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Introduction About SESTEC NP TABLET
SESTEC NP TABLET is a combination of Nimesulide, Paracetamol and Serratiopeptidase which belongs to the group of medicines called Nonsteroidal Anti-inflammatory drugs and Analgesics & Antipyretics respectively. It is used to manage acute pain in extra-articular (other than joint) disorders and osteoarthritis (disorder affecting weight-bearing joints). It can also be used to manage post-operative pain, and primary dysmenorrhea (period cramps).
Pain can be defined as an unpleasant sensory and emotional experience related to actual or potential tissue damage. It is always a personal experience that varies by biological, psychological and social factors.
Before taking SESTEC NP TABLET, inform your doctor if you have any severe liver, kidney, heart, or bleeding problems, stomach ulcers, or diabetes.
SESTEC NP TABLET is not recommended for use in third trimester of pregnancy and in breastfeeding women, so consult your doctor before taking it.
SESTEC NP TABLET is not recommended for use in children and adolescents (below 12 years of age). Consult your doctor before taking it.
The most common side effects of taking SESTEC NP TABLET are ulcers in the stomach and upper part of the small intestine, hole in the intestinal wall, bleeding of the digestive tract, diarrhoea, nausea, vomiting. Contact your doctor if any of the side effects worsen.
Uses Of SESTEC NP TABLET
It is used to relieve acute pain in:
- extra-articular disorders
- osteoarthritis
- post-operative pain
- primary dysmenorrhea
How SESTEC NP TABLET Works
SESTEC NP TABLET relieves pain and inflammation where Nimesulide and Paracetamol works by blocking the release of certain chemical messengers in the brain that are responsible for inducing pain and fever, and Serratiopeptidase works by breaking down abnormal proteins at the site of inflammation and aids healing.
How to use SESTEC NP TABLET
Take SESTEC NP TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of SESTEC NP TABLET
Common
- ulcers in the stomach and upper section of the small intestine
- hole in the intestinal wall
- bleeding in the digestive tract
- diarrhoea
- nausea, vomiting
- minor changes in liver function tests
Uncommon
- breathlessness
- dizziness
- increased blood pressure
- constipation
- flatulence
- stomach inflammation
- sweating
- swelling
Rare
- anaemia, decrease or increase (in white blood cells)
- blood pressure changes
- increased heart rate
- trouble passing urine, stoppage of urine, blood in urine
- increased blood potassium levels
- anxiety, nervousness, nightmares
- blurred eyesight
- skin flushing, redness, or inflammation
- feeling generally unwell, tiredness
Stop taking SESTEC NP TABLET and contact your doctor immediately if you experience any of the following side effects:
- stomach discomfort or pain, bleeding from your stomach or intestine, passing black stools
- wheezing
- abnormal change in the amount or color of urine
- swollen face, feet or legs
- hypersensitivity reaction (skin rash or redness, blisters, hives, itching, breathlessness, swelling)
- severe skin problems (steven johnson-syndrome or Lyell syndrome)
- respiratory disorders (Loffler-Syndrome or pneumonitis)
- low blood pressure
- abnormal liver condition (loss of appetite, nausea, vomiting, stomach pain, persistent tiredness or dark urine, yellow skin or the whites of your eyes)
- fever, flu-like symptoms (feeling generally achy and unwell, chills, or shivering)
How To Manage Side Effects
Nausea or Vomiting:
Take SESTEC NP TABLET with, or just after meals. Stick to simple meals. Avoid eating oily or spicy foods. Get adequate rest. Drink lots of fluids, especially water. Have small sips if you feel sick. Do not take any medicine for nausea or vomiting without asking your doctor. If vomiting does not improve, contact your doctor.
Diarrhoea:
Drink lots of fluids, like water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor. If diarrhea does not improve, contact your doctor.
Warning & Precautions
Pregnancy
SESTEC NP TABLET is not recommended for use in third trimester (last three months) of pregnancy. Consult your doctor before taking it.
Breastfeeding
SESTEC NP TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking it.
Driving and Using Machines
Do not drive or use any machines if you experience dizziness, spinning sensation, sleepiness, nausea, tiredness, or headache after taking SESTEC NP TABLET.
Alcohol
SESTEC NP TABLET is not recommended for use in patients suffering from alcoholism. Consult your doctor before taking it.
Kidney
SESTEC NP TABLET is not recommended for use in patients with non-dialyzed severe kidney failure. SESTEC NP TABLET should be used with caution in patients with mild to moderate kidney problems. Consult your doctor before taking it.
Liver
SESTEC NP TABLET is not recommended for use in patients with an impaired liver function. Consult your doctor before taking it.
Allergy
Do not drive or use any machines if you experience dizziness, spinning sensation, sleepiness, nausea, tiredness, or headache after taking SESTEC NP TABLET.
Heart Disease
SESTEC NP TABLET is not recommended for use in patients with severe heart failure. SESTEC NP TABLET should be used with caution in patients with high blood pressure or cholesterol, mild heart disease, or circulatory problems. Consult your doctor before taking it.
Others
SESTEC NP TABLET is not recommended for use if you:
- had bleeding or holes in your stomach or intestines
- have or had stomach or bowel ulcers or bleeding
- had a stroke (bleeding into the brain)
- have any other bleeding problem due to your blood not clotting
- have fever or flu
Before taking SESTEC NP TABLET inform your doctor if you:
- have diabetes
- are a smoker
- have ulcerative colitis or crohn’s disease
Use in pediatrics:
SESTEC NP TABLET is not recommended for use in children and adolescents (below 12 years of age). Consult your doctor before taking it.
Use in geriatrics:
SESTEC NP TABLET should be used with caution in elderly patients. Consult your doctor before taking it.
