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Introduction About RYZODEG PENFILL 100IU CARTRIDGE
Ryzodeg Penfill Cartridge 100 IU is used to improve glycemic control in patients with diabetes mellitus (both Type I and Type II). It contains Insulin Aspart and Insulin Degludec, which belong to the group of medicines called Antidiabetic agents, which help your body make use of the circulating blood glucose. It helps in the transport of glucose from the blood into the muscles and fat tissues. It also stops the production of glucose by the liver.
Diabetes mellitus is a chronic disease characterized by abnormally high levels of glucose in the blood. It is caused either by inadequate production of a hormone called insulin (produced by the pancreas to metabolize glucose) in the body or by inadequate sensitivity of body cells to the actions of insulin.
Ryzodeg Penfill Cartridge 100 IU is suitable for use both in adults and in children (aged 6 years or older). It must be injected beneath the skin (such as on the thigh, upper arm, or abdomen). Avoid sharing needles, as it may increase the risk of infection. Along with the management, avoid smoking and alcohol consumption, and diet with regular physical activity as advised by your doctor.
Talk to your doctor before starting therapy with Ryzodeg Penfill Cartridge 100 IU if you have any liver, kidney, or heart problems. You must also inform your doctor if you have any hormonal problems, have made sudden changes to your diet, or have performed intense exercise as a precaution.
Do not use this medicine if you have hypoglycemia (low blood sugar levels). Consult your doctor before using this medicine if you are pregnant or breastfeeding.
The most common side effects of receiving Ryzodeg Penfill Cartridge 100 IU are low blood sugar levels, pain, redness, itching, swelling or thickening at the injection site, lump formation under the skin, and swelling of body parts. Consult your doctor if any of these side effects trouble you.
Uses Of RYZODEG PENFILL 100IU CARTRIDGE
- It is used to improve glycemic control in patients with diabetes mellitus (both Type I and Type II)
How RYZODEG PENFILL 100IU CARTRIDGE Works
Ryzodeg Penfill Cartridge 100 IU helps your body make use of the circulating blood glucose. It helps in the transport of glucose from the blood into the muscles and fat tissues. It also stops the production of glucose by the liver. As a result, it controls blood sugar levels and improves sugar control in patients with diabetes mellitus.
How to use RYZODEG PENFILL 100IU CARTRIDGE
Use the Ryzodeg Penfill Cartridge 100 IU under careful medical supervision. Inject Ryzodeg Penfill Cartridge 100 IU into your thighs, buttocks, upper arm, or abdomen (i.e., subcutaneously). Do not administer this medicine into the vein or muscle directly. It should be administered at least 10 minutes before meals. Eat a meal or snack containing carbohydrates within 20 minutes of the injection to avoid low blood sugar.
Before administration, roll the vial or cartridge between your hands until the liquid becomes uniformly white and cloudy. While injecting, keep the needle under the skin for at least 6 seconds to make sure that the entire dose is injected.
Prior to administration, visualize the cartridge or vial for any visible particulate matter and discoloration. Discard the needle and syringe after use, and do not share your needles with others to avoid the risk of infection transmission.
Avoid repeatedly injecting the medicine at the same site to manage skin damage. Instead, rotate the injection site. Make sure to consult your doctor before changing the injection site as a precaution.
Ryzodeg Penfill Cartridge 100 IU should not be mixed with any other insulins before use. Do not stop therapy with Ryzodeg Penfill Cartridge 100 IU without consulting your doctor. Your doctor will decide the correct dose and frequency of administration depending on your age, body weight, and health condition.
