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Sun Pharmaceutical Industries Ltd

Sompraz D 40mg Capsule 15'S

Ulcer/Reflux/Flatule...
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    Introduction About SOMPRAZ D 40MG CAPSULE

    Sompraz D 40mg Capsule is a medication used to manage acid reflux, heartburn, GERD, and stomach ulcers. It contains two active ingredients such as domperidone and esomeprazole which work together to reduce acid secretion and improve digestion.

    Sompraz D 40 Capsule should be taken as prescribed by your doctor, typically on an empty stomach. The dosage and duration will vary depending on your condition and how you respond to the medication. It is important to continue the management for as long as recommended by your doctor, as stopping too soon may cause your symptoms to return or worsen. Be sure to inform your doctor about any other medications you are taking, as some may interact with this medicine.

    Common side effects of Sompraz D 40mg Capsule include headache, stomach pain, diarrhea or constipation, flatulence (gas), skin rash or irritation, dryness in mouth. Most of these side effects are temporary and typically resolve over time. However, if you are concerned about any of them, contact your doctor immediately. This medication may also cause drowsiness and dizziness, so avoid driving or engaging in activities that require focus until you are familiar with how it affects you. It is also important to refrain from drinking alcohol while using this medication, as it can increase sleepiness. To improve results, consider lifestyle changes such as drinking cold milk and avoiding hot tea, coffee, spicy foods, or chocolate.

    Before taking this medication, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Additionally, let your doctor know if you have any liver conditions so that they can adjust the dosage accordingly.

    Uses Of SOMPRAZ D 40MG CAPSULE

    • Acid reflux
    • Heartburn
    • GERD
    • Stomach ulcers

    Benefits of SOMPRAZ D 40MG CAPSULE

    1. Manages Acid Reflux: Helps reduce acid production in the stomach, providing relief from heartburn.
    2. Manages Stomach Ulcers: Reduces the likelihood of ulcers and promotes healing in the stomach lining.
    3. Relieves GERD Symptoms: Effective in managing gastroesophageal reflux disease (GERD) symptoms.
    4. Supports Digestive Health: Reduces bloating, nausea, and indigestion caused by excessive stomach acid.

    How SOMPRAZ D 40MG CAPSULE Works

    Domperidone is a dopamine antagonist that works by increasing the movement of the stomach and intestines, helping to relieve symptoms like nausea, vomiting, and bloating. Esomeprazole is a proton pump inhibitor (PPI) that reduces the production of stomach acid by blocking the proton pumps in the stomach lining, thus helping to treat conditions like acid reflux, GERD (gastroesophageal reflux disease), and ulcers. Together, they work synergistically to alleviate digestive discomfort, improve gastric motility, and reduce acid-related issues.

    How to use SOMPRAZ D 40MG CAPSULE

    Follow your doctor's instructions regarding the exact dosage. Do not exceed the recommended daily dosage.

    How to Take Sompraz D 40mg Capsule?

    • Take one capsule per day at least 30 minutes before a meal to allow for proper absorption
    • Swallow the tablet whole with a glass of water. Do not crush or chew the medication.
    • For best results, take the tablet at the same time each day.

    What if I forgot to take SOMPRAZ D 40MG CAPSULE

    • If you forget to take your dose, take it as soon as you remember.
    • Do not take two doses to make up for a missed dose. This could increase your risk of side effects.
    • If it is almost time for your next dose, skip the missed dose and take your regular dose at the usual time.

    Side Effects Of SOMPRAZ D 40MG CAPSULE

    Like all medicines, Sompraz D 40mg Capsule may cause certain side effects in some individuals, although not everybody gets them.

    The most common side effects of taking Sompraz D 40mg Capsule are:

    • Headache
    • Stomach pain
    • Diarrhea
    • Constipation
    • Flatulence (gas)
    • Skin rash or irritation
    • Dryness in mouth

    When to consult your doctor?

