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Introduction About SEVLAREN 400 TABLET
SEVLAREN 400 TABLET contains Sevelamer, which belongs to the group of medicines called Phosphate Binding Agents. It is used to control the serum phosphorous levels in patients with long-term kidney disease who are on dialysis. Renal failure is the most common cause of high phosphorous levels, as there is reduced filtration of inorganic phosphate, increasing its serum levels.
During management, your doctor might ask you to take certain tests to avoid any untoward side effects. Follow the diet as advised by your doctor.
SEVLAREN 400 TABLET is not recommended for use in patients with low levels of phosphorus in the blood or bowel obstruction. SEVLAREN 400 TABLET should be used with caution in patients who have trouble swallowing, motility problems in the stomach and bowel, and in those who have undergone major bowel surgery.
SEVLAREN 400 TABLET should be used in pregnant women only if your doctor finds it clearly necessary. It is unknown whether SEVLAREN 400 TABLET is excreted in breast milk and may affect your baby, so consult your doctor before taking it during breastfeeding. SEVLAREN 400 TABLET is not intended for use in children and adolescents (below 18 years of age).
The most common side effects of taking SEVLAREN 400 TABLET are constipation, vomiting, upper abdominal pain, nausea, diarrhea, indigestion, flatulence (gas), etc. Ask for your doctor’s advice if any of these worsen or don’t improve.
Uses Of SEVLAREN 400 TABLET
- Used to control the serum phosphorous levels in patients with chronic kidney disease who are on dialysis
How SEVLAREN 400 TABLET Works
SEVLAREN 400 TABLET is a chelating agent that helps in reducing the phosphorus levels in the blood by binding to the phosphate that enters the body with food and managing its absorption.
How to use SEVLAREN 400 TABLET
Take SEVLAREN 400 TABLET as advised by your physician. Swallow it with a glass of water. Do not crush or chew the medicine. Your doctor will decide an appropriate dose and duration of SEVLAREN 400 TABLET for you depending upon your age, body weight, and disease condition. Do not stop taking SEVLAREN 400 TABLET unless your doctor advises you to stop.
Overdose
If you or anyone else accidentally takes too much of SEVLAREN 400 TABLET, consult your doctor immediately or visit the nearby hospital.
Side Effects Of SEVLAREN 400 TABLET
Common side effects of SEVLAREN 400 TABLET:
- nausea, vomiting, and upper abdominal pain
- diarrhea, constipation
- indigestion, flatulence
Stop taking SEVLAREN 400 TABLET and contact your doctor immediately if you experience any of the following side effects:
- blockage in the intestine (abdominal pain, severe bloating, swelling or cramps, severe constipation)
- allergic reaction (rash, swelling, hives, trouble breathing)
- rupture in the intestinal wall (severe stomach pain, chills, fever, nausea, vomiting, tender stomach)
- serious inflammation of the large bowel (severe stomach pain, stomach or intestine disorders, blood in the stool, crystal deposit in the intestine)
How To Manage Side Effects
Constipation
Consume enough fiber-rich foods like fresh fruits, vegetables, and cereals, and drink ample amounts of water. Exercise more regularly. If the symptom persists, contact your doctor.
Diarrhea
Drink plenty of liquids, like water or fruit juice, to maintain hydration. If the symptom persists, contact your doctor.
Indigestion
Keep your head and shoulders raised while sleeping so that stomach acid won’t come up. Do not eat for 3 to 4 hours before going to sleep, and avoid tea, coffee, cola, or alcohol. If the symptom persists, contact your doctor.
Nausea And Vomiting
Take SEVLAREN 400 TABLET with or just after meals. Stick to simple meals. Avoid eating oil-rich or spicy foods. Consult your doctor if your nausea worsens.
Stomach Pain
Try to rest and relax. Eat and drink slowly or try to eat smaller meals with small breaks. Keep a heat pad on your stomach. If the symptom persists, contact your doctor.
Warning & Precautions
Pregnancy
Consult your doctorSEVLAREN 400 TABLET should be used in pregnant women only if your doctor finds it clearly necessary. Consult your doctor before taking it.
Breastfeeding
Consult your doctorIt is unknown whether SEVLAREN 400 TABLET is excreted in breast milk and may affect your baby. Consult your doctor before taking it.
Driving and Using Machines
Use with CautionSEVLAREN 400 TABLET does not impair your ability to drive or use machines.
Allergy
ContraindicatedDo not take SEVLAREN 400 TABLET if you are allergic to Sevelamer or any of the other ingredients in this medicine.
Use In Pediatrics
ContraindicatedSEVLAREN 400 TABLET is not recommended for use in children and adolescents under 18 years of age. Consult your child’s doctor for advice.
Use In Geriatrics
Consult your doctorThere are no special considerations when SEVLAREN 400 TABLET is given to elderly patients. Consult your doctor for advice.
