SITAPIL DM 500 Tablet 10's

Introduction About SITAPIL DM 500 TABLET

Dapagliflozin, Metformin and Sitagliptin is a triple combination medicine formulated for the management of high blood sugar levels in adults with type 2 diabetes mellitus. It brings together three scientifically proven ingredients: Metformin (a first-line blood sugar modulator), Dapagliflozin (a sodium-glucose cotransporter-2 inhibitor), and Sitagliptin (a DPP-4 inhibitor). This combined approach helps the body control excess glucose by improving insulin function, reducing glucose production in the liver, and promoting glucose loss through urine. It may be recommended for people whose blood sugar remains high on Metformin alone or with dual therapy, and who require a comprehensive yet convenient option. 

This medicine is usually taken once or twice daily with meals to reduce stomach discomfort and improve digestive tolerance. Your doctor will guide the exact dose based on blood sugar levels, previous treatments, and other medical conditions. It is vital to pair this medication with a balanced diet, regular physical activity, and routine blood sugar monitoring for best results. Avoid skipping meals, and stay well-hydrated to support kidney health. Do not crush or chew the tablets unless specified by your healthcare provider. 

Certain precautions are necessary with this combination. It is not advised during pregnancy or breastfeeding unless recommended by a doctor due to potential effects on the mother and baby. Regular kidney function tests, blood sugar checks, and vitamin B12 monitoring might be suggested during long-term use. Patients with a history of pancreatitis, severe dehydration, or ketoacidosis should avoid this medication unless advised otherwise. Limit alcohol intake as it may increase the risk of lactic acidosis (a rare but serious condition linked to Metformin).

Common side effects may include increased urination, nausea, stomach discomfort, loss of appetite, or mild urinary discomfort. Rarely, symptoms like severe abdominal pain, excessive thirst, or infections may occur and require medical attention. This triple-combination therapy offers an effective and research-backed way to support healthy blood sugar management for eligible patients who require multiple targets addressed in a single tablet or dosage form

Uses Of SITAPIL DM 500 TABLET

• Type II diabetes mellitus

Benefits of SITAPIL DM 500 TABLET

SITAPIL DM 500 TABLET for Blood Sugar Control

SITAPIL DM 500 TABLET is a powerful combination of three active ingredients Dapagliflozin, Metformin, and Sitagliptin designed to support effective blood sugar control in individuals with type 2 diabetes. This triple-action tablet helps manage blood glucose levels by targeting different pathways responsible for sugar regulation in the body.

• Reduces excess sugar naturally
  Dapagliflozin helps the kidneys eliminate extra glucose through urine, which lowers overall blood sugar levels without relying on insulin.
• Improves body’s response to insulin
  Metformin works by decreasing the amount of glucose produced by the liver and increasing insulin sensitivity in muscles.
• Enhances insulin secretion after meals
  Sitagliptin increases the levels of incretin hormones, which stimulate insulin release when blood sugar rises after eating, and reduce glucose output.

How SITAPIL DM 500 TABLET Works

Mechanism of action of SITAPIL DM 500 TABLET

This combination of Dapagliflozin, Metformin, and Sitagliptin brings together three complementary mechanisms to help support blood sugar control in adults with type 2 diabetes. Each ingredient targets a different pathway to help improve glucose balance in the body.

• Dapagliflozin is a sodium-glucose cotransporter-2 (SGLT2) inhibitor. It acts on the kidneys by preventing glucose reabsorption, which leads to the excretion of excess sugar through urine. This mechanism not only lowers blood sugar but may also support heart and kidney health.
• Metformin is a biguanide and serves as the foundation of most diabetes therapies. It works by reducing glucose production in the liver, improving insulin sensitivity, and enhancing glucose uptake by the muscles. Metformin also helps reduce the amount of sugar absorbed from food.
• Sitagliptin belongs to a class of medicines called DPP-4 inhibitors. It increases levels of incretin hormones, which improve insulin release in response to meals and reduce glucose production in the liver. It helps maintain blood sugar control throughout the day, particularly after food intake.

