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Introduction About SACURISE 50 TABLET
What is SACURISE 50 Tablet?
SACURISE 50 Tablet is a combination of Sacubitril (24 mg) and Valsartan (26 mg), medications that assist in managing chronic heart conditions by helping relax blood vessels and improving heart pumping efficiency. This combination helps support better blood flow and reduces strain on the heart for individuals with heart function concerns.
Monitor blood pressure and kidney function regularly during use. Discuss all existing health conditions and medications with your healthcare provider before starting SACURISE 50 Tablet.
Before taking SACURISE 50 TABLET inform your doctor if you have liver, kidney or heart problems. It is not recommended for use in pregnant and breast-feeding women. It is not suitable for use in children and adolescents under 18 years of age and it should be used with caution in elderly patients (65 years of age and above).
The most common side effects of taking SACURISE 50 TABLET are dizziness, cough, headache, tiredness, nausea and weakness. Consult your doctor if any of the side effects worsen.
Uses Of SACURISE 50 TABLET
- Manages long-term heart failure in adults
Benefits of SACURISE 50 TABLET
- Helps improve heart function and ease symptoms linked to reduced heart efficiency
- Supports lowering the risk of hospitalization and cardiovascular events in chronic heart conditions
- Sacubitril relaxes and widens blood vessels, aiding smooth blood circulation
- Valsartan blocks substances that tighten blood vessels, promoting better heart efficiency
How SACURISE 50 TABLET Works
SACURISE 50 TABLET helps to manage long-term heart failure, where Sacubitril works by relaxing and widening the blood vessels and makes it easier for the heart to pump blood throughout the body and Valsartan works by relaxing the blood vessels by blocking a substance called angiotensin-II (causing blood vessels to tighten) which is produced in the body and thus lowers the blood pressure.
How to use SACURISE 50 TABLET
Usage Guidance
- Take SACURISE 50 Tablet exactly as prescribed, commonly twice daily
- Swallow tablets whole with water, can be taken with or without food
- Do not adjust dosage or frequency without medical advice to ensure safety
Overdose
If you or anyone else accidentally take too much of SACURISE 50 TABLET, contact your doctor immediately or go to a nearest hospital straight away. Overdosage symptoms of SACURISE 50 TABLET includes severe dizziness and fainting.
Side Effects Of SACURISE 50 TABLET
Possible side effects
- Dizziness
- Cough
- Nausea
- fatigue
When to consult a doctor?
- Severe allergic reactions (swelling of the face, lips, tongue or throat, which may cause difficulties in breathing or swallowing (angioedema))
How To Manage Side Effects
Nausea And Vomiting
Stick to simple meals. Avoid eating oily, fried and spicy foods. Do not perform any strenuous activities immediately after eating. Consult your doctor if the symptom did not improve.
Tiredness
Drink plenty of fluids and eat balanced diet and frequent meals. Do regular minimal exercise and follow regular sleep schedule. Consult your doctor if your symptom did not improve.
Warning & Precautions
Pregnancy
ContraindicatedSACURISE 50 TABLET is not recommended for use in early pregnancy and must not be used in pregnant women when more than 3 months pregnant, as it may cause serious harm to the baby.
Breastfeeding
ContraindicatedSACURISE 50 TABLET is not recommended for use in breastfeeding women.
Driving and Using Machines
Use with CautionAvoid driving or handling any machines while taking SACURISE 50 TABLET because it may cause dizziness or tiredness.
Kidney
Use with CautionSACURISE 50 TABLET should be used with caution in patients with severe kidney disease and with narrowed kidney artery.
Liver
Consult your doctorSACURISE 50 TABLET is not recommended for use in patients with severe liver disease and it should be used with caution in patients with liver disease.
Allergy
ContraindicatedDo not take SACURISE 50 TABLET if you are allergic (hypersensitive) to Sacubitril or Valsartan.
Use In Pediatrics
ContraindicatedSACURISE 50 TABLET is generally not recommended for use in children and adolescents (under 18 years of age).
Use In Geriatrics
Use with CautionSACURISE 50 TABLET should be used with caution in elderly patients (above 65 years of age).
Other Warnings for SACURISE 50 TABLET
Before taking SACURISE 50 TABLET inform your doctor if you have:
- history of angioedema
- low blood pressure
- vomiting or diarrhea
- dehydration
- hallucinations, paranoia or changes in sleeping pattern
Who should not take SACURISE 50 TABLET
SACURISE 50 TABLET is not recommended for use, if you have:
- diabetes or impaired kidney function
- personal or family history of angioedema
Diet and Lifestyle Advice
Diet Advice
- Maintain a low-salt diet to support healthy blood pressure and heart function.
- Prefer foods rich in whole grains, vegetables, and fruits for overall cardiovascular health.?
- Avoid potassium-rich foods (such as bananas, broccoli, and potassium-based salt substitutes), unless your healthcare provider specifically allows them.?
- Limit intake of high-fat foods to reduce strain on the heart and blood vessels.?
- Discuss all supplements with your healthcare provider before use.
Lifestyle Advice
- Engage in regular, moderate physical activity such as walking or cycling, as advised by your provider.?
- Maintain a healthy weight through proper diet and exercise.
- Avoid smoking and reduce alcohol consumption to support overall heart and vascular health.?
- Stand up slowly from sitting or lying positions to minimize dizziness due to blood pressure changes.?
- Manage stress with relaxation activities such as yoga, stretching, or meditation.?