Side Effects Of RYZODEG PENFILL 100IU CARTRIDGE
Common
- Injection site reactions (such as pain, redness, itching, or swelling)
- Lipodystrophy (shrinkage of fat tissues beneath the skin)
- Lumps under the skin
- Weight gain, swelling of body parts
- Hypoglycemia (low blood sugar levels)
Consult your doctor immediately if you experience any of the following side effects:
- Allergic reaction (generalized skin rash with itching, sweating, and swelling of layers under the skin, difficulties in breathing, palpitation, vomiting, stomach upset, reduction in blood pressure, and fainting)
- Signs of severe hypoglycemia (such as cold sweats, cool pale skin, headache, rapid heartbeat, nausea, increased hunger, temporary vision changes, drowsiness, tiredness and weakness, nervousness or tremor, anxiety, confusion, and difficulty concentrating)
- Signs of heart failure (such as shortness of breath, edema, and rapid weight gain)
How To Manage Side Effects
Hypoglycemia
Managing hypoglycemia, or low blood sugar, involves prompt action to raise blood glucose levels and manage complications. When experiencing hypoglycemia, individuals should quickly consume a source of rapidly-absorbed carbohydrates, such as glucose tablets, fruit juice, or regular soda. Waiting for about 15 minutes and rechecking blood sugar levels is crucial to ensuring they rise to a safe range. If hypoglycemia persists, additional carbohydrate intake may be necessary. Once blood sugar levels stabilize, a small snack containing both carbohydrates and protein can help sustain them. Regular monitoring and consultation with a healthcare professional are essential for developing a personalized plan to manage hypoglycemia effectively. In severe cases, emergency assistance may be required.
Injection Site Reactions
Managing injection site reactions is essential for individuals who regularly administer injections. To alleviate discomfort and minimize potential issues, it is crucial to follow proper injection techniques. Rotate injection sites to manage overuse of a single area, allowing tissues to heal. Use a clean, sterile needle and syringe for each injection. Apply an ice pack to the injection site before and after administration to reduce pain and swelling. If redness, swelling, or irritation persist, consult a healthcare professional for guidance. It is essential to report any severe or persistent reactions to ensure appropriate adjustments to the injection routine and manage potential complications.
Warning & Precautions
Pregnancy
Monitoring requiredRyzodeg Penfill Cartridge 100 IU can be used during pregnancy if prescribed by the physician. However, consult your doctor before administration.
Breastfeeding
Use with CautionRyzodeg Penfill Cartridge 100 IU should be used with caution by breastfeeding women. Therefore, consult your doctor before administration.
Driving and Using Machines
Use with CautionDo not drive or operate any heavy tools or machines if your ability is affected by the Ryzodeg Penfill Cartridge 100 IU.
Alcohol
Consult your doctorAvoid consuming alcohol while taking this medicine, as it could aggravate your existing disease condition.
Kidney
Use with CautionRyzodeg Penfill Cartridge 100 IU should be used with caution in patients with kidney problems. Therefore, consult your doctor before administration.
Liver
Use with CautionRyzodeg Penfill Cartridge 100 IU should be used with caution in patients with liver problems. Therefore, consult your doctor before administration.
Allergy
ContraindicatedTalk to your doctor before receiving Ryzodeg Penfill Cartridge 100 IU if you are allergic to Insulin Aspart, Insulin Degludec, or any insulin type (Ex. Lente, ultra-Lente).
Heart Disease
Use with CautionRyzodeg Penfill Cartridge 100 IU should be taken with caution in patients with heart disease (such as heart failure). Therefore, consult your doctor before administration.
Use In Pediatrics
Monitoring requiredRyzodeg Penfill Cartridge 100 IU can be used in children and adolescents (aged 6 years or older) if prescribed by the physician. Therefore, consult your doctor before administration.
Use In Geriatrics
Use with CautionRyzodeg Penfill Cartridge 100 IU should be used with caution in elderly patients (aged 65 years or older). Therefore, consult your doctor before administration.