Together, these three agents work synergistically to lower blood sugar through different mechanisms promoting glucose loss, reducing liver glucose output, enhancing insulin action, and controlling post-meal glucose spikes. This triple-action formula offers a comprehensive approach to managing blood sugar levels in suitable adults with type 2 diabetes under medical guidance.

How to use SITAPIL DM 500 TABLET

How to take SITAPIL DM 500 TABLET tablet

• Take SITAPIL DM 500 TABLET exactly as prescribed by your doctor, usually once or twice daily based on your blood sugar levels and treatment goals.
• Consume the tablet with meals to minimize stomach discomfort, especially due to the metformin component.
• Swallow the tablet whole with a glass of water; do not crush or chew unless advised by your healthcare provider.
• Take it at the same time each day to maintain consistent blood levels and maximize effectiveness.
• Follow your doctor’s instructions regarding dose adjustments, especially if you are starting or stopping other medications or experiencing changes in your blood sugar.
• Do not skip meals or doses, as this may cause fluctuations in blood sugar levels

What if I forgot to take SITAPIL DM 500 TABLET

• Take the missed dose as soon as you remember, unless it is almost time for your next scheduled dose.
• If it’s close to the next dose, skip the missed dose and continue with your regular dosing schedule.
• Do not take two doses at the same time to make up for the missed one, as this may lead to a sudden drop in blood sugar or increase side effects.
• Monitor your blood sugar levels if you missed a dose, especially if you feel unusual symptoms like tiredness, excessive thirst, or frequent urination.
• If you frequently forget doses, consider using reminders or alarms, or discuss alternative dosing strategies with your doctor.
• Always consult your healthcare provider if you miss multiple doses or are unsure about what to do to avoid fluctuations in your blood sugar levels.

Overdose

If you or someone else accidentally consumes more than the recommended dose of this medicine, contact your doctor right away. An overdose can lead to low blood sugar (hypoglycemia) or a serious condition called lactic acidosis. Warning signs may include feeling unusually cold or unwell, intense nausea or vomiting, abdominal discomfort, sudden weight loss, muscle cramps, or rapid breathing. Seek immediate medical attention if any of these symptoms occur.

Side Effects Of SITAPIL DM 500 TABLET

Common side effects of SITAPIL DM 500 TABLET:

• Hypoglycemia (low blood glucose level)
• Nausea, vomiting
• Headache
• Flatulence
• Genital infections
• Increased or more frequent urination
• Drowsiness, dizziness
• Diarrhoea, constipation
• Stomach pain
• Itching
• Dry mouth
• Decreased weight
• Thirst

When to Seek Medical Attention?

Stop taking SITAPIL DM 500 TABLET and consult your doctor immediately if you experience any of the following side effects:

• Symptoms of acute pancreatitis, such as severe and persistent abdominal pain that might reach through your back with or without nausea and vomiting
• Symptoms of allergic reactions such as rash, hives, blisters on the skin or peeling skin, and swelling of the face, lips, tongue, and throat that may cause difficulty breathing or swallowing
• Signs of bullous pemphigoid, such as blistering of the skin
• Symptoms of lactic acidosis include vomiting, abdominal pain, muscle cramps, a general feeling of not being well, severe tiredness, difficulty breathing, reduced body temperature, and a slow heartbeat
• The symptoms of diabetic ketoacidosis are nausea, vomiting, stomach pain, excessive thirst, fast and deep breathing, confusion, unusual sleepiness or tiredness, a sweet smell to your breath, a sweet or metallic taste in your mouth, or a different odour to your urine or sweat, or rapid weight loss
• Signs of severe infections of the urinary tract include fever, chills, a burning sensation during urination, pain in your back or side, and blood in your urine

How To Manage Side Effects

Warning & Precautions

Other Warnings for SITAPIL DM 500 TABLET

Before taking SITAPIL DM 500 TABLET, inform your doctor if you:

• Have a history of pancreatitis
• Have or have had gallstones
• Have very high levels of triglycerides (a form of fat) in your blood

Who should not take SITAPIL DM 500 TABLET

SITAPIL DM 500 TABLET is not recommended for use if you:

• Have type 1 diabetes mellitus
• Have acute metabolic acidosis (such as lactic acidosis or diabetic ketoacidosis)
• Have diabetic pre-coma
• Have dehydration
• Have a severe infection
• Have shock
• Are scheduled for a lab test
• Are planned for surgery

Safety Advice

• Monitor for Signs of Ketoacidosis: Though rare, dapagliflozin may trigger euglycemic diabetic ketoacidosis (even with normal blood sugar). Watch for symptoms like nausea, vomiting, abdominal pain, confusion, and rapid breathing. Seek medical help if these occur. 
• Foot Care Advice: People with diabetes are at higher risk of foot ulcers and infections. Regularly check your feet, avoid injuries, keep them clean, and report any sores or redness promptly to your doctor.
• Stay Alert for Allergic Reactions: Stop the medication and seek immediate medical help if you experience symptoms such as rash, itching, facial swelling, or difficulty breathing, which could indicate a serious allergic reaction, particularly to sitagliptin.
• Regular Eye Check-ups: Rapid control of blood sugar can temporarily affect vision. Maintain regular eye exams, especially if you have existing diabetic retinopathy or experience blurred vision.
• Avoid in Severe Dehydration or Low Blood Pressure: If you're ill with vomiting, diarrhoea, or are unable to drink enough fluids, temporarily stop the medicine and call your doctor, as dapagliflozin may worsen dehydration and lower blood pressure.  

Diet and Lifestyle Advice

1. Follow a Balanced Meal Plan

• Choose whole grains, lean proteins, low-fat dairy, and fiber-rich vegetables to keep your energy levels stable.
• Limit your intake of sugary foods, processed snacks, and refined carbohydrates that cause rapid spikes in blood glucose.
• Spread meals evenly throughout the day skipping meals can result in sudden fluctuations in blood sugar levels.

2. Watch Your Carb Intake

• Carbohydrates have the most impact on blood sugar. Learn to count carbs or follow a diabetic-friendly plate method.
• Choose complex carbs (like brown rice, oats, and legumes) over simple sugars (like sweets and white bread).
• Include healthy fats like olive oil, nuts, and seeds in moderation.

3. Stay Hydrated

• Drink plenty of water to help your kidneys flush out excess sugar.
• Limit sugary drinks and avoid energy drinks and high-sugar fruit juices.

4. Regular Exercise

• Aim for at least 30 minutes of moderate physical activity most days of the week (e.g., brisk walking, cycling, swimming).
• Incorporate strength training or resistance exercises to improve muscle strength and insulin sensitivity.
• Always carry a quick source of sugar (like glucose tablets) in case of low blood sugar during exercise.

5. Maintain a Healthy Weight

• Weight management plays a key role in improving glucose metabolism. Losing even 5–7% of body weight can improve outcomes.
• Combine exercise with a calorie-controlled diet for better results. 

6. Avoid Smoking and Limit Alcohol

• Smoking can worsen diabetes-related complications. Seek help to quit if needed.
• If you consume alcohol, do so in moderation and preferably with food to avoid sudden sugar dips or lactic acidosis.

7. Track Your Progress

• Monitor your blood sugar regularly as advised by your doctor. Keeping a log can help identify patterns or triggers.
• Consider using wearable diabetic monitoring tools or tracking apps if recommended.

8. Foot and Skin Care

• Inspect your feet daily for cuts, blisters, or infections diabetes can slow healing.
• Keep your feet clean and dry, wear comfortable shoes, and avoid walking barefoot.

9. Manage Stress

• Long-term stress can influence blood sugar levels. Practice mindfulness, yoga, deep breathing, or hobbies to stay mentally balanced.

10. Stay Informed and Involved

• Attend regular follow-ups, and stay updated on your sugar levels, kidney function, and overall health.
• Collaborate with your healthcare team to adjust your diet, activity, and medication when needed.