Interactions
A. Drug-Drug interactions:
Before taking SESTEC NP TABLET inform your doctor if you are taking any of the following medicine:
- medicines used to manage inflammatory conditions (Ex. hydrocortisone, prednisolone)
- medicine used to thin the blood (Ex. warfarin, aspirin)
- medicines used to control blood pressure or heart conditions (Ex, propranolol, furosemide)
- lithium (used to manage mood disorders)
- medicines used to manage depression (Ex. citalopram, escitalopram, fluoxetine)
- methotrexate (used to manage rheumatoid arthritis and cancer)
- cyclosporin (used after transplantation or to manage immune system disorders)
- medicines used to relieve pain and inflammation (Ex. paracetamol, celecoxib)
- medicines that cause addiction (Ex. codeine, fentanyl)
Overdosage:
If you or anyone else accidentally took too much of SESTEC NP TABLET contact your doctor immediately. Symptoms of SESTEC NP TABLET overdose include drowsiness, nausea, stomach pain or bleeding, difficulty breathing, or liver damage.
Synopsis
| Drug | : | Nimesulide, Paracetamol, Serratiopeptidase |
| Pharmacological Category | : | Nonsteroidal anti-inflammatory drug (NSAID), Analgesic & Antipyretics |
| Therapeutic Indication | : | Pain relief |
| Dosage Forms | : | Tablet |
More Information
- Keep SESTEC NP TABLET out of reach of children
- Store SESTEC NP TABLET below 25°C
FAQs About SESTEC NP TABLET
Q: Is it safe to consume alcohol while taking SESTEC NP TABLET?
A: SESTEC NP TABLET is not recommended for use in patients suffering from alcoholism (regular heavy consumption of alcohol). So, avoid drinking alcohol and consult your doctor before taking it.
Q: Can SESTEC NP TABLET be given to children?
A: No. SESTEC NP TABLET is not recommended for children and adolescents below 12 years of age. Your doctor will decide the correct dose or select a suitable alternative management for your child.
Q: What if I forget to take a dose of SESTEC NP TABLET?
A: If you forget to take a dose of SESTEC NP TABLET, take it as soon as you remember. However, omit the missed dose if it is almost time for the next dose. Do not take SESTEC NP TABLET twice to make up for a forgotten dose.
Q: Can SESTEC NP TABLET be stopped?
A: Continue taking SESTEC NP TABLET until your doctor tells you to stop, unless you experience any unwanted effects, worsening of your condition or any new symptoms. In such case, contact your doctor right away.
Q: Can SESTEC NP TABLET cause diarrhoea?
A: Diarrhea is a common side effect of SESTEC NP TABLET. In such case, drink lots of fluids, like water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor. If diarrhea does not improve, contact your doctor.
Q: What precautions do I need to follow while taking SESTEC NP TABLET?
A: Patients taking SESTEC NP TABLET must inform their doctor about their pre-existing conditions like liver, kidney, heart, or bleeding problems, stomach ulcers, or diabetes. Consult your doctor if you experience unusual symptoms while taking SESTEC NP TABLET.
Q: Can SESTEC NP TABLET be taken in pregnancy?
A: SESTEC NP TABLET is not recommended for use in third trimester (last three months) of pregnancy. If you are pregnant, think you may be pregnant or are planning to get pregnant, consult your doctor before taking SESTEC NP TABLET.
Q: Can I take other medicines with SESTEC NP TABLET?
A: Before taking SESTEC NP TABLET, inform your doctor if you are taking, have taken, or might take any other medicine, including prescription, non-prescription or any herbal medicine, as these might interact with each other and cause serious side effects.
Q: Can I drive a car after taking SESTEC NP TABLET?
A: Do not drive or use any machines if you experience dizziness, spinning sensation, sleepiness, nausea, tiredness, or headache after taking SESTEC NP TABLET. Consult your doctor if you feel any side effect during management with SESTEC NP TABLET that may stop you from driving or using machines.
Q: Can SESTEC NP TABLET cause nausea?
A: Yes, it may cause nausea in some individuals. If you feel nauseous, take SESTEC NP TABLET with, or just after meals. Avoid eating oily or spicy foods. If nausea does not improve, contact your doctor.
References
1. KD. Tripathi. NSAIDs and Antipyretics-Analgesics. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 203.
2. Manju Tiwari. The role of serratiopeptidase in the resolution of inflammation. May 2017. [Accessed on 11th July 2022] https://www.sciencedirect.com/science/article/pii/S181808761630160X
3. Helsinn Birex Pharmaceuticals Ltd. Nimesulide. [Revised in July 2020] [Accessed on 11th July 2022] https://file.wuxuwang.com/hma/IT_H_0151_002_FinalPI.pdf
4. Reliable 1 Laboratories LLC. Acetaminophen. [Revised in October 2021] [Accessed on 11th July 2022] file:///C:/Users/NMSLAP468/Downloads/20211029_25626b46-78f8-7226-e054-00144ff8d46c.pdf
5. Kusum Healthcare Pvt. Ltd. Serratiopeptidase. [Revised in August 2019] [Accessed on 11th July 2022] https://quest3plus.bpfk.gov.my/front-end/attachment/627/pharma/76009/V_34031_20190827_170339_D4.pdf
6. Taj Pharma. Nimesulide + Paracetamol + Serratiopeptidase. [Accessed on 11th July 2022] https://tajpharma.in/portfolio-item/nimesulide-paracetamol-serratiopeptidase-100mg325mg10mg-tablets-taj-pharma/
7. Ellanjay Lifesciences. Nimesulide + Paracetamol + Serratiopeptidase. [Accessed on 11th July 2022] https://ellanjey.com/product/nimesulide-100mg-paracetamol-325-mg-serratiopeptidase-15-mg-alu/
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