Others
Ryzodeg Penfill Cartridge 100 IU is not recommended for use if you:
- Have or are at risk of developing hypoglycemia (low blood sugar levels)
Talk to your doctor before receiving Ryzodeg Penfill Cartridge 100 IU if you:
- Have problems in the adrenal, pituitary, or thyroid glands
- Have or ever had stroke
- Have recently changed your diet plan and lifestyle
- Are exercising more than usual
- Recently became ill or had any infections
- Are planning to go abroad (as mealtime and injection timings may get changed)
Interactions
A. Drug-Drug interactions:
Before Ryzodeg Penfill Cartridge 100 IU is administered, inform your doctor if you are taking any of the following medicines, such as:
- Other antidiabetic agents (Ex. tolbutamide, glibenclamide, glipizide, metformin, phenformin, pioglitazone, sitagliptin, vildagliptin, and remogliflozin)
- Antidepressants (Ex. rasagiline, selegiline, and phenelzine)
- Heart medicines (Ex. propranolol, atenolol, nebivolol, captopril, enalapril, and lisinopril)
- Non-steroidal anti-inflammatory agents (Ex. aspirin)
- Anabolic steroids (Ex. testosterone, nandrolone, and oxandrolone)
- Sulphonamide antibiotics (Ex. sulfasalazine, sulfadiazine, and sulfamethoxazole)
- Oral contraceptives (Ex. mifepristone)
- Thiazide diuretics (Ex. chlorothiazide, hydrochlorothiazide)
- Glucocorticoids (Ex. cortisone, betamethasone, beclomethasone, dexamethasone, budesonide, and prednisone)
- Thyroid hormone (Ex. thyroxine, triiodothyronine)
- Sympathomimetic agents (Ex. ephedrine, adrenaline, salbutamol, or terbutaline)
- Growth hormone
- Androgenic hormones (Ex. Danazol)
- Octapeptides (Ex. Octreotide)
- Somatostatin agonists (Ex. Lanreotide)
B. Interaction with food or drink:
Ryzodeg Penfill Cartridge 100 IU should be administered 30 minutes before a meal.
Overdosage:
If you or anyone else took too much of this medicine, contact your doctor immediately or go to a hospital right away, as it may cause severe hypoglycemia. Symptoms of hypoglycemia might include fainting, feeling unwell, sweating, vomiting, difficulty breathing, a fast heartbeat, and dizziness.
Synopsis
| Drug | : | Insulin Aspart, Insulin Degludec |
| Pharmacological Category | : | Insulin Analogs |
| Therapeutic Indication | : | Diabetes mellitus |
| Dosage Forms | : | Injection, Flex pen |
More Information
- Keep out of reach of children
- Store the unopened pack in the refrigerator at 2-8°C. Do not freeze
- During use or when carried as a spare, keep it at room temperature
- Always place the vial/cartridge in the outer carton to protect from light
- Do not use the medicine after 28 days of opening
FAQs About RYZODEG PENFILL 100IU CARTRIDGE
Q: Should Ryzodeg Penfill Cartridge 100 IU be refrigerated?
A: Yes. An unopened pack must be stored in the refrigerator (2–8 °C). During use or while carrying it as a spare, keep it at room temperature to ensure uniform resuspension.
Q: Can Ryzodeg Penfill Cartridge 100 IU be mixed with other insulins?
A: Do not mix Ryzodeg Penfill Cartridge 100 IU with other insulins. Always consult your doctor before mixing insulins.
Q: Is Ryzodeg Penfill Cartridge 100 IU safe during pregnancy?
A: Yes. Ryzodeg Penfill Cartridge 100 IU can be used during pregnancy if prescribed by the physician. Therefore, consult your doctor before administration.
Q: How long does it take for the Ryzodeg Penfill Cartridge to start working?
A: Ryzodeg Penfill Cartridge is a fast-acting medicine that begins to lower blood sugar levels about 30 minutes post-administration, and its effect lasts for about 24 hours.
Q: Can Ryzodeg Penfill Cartridge be given intravenously?
A: No. Ryzodeg Penfill Cartridge is meant for subcutaneous use only (i.e., thighs, buttocks, abdomen, or upper arms). It should not be directly injected into the vein or muscle, as it may cause severe hypoglycemia.
Q: What is the best area for injecting Ryzodeg Penfill Cartridge 100 IU? Should I inject it at the same site every day?
