Silynova 200mg Capsule 10'S

Introduction About SILYNOVA 200MG CAPSULE

SILYNOVA 200MG CAPSULE contains Silymarin which belongs to the group of medicines called Flavonoids. Silymarin is a flavonoid isolated from the plant species called Silybum marianum which is commonly known as milk thistle.

SILYNOVA 200MG CAPSULE is indicated as adjunctive therapy in the management of liver disease of varying conditions like acute hepatitis, chronic persistent and chronic aggressive hepatitis, cirrhosis of liver, fatty liver, toxic metabolic or toxic metabolic liver damage. It has been shown to protect the liver from damage caused by general anaesthesia because of its excellent hepatoprotective action.

Before taking SILYNOVA 200MG CAPSULE, inform your doctor if you have allergic to milk thistle or plants of the Asteraceae/Compositae family such as daisies, marigolds, or artichokes.

SILYNOVA 200MG CAPSULE is generally not recommended during pregnancy and breast-feeding. Consult your doctor for advice.

SILYNOVA 200MG CAPSULE should be used with caution in elderly patients and is contraindicated in children and adolescents below 18 years of age.

Generally, SILYNOVA 200MG CAPSULE is well tolerated, however a few side effects like gastro-intestinal discomfort including anorexia, nausea or diarrhoea and headache may be seen. If any of these side effects worsen, contact your doctor for advice.

Uses Of SILYNOVA 200MG CAPSULE

• Used for supportive management in chronic liver disease, cirrhosis and indigestion

How SILYNOVA 200MG CAPSULE Works

SILYNOVA 200MG CAPSULE contains Silymarin, is an herbal remedy that has been used for centuries for liver diseases. The hepatoprotective and antioxidant activities of silymarin effectively lowers the oxidative liver damage by inhibiting the formation of free radicals. Silymarin also enhances the cellular regeneration of hepatocytes (liver cells) by stimulating the activity of an enzyme called RNA polymerase. It also improves the overall functional capacity of the liver and aids in metabolism and digestion.

How to use SILYNOVA 200MG CAPSULE

Take SILYNOVA 200MG CAPSULE as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Side Effects Of SILYNOVA 200MG CAPSULE

How To Manage Side Effects

Diarrhoea:

Drink lots of fluids and water to keep yourself hydrated. Try to avoid taking any medicine on your own to manage diarrhoea and consult your doctor if the symptom gets worse.

Stomach upset:

Try to eat small and frequent meals. Increase the fluid intake. You can also use homemade ginger or other lozenges to increase the palatability of your food.

Nausea:  

Try to relax and rest. Eat and drink slowly or try to have smaller and frequent meals. If symptoms do not improve, contact your doctor.

Headache:  

Rest and drink plenty of fluids. Ask your doctor to recommend a painkiller. Consult your doctor for advice.

Warning & Precautions

Pregnancy

SILYNOVA 200MG CAPSULE is not recommended for use in pregnant women. Consult your doctor before taking the medicine.

Breastfeeding

SILYNOVA 200MG CAPSULE is generally not recommended for use in breastfeeding women as it may pass through the breast milk. Consult your doctor before taking the medicine.

Driving and Using Machines

SILYNOVA 200MG CAPSULE is not known to have any effect on driving or operating machines. Consult your doctor for advice.

Alcohol

Alcohol is contraindicated during the management with SILYNOVA 200MG CAPSULE. Consult your doctor for advice.

Liver

SILYNOVA 200MG CAPSULE should be used with caution in patients with history of hepatic encephalopathy. Consult your doctor before taking SILYNOVA 200MG CAPSULE.

Allergy

Do not take SILYNOVA 200MG CAPSULE if you are allergic to Silymarin or any other ingredients of this medicine.

Interactions

A. Drug-Drug interactions:

Before taking SILYNOVA 200MG CAPSULE inform your doctor if you are taking any prescription, non-prescription or herbal medicines.

Overdosage:

If you or anyone else accidentally takes too much of SILYNOVA 200MG CAPSULE, consult your doctor immediately or visit the nearby hospital.

