SILODAL M 25 Tablet 10's

Introduction About SILODAL M 25 TABLET

SILODAL M 25 Tablet is a combination medicine formulated to manage urinary problems in men, especially those caused by Benign Prostatic Hyperplasia (BPH) and bladder storage issues. This medicine combines Silodosin, an alpha-1 blocker that relaxes the muscles of the prostate and bladder neck, and Mirabegron, a beta-3 adrenergic receptor agonist that relaxes the bladder muscle to reduce urgency and frequency. Together, they provide both immediate relief in urinary flow and improved bladder storage, making it a suitable option for men experiencing multiple urinary symptoms such as weak stream, frequent urination, and urgency.

This tablet is ideal for adult men with moderate to severe urinary symptoms due to an enlarged prostate or overactive bladder. It is not recommended for women, children, or adolescents. SILODAL M 25 is usually taken once daily, preferably with food, and should be swallowed whole with water. Taking it at the same time every day ensures steady blood levels and optimal symptom control. Patients should follow their doctor’s instructions carefully for duration and dosage, as both components work together to provide balanced and effective relief.

Precautions and safety measures include monitoring for dizziness, low blood pressure, or rapid heartbeat, particularly when standing up suddenly. Men with kidney or liver problems should consult their doctor before starting the tablet, as dose adjustments may be required. It is important to inform your doctor about other medications you take, including antihypertensives, antibiotics, or herbal supplements, to avoid interactions. This medicine is not intended for women who are pregnant or breastfeeding, as both Silodosin and Mirabegron can affect hormonal and bladder function.

Common side effects may include dizziness, headache, nasal congestion, dry mouth, or mild urinary retention, which are usually mild and manageable. Severe reactions, such as allergic symptoms, fainting, or persistent heart palpitations, require immediate medical attention. Regular follow-ups with the doctor help ensure safe and effective use, monitor blood pressure, and assess improvement in urinary symptoms. With proper adherence, SILODAL M 25 Tablet can significantly enhance urinary comfort and overall quality of life for men with BPH and overactive bladder symptoms.

Uses Of SILODAL M 25 TABLET

• Used to manage Benign Prostatic Hyperplasia complicated by an overactive bladder

Benefits of SILODAL M 25 TABLET

Silodal M 25 Tablet for benign prostatic hyperplasia (relieve symptoms like difficulty in passing urine):

Silodal M 25 Tablet combines Silodosin and Mirabegron to manage Benign Prostatic Hyperplasia (BPH), a condition where the prostate enlarges and causes urinary problems. Silodosin relaxes the muscles of the prostate and bladder neck, helping improve urine flow and reduce difficulty in starting urination. Mirabegron works on the bladder muscle, reducing urgency, frequency, and sudden urges to urinate.

How SILODAL M 25 TABLET Works

Silodal M 25 Tablet (Mirabegron + Silodosin) Mechanism of Action

Silodal M 25 Tablet works through the combination of Silodosin and Mirabegron to improve urinary symptoms caused by Benign Prostatic Hyperplasia (BPH) and overactive bladder.

• Silodosin is an alpha-1 adrenergic receptor blocker. It relaxes the smooth muscles in the prostate and bladder neck, making it easier to start urination and increasing urine flow. This helps relieve symptoms like difficulty in passing urine or weak urine stream.
• Mirabegron is a beta-3 adrenergic receptor agonist. It relaxes the bladder muscle during the storage phase, which reduces urinary urgency and frequency and improves bladder capacity.

Together, the dual action of Silodosin + Mirabegron provides immediate relief in urinary flow while also addressing bladder storage issues, making it effective for men with BPH and symptoms of overactive bladder.

How to use SILODAL M 25 TABLET

How to Take Silodal M 25 Tablet

• Take Silodal M 25 Tablet once daily, preferably at the same time each day.
• Swallow the tablet whole with water; do not crush, chew, or break it.
• It is recommended to take the tablet after a meal to improve absorption and reduce stomach discomfort.
• Avoid missing doses; if you forget, take it as soon as you remember. Do not double the dose to make up for a missed one.