A: The best place for injecting this medicine is in front of your thighs, buttocks, abdomen, or upper arms. The insulin would work more quickly if it were injected into the waist (abdomen). Do not repeatedly inject the medicine at the same site. Instead, rotate the injection sites within the same area to avoid the risk of developing lumps or skin pitting.
Q: What is Ryzodeg Penfill Cartridge 100 IU used for?
A: Ryzodeg Penfill Cartridge 100 IU is used in the management of diabetes mellitus (both type I and II). If you wish to buy Ryzodeg Penfill Cartridge 100 IU on Netmeds, you need a prescription from a registered medical practitioner. Netmeds has made buying online medicines more easy for consumers and is one of India's leading online pharmacies.
Q: What are the most common side effects of taking Ryzodeg Penfill Cartridge 100 IU?
A: The most common side effects of injecting Ryzodeg Penfill Cartridge 100 IU are low blood sugar levels, pain, redness, itching, swelling or thickening at the injection site, lump formation under the skin, and swelling of body parts. Consult your doctor if any of these side effects trouble you.
Q: Can I stop therapy with Ryzodeg Penfill Cartridge 100 IU without consulting your doctor?
A: No. You should not stop therapy with Ryzodeg Penfill Cartridge 100 IU without consulting your doctor because it may lead to a reversal of symptoms. If you feel better after using Ryzodeg Penfill Cartridge 100 IU, consult your doctor for advice.
Q: Will taking a higher dose of Ryzodeg Penfill Cartridge 100 IU be more effective?
A: No, taking a higher dose of Ryzodeg Penfill Cartridge 100 IU will not be effective; rather, it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
Q: Can I take medication for high blood pressure along with Ryzodeg Penfill Cartridge 100 IU?
A: It is not advisable to take medicines to control blood pressure while taking Ryzodeg Penfill Cartridge without consulting your doctor. Therefore, consult your doctor before taking any antihypertensive medications along with Ryzodeg Penfill Cartridge, as they have known interactions with Ryzodeg Penfill Cartridge.
Q: Can Ryzodeg Penfill Cartridge 100 IU cause weight gain?
A: Yes. Ryzodeg Penfill Cartridge 100 IU may cause weight gain in some individuals, although not everybody gets them. If you are worried about excessive weight gain, eat a healthy low-carb/fat diet with regular physical activity. Consult your doctor if the symptom does not improve.
References
1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 265-270.
2. Alvin C. Powers and David D’Alessio. Endocrine pancreas and Pharmacotherapy of diabetes mellitus and hypoglycemia. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page-1251.
3. Gerald G. Briggs and Roger K. Freeman. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 2020- 2022 & -2775.
4. Lisa A. Raedler. Tresiba (Insulin Degludec Injection) and Ryzodeg 70/30 (Insulin Degludec and Insulin Aspart Injection): Two New Insulin Analogs for Glycemic Control in Diabetes Mellitus. NCBI; PMC US National Library of Medicine, National Institute of Health. March 2016. [Accessed on 22nd January 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013846/
5. Novo Nordisk A/S. U.S. Food & Drug Administration. [Revised in September 2015] [Accessed on 22nd January 2024] https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/203313lbl.pdf
6. Novo Nordisk A/S. RYZODEG® 70/30 FlexTouch® and Penfill® (insulin degludec/insulin aspart) solution for injection. [Revised in October 2020]. [Accessed on 22nd January 2024] https://www.novonordisk.com.au/content/dam/nncorp/au/en/pdfs/ryzodeg-product-information-13.pdf
7. Novo Nordisk A/S. RYZODEG® 70/30 FlexTouch 3ml. [Revised in July 2020]. [Accessed on 22nd January 2024] https://www.novonordisk.com.au/content/dam/nncorp/au/en/pdfs/new-ryzodeg-70-30-flextouch-consumer-medicine-information-2020.pdf
Useful Diagnostic Tests
- HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin
- Blood Glucose Fasting (FBS)
- Insulin-Fasting
- Netmeds Diabetic Checkup
- Advance Diabetes Monitoring (Senior Female)
- Jaanch Diabetic Profile Basic
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