    • Allergic Reactions symptoms such as swelling of the face, lips, tongue, or throat, difficulty breathing, rash, or itching
    • Severe Dizziness or Lightheadedness
    • Severe Abdominal Pain
    • Severe chest Pain or Tightness
    • Severe Vomiting or Diarrhea
    • Liver Problems symptoms such as yellowing of the skin or eyes (jaundice), dark urine, unexplained fatigue or weakness and loss of appetite
    • Irregular Heartbeat or Palpitations
    • Movement Disorders (Dystonia, Tremors) symptoms such as involuntary muscle movements, tremors, or stiffness
    • Severe Skin Rash or Blistering
    • Mental/Mood Changes symptoms such as confusion, agitation, or hallucinations

    How To Manage Side Effects

    Diarrhea

    • Drink Fluids: Drink clear fluids such as water, broths, and oral rehydration solutions (ORS).
    • Electrolytes: If you are losing a lot of fluids (for example, from frequent diarrhea), consider drinking an electrolyte solution to help replenish lost minerals like potassium and sodium.
    • BRAT Diet: Try to take Bananas, Rice (white rice), Apple sauce and Toast (plain, without butter) to control diarrhoea management.
    • Avoid Certain Foods: While recovering avoid the following food items such as fatty, greasy, or fried foods, spicy foods, dairy products (especially if you have a temporary lactose intolerance), caffeinated drinks and alcohol and artificial sweeteners like sorbitol.
    • Over-the-Counter Medications: You can take over-the-counter anti-diarrheal medications such as loperamide, Bismuth subsalicylate if appropriate for you. Follow the recommended dosage.

    Headache

    • Rest in a Quiet, Dark Room: Find a calm, quiet space away from bright lights and loud noises. Lie down and close your eyes.
    • Hydrate: Dehydration can contribute to headaches, so drink plenty of water.
    • Apply a Cold or Warm Compress: A cold pack on your forehead may reduce pain, or a warm compress on your neck or shoulders can relieve tension.
    • Over-the-Counter Pain Relief: You can take over-the-counter pain relievers like acetaminophen or ibuprofen if appropriate for you. Follow the recommended dosage.
    • Practice Relaxation Techniques: Deep breathing exercises, meditation, or gentle stretching can help reduce stress and alleviate headache symptoms.

    Warning & Precautions

    Pregnancy

    Monitoring required

    Sompraz D 40mg Capsule should be used in pregnant women only if it is considered necessary by the physician. Therefore, consult your doctor before taking it.

    Breastfeeding

    Monitoring required

    Sompraz D 40mg Capsule may pass through breast milk. Therefore, it is not recommended for use in breastfeeding women unless considered necessary by the physician.

    Driving and Using Machines

    Use with Caution

    Sompraz D 40mg Capsule does not affect your ability in driving or handling heavy tools or machines. However, do not drive or handle heavy tools or machines if your ability is affected by Sompraz D 40mg Capsule.

    Alcohol

    Consult your doctor

    Avoid consumption of alcohol while taking Sompraz D 40mg Capsule, as it could aggravate your existing condition.

    Kidney

    Use with Caution

    Sompraz D 40mg Capsule should be used with caution in patients with kidney problems. Therefore, consult your doctor before taking it.

    Liver

    Consult your doctor

    Sompraz D 40mg Capsule is not recommended for use in patients with moderate or severe liver impairment. It should be used with caution in patients with other mild liver problems. Therefore, consult your doctor before taking it.

    Allergy

    Contraindicated

    Do not take this medicine if you are allergic to Domperidone or Esomeprazole or to any other proton pump inhibitors (such as rabeprazole, pantoprazole).

    Heart Disease

    Contraindicated

    Sompraz D 40mg Capsule is not recommended for use in patients having heart problems (such as prolongation of QT wave, congestive heart failure or arrhythmia). Therefore, consult your doctor before taking it.

