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Introduction About SEPTRAN ORAL SUSPENSION
SEPTRAN ORAL SUSPENSION is a combination of Sulphamethoxazole and Trimethoprim which belongs to the group of medicines called Antibiotics. It is used in infants and in children (aged between 6 weeks-12 years) to manage severe lung infections and toxoplasmosis (an infection with the Toxoplasma gondii parasite).
It can also be used to manage urinary tract infections, respiratory tract infections (such as bronchitis), ear infections (such as otitis media) and an infection called nocardiosis which can affect the lungs, skin and brain.
SEPTRAN ORAL SUSPENSION must be taken for the stipulated duration as instructed by your doctor to achieve better results. Failing to complete the full course of the therapy or skipping doses in between the therapy may not result in adequate infection control.
Talk to your doctor before administering this medicine to your child, if your child has any problems in their liver or kidneys. You must also inform your doctor if your child has asthma, any allergic conditions, genetic disorders, blood-related disorders, folic acid deficiency or high blood potassium levels as a precaution.
The most common side effects of taking SEPTRAN ORAL SUSPENSION are headache, nausea, diarrhea, high blood potassium levels, fungal infections of mouth or vagina and skin rashes. Consult your doctor if any of these side effect troubles your child.
Uses Of SEPTRAN ORAL SUSPENSION
It is used in infants and in children (aged between 6 weeks-12 years) to manage the following bacterial infections:
- Lung infections (Ex. Pneumonia or Pneumocystis jiroveci pneumonia) caused by a bacteria called Pneumocystis jirovecii
- Toxoplasmosis (an infection with the Toxoplasma gondii parasite)
- Urinary tract infections
- Respiratory tract infections (Ex. bronchitis)
- Ear infections (Ex. otitis media)
- Nocardiosis (a bacterial infection that affects lungs, skin and brain)
How SEPTRAN ORAL SUSPENSION Works
SEPTRAN ORAL SUSPENSION is a powerful antibiotic. It kills the susceptible bacteria by blocking the production of certain essential vitamins (folate) that is necessary for the bacteria to grow, multiply and survive. Therefore, it destroys the susceptible bacteria and manage their further growth and multiplication within the body which helps in reducing the severity of the infection.
How to use SEPTRAN ORAL SUSPENSION
Administer SEPTRAN ORAL SUSPENSION to your child as advised by your physician. Shake well before use. Measure the required quantity of the medicine in a measuring cup and administer it to your child.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Do not stop therapy with SEPTRAN ORAL SUSPENSION without consulting the doctor as it may make the symptoms re-appear once again. It is important to take SEPTRAN ORAL SUSPENSION for the stipulated duration as recommended by your doctor to achieve better results.
Side Effects Of SEPTRAN ORAL SUSPENSION
Common
- high potassium levels in blood causing abnormal heart beats
- fungal infection (thrush or candidiasis) of mouth or vagina
- headache, nausea, diarrhoea
- skin rashes
Uncommon
- vomiting
Rare
Stop administering SEPTRAN ORAL SUSPENSION to your child and contact your doctor immediately if your child experiences any of the following side effects:
- severe allergic reactions (such as skin rashes, itching, swelling of the face, lips, tongue or throat causing difficulty in breathing or swallowing, chest pain and fainting)
- severe skin reactions (such as generalised skin redness with pustules accompanied by fever, ulcers in the mouth, throat, nose, genitals, red, swollen eyes, severe skin rash with blistering and peeling of the skin, red pinpoint targets under the skin)
- signs of abnormal WBC count (such as fever, swollen glands, weakness, light-headedness, shortness of breath, bruising with or without skin rash)
- unexpected worsening of cough and shortness of breath
How To Manage Side Effects
Diarrhea
Make sure that your child drinks plenty of fluids, such as water or fruit juice to keep themself hydrated. Consuming ORS can also be beneficial. If diarrhea worsens, contact your doctor immediately.
Headache
Make your child rest and relax. Keep them hydrated by making them drink plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on their forehead can be beneficial. Consult your doctor if the headache worsens in your child.