1. Is SITAPIL DM 500 TABLET more effective than a dual combination like Metformin + Sitagliptin?

Aspect	SITAPIL DM 500 TABLET (Metformin + Sitagliptin + Dapagliflozin)	Dual Therapy (Metformin + Sitagliptin)
Glucose-lowering strength	Stronger (acts through three pathways)	Moderate (acts through two pathways)
Mechanisms covered	Liver glucose control + incretin boost + urinary glucose excretion	Liver glucose control + incretin boost
HbA1c reduction	Greater overall reduction	Lower reduction compared to triple therapy
Weight effect	Mild weight loss (due to SGLT2 inhibitor)	Weight-neutral
Blood pressure effect	May slightly reduce BP	No BP benefit
Suitability	Better for patients uncontrolled on dual therapy	Suitable for early or moderate control needs

2. Is SITAPIL DM 500 TABLET more effective for reducing HbA1c than dual oral antidiabetic therapies?

Aspect	SITAPIL DM 500 TABLET (Triple Therapy)	Dual Oral Therapies (e.g., Metformin + Sitagliptin / Metformin + Dapagliflozin)
HbA1c-lowering	Greater reduction (typically 0.5–1% more)	Moderate reduction depending on combination
Number of pathways targeted	Three complementary mechanisms	Two mechanisms only
Effectiveness in uncontrolled diabetes	More likely to achieve target HbA1c	May be insufficient for high HbA1c levels
Effect on fasting sugar	Strong improvement	Moderate improvement
Effect on post-meal sugar	Strong due to dual incretin + SGLT2 action	Moderate
Overall glycemic control	More comprehensive	Less comprehensive than triple therapy

Drug - Drug interaction

1. Other Blood Pressure Medicines (e.g., Beta Blockers, ACE Inhibitors)

• Interaction: Combined use may excessively lower blood pressure, causing symptoms like dizziness or fainting.
• Management: Monitor blood pressure closely, especially during the first few days. Report any unusual symptoms like severe dizziness or lightheadedness to your doctor.

2. Diuretics (e.g., Furosemide, Torsemide)

• Interaction: Can increase the risk of dehydration, low potassium or sodium, and kidney function changes.
• Management: Ensure adequate fluid intake. Regularly monitor electrolytes and kidney function through lab tests.

3. Painkillers (NSAIDs such as Ibuprofen, Diclofenac)

• Interaction: May reduce the effectiveness of the tablet and increase the risk of kidney issues.
• Management: Avoid long-term or frequent use of NSAIDs. Use only under medical guidance and stay hydrated.

4. Lithium

• Interaction: Telmisartan may increase lithium levels, leading to toxicity.
• Management: Frequent monitoring of lithium levels. Immediate medical attention if symptoms like tremor or confusion occur.

5. Antidiabetic Medicines (e.g., Insulin, Metformin)

• Interaction: Chlorthalidone may reduce the effectiveness of some diabetes medications, causing blood sugar fluctuations.
• Management: Monitor blood sugar levels more frequently. Your doctor may adjust your antidiabetic dose as needed.

6. Cholesterol-lowering Drugs (e.g., Atorvastatin)

• Interaction: Cilnidipine may interact with statins in rare cases and affect muscle function.
• Management: Notify your doctor if you notice muscle pain, fatigue, or unusual weakness.

Drug - Food interaction

1. High-Sodium Foods (Processed or Packaged Food)

• Interaction: Excess salt can counteract the blood pressure-lowering effects of the tablet.
• Management: Limit intake of high-sodium items such as chips, pickles, instant soups, or fast foods. Use herbs and spices for flavouring instead of salt.

2. Grapefruit or Grapefruit Juice

• Interaction: May affect how cilnidipine (a component of SITAPIL DM 500 TABLET) is processed in the body.
• Management: Avoid grapefruit products unless verified safe by your doctor. Choose other fruits or juices like orange or apple instead.

3. Potassium-rich Foods (e.g., Bananas, Oranges, Coconut Water)

• Interaction: Telmisartan may increase potassium levels, and consuming too much potassium-rich food can enhance this effect, leading to imbalances.
• Management: Consume potassium-rich foods in moderation. Periodically check electrolyte levels in long-term therapy, especially if using supplements.

4. Calcium or Magnesium Supplements

• Interaction: May reduce the absorption of some components in the tablet.
• Management: Take supplements at least 2 hours apart from the SITAPIL DM 500 TABLET dose. Discuss supplement use with your doctor for proper timing.