    Use In Pediatrics

    Contraindicated

    Sompraz D 40mg Capsule is not recommended for use in children and adolescents (aged below 18 years) due to lack of safety data. Consult your pediatrician before taking it.

    Use In Geriatrics

    Use with Caution

    Sompraz D 40mg Capsule should be used with caution in elderly patients (aged 65 years and above). Therefore, consult your doctor before taking it.

    Other Warnings for SOMPRAZ D 40MG CAPSULE

    Before taking Sompraz D 40mg Capsule inform your doctor if you:

    • have osteoporosis
    • have vitamin B12 deficiency (sore tongue, mouth ulcers, pale skin, depression)
    • are going to test Chromogranin A level

    Who should not take [GBNKEYWORD

    Sompraz D 40mg Capsule is not recommended for use if you:

    • have bloody stools or bleeding in the gut
    • have blockage or tear in the intestines
    • have severe fluid or electrolyte disturbances
    • have prolactinoma (a non-cancerous tumor of pituitary gland)
    • have low blood potassium or magnesium levels
    • have hyperkalemia (high blood potassium levels)

    Safety Advice

    • Follow your doctor's instructions regarding the exact dosage.
    • Do not exceed the recommended daily dosage.
    • Take one capsule per day at least 30 minutes before a meal to allow for proper absorption
    • Swallow the tablet whole with a glass of water. Do not crush or chew the medication.
    • For best results, take the tablet at the same time each day.
    • Let your doctor know if you are in pregnancy or breastfeeding women.
    • If you have liver or kidney problems, it's important to consult your doctor before taking Sompraz D 40mg Capsule, as they may need to adjust the dosage.
    • Avoid alcohol while taking this medication, as it can increase the risk of side effects.
    • If you do not feel better after taking it for 14 days, inform your doctor, as you might be dealing with another issue that requires attention.
    • Prolonged use can lead to weakened bones and a deficiency in minerals like magnesium. Ensure you have an adequate intake of calcium and magnesium through your diet or supplements, as recommended by your doctor.

    Diet and Lifestyle Advice

    Dietary Advice:

    Dietary Recommendation

    Explanation

    Avoid Spicy Foods

    Spicy foods can irritate the stomach lining and worsen acid reflux symptoms.

    Limit Acidic Foods

    Foods like citrus fruits, tomatoes, and vinegar can increase acid production.

    Eat Small, Frequent Meals

    Smaller meals reduce the burden on the stomach and prevent acid reflux.

    Avoid Fatty Foods

    High-fat foods, such as fried foods, can relax the lower esophageal sphincter, leading to acid reflux.

    Limit Caffeine

    Caffeine can increase stomach acid production and relax the esophageal sphincter.

    Avoid Carbonated Beverages

    Carbonated drinks can increase gas and bloating, leading to discomfort.

    Stay Hydrated

    Drink plenty of water to help with digestion and prevent acid buildup.

    Incorporate Fiber-rich Foods

    Fiber helps with digestion and can prevent constipation, which can exacerbate acid reflux.

    Opt for Lean Proteins

    Choose lean meats like chicken, turkey, and fish to avoid excessive fat intake.

    Include Non-Citrus Fruits

    Apples, bananas, and melons are gentle on the stomach and are less likely to trigger acid reflux.

    Limit Chocolate

    Chocolate can trigger acid reflux due to its caffeine and fat content.

    Avoid Alcohol

    Alcohol can irritate the stomach lining and increase acid production.

    02. Exercise Tips:

    Exercise Type

    Description

    Benefits

    Timing/Duration

    Walking after meals

    Taking a light walk (5-10 minutes) after eating.

    Improves digestion, prevents bloating, reduces blood sugar spikes.

    Post-meal, 5-10 minutes.

    Yoga (specific poses)

    Poses like Child’s Pose, Seated Twist, and Cat-Cow for digestion.