Nausea And Vomiting
Make sure that your child takes SEPTRAN ORAL SUSPENSION with, or just after meals. Provide your child with simple meals. Avoid giving them oil rich or spicy foods. Please consult your doctor immediately if your child experience severe nausea or vomiting.
Warning & Precautions
Driving and Using Machines
Use with CautionDo not let your child drive or handle any heavy tools if their ability is affected by SEPTRAN ORAL SUSPENSION.
Kidney
Consult your doctorSEPTRAN ORAL SUSPENSION is not recommended for use in children with severe kidney problems. It should be used with caution in children with other kidney problems. Therefore, consult your doctor before administering it to your child.
Liver
ContraindicatedSEPTRAN ORAL SUSPENSION is not recommended for use in children with severe liver problems. Therefore, consult your doctor before administering it to your child.
Allergy
ContraindicatedDo not administer SEPTRAN ORAL SUSPENSION to your child if your child is allergic to Sulphamethoxazole, trimethoprim, sulphonamide medicines (such as gliclazide, glibenclamide) or to thiazide diuretics (such as Bendroflumethiazide).
Lungs
Use with CautionSEPTRAN ORAL SUSPENSION should be used with caution in children with asthma. Therefore, consult your doctor before administering it to your child.
Use In Pediatrics
Consult your doctorSEPTRAN ORAL SUSPENSION is suitable for use in infants and in children (aged between 6 weeks to 12 years). It is not recommended for use in infants aged less than 6 weeks. Therefore, consult your doctor before administering it to your child.
Others
SEPTRAN ORAL SUSPENSION is not recommended for use if your child:
- has a history of bleeding problems (such as thrombocytopenia)
- has porphyria (a rare blood disorder)
Before administering SEPTRAN ORAL SUSPENSION, consult your doctor if your child:
- has any allergic conditions (such as watery eyes, itchy nose, repeated sneezing)
- has anemia or vitamin B9 (folic acid) deficiency
- has G6PD deficiency (a genetic disorder that affects metabolism)
- has phenylketonuria (build-up of an amino acid called phenylalanine in the body)
- is underweight or malnourished
- has high blood potassium levels
- has a very low RBC, WBC and platelet counts in blood
Interactions
A. Drug-Drug Interactions:
Before administering SEPTRAN ORAL SUSPENSION to your child, inform your doctor if your child is taking any of the following medicines such as:
- pyrimethamine (a medicine used to manage malaria)
- medicines used for blood thinning (such as warfarin)
- phenytoin (a medicine used to manage epilepsy)
- medicines used to manage diabetes (such as glibenclamide, glipizide, tolbutamide or repaglinide)
- rifampicin (an antibiotic used to manage tuberculosis)
- medicines used to manage heart problems (such as digoxin or procainamide)
- amantadine (a medicine used to manage Parkinson’s disease)
- medicines used to manage HIV infections (such as zidovudine or lamivudine)
- medicines that can increase the amount of potassium in blood, such as potassium-sparging diuretics (Ex. spironolactone, acetazolamide), certain steroids (like prednisolone) or ACE inhibitors (Ex. captopril, enalapril, lisinopril)
- medicines used to suppress immune function and to manage graft rejection (such as ciclosporin, azathioprine)
- methotrexate (a medicine used to manage certain cancers or joint pain)
- folinic acid (a type of vitamin B9 supplement)
B. Drug-Food Interaction:
SEPTRAN ORAL SUSPENSION is preferably taken with meals to avoid unwanted stomach problems. However, it can also be taken on an empty stomach. Avoid consuming foods rich in potassium while taking this medicine.
Overdosage:
If your child accidentally swallowed more SEPTRAN ORAL SUSPENSION, consult your doctor immediately or visit the nearby hospital. Symptoms of overdoage might include nausea, vomiting, dizziness and confusion.