- Maintain regular check-ups to monitor blood pressure, kidney function, and general health status.
Drug - Drug interaction
|
Drug/Class |
Interaction Description |
Potential Effect |
Precaution / Recommendation |
|
ACE inhibitors |
Combined use may increase risk of high potassium and kidney issues |
Elevated potassium and kidney function changes |
Avoid concurrent use; monitor potassium & kidney function regularly |
|
Angiotensin receptor blockers (ARBs) |
May increase risk of low blood pressure and kidney effects when used together |
Excessive blood pressure lowering and kidney stress |
Use under strict medical supervision |
|
Potassium supplements |
May cause high potassium levels when taken with SACURISE 50 |
Risk of hyperkalemia affecting heart rhythm |
Use potassium supplements only if directed by healthcare provider |
|
NSAIDs (e.g., ibuprofen) |
May reduce effectiveness and worsen kidney impact |
Decreased heart support, kidney stress |
Use cautiously; consult healthcare provider |
|
Diuretics |
Additive effect on potassium levels and blood pressure |
Increased risk of dehydration and electrolyte imbalance |
Monitor electrolyte levels and hydration |
|
Lithium |
May increase risk of lithium toxicity |
Higher lithium concentration in blood |
Monitor lithium levels if used together |
Synopsis
| Drug | : | Sacubitril and Valsartan |
| Pharmacological Category | : | Neprilysin Inhibitor, Angiotensin II Receptor Blocker |
| Therapeutic Indication | : | Heart failure |
| Dosage Forms | : | Tablet |
More Information
Storage
- Store in a cool, dry place below 30°C away from sunlight
- Keep out of reach of children
FAQs About SACURISE 50 TABLET
Q: What is SACURISE 50 TABLET used for?
A: SACURISE 50 TABLET is used in managing chronic heart conditions by helping relax blood vessels and improving heart pumping efficiency.
Q: How does SACURISE 50 Tablet support heart function?
A: SACURISE 50 Tablet supports heart function by combining sacubitril and valsartan, which together relax and widen blood vessels, making it easier for the heart to pump blood efficiently. This action improves heart pumping ability, helps lower blood pressure, reduces symptoms like breathlessness and fatigue, and lowers the risk of hospitalization and cardiovascular events in chronic heart failure patients.
Q: Who should consult a doctor before using this medication?
A: Consult a doctor before using SACURISE 50 Tablet if you have allergies to sacubitril or valsartan, kidney or liver problems, low blood pressure, a history of angioedema (swelling of face, lips, tongue, or throat), diabetes treated with aliskiren, are pregnant or breastfeeding, or if you are elderly (above 65 years). Also, seek medical advice if you experience symptoms like dizziness, vomiting, diarrhea, dehydration, or mental health changes before starting the medication.
Q: What should be monitored while taking SACURISE 50 Tablet?
A: While taking SACURISE 50 Tablet, it is important to regularly monitor blood pressure, kidney function, and potassium levels. Monitoring helps ensure the medication's safety and effectiveness, detects any signs of low blood pressure or kidney problems early, and manages complications from abnormal potassium levels. Patients should also be aware of symptoms like dizziness, muscle weakness, or irregular heartbeat and inform their healthcare provider promptly.
Q: What are the common side effects of taking SACURISE 50 TABLET?
A: The most common side effects of taking SACURISE 50 TABLET are dizziness, light-headedness (low blood pressure), signs of high levels of potassium in the blood (irregular heartbeat, muscle weakness), decrease in renal function, cough, diarrhea, signs of low red blood cells (anemia), tiredness, headache, fainting or spinning sensation. Consult your doctor immediately if any of the side effects worsen.
Q: Can SACURISE 50 TABLET be used in pregnant women?
A: No. SACURISE 50 TABLET is not recommended for use in early pregnancy and must not be used in pregnant women when more than 3 months pregnant, as it may cause serious harm to the baby.
Q: Is SACURISE 50 TABLET safe to use in liver disease patients?
A: SACURISE 50 TABLET is not recommended for use in patients with severe liver disease and it should be used with caution in patients with liver disease.
Q: What to do If I forget to take SACURISE 50 TABLET?
A: You should take SACURISE 50 TABLET immediately when you remember. If it is time for your next dose skip the missed dose and follow your regular dose schedule. Do not double the dose to match up your missed dose.
Q: Can I stop taking SACURISE 50 Tablet if I feel better?
A: No, do not stop without consulting your doctor, as sudden discontinuation may worsen your condition.
Q: Do I need dosage adjustments?
A: Your doctor may adjust the dose based on your health condition and response.
References
1. KD Tripathi MD. Cardiovascular drugs. Essentials of Medical Pharmacology. Seventh Edition. New Delhi, May 2013. Page-508.
2. Loretta Fala. Entresto (Sacubitril/Valsartan): First-in-Class Angiotensin Receptor Neprilysin Inhibitor FDA Approved for Patients with Heart Failure. NCBI; PMC. Pubmed Central. National Library of Medicine, National Institute of Health. September 2018. [Accessed on November 24th 2025] 
3. Peter Khalil, Ghazal Kabbach, Sarmad Said and Debabrata Mukherje. Entresto, a New Panacea for Heart Failure. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. 2018. [Accessed on November 24th 2025] 
4. Novartis Pharmaceuticals UK Ltd. Electronic Medicines Compendium (EMC) [Revised in May 2021] [Accessed on November 24th 2025]
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