Synopsis

More Information

• Keep SILYNOVA 200MG CAPSULE out of reach of children
• Store at room temperature

FAQs About SILYNOVA 200MG CAPSULE

What are the uses of SILYNOVA 200MG CAPSULE?

SILYNOVA 200MG CAPSULE is indicated as adjunctive therapy in the management of liver disease of varying conditions like acute hepatitis, chronic persistent and chronic aggressive hepatitis, cirrhosis of liver, fatty liver, toxic metabolic or toxic metabolic liver damage.

How to use SILYNOVA 200MG CAPSULE?

Take SILYNOVA 200MG CAPSULE as advised by your physician. Swallow SILYNOVA 200MG CAPSULE with a glass of water and do not chew or crush the medicine. Your doctor will decide the correct dose for you depending upon your age, body weight and disease condition.

Does SILYNOVA 200MG CAPSULE has any side effects?

Generally, SILYNOVA 200MG CAPSULE is well tolerated. However, a few side effects like gastro intestinal discomfort including anorexia, nausea, diarrhoea and headache may be seen. If any of these side effects become worsen, contact your doctor for advice.

Can we use SILYNOVA 200MG CAPSULE for pregnant women?

It is generally not recommended during pregnancy. Consult your doctor for advice before taking SILYNOVA 200MG CAPSULE.

How does SILYNOVA 200MG CAPSULE work?

SILYNOVA 200MG CAPSULE contains silymarin, is an herbal remedy that has been used for liver disease. The hepatoprotective and antioxidant activities of silymarin effectively lowers the oxidative liver damage by inhibiting the formation of free radicals. Silymarin also enhances the cellular regeneration of hepatocytes (liver cells) by stimulating the activity of an enzyme called RNA polymerase. It also improves the overall functional capacity of the liver and aids in metabolism and digestion.

References

1. Harsh Mohan. The liver, Biliary tract, and Exocrine pancreas. Textbook of Pathology. 6th Edition. Page – 604.

2. Nancy Vargas-Mendoza, Eduardo Madrigal-Santillan, Angel Morales-González, Jaime Esquivel-Soto, Cesar Esquivel-Chirino, Manuel García-Luna y González-Rubio, Juan A Gayosso-de-Lucio, and José A Morales-González. Hepatoprotective effect of silymarin. National Library of Medicine. [Revised in March 2014] [Accessed on 26th August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959115/#:~:text=Silymarin%20has%20both%20hepatoprotective%20and,hepatocyte%20external%20cell%20membrane%20modification.

3. Nitin Dixit1, Sanjula Baboota1, Kanchan Kohli1, S Ahmad2, Javed Ali1. Silymarin A review of pharmacological aspects and bioavailability enhancement approaches. [Accessed on 26th August 2022] https://www.ijp-online.com/article.asp?issn=0253-7613;year=2007;volume=39;issue=4;spage=172;epage=179;aulast=Dixit

4. MIMS. Silymarin. [Accessed on 26th August 2022] https://www.mims.com/philippines/drug/info/silymarin?mtype=generic

5. Abbott Laboratories (Pakistan) Limited, Pharmaceutical. Silymarin. [Accessed on 26th August 2022] https://www.medicine.abbott/content/dam/bss/divisionalsites/epd/pk/Product%20Information/Leaflet%20silliver%20Tabs.pdf

6. Sopharma AD 16 Iliensko Shosse Silymarin. [Revised in Sept 2018] [Accessed in August 2022] https://www.ravimiregister.ee/Data/PIL_ENG/PIL_15708_ENG.pdf

7. ClinicalTrials.gov National Library of Medicine. Silymarin.  [Accessed on 26th August 2022] https://clinicaltrials.gov/ct2/show/NCT02006498

8. Silybum Marianum Silybum marianum, improved liver function and antioxidant activity of blood cells. Silymarin.  [Accessed on 26th August 2022] https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/silybum-marianum

Author Details

Written By Dr. Janet.C - Pharm.D

Reviewed For Accuracy By Dr. Vrushabhakumar Jitendra Shah. - MBBS

Last updated on 29 Nov 2022 | 03:23 PM(IST)