    Reduces stress, enhances gut movement, relieves bloating.

    10-20 minutes daily.

    Gentle stretching

    Slow, full-body stretches, focusing on torso and abdomen.

    Relieves tension, supports digestion, and improves circulation.

    10-15 minutes, any time of day.

    Deep breathing exercises

    Focused diaphragmatic breathing (inhale through nose, exhale through mouth).

    Enhances gut motility, reduces stress, and improves gut health.

    5-10 minutes, especially after meals.

    Cycling (light)

    Light cycling or stationary biking.

    Promotes gut movement, supports metabolism, increases circulation.

    15-30 minutes, 3-4 times a week.

    Swimming (easy strokes)

    Low-impact swimming with gentle strokes.

    Relieves pressure on the gut, improves circulation, supports digestion.

    20-30 minutes, 2-3 times a week.

    Tai Chi

    Slow, flowing movements focusing on balance and coordination.

    Reduces stress, enhances digestion, improves balance and circulation.

    20-30 minutes daily.

    Drug - Drug interaction

    Before taking Sompraz D 40mg Capsule, inform your physician if you are currently taking any of the following medications including over-the-counter drugs or supplements.

    1. Interactions with Other Proton Pump Inhibitors (PPIs):

    • Interaction: Other PPIs like esomeprazole, lansoprazole, or pantoprazole can have additive effects when taken with Sompraz D, leading to excessive reduction in gastric acid.
    • Effect: This could result in nutrient malabsorption, such as vitamin B12 or magnesium deficiency.
    • Management: Monitor for deficiencies in long-term use. It may be advisable to avoid combining multiple PPIs unless specifically instructed by a healthcare provider.

    2. Interaction with Antacids:

    • Interaction: Taking antacids containing magnesium or aluminum may interfere with the absorption of omeprazole and reduce the effectiveness of Sompraz D.
    • Effect: Reduced efficacy in controlling acid reflux or peptic ulcers.
    • Management: It’s advised to space out the timing between antacids and Sompraz D by at least 1-2 hours.

    3. CYP2C19 Inhibitors (e.g., Fluconazole, Clopidogrel):

    • Interaction: Omeprazole is metabolized by the enzyme CYP2C19. Drugs like fluconazole or clopidogrel that inhibit this enzyme can increase the blood levels of omeprazole.
    • Effect: Higher levels of omeprazole may lead to excessive suppression of gastric acid, increasing the risk of gastrointestinal infections or malabsorption.
    • Management: If such drugs are needed, adjust the dose of Sompraz D or use an alternative PPI if clinically indicated. Close monitoring is necessary.

    4. Domperidone and Anticholinergic Drugs (e.g., Antihistamines, Antidepressants):

    • Interaction: Domperidone’s action may be antagonized by anticholinergic medications.
    • Effect: The effectiveness of domperidone in improving gastric motility could be reduced.
    • Management: Consider alternative treatments or adjust dosages to avoid compromising domperidone’s effect.

    5. Domperidone and QT Prolonging Drugs (e.g., Amiodarone, Erythromycin):

    • Interaction: Domperidone has been linked to QT prolongation, and drugs that also have this effect can increase the risk of arrhythmias.
    • Effect: Potentially severe cardiac arrhythmias, including torsades de pointes.
    • Management: Avoid co-administration with QT-prolonging drugs, or monitor ECG if their use is necessary.

    6. Domperidone and CYP3A4 Inhibitors (e.g., Ketoconazole, Ritonavir):

    • Interaction: Drugs that inhibit CYP3A4 (which metabolizes domperidone) can increase the concentration of domperidone in the bloodstream.
    • Effect: Higher domperidone levels may elevate the risk of side effects such as cardiac arrhythmias.
    • Management: If combined use is essential, reduce the dose of domperidone and monitor for adverse effects.