What if I forgot to take SILODAL M 25 TABLET

• If you miss a dose, take it as soon as you remember.
• Do not take a double dose to make up for the missed one, as this may increase the risk of dizziness, low blood pressure, or other side effects.
• If it is almost time for your next dose, skip the missed dose and continue with your regular schedule.
• Try to take the medicine at the same time each day to maintain consistent blood levels and optimal relief of urinary symptoms.
• Set a daily reminder or use a pill organizer to help prevent missed doses in the future.

Overdose

If you or anyone else accidentally takes too much of Silodal M 25 Tablet, consult your doctor immediately. Symptoms of an overdose include abnormal blood pressure or heart rate.

Side Effects Of SILODAL M 25 TABLET

Common side effects of Silodal M 25 Tablet:

• abnormal ejaculation  
• increased heart rate  
• urinary tract infections
• dizziness
• runny or blocked nose
• constipation
• nausea

When to Seek Medical Attention?

Stop taking Silodal M 25 Tablet and consult your doctor immediately if you experience any of the following side effects:

• swelling of the face, lips, tongue, and/or throat, causing difficulty breathing

How To Manage Side Effects

Constipation

• Increase Fiber Intake: Eat more fruits, vegetables, whole grains, and legumes. Fiber helps soften stool and improves bowel movements.
• Drink Plenty of Water: Staying hydrated makes stools softer and easier to pass. Aim for at least 6–8 glasses of water daily.
• Exercise Regularly: Light exercises like walking, yoga, or stretching can stimulate bowel movements.
• Avoid Processed Foods: Reduce intake of fast food, fried items, and excessive dairy, as they can worsen constipation.
• Warm Liquids: Drinking warm water, herbal teas, or warm lemon water in the morning can help kickstart digestion.
• Set a Routine: Try to use the toilet at the same time daily, preferably after meals, to train your bowel.
• Gentle Laxatives (if needed): Only use stool softeners or mild laxatives after consulting your doctor. Avoid overuse.

Dizziness Or Drowsiness

• Stand Up Slowly: Always get up gently from sitting or lying positions. Sudden movements can drop your blood pressure and make dizziness worse.
• Stay Hydrated: Drink enough water through the day, as dehydration is a common cause of dizziness. Avoid skipping fluids unless your doctor restricts them.
• Eat Small Meals: Large, heavy meals can sometimes lower blood pressure. Choose smaller, frequent meals to keep energy stable.
• Limit Caffeine: It can worsen dizziness and affect balance. Keep intake minimal or avoid altogether.
• Deep Breathing & Rest: If you feel dizzy, sit or lie down immediately. Take slow, deep breaths until the feeling passes.
• Compression Stockings (if advised): They help improve circulation and prevent blood pooling in the legs, which can cause light-headedness.
• Balanced Diet: Include foods rich in iron and vitamin B12 (like leafy greens, eggs, lean meat) to avoid anemia-related dizziness.

Warning & Precautions

Pregnancy

Contraindicated

Silodal M 25 Tablet is not recommended for use in pregnant women. Consult your doctor before taking the medicine. 

Breastfeeding

Contraindicated

Silodal M 25 Tablet is not recommended for use in breastfeeding women as it may pass into the breast milk. Consult your doctor before taking it. 

Driving and Using Machines

Use with Caution

Do not drive or operate heavy machinery if you feel dizziness after taking Silodal  M 25 Tablet.

Kidney

Consult your doctor

Silodal M 25 Tablet is not recommended for use if you have severe kidney disease. It should be used with caution in patients with mild to moderate kidney disease. Consult your doctor before taking it. 

Liver

Consult your doctor

Silodal M 25 Tablet is not recommended for use if you have severe liver disease. It should be used with caution in patients with mild-to-moderate liver disease. Consult your doctor before taking it. 