Other Warnings for SEVLAREN 400 TABLET
Before taking SEVLAREN 400 TABLET, tell your doctor if you:
- have trouble swallowing
- have motility problems in the stomach and bowel, like severe constipation
- have bowel inflammation
- have undergone major bowel surgery
- frequently become sick
Who should not take SEVLAREN 400 TABLET
SEVLAREN 400 TABLET is not recommended for use if you:
- have reduced levels of phosphorus in the blood
- have bowel obstruction
Drug - Drug interaction
Inform your physician if you are taking any of the following medicines before taking SEVLAREN 400 TABLET:
- antibiotics such as ciprofloxacin (medicines used to manage bacterial infections)
- ciclosporin, tacrolimus, and mycophenolate mofetil (used to suppress the immune system)
- levothyroxine (used in managing low thyroid hormone levels)
- proton pump inhibitors such as omeprazole, lansoprazole, and pantoprazole (used to manage heartburn and reflux from the stomach or food pipe)
- medicines used for heart rhythm problems (Ex. nicorandil, procainamide)
- medicines used for fits (Ex. phenytoin, carbamazepine)
Synopsis
|
Drug |
Sevelamer |
|
Pharmacological Category |
Chelating Agents |
|
Therapeutic Indication |
Hyperphosphatemia |
|
Dosage Forms |
Tablet, Sachet, Granules, Powder |
More Information
- Keep SEVLAREN 400 TABLET out of reach of children
- Store below 25°C
FAQs About SEVLAREN 400 TABLET
Q: What is SEVLAREN 400 TABLET and why is it prescribed?
A: SEVLAREN 400 TABLET contains sevelamer, which belongs to the group of medicines called phosphate-binding agents. It is indicated for the control of serum phosphorus in patients with chronic kidney disease on dialysis.
Q: Can I stop taking SEVLAREN 400 TABLET on my own?
A: You should not stop taking SEVLAREN 400 TABLET until your doctor advises you to. Taking SEVLAREN 400 TABLET is important to maintain an appropriate phosphate level in the blood. Stopping SEVLAREN 400 TABLET may lead to consequences such as calcification in the blood vessels, making it hard for your body to pump blood, itchy skin, red eyes, bone pain, and fractures. If you wish to discontinue taking SEVLAREN 400 TABLET, contact your doctor first.
Q: What other precautions shall I take while taking SEVLAREN 400 TABLET?
A: Due to either your kidney condition or your dialysis management, you may have disturbed levels of calcium, vitamin A, E, K, D, folic acid, and bicarbonates in your blood. SEVLAREN 400 TABLET should be used with calcium supplements and vitamin D to manage the development of bone disease. Your doctor might check these levels in your blood frequently.
Q: Can SEVLAREN 400 TABLET be taken on an empty stomach?
A: It is suggested to take SEVLAREN 400 TABLET after your meal or with food. Avoid taking it on an empty stomach, as it may cause unwanted side effects. Consult with your doctor.
Q: Is SEVLAREN 400 TABLET meant for use with children?
A: SEVLAREN 400 TABLET is not recommended for use in children and adolescents (under 18 years of age) as the safety and efficacy have not been established in this age group. Consult your child’s doctor for advice. The doctor will determine an appropriate dose or select a suitable alternative management for your child.
Q: Is constipation a side effect of SEVLAREN 400 TABLET?
A: Constipation is a very common side effect of taking SEVLAREN 400 TABLET. It can also be an early symptom of a blockage in your intestine. If you experience constipation, please inform your doctor immediately.
References
1. Barbara G. Wells, Joseph T. DiPiro, Terry L. Schwinghammer, Cecily V. DiPiro. Chronic Kidney Disease: Management of Complications. Pharmacotherapy Handbook. Ninth Edition. 2011. Page-794.
2. Claudia Yuste, Evangelina Mérida, Eduardo Hernández, Ana García-Santiago, Yolanda Rodríguez, Teresa Muñoz, Gonzalo Jesús Gómez, Ángel Sevillano, Manuel Praga. Gastrointestinal complications induced by sevelamer crystals. Oxford Academy. Clinical Kidney Journal. April 2017. [Accessed on 4th November 2026] 
3. Caroline M Perry, Greg L Plosker. Sevelamer carbonate: a review in hyperphosphataemia in adults with chronic kidney disease. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. May 2014. [Accessed on 4th November 2026] 
4. NIH National Library of Medicine, National center for biotechnology information. PubMed Central. Sevelamer. [Revised in September 2022] [Accessed on 4th November 2026]
5. Genzyme Ireland Limited. Electronic Medicines Compendium (EMC). [Revised in June 2021] [Accessed on 4th November 2026]
6. Dailymed. Sevelamer Hydrochloride. [Revised in June 2020] [Accessed on 4th November 2026]
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