5. Licorice (Mulethi)

• Interaction: Natural licorice can reduce potassium levels, worsening effects like muscle weakness or irregular heartbeat when used with diuretics (chlorthalidone).
• Management: Avoid consuming licorice in any form (tea, candy, or herbal products) while on this medicine.

Synopsis

Drug	:	Dapagliflozin, Metformin, and Sitagliptin
Pharmacological Category	:	Antidiabetics
Therapeutic Indication	:	Type 2 diabetes mellitus
Dosage Forms	:	Tablet

More Information

FAQs About SITAPIL DM 500 TABLET

Q: What is SITAPIL DM 500 TABLET used for?

A: SITAPIL DM 500 TABLET is typically prescribed for adults with high blood sugar levels where more than one medication is needed. It is a 3-in-1 combination of Glimepiride, Metformin, and Pioglitazone. These ingredients support balanced sugar regulation in the body through different mechanisms. Doctors may recommend it when single medicines are not enough. It comes as a once-daily tablet for easier routine integration. Always follow your doctor’s advice for dosage and timing.

Q: Can SITAPIL DM 500 TABLET be used by older adults?

A: Yes, older adults may use SITAPIL DM 500 TABLET, but with close monitoring. As age increases, kidney and liver functions may change, affecting how the tablet works. Doctors may prescribe a lower strength or suggest regular check-ups. Seniors should also watch for dizziness or weakness. Inform your doctor if you feel lightheaded or overly tired. Follow all safety precautions recommended by your healthcare provider.

Q: What are the common side effects of SITAPIL DM 500 TABLET?

A: Some users may experience side effects such as nausea, stomach upset, dizziness, or mild swelling in the hands or feet. Low blood sugar (hypoglycemia) can also occur, especially if meals are skipped. You might feel tired or notice weight changes. These effects are usually manageable but should be reported to your doctor. Regular monitoring helps prevent complications.

Q: Can I take SITAPIL DM 500 TABLET with other medications?

A: It depends on the other medications you’re taking. SITAPIL DM 500 TABLET may interact with medicines like steroids, diuretics, and some heart tablets. Always share your full medication list with your doctor. Certain supplements or herbal products could also influence how it works. Your healthcare provider can adjust your dose accordingly. Never change medicines without expert guidance.

Q: Should I take SITAPIL DM 500 TABLET before or after meals?

A: It is generally advised to take SITAPIL DM 500 TABLET with meals. Taking it with food supports better absorption and reduces the risk of stomach-related side effects. Try to maintain a consistent schedule, such as taking it with breakfast or your largest meal. If you’re unsure, ask your doctor or pharmacist for personalized advice. Never skip meals if you are on this tablet.

Q: What should I do if I feel dizzy or weak after taking SITAPIL DM 500 TABLET?

A: Feeling dizzy or weak could be a sign of low sugar or dehydration. Try eating a snack or drinking water if you suspect your sugar has dropped. Sit or lie down if you feel lightheaded. Monitor your levels if you use a glucose testing device. Inform your doctor if this happens frequently. They may adjust your dosage or provide other advice.

Q: Can SITAPIL DM 500 TABLET cause low sugar levels?

A: Yes, low sugar levels (hypoglycemia) are possible, especially if meals are skipped or after heavy exercise. You might feel shaky, sweaty, hungry, or faint. Carry a quick source of sugar, like glucose tablets or fruit juice. Always monitor your sugar levels if advised by your doctor. Discuss preventive steps with your healthcare provider to stay safe.

Q: How long does it take for SITAPIL DM 500 TABLET to show results?

A: The effect of SITAPIL DM 500 TABLET varies from person to person. Some may notice improvements within a few days, while others may need several weeks. Regular use and monitoring are important. Your doctor may suggest follow-ups at specific intervals to track progress. Make sure to follow lifestyle advice alongside medication. Never adjust your dose without consulting your healthcare provider.

Q: Can I stop taking SITAPIL DM 500 TABLET once my sugar levels are normal?