Synopsis
| Drug | : | Sulphamethoxazole, Trimethoprim |
| Pharmacological Category | : |
Sulphonamides, Diaminopyrimidine |
| Therapeutic Indication | : | Bacterial Infections |
| Dosage Forms | : | Tablet, Syrup, Suspension, Injection, Infusion, Eye drops |
More Information
- Keep SEPTRAN ORAL SUSPENSION out of reach of children
- Store SEPTRAN ORAL SUSPENSION at room temperature
FAQs About SEPTRAN ORAL SUSPENSION
Q: What is the use of SEPTRAN ORAL SUSPENSION?
A: SEPTRAN ORAL SUSPENSION is used in infants and in children (aged between 6 weeks-12 years) to manage severe lung infections and toxoplasmosis (an infection with the Toxoplasma gondii parasite). It can also be used to manage urinary tract infections, respiratory tract infections (such as bronchitis), ear infections (such as otitis media) and an infection called nocardiosis which can affect the lungs, skin and brain.
Q: How SEPTRAN ORAL SUSPENSION works in my body?
A: SEPTRAN ORAL SUSPENSION is a powerful antibiotic. It kills the susceptible bacteria by blocking the production of certain essential vitamins (folate) that is necessary for the bacteria to grow, multiply and survive. Therefore, it destroys the susceptible bacteria and manage their further growth and multiplication within the body which helps in reducing the severity of the infection.
Q: Is SEPTRAN ORAL SUSPENSION safe?
A: SEPTRAN ORAL SUSPENSION is considered safe at doses prescribed by the physician.
Q: How should I take SEPTRAN ORAL SUSPENSION?
A: Shake well before use. Measure the required quantity of the medicine in a measuring cup and administer it to your child.
Q: For how long should I take SEPTRAN ORAL SUSPENSION?
A: Take SEPTRAN ORAL SUSPENSION for the stipulated duration as prescribed by your doctor. Do not skip the medicine or stop taking it on your own as it can cause the infection to reappear.
Q: What are the common side effects of taking SEPTRAN ORAL SUSPENSION?
A: The most common side effects of taking SEPTRAN ORAL SUSPENSION are headache, nausea, diarrhea, high blood potassium levels, fungal infections of mouth or vagina and skin rashes. Consult your doctor if any of these side effect troubles your child.
Q: Can I stop taking SEPTRAN ORAL SUSPENSION once my symptoms subside?
A: Do not stop taking this medicine once the symptom subsides. It is important to take the full course of SEPTRAN ORAL SUSPENSION to achieve better results. Failing to complete the full course of the therapy or skipping doses in between the therapy may not result in adequate infection control. It may also cause your symptoms to reappear.
Q: Can the use of SEPTRAN ORAL SUSPENSION cause diarrhea?
A: SEPTRAN ORAL SUSPENSION may cause diarrhea in some children. If your child experience diarrhea, make sure that they drink plenty of water or fruit juice to manage dehydration. Consuming ORS can also be beneficial. If diarrhea worsens, contact your doctor immediately.
Q: What should I do if I forgot to take a dose of SEPTRAN ORAL SUSPENSION?
A: If you forgot to take a dose of SEPTRAN ORAL SUSPENSION, take it as soon as you remember. However, if it is time to take the next dose, skip the missed dose and take the next one at regular times. Do not take a double dose to compensate the forgotten dose.
References
1. KD. Tripathi. Antimicrobial Drugs. Essentials of Medical Pharmacology. 7th Edition. 2013. Page – 689, 705 & 706.
2. Tyler R. Kemnic, Meghan Coleman. Trimethoprim Sulfamethoxazole. StatPearls. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. November 2022. [Accessed on 16th February 2023]. https://www.ncbi.nlm.nih.gov/books/NBK513232/#:~:text=Trimethoprim%2Fsulfamethoxazole%2C%20also%20known%20as,for%20many%20types%20of%20illnesses.
3. Aspen Pharma Trading Limited. Co-Trimoxazole 40 mg/200 mg per 5ml Paediatric Suspension. Electronic Medicines Compendium. [Revised in July 2021]. [Accessed on 16th February 2023]. https://www.medicines.org.uk/emc/files/pil.6994.pdf
Useful Diagnostic Tests
- Complete blood count
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