitoxin (medicines used for heart failure)
- amoxicillin/clavulanic acid (medicines used for infections)
- chemotherapy (medicines used to manage cancer)
Overdosage:
If you or anyone else accidentally takes too much of STIMUCART 50MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are diarrhea.
Synopsis
| Drug | : | Diacerein |
| Pharmacological Category | : | Anthraquinones |
| Therapeutic Indication | : | Osteoarthritis |
| Dosage Forms | : | Tablet, Capsule |
More Information
- Keep STIMUCART 50MG TABLET out of the sight and reach of children
- Store STIMUCART 50MG TABLET below 25°C
FAQs About STIMUCART 50MG TABLET
Is STIMUCART 50MG TABLET a painkiller?
No. STIMUCART 50MG TABLET belongs to a group of medicines called Anthraquinones with mild anti-inflammatory and anti-catabolic properties. Contact your doctor before taking.
What is STIMUCART 50MG TABLET is used for?
STIMUCART 50MG TABLET is used for the symptomatic management of functional symptoms of osteoarthritis.
Who should avoid taking STIMUCART 50MG TABLET?
STIMUCART 50MG TABLET is avoided in patients with liver or kidney disease, colitis or crohn’s disease, partial or complete intestinal obstruction or abdominal pain with an unknown cause, rapidly progressive osteoarthritis of hip, allergic to STIMUCART 50MG TABLET or rhein, pregnant or lactating women, children and elderly patients. Consult your doctor before taking.
Can I take alcohol while using STIMUCART 50MG TABLET?
No. Do not take alcohol with STIMUCART 50MG TABLET as it may increases the risk of liver damage. Contact your doctor before taking.
What are the side effects of STIMUCART 50MG TABLET?
The most common side effects of taking STIMUCART 50MG TABLET are diarrhea, soft stools, pain in abdomen, frequent bowel movements, flatulence, skin rash, itching, and eczema.
How STIMUCART 50MG TABLET works?
STIMUCART 50MG TABLET belongs to proteoglycan synthesis stimulator which works by building cartilage (soft connective tissue around the joints) leading to joint repair. It also lowers pain and inflammation (swelling).
Does STIMUCART 50MG TABLET cause liver damage?
Yes. STIMUCART 50MG TABLET may increase the risk of liver injury. If you experience any unusual symptoms like tiredness, anorexia, yellowish discoloration of skin and white of eyes (jaundice), abdominal pain, nausea, vomiting, change in stool and urine colour, itchy skin. Stop taking STIMUCART 50MG TABLET and immediately consult your doctor.
References
1. Pavelka K, Bruyere O, Cooper C, Kanis JA, Leeb BF, Maheu E, Martel-Pelletier J, Monfort J, Pelletier JP, Rizzoli R, Reginster JY. Uses and mechanism of Diacerein. National Institute of Health. National Library of Medicine. National Center for Biotechnology Information. Pubmed.gov. February 2016. [Accessed on 7th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756045/
2. Solignac M. Les. Mechanism of action of Diacerein. National Institute of Health. National Library of Medicine. National Center for Biotechnology Information. Pubmed.gov. May 2004. [Accessed on 7th May 2022] https://pubmed.ncbi.nlm.nih.gov/15226683/
3. Diacerein. European Medical Agency. [Accessed on 7th May 2022] https://www.ema.europa.eu/en/documents/referral/diacerein-article-31-referral-annex-iii_en.pdf
4. Diacerein. Mims.com. [Accessed on 7th May 2022] https://www.mims.com/india/drug/info/diacerein?type=full&mtype=generic#special-precautions
5. Israel pharmaceutical products. Diacerein. [Accessed on 7th May 2022] https://mohpublic.z6.web.core.windows.net/IsraelDrugs/ArcRishum01_1_158963216.pdf
6. Trima Israel Pharmaceutical Products Ltd. Diacerein. [Accessed on 7th May 2022] https://mohpublic.z6.web.core.windows.net/IsraelDrugs/ArcRishum01_6_164528016.pdf
7. Wellona pharma. Diacerein. [Accessed on 7th May 2022] https://wellonapharma.com/product/finished/diacerein-capsules
8. Diacerein. CDSCO. [Accessed on 6th May 2022] https://cdscoonline.gov.in/CDSCO/Drugs
Useful Diagnostic Tests
- Calcium
- Rheumatoid Factor IgG Antibody
- Rheumatoid Factor IgM Antibody
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