    7. Warfarin (Anticoagulants):

    • Interaction: Omeprazole can enhance the anticoagulant effect of warfarin by inhibiting its metabolism, potentially leading to increased INR (International Normalized Ratio).
    • Effect: Increased risk of bleeding.
    • Management: Monitor INR closely and adjust warfarin dosage as needed.

    8. Methotrexate (High-Dose Therapy):

    • Interaction: Omeprazole can increase the blood levels of methotrexate, especially when given in high doses.
    • Effect: Toxicity from methotrexate, including kidney damage.
    • Management: Consider temporary discontinuation of Sompraz D or monitoring for methotrexate toxicity, depending on the clinical situation.

    9. HIV Protease Inhibitors (e.g., Atazanavir):

    • Interaction: Omeprazole can decrease the absorption of protease inhibitors like atazanavir, reducing their efficacy.
    • Effect: Reduced effectiveness of HIV treatment.
    • Management: Avoid combining Sompraz D with HIV protease inhibitors if possible, or adjust the HIV medication regimen as necessary.

    10. Cyclosporine:

    • Interaction: Omeprazole can alter the absorption of cyclosporine, potentially leading to increased blood levels.
    • Effect: Increased risk of cyclosporine toxicity.
    • Management: Monitor cyclosporine levels and adjust the dose accordingly.

    Synopsis

    Drug :   Domperidone, Esomeprazole
    Pharmacological Category :   Dopamine antagonist, Proton-pump inhibitor
    Therapeutic Indication :   GERD, Peptic ulcer, Zollinger-Ellison syndrome Acidity, Heartburn, Indigestion           
    Dosage Forms :   Tablet, Capsule

    More Information

    01. Could you provide a comparison between Sompraz D and other similar medications like Prilosec and Pan tablets, focusing on their effectiveness, side effects, and cost?

    Aspect

    Sompraz D

    Prilosec Tablet

    Pan Tablet

    Generic Name

    Esomeprazole & Domperidone

    Omeprazole

    Pantoprazole

    Brand Name

    Sompraz D

    Prilosec

    Pan

    Type of Medication

    Proton pump inhibitor & antiemetic

    Proton pump inhibitor

    Proton pump inhibitor

    Uses

    GERD, acid reflux, gastric ulcers, nausea

    GERD, heartburn, ulcers, Zollinger-Ellison syndrome

    GERD, acid reflux, ulcers

    Mechanism of Action

    Pantoprazole reduces acid, Domperidone improves motility

    Omeprazole reduces stomach acid production

    Pantoprazole reduces stomach acid production

    Effectiveness

    High effectiveness in managing acid reflux & nausea

    High effectiveness for acid reflux & ulcers

    Effective in treating acid reflux and ulcers

    Onset of Action

    30–60 minutes

    1 hour (oral)

    30–60 minutes

    Duration of Action

    24 hours

    24 hours

    24 hours

    Side Effects

    Common: Headache, dizziness, nausea, diarrhea, constipation

    Common: Headache, nausea, diarrhea, abdominal pain

    Common: Headache, nausea, abdominal pain, dizziness

    Serious Side Effects

    Long-term use can cause bone fractures, kidney issues

    Risk of bone fractures, kidney problems with prolonged use

    Similar risks to long-term use as Sompraz D & Prilosec

    Cost (Approx.)

    ? 100–200 per pack (30 tablets)

    ? 150–300 per pack (28 tablets)

    ? 50–100 per pack (30 tablets)

    Prescription Required

    Yes

    Yes

    Yes

    FDA Approval

    Yes

    Yes

    Yes

    02. Is Sompraz D better than other heartburn medications like Zantac or Nexium?

    When comparing Sompraz D with other heartburn medications like Zantac (ranitidine) and Nexium (Esomeprazole), there are a few factors to consider:

    1. Mechanism of Action:
      • Sompraz D: Esomeprazole works by reducing stomach acid production, while Domperidone helps with gastric emptying and prevents nausea. The combination is particularly useful for people who suffer from both acid reflux and delayed gastric emptying.
      • Zantac (Ranitidine): Zantac is an H2 blocker that reduces acid production by blocking histamine receptors in the stomach. It works differently from PPIs like Esomeprazole and is usually less potent.
      • Nexium (Esomeprazole): Nexium is a PPI like Esomeprazole in Sompraz D, and it is typically used for reducing stomach acid production. It is generally more effective at suppressing acid than H2 blockers like Zantac.
    2. Effectiveness:
      • Sompraz D may be more effective for people who experience both heartburn and gastrointestinal motility issues (delayed stomach emptying or nausea). The Domperidone component can be particularly beneficial in these cases.
      • Nexium is a stronger PPI and may provide more potent acid suppression than Zantac and is often used for conditions like GERD (gastroesophageal reflux disease).
      • Zantac may be effective for mild to moderate heartburn but typically doesn't suppress acid production as effectively as PPIs.
    3. Side Effects:
      • Sompraz D: Esomeprazole can have side effects like headaches, diarrhea, and potential long-term risks if used for extended periods (e.g., osteoporosis, kidney issues). Domperidone may cause side effects like dry mouth, dizziness, or an increased risk of heart problems in certain people.
      • Zantac: While Zantac was commonly used for heartburn, recent concerns about its safety (due to potential links to cancer-causing substances) have led to its removal from the market in some regions.
      • Nexium: Similar to other PPIs, it may cause side effects like stomach infections, magnesium deficiency, and potential kidney problems with long-term use.
    4. Target Use:
      • Sompraz D is often prescribed for people with more complex symptoms, such as those who experience both acid reflux and gastric motility issues.
      • Zantac is usually used for milder forms of heartburn, though it is being phased out in some places due to safety concerns.
      • Nexium is effective for long-term acid suppression and is used in treating conditions like GERD, ulcers, and Zollinger-Ellison syndrome.

    Conclusion:

    • Sompraz D may be more suitable for individuals who need both acid suppression and help with gastric motility (like nausea or delayed stomach emptying).
    • Nexium is generally considered more effective for acid suppression than Zantac, making it a good choice for more severe or chronic heartburn.
    • Zantac, while effective for milder heartburn, has safety concerns and is no longer widely recommended.

    FAQs About SOMPRAZ D 40MG CAPSULE

    Q: What is Sompraz D 40mg Capsule used for?

    A: Sompraz D 40mg Capsule contains a combination of Domperidone and Esomeprazole. It is primarily used to manage symptoms of acid reflux, heartburn, and other digestive disorders like gastroesophageal reflux disease (GERD). It helps to reduce stomach acid and alleviate nausea and vomiting.

    Q: How does Sompraz D 40mg Capsule work?

    A: Sompraz D 40mg Capsule works by combining two active ingredients: Esomeprazole, which reduces the production of stomach acid, and Domperidone, which helps in improving the movement of food through the stomach and intestines, preventing nausea and vomiting.

    Q: What are the side effects of Sompraz D 40mg Capsule?

    A: Common side effects of Sompraz D 40mg Capsule may include headache, dizziness, diarrhea, or abdominal discomfort. If any severe reactions occur, such as allergic reactions, skin rash, or swelling, consult your doctor immediately.

    Q: Can I take Sompraz D 40mg Capsule with other medications?

    A: Sompraz D 40mg Capsule may interact with other medications. Always inform your healthcare provider about any other medications or supplements you are taking to avoid any potential interactions.

    Q: Is Sompraz D 40mg Capsule safe during pregnancy?

    A: Sompraz D 40mg Capsule should only be used during pregnancy if prescribed by a doctor. The safety of its use during pregnancy has not been fully established, so it is essential to consult a healthcare professional before taking it.

    Q: How should I take Sompraz D 40mg Capsule?