A: No, do not stop this tablet without speaking to your doctor. Even if your sugar levels improve, it may be due to the medicine’s ongoing action. Sudden discontinuation might impact your health. Your doctor may adjust the dose or recommend a gradual change. Regular check-ups are essential to manage your condition effectively.

Q: Is SITAPIL DM 500 TABLET available in different strengths?

A: Yes, SITAPIL DM 500 TABLET may be available in different strengths depending on the composition. Doctors choose the strength based on your sugar control needs and health condition. Never switch strengths without your doctor’s guidance. If the pharmacy gives a different-looking tablet, check with your pharmacist. Keeping dosage consistent is important for safety.

Q: Can SITAPIL DM 500 TABLET be taken long-term?

A: Yes, SITAPIL DM 500 TABLET is often used as part of long-term diabetes management. Regular monitoring of kidney, liver function, and blood sugar is important. Your doctor will advise safety checks and lifestyle guidance during long-term use. Follow the recommended diet and exercise plan. Consistency is key in maintaining stable sugar levels.

Q: Is SITAPIL DM 500 TABLET the same as taking separate medicines?

A: SITAPIL DM 500 TABLET combines three medicines in one tablet, which may simplify your routine. Taking separate medicines could offer flexibility in dose adjustments but requires careful scheduling. Doctor-prescribed fixed-dose combinations like this tablet are convenient for many users. Always discuss the pros and cons with your healthcare provider. Never split or separate the components yourself.

Q: Can SITAPIL DM 500 TABLET help with weight management?

A: Some people may notice weight changes while using SITAPIL DM 500 TABLET, depending on lifestyle and diet. Glimepiride and pioglitazone can sometimes lead to weight gain, while metformin is known for weight-neutral effects. Regular exercise and balanced nutrition play a key role. Always discuss your goals with your doctor. Avoid making changes without expert support.

Q: What follow-up tests are required while using SITAPIL DM 500 TABLET?

A: Doctors may suggest regular blood sugar checks, HbA1c reports, kidney and liver function tests. These help assess how well the tablet is working and whether your body is tolerating it. Monitoring is especially important during long-term use. Keep all scheduled appointments and follow lab advice. Ask your doctor which tests are most essential for you.

Q: Can I take SITAPIL DM 500 TABLET if I have a fever or infection?

A: Infections or fever can affect your blood sugar levels. Inform your doctor if you are unwell while on SITAPIL DM 500 TABLET. They may adjust your dose or advise frequent monitoring. Always drink plenty of fluids and rest when sick. Never change the dose on your own during illness.

Q: Should I change my diet while using SITAPIL DM 500 TABLET?

A: Healthy eating supports balanced blood sugar and helps the tablet work effectively. Your doctor or dietitian may suggest a balanced diet plan based on your condition. Avoid skipping meals, especially if taking this tablet. Sugar spikes or drops might happen with irregular eating. Always combine your medication with lifestyle guidance for best results.

Q: What basic precautions should I take while on SITAPIL DM 500 TABLET?

A: Always take the tablet exactly as prescribed. Stay consistent with your meals and exercise routine. Inform your doctor about any unusual symptoms or health changes. Avoid alcohol or drastic diet changes without medical advice. Carry a sugar source in case of hypoglycemia. Follow regular check-ups for safe results.

References

1. K.D. Tripathi. Insulin, oral hypoglycaemic drugs and glucagon. Essentials of Medical Pharmacology. Seventh Edition. 2013. Page - 278, 275.

2. Clifford J Bailey, Jorge L Gross, Delphine Hennicken, Nayyar Iqbal, Traci A Mansfield, and James F List. Uses of metformin and dapagliflozin. Biomed Central (BMC). [Revised in 20th February 2013]. [Accessed on 20th November 2025] 

3. La Renon Healthcare. Dapagliflozin+Metformin+Sitagliptin. [Accessed on 20th November 2025] 

Useful Diagnostic Tests

• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin
• Blood Glucose Fasting (FBS)
• Random Blood Sugar (RBS)
• Post Prandial Blood Sugar (PPBS)
• Vital Diabetes Care
• Extended Diabetes Care
• Advance Diabetes Care
• Comprehensive Diabetes Care

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