Allergy

Contraindicated

Do not take Silodal M 25 Tablet if you are allergic to Mirabegron, Silodosin or any of the other ingredients of this medicine.

Heart Disease

Consult your doctor

Silodal M 25 Tablet is not recommended for use if you have severe, uncontrolled high blood pressure. It should be used with caution in patients with ECG abnormalities (QT prolongation). Consult your doctor before taking it. 

Use In Pediatrics

Contraindicated

Silodal M 25 Tablet is not recommended for use in children and adolescents under 18 years of age since there is no relevant indication for this age group. Consult your doctor before taking it. 

Use In Geriatrics

Use with Caution

Silodal M 25 Tablet should be used with caution in elderly patients. Consult your doctor before taking it.

Other Warnings for SILODAL M 25 TABLET

Before taking Silodal M 25 Tablet, inform your doctor if you:

• have bladder outlet obstruction
• have prostate cancer
• are scheduled for cataract surgery
• have ever fainted or felt dizzy when suddenly standing up

Safety Advice

• Take as Prescribed: Always take the tablet exactly as your doctor tells you. Do not change the dose or stop suddenly without medical advice.
• Use in Men Only: This medicine is meant only for men with prostate problems. Women, children, and adolescents should not use it.
• Sexual Side Effects: Some men may notice reduced sexual desire or ejaculation issues. These usually improve after stopping treatment. Inform your doctor if they bother you.
• Regular Monitoring: Your doctor may check your prostate size, PSA levels, and urinary flow regularly to track progress. Do not miss follow-up visits.
• Allergic Reactions: If you notice swelling of lips, tongue, face, severe rash, or difficulty breathing, seek medical help immediately. These may indicate an allergic reaction.

Diet and Lifestyle Advice

Diet Advice:

• Balanced Meals: Eat a diet rich in fruits, vegetables, whole grains, and lean proteins to support overall health.
• Stay Hydrated: Drink enough water during the day but avoid excessive fluids late at night to reduce nighttime urination.
• Limit Caffeine: Reduce coffee, tea, and energy drinks, as they can irritate the bladder and worsen urinary frequency.
• Cut Down on Spicy and Processed Foods: These may irritate the bladder in some men and worsen symptoms.
• Healthy Fats: Choose foods rich in omega-3 fatty acids (fish, flaxseeds, walnuts) which support prostate and heart health.

Lifestyle advice:

• Regular Exercise: Aim for at least 30 minutes of walking, swimming, or light workouts most days. This improves blood flow and helps reduce urinary issues.
• Maintain Healthy Weight: Excess belly fat can put pressure on the bladder and worsen symptoms.
• Avoid Holding Urine: Empty your bladder whenever you feel the urge to prevent discomfort and infection risk.
• Limit Evening Fluids: Reduce drinking fluids 2–3 hours before bedtime to minimize nighttime trips to the bathroom.
• Safe Movements: Stand up slowly to avoid dizziness from low blood pressure caused by the medicine.
• Stress Management: Practice relaxation techniques like deep breathing or yoga, as stress can worsen urinary urgency.
• No Smoking: Smoking irritates the bladder and increases the risk of prostate complications.

Drug - Drug interaction

1. Blood Pressure Medications (e.g., Amlodipine, Losartan, Beta-blockers)

• Interaction: Silodosin may enhance the blood pressure-lowering effects of these drugs, causing dizziness, light-headedness, or fainting.
• Management: Blood pressure should be monitored regularly. Stand up slowly and report persistent dizziness to your doctor. Dose adjustments may be needed.

2. CYP3A4 Inhibitors (e.g., Ketoconazole, Itraconazole, Clarithromycin, Ritonavir)

• Interaction: Both Silodosin and Mirabegron are metabolized in the liver. CYP3A4 inhibitors can increase their levels in the blood, increasing side effects like dizziness, palpitations, or urinary retention.
• Management: Doctors may choose alternative medications or adjust the dose of Silodal M 25. Close monitoring for side effects is necessary.

