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Introduction About STAFLOWIN 500 INJECTION
STAFLOWIN 500 INJECTION contains Flucloxacillin that belongs to the group of medicines called the Antibiotics. It is used to manage wide range of bacterial infections in the chest (pneumonia, emphysema, lung abscess), tonsils (tonsillitis, quinsy), throat (pharyngitis), sinuses (sinusitis), ears (otitis media, otitis externa), skin & soft tissues (boils, abscesses, carbuncles, impetigo, cellulites, furunculosis, ulcers, acne), wounds, burns, heart (endocarditis), bones & joints (osteomyelitis), membranes of the brain (meningitis), gut (enteritis), blood (septicaemia), kidney, bladder, or the urethra.
STAFLOWIN 500 INJECTION is also used to manage infections occurring after skin grafting or during major surgeries, especially heart or orthopaedic surgery.
A bacterial infection occurs when the bacteria invade the body's defences, increase in number, and cause abnormal reactions in the body such as fever, lymph node swelling, inflammation of the skin, pain (in the heart, muscles, bones, and joints), generalised weakness, cough, soreness, and a burning sensation while urinating. The bacterial infection can become fatal if it spreads widely in the blood.
STAFLOWIN 500 INJECTION is not recommended for use in patients allergic to flucloxacillin, cephalosporins, or other antibiotics. STAFLOWIN 500 INJECTION is also not recommended for use if you have a history of liver diseases such as jaundice after taking flucloxacillin.
STAFLOWIN 500 INJECTION should be used with caution in patients who are being managed for liver problems, kidney problems such as severe kidney failure, or heart problems. STAFLOWIN 500 INJECTION should be used with caution by pregnant and breastfeeding women. STAFLOWIN 500 INJECTION should be used with caution in children and adolescents (below 14 years) and elderly patients (aged 50 years or above). Consult your doctor before taking it.
The common side effects associated with the use of STAFLOWIN 500 INJECTION are minor abdominal disturbances such as stomach upset or diarrhoea. Contact your doctor or a nearby hospital if any of the symptoms worsen.
Uses Of STAFLOWIN 500 INJECTION
It is used to manage wide range of bacterial infections in conditions such as:
- chest (pneumonia, emphysema, lung abscess)
- tonsils (tonsillitis, quinsy)
- throat (pharyngitis)
- sinuses (sinusitis)
- ears (otitis media, otitis externa)
- skin & soft tissues (boils, abscesses, carbuncles, impetigo, cellulites, furunculosis, ulcers, acne)
- wounds
- burns
- heart (endocarditis)
- bones & joints (osteomyelitis)
- membranes of the brain (meningitis)
- gut (enteritis)
- blood (septicaemia)
- kidney
- bladder
- urethra (the tube which carries urine from the bladder)
It is also used to manage infections in conditions such as:
- after skin grafting
- during major surgeries especially heart or orthopaedic surgery
How STAFLOWIN 500 INJECTION Works
STAFLOWIN 500 INJECTION manages the bacterial infection where Flucloxacillin binds to specific sites in the bacterial cell wall and inhibits its process of cell wall synthesis and then kills the bacteria by mediating certain enzymes into it, thereby causing the destruction of the bacterial cell.
How to use STAFLOWIN 500 INJECTION
STAFLOWIN 500 INJECTION will be given to you only by a doctor or a nurse into muscle (intramuscular) or into a vein (intravenous). It can also be given to you by injection into a joint, injection into the lining of the lung, or by breathing in the medicine from a mask (nebuliser). Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of STAFLOWIN 500 INJECTION
Common
- minor abdominal disturbances such as stomach upset or diarrhoea
Stop taking STAFLOWIN 500 INJECTION and contact your doctor if you experience any of the following side effects:
- severe diarrhoea with bleeding
- yellowing of eyes and skin
- dark urine faeces
- any unusual bleeding or bruising or skin discolouration
- convulsions (fits) at high doses
- signs of anaemia (low red blood cell count) such as tiredness, breathlessness, light-headedness, a rapid weak pulse, awareness of heartbeat, or headaches
- skin rashes and itching
- blisters in skin, mouth, eyes, or genitals
- sudden wheezing (noisy breathing), difficulty in breathing, or dizziness
- any swelling in face, tongue, or neck
- serious skin reactions
- exanthematous pustulosis (a red scaly rashes and blisters)
How To Manage Side Effects
Diarrhea
Drink lots of fluids, such as water to keep yourself hydrated. Try to avoid taking any medicine on your own to manage diarrhoea and consult your doctor if the symptom gets worse.
