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Silybon 140mg Tablet 10'S

Liver Disease
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    Introduction About SILYBON 140MG TABLET

    SILYBON 140MG TABLET contains Silymarin which belongs to the group of medicines called Flavonoids. Silymarin is a flavonoid isolated from the plant species called Silybum marianum which is commonly known as milk thistle.

    SILYBON 140MG TABLET is indicated as adjunctive therapy in the management of liver disease of varying conditions like acute hepatitis, chronic persistent and chronic aggressive hepatitis, cirrhosis of liver, fatty liver, toxic metabolic or toxic metabolic liver damage. It has been shown to protect the liver from damage caused by general anaesthesia because of its excellent hepatoprotective action.

    Before taking SILYBON 140MG TABLET, inform your doctor if you have allergic to milk thistle or plants of the Asteraceae/Compositae family such as daisies, marigolds, or artichokes.

    SILYBON 140MG TABLET is generally not recommended during pregnancy and breast-feeding. Consult your doctor for advice.

    SILYBON 140MG TABLET should be used with caution in elderly patients and is contraindicated in children and adolescents below 18 years of age.

    Generally, SILYBON 140MG TABLET is well tolerated, however a few side effects like gastro-intestinal discomfort including anorexia, nausea or diarrhoea and headache may be seen. If any of these side effects worsen, contact your doctor for advice.

    Uses Of SILYBON 140MG TABLET

    • Used for supportive management in chronic liver disease, cirrhosis and indigestion

    How SILYBON 140MG TABLET Works

    SILYBON 140MG TABLET contains Silymarin, is an herbal remedy that has been used for centuries for liver diseases. The hepatoprotective and antioxidant activities of silymarin effectively lowers the oxidative liver damage by inhibiting the formation of free radicals. Silymarin also enhances the cellular regeneration of hepatocytes (liver cells) by stimulating the activity of an enzyme called RNA polymerase. It also improves the overall functional capacity of the liver and aids in metabolism and digestion.

    How to use SILYBON 140MG TABLET

    Take SILYBON 140MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

    Side Effects Of SILYBON 140MG TABLET

    Common

    • nausea (feeling sick)
    • upset stomach
    • diarrhoea
    • headache

    Uncommon

    • anaphylaxis (a sudden, severe allergic reaction with swelling and breathing difficulties)
    • mild allergic reactions such as itching and/or skin rash, urticaria, hives, pruritus

    Rare

    Stop taking SILYBON 140MG TABLET and contact your doctor immediately if you experience any of the following side effects:

    • allergic reactions such as skin rash, red, itchy skin, difficulty breathing, swelling of the facial area, neck, tongue, or throat (anaphylactic shock)

    How To Manage Side Effects

    Diarrhoea:

    Drink lots of fluids and water to keep yourself hydrated. Try to avoid taking any medicine on your own to manage diarrhoea and consult your doctor if the symptom gets worse.

    Stomach upset:

    Try to eat small and frequent meals. Increase the fluid intake. You can also use homemade ginger or other lozenges to increase the palatability of your food.

    Nausea:  

    Try to relax and rest. Eat and drink slowly or try to have smaller and frequent meals. If symptoms do not improve, contact your doctor.

    Headache:  

    Rest and drink plenty of fluids. Ask your doctor to recommend a painkiller. Consult your doctor for advice.

    Warning & Precautions

    Pregnancy

    SILYBON 140MG TABLET is not recommended for use in pregnant women. Consult your doctor before taking the medicine.

    Breastfeeding

    SILYBON 140MG TABLET is generally not recommended for use in breastfeeding women as it may pass through the breast milk. Consult your doctor before taking the medicine.

    Driving and Using Machines

    SILYBON 140MG TABLET is not known to have any effect on driving or operating machines. Consult your doctor for advice.

    Alcohol

    Alcohol is contraindicated during the management with SILYBON 140MG TABLET. Consult your doctor for advice.

    Liver

    SILYBON 140MG TABLET should be used with caution in patients with history of hepatic encephalopathy. Consult your doctor before taking SILYBON 140MG TABLET.

    Allergy

    Do not take SILYBON 140MG TABLET if you are allergic to Silymarin or any other ingredients of this medicine.

    Others

    Use in pediatrics:

    SILYBON 140MG TABLET is not recommended for use in children and adolescents below 18 years of age. Consult your doctor before taking the medicine.

    Use in geriatrics:

    SILYBON 140MG TABLET should be used with caution in elderly (above 65 years of age). Consult your doctor for advice.