3. Other Alpha-Blockers (e.g., Tamsulosin, Alfuzosin, Doxazosin)

• Interaction: Combining multiple alpha-blockers can cause excessive blood pressure to drop and increased risk of fainting.
• Management: Avoid concurrent use unless specifically prescribed by a doctor. Only one alpha-blocker should be used at a time.

4. Anticholinergic Drugs (e.g., Oxybutynin, Tolterodine)

• Interaction: These drugs may reduce the effectiveness of Mirabegron or increase urinary retention.
• Management: Use under close supervision. Your doctor may adjust doses or suggest alternative therapies to avoid complications.

5. Digoxin (Heart Medication)

• Interaction: Mirabegron may increase digoxin levels in the blood, potentially causing irregular heartbeat or toxicity.
• Management: Regular monitoring of digoxin levels is required. Dose adjustments may be made by your doctor.

6. Warfarin (Blood Thinner)

• Interaction: Mirabegron may slightly alter the effect of Warfarin, affecting clotting parameters.
• Management: Regular INR monitoring is recommended. Report unusual bleeding or bruising immediately.

7. Drugs Affecting Heart Rhythm (QT-Prolonging Drugs)

• Interaction: Silodosin or Mirabegron may slightly affect heart rhythm, especially if taken with other QT-prolonging drugs (e.g., certain antiarrhythmics).
• Management: ECG monitoring may be required. Inform your doctor about any history of heart problems.

Drug - Food interaction

1. High-Fat Meals

• Interaction: Taking the tablet with a very high-fat meal may increase absorption of Silodosin, leading to a higher risk of dizziness, nasal congestion, or low blood pressure.
• Management: Take the tablet with a light or moderate meal rather than a very fatty meal. Try to take it at the same time each day after food.

2. Grapefruit and Grapefruit Juice

• Interaction: Grapefruit can increase Mirabegron and Silodosin blood levels, potentially raising the risk of side effects such as rapid heartbeat, dizziness, or urinary retention.
• Management: Avoid grapefruit or grapefruit juice during treatment. Opt for other fruits like oranges or apples.

3. Caffeine (Coffee, Tea, Energy Drinks)

• Interaction: Excessive caffeine may increase urinary frequency and worsen side effects like palpitations or nervousness.
• Management: Limit intake of caffeinated beverages. Drink water or herbal teas instead to stay hydrated.

4. High-Sodium or Processed Foods

• Interaction: Foods high in salt can worsen blood pressure changes caused by Silodosin and may affect heart rhythm indirectly.
• Management: Maintain a balanced diet with low-to-moderate sodium intake to reduce side effects and support overall health.

5. Herbal Supplements (e.g., St. John’s Wort, Saw Palmetto)

• Interaction: Some herbal products may interfere with metabolism of Silodosin or Mirabegron, reducing effectiveness or increasing side effects.
• Management: Avoid herbal supplements unless approved by your doctor. Safer alternatives may be recommended.

Synopsis

More Information

1. Silodal M 25 Tablet vs Veltam Plus Tablet

2. Silodal M 25 Tablet vs Tamsulosin Alone

FAQs About SILODAL M 25 TABLET

References

1. KD. Tripathi. Drugs Acting on ANS. Essentials of Medical Pharmacology. Eighth edition. 2019. Page-139.

2. Khumukcham Somarendra, and Dr. Bijit Lodh. Efficacy of mirabegron add-on therapy to silodosin for the treatment of persistent storage symptoms in patients with benign prostatic hyperplasia. Journal of Population Therapeutics and Clinical Pharmacology. [Revised in 21st February 2024]. [Accessed on 15th October 2025] 

3. Medline Plus. Silodosin [Revised in 15th October 2016]. [Accessed on 15th October 2025] 

Useful Diagnostic Tests

• Prostate Specific Antigen (PSA)
• Prostate Specific Antigen (PSA) - Free
• Liver Function Test (LFT)

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Pushpraj Singh - MBBS

Last updated on 17 Oct 2025 | 10:43 AM(IST)