Stomach Pain
Try to eat more high-fibre foods such as fresh fruit, vegetables, cereals, and drink plenty of water. Try doing exercise regularly (going for a daily walk or run). If this does not help, inform your doctor for receiving alternate managements for constipation.
Warning & Precautions
Pregnancy
Use with CautionSTAFLOWIN 500 INJECTION should be used with caution if you are pregnant or planning to have a baby. Consult your doctor before taking it.
Breastfeeding
Use with CautionSTAFLOWIN 500 INJECTION should be used with caution in breastfeeding women. Consult your doctor taking it.
Kidney
Use with CautionSTAFLOWIN 500 INJECTION is used with caution in patients being managed for kidney problems such as severe kidney failure. In such cases, the doctor may lower or fewer your dose. Consult your doctor before taking it.
Liver
Consult your doctorSTAFLOWIN 500 INJECTION is not recommended for use in patients with the history of liver diseases such as jaundice (yellowing of skin and the whites of the eyes) after taking flucloxacillin. It should be used with caution in patients who are being managed for liver problems. Consult your doctor before taking it.
Allergy
ContraindicatedSTAFLOWIN 500 INJECTION is not recommended for use in patients allergic to flucloxacillin, cephalosporins, or other antibiotics. Consult your doctor before taking it.
Heart Disease
Use with CautionSTAFLOWIN 500 INJECTION is used with caution in patients being managed for heart problems. Consult your doctor before taking it.
Use In Pediatrics
Use with CautionSTAFLOWIN 500 INJECTION should be used with caution in children and (below 14 years). Consult your doctor before taking it.
Use In Geriatrics
Use with CautionSTAFLOWIN 500 INJECTION should be used with caution in elderly patients (aged 50 years or above). Consult your doctor before taking it.
Others
Before taking STAFLOWIN 500 INJECTION, inform your doctor if you:
- have any serious illness except from the infection for which this management is undertaken
- are taking sodium-restricted diet
- have history of swelling of the face or skin rash while taking an antibiotic
- are getting managed for infections such as syphilis or leptospirosis
- have porphyria (a disorders causing build-up of porphyrin in the body)
- are a carrier of the HLA-B* 5701 allele (gene that increases that makes you susceptible to get allergic reactions with certain drugs such as abacavir)
Interactions
A. Drug-Drug Interactions:
Before taking STAFLOWIN 500 INJECTION, inform your doctor, if you are taking any of the following medicine:
- medicines used to manage gout Ex. probenecid, sulfinpyrazone
- methotrexate (medicine used to manage cancer)
- other types of antibacterial managements such as bacteriostatic agents Ex. chloramphenicol or tetracyclines (Ex. doxycycline)
- paracetamol (medicine used to manage fever)
Overdosage:
STAFLOWIN 500 INJECTION will be given to you only by a doctor or nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor if you experience any unusual symptoms.
Synopsis
| Drug | : | Flucloxacillin |
| Pharmacological Category | : | Antibiotic |
| Therapeutic Indication | : | Bacterial infections |
| Dosage Forms | : | Tablet, Injection |
More Information
- Keep the medicine out of reach of children
- Store STAFLOWIN 500 INJECTION at room temperature
FAQs About STAFLOWIN 500 INJECTION
Q: What is STAFLOWIN 500 INJECTION used for?
A: STAFLOWIN 500 INJECTION is used to manage a wide variety of bacterial infections of the chest (pneumonia, emphysema, lung abscess), tonsils (tonsillitis, quinsy), throat (pharyngitis), sinuses (sinusitis), ears (otitis media, otitis externa), skin & soft tissues (boils, abscesses, carbuncles, impetigo,STAFLOWIN 500 INJECTION is also used to manage infections occurring after skin grafting or during major surgeries, especially heart or orthopaedic surgery.