    Interactions

    A. Drug-Drug interactions:

    Before taking SILYBON 140MG TABLET inform your doctor if you are taking any prescription, non-prescription or herbal medicines.

    Overdosage:

    If you or anyone else accidentally takes too much of SILYBON 140MG TABLET, consult your doctor immediately or visit the nearby hospital.

    Synopsis

    Drug :   Silymarin
    Pharmacological Category :   Hepatoprotection, Antioxidant, Flavonoids
    Therapeutic Indication :   Liver disease, Cirrhosis, Indigestion        
    Dosage Forms :   Tablet, Capsule, Syrup

    More Information

    • Keep SILYBON 140MG TABLET out of reach of children
    • Store at room temperature

    FAQs About SILYBON 140MG TABLET

    What are the uses of SILYBON 140MG TABLET?

    SILYBON 140MG TABLET is indicated as adjunctive therapy in the management of liver disease of varying conditions like acute hepatitis, chronic persistent and chronic aggressive hepatitis, cirrhosis of liver, fatty liver, toxic metabolic or toxic metabolic liver damage.

    How to use SILYBON 140MG TABLET?

    Take SILYBON 140MG TABLET as advised by your physician. Swallow SILYBON 140MG TABLET with a glass of water and do not chew or crush the medicine. Your doctor will decide the correct dose for you depending upon your age, body weight and disease condition.

    Does SILYBON 140MG TABLET has any side effects?

    Generally, SILYBON 140MG TABLET is well tolerated. However, a few side effects like gastro intestinal discomfort including anorexia, nausea, diarrhoea and headache may be seen. If any of these side effects become worsen, contact your doctor for advice.

    Can we use SILYBON 140MG TABLET for pregnant women?

    It is generally not recommended during pregnancy. Consult your doctor for advice before taking SILYBON 140MG TABLET.

    How does SILYBON 140MG TABLET work?

    SILYBON 140MG TABLET contains silymarin, is an herbal remedy that has been used for liver disease. The hepatoprotective and antioxidant activities of silymarin effectively lowers the oxidative liver damage by inhibiting the formation of free radicals. Silymarin also enhances the cellular regeneration of hepatocytes (liver cells) by stimulating the activity of an enzyme called RNA polymerase. It also improves the overall functional capacity of the liver and aids in metabolism and digestion.

    References

    1. Harsh Mohan. The liver, Biliary tract, and Exocrine pancreas. Textbook of Pathology. 6th Edition. Page – 604.

    2. Nancy Vargas-Mendoza, Eduardo Madrigal-Santillan, Angel Morales-González, Jaime Esquivel-Soto, Cesar Esquivel-Chirino, Manuel García-Luna y González-Rubio, Juan A Gayosso-de-Lucio, and José A Morales-González. Hepatoprotective effect of silymarin. National Library of Medicine. [Revised in March 2014] [Accessed on 26th August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959115/#:~:text=Silymarin%20has%20both%20hepatoprotective%20and,hepatocyte%20external%20cell%20membrane%20modification.

    3. Nitin Dixit1, Sanjula Baboota1, Kanchan Kohli1, S Ahmad2, Javed Ali1. Silymarin A review of pharmacological aspects and bioavailability enhancement approaches. [Accessed on 26th August 2022] https://www.ijp-online.com/article.asp?issn=0253-7613;year=2007;volume=39;issue=4;spage=172;epage=179;aulast=Dixit

    4. MIMS. Silymarin. [Accessed on 26th August 2022] https://www.mims.com/philippines/drug/info/silymarin?mtype=generic

    5. Abbott Laboratories (Pakistan) Limited, Pharmaceutical. Silymarin. [Accessed on 26th August 2022] https://www.medicine.abbott/content/dam/bss/divisionalsites/epd/pk/Product%20Information/Leaflet%20silliver%20Tabs.pdf

    6. Sopharma AD 16 Iliensko Shosse Silymarin. [Revised in Sept 2018] [Accessed in August 2022] https://www.ravimiregister.ee/Data/PIL_ENG/PIL_15708_ENG.pdf

    7. ClinicalTrials.gov National Library of Medicine. Silymarin.  [Accessed on 26th August 2022] https://clinicaltrials.gov/ct2/show/NCT02006498

    8. Silybum Marianum Silybum marianum, improved liver function and antioxidant activity of blood cells. Silymarin.  [Accessed on 26th August 2022] https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/silybum-marianum

    Author Details

    Written By Dr. Janet.C - Pharm.D
    Reviewed For Accuracy By Dr. Vrushabhakumar Jitendra Shah. - MBBS
    Last updated on 29 Nov 2022 | 03:29 PM(IST)
    Lab updated