    A: It is typically taken once daily, preferably in the morning, before food. Swallow the capsule whole with a glass of water. Follow your doctor's instructions for the dosage and duration of treatment.

    Q: Can Sompraz D 40mg Capsule be used for managing indigestion?

    A: Yes, Sompraz D 40mg Capsule can help manage indigestion by reducing acid production and improving the movement of food through the digestive system, thus relieving discomfort associated with indigestion.

    Q: What should I do if I miss a dose of Sompraz D 40mg Capsule?

    A: If you miss a dose, take it as soon as you remember unless it's almost time for the next dose. Do not take two doses at once to make up for the missed dose. Consult your healthcare provider for advice if you miss a dose regularly.

    Q: Can Sompraz D 40mg Capsule cause weight gain or loss?

    A: Weight changes are not common side effects of Sompraz D 40mg Capsule. However, any unusual changes in your weight or appetite should be discussed with your doctor.

    Q: What should I do if I experience severe side effects while taking Sompraz D 40mg Capsule?

    A: If you experience severe side effects such as persistent abdominal pain, chest pain, or difficulty breathing, seek immediate medical help. It is important to discuss any concerns with your doctor.

    Q: What is the difference between Sompraz D and Sompraz 20mg?

    A: Sompraz D is a combination medication containing Domperidone and Esomeprazole, used for conditions like GERD and nausea. Sompraz 20mg contains only Esomeprazole (a proton pump inhibitor), used to treat acid-related issues like heartburn and ulcers.

    Q: Can Sompraz D 40mg Capsule be used long-term?

    A: Sompraz D should not be used long-term unless directed by a doctor. Long-term use can lead to potential side effects, such as vitamin B12 deficiency, bone issues, and other complications.

    Q: What should I do if I accidentally overdose on Sompraz D 40mg Capsule?

    A: If you accidentally overdose, contact a doctor immediately or go to the nearest emergency department. Symptoms of an overdose may include dizziness, nausea, and rapid heart rate.

    References

    1. KD. Tripathi. Antiemetic, Prokinetic and Digestant drugs & Drugs for Peptic Ulcer and Gastroesophageal Reflux Disease. Essentials of medical pharmacology. Seventh edition. 2013. Page-666 & 651-653.
    2. Keith A. Sharkey and John L. Wallace. Treatment of disorders of bowel motility and water flux; Antiemetics; Agents used in biliary and pancreatic disease and Pharmacotherapy of gastric acidity, peptic ulcer, and gastroesophageal reflux disease. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page-1326 & 1311-1313.
    3. Gerald G. Briggs and Roger K. Freeman. D & E. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page-1232 & 1427-1431.
    4. KY Marakhouski, GA Karaseva, DN Ulasivich and Y Kh Marakhouski. Omeprazole-Domperidone Fixed Dose Combination vs Omeprazole Monotherapy: A Phase 4, Open-Label, Comparative, Parallel Randomized Controlled Study in Mild to Moderate Gastroesophageal Reflux Disease. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. May 2017. [Accessed on 7th March 2025]
    5. TORRENT PHARMACEUTICALS LTD. IZRA D. Torrentian.com. [Revised in February 2022] [Accessed on 7th March 2025]
    6. Cipla Ltd. ESOMAC-D Capsules (Esomeprazole magnesium + Domperidone). Ciplamed. [Revised in April 2020] [Accessed on 7th March 2025]
    7. Sun Pharmaceutical Industries Europe B.V., and Terapia SA. Electronic Medicines Compendium (EMC). [Revised in July 2022] [Accessed on 7th March 2025]
    8. Vibcare Pharma Pvt Ltd. ESOVIB DSR. [Accessed on 7th March 2025]

    Author Details

    Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)
    Reviewed For Accuracy By Dr. Vrushabhakumar Jitendra Shah. - MBBS
    Last updated on 07 Mar 2025 | 03:22 PM(IST)
    Lab updated