Q: What happens if you take more STAFLOWIN 500 INJECTION than your required dose?
A: STAFLOWIN 500 INJECTION will be given to you only by a doctor or nurse in a hospital, and so it is unlikely that you will receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.
Q: What side effects are seen with STAFLOWIN 500 INJECTION?
A: The common side effects associated with the use of STAFLOWIN 500 INJECTION are minor abdominal disturbances such as stomach upset or diarrhoea. Contact your doctor or a nearby hospital if any of the symptoms worsen.
Q: Who should avoid taking STAFLOWIN 500 INJECTION?
A: STAFLOWIN 500 INJECTION is not recommended for use in patients allergic to flucloxacillin, cephalosporins, or other antibiotics. STAFLOWIN 500 INJECTION is also not recommended for use if you have a history of liver diseases such as jaundice after taking flucloxacillin. Consult your doctor before taking.
Q: How does STAFLOWIN 500 INJECTION work?
A: STAFLOWIN 500 INJECTION manages the bacterial infection where Flucloxacillin binds to specific sites in the bacterial cell wall and inhibits its process of cell wall synthesis and then kills the bacteria by mediating certain enzymes into it, thereby causing the destruction of the bacterial cell.
Q: What is the method of taking STAFLOWIN 500 INJECTION?
A: STAFLOWIN 500 INJECTION will be given to you only by a doctor or a nurse and will be injected into a muscle (intramuscular) or into a vein (intravenous). STAFLOWIN 500 INJECTION can also be given to you by injection into a joint, injection into the lining of the lung, or by breathing in the medicine from a mask (a nebulizer). Your doctor will determine the correct dose and duration for you depending upon your age, body weight, and disease condition.
Q: Is STAFLOWIN 500 INJECTION safe to be used in children and elderly patients?
A: STAFLOWIN 500 INJECTION should be used with caution in children and adolescents (below 14 years of age) and elderly patients (aged 50 years or above) to avoid any potential side effects. Consult your doctor before taking STAFLOWIN 500 INJECTION.
Q: Is STAFLOWIN 500 INJECTION safe to be used in patients with liver disease?
A: STAFLOWIN 500 INJECTION is not recommended for use in patients with a history of liver diseases such as jaundice (yellowing of the skin and the whites of the eyes) after taking flucloxacillin. It should be used with caution in patients who are being managed for liver problems. Consult your doctor before taking STAFLOWIN 500 INJECTION.
Q: Is STAFLOWIN 500 INJECTION safe to be used in kidney patients?
A: STAFLOWIN 500 INJECTION is used with caution in managing patients. In such cases, the doctor may lower or reduce your dose. Consult your doctor before taking STAFLOWIN 500 INJECTION.
Q: Is STAFLOWIN 500 INJECTION safe to be used by pregnant or breastfeeding women?
A: STAFLOWIN 500 INJECTION should be used with caution if you are pregnant or planning to become pregnant, and with caution in women who are breastfeeding their babies. Consult your doctor before taking STAFLOWIN 500 INJECTION.
References
1. Andrew Kingsnorth, Aljafri Majid. Infections in Surgery. Principles of Surgical Practice. 2001. Page – 328.
2. Nick A. Francis, Kerenza Hood, Ronan Lyons, Christopher C. Understanding flucloxacillin prescribing trends and treatment non-response in UK primary care: a Clinical Practice Research Datalink (CPRD) study. NIH National Library of Medicine. National Centre for Biotechnology Information. PubMed Central (PMC). [Assessed on 11th August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896409/
3. Istituto Biochimico Italiano S.p.A. Electronic Medicines Compendium (EMC). [Revised in February 2021] [Assessed on 11th August 2022] https://www.medicines.org.uk/emc/files/pil.8745.pdf
Useful Diagnostic Tests
- Kidney Function Test
- Liver Function Test
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