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Introduction About RYNAZMA INJECTION
RYNAZMA INJECTION contains Doxofylline which belongs to the group of medicines called Bronchodilators. It is used to manage asthma and chronic obstructive pulmonary disease (COPD). It can also be used to reduce apnea (lack of breathing) and other respiratory diseases associated with bronchospasm (tightening of airways).
Asthma is a long-term respiratory disease in which your airways become inflamed, swollen and narrowed. It also causes excessive mucous secretion in the airways which makes it difficult for the air to pass through, leading to unpleasant symptoms like wheezing, difficulty in breathing, chest pain and/or cough.
COPD is a lung disease characterized by chronic lung inflammation and obstructed air flow within the airways. It causes wheezing, breathing difficulties, cough with mucus production and chest pain.
During management with RYNAZMA INJECTION your doctor will periodically monitor the levels of doxofylline in your blood as a precaution and would adjust the dose accordingly. Limit the consumption of caffeine containing foods and beverages (such as coffee) while receiving RYNAZMA INJECTION.
Before receiving RYNAZMA INJECTION inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have hypertension, hyperthyroidism, stomach ulcers or any concomitant infections as a precaution.
RYNAZMA INJECTION is not recommended for use in patients with severe hypotension or heart problems (such as myocardial infarction). It is also not suitable for use in breastfeeding women.
Inform your doctor before receiving RYNAZMA INJECTION if you are pregnant or planning to become pregnant. The most common side effects of receiving RYNAZMA INJECTION are nausea, vomiting, upper stomach pain, irritability, lack of sleep and fast heartbeat or breathing. Consult your doctor if any of these side effect worsens.
Uses Of RYNAZMA INJECTION
It is used to manage:
- Bronchial Asthma
- Chronic Obstructive Pulmonary Disease (COPD)
- Apnea (breathing stops for a brief period)
How RYNAZMA INJECTION Works
RYNAZMA INJECTION is a bronchodilator. It relaxes the smooth muscles of the airways by blocking the release of certain enzymes (phosphodiesterase) in the respiratory tract that triggers narrowing. As a result, it widens the airways, allows the air to pass through more freely and makes breathing easier.
How to use RYNAZMA INJECTION
RYNAZMA INJECTION will be administered to you only by a doctor or a nurse into the vein (intravenously).
Your doctor will decide the correct dose, duration of therapy and number of doses per day depending upon your age, body weight and disease condition.
Side Effects Of RYNAZMA INJECTION
Common
- nausea, vomiting
- upper stomach pain
- headache
- irritability
- lack of sleep (insomnia)
- abnormal or rapid heartbeat
- fast breathing
Rare
- hyperglycemia (high blood sugar levels)
- albuminuria (presence of albumin in urine)
Consult your doctor if you experience any of the following side effects after receiving RYNAZMA INJECTION:
- cardiac arrhythmias
- fits (tonic-clonic seizures)
How To Manage Side Effects
Nausea and Vomiting:
Stick to simple meals. Avoid eating oil rich or spicy foods. Consult your doctor if your symptom worsens.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Warning & Precautions
Pregnancy
There is no adequate information regarding the use of RYNAZMA INJECTION in pregnant women. Therefore, it should be used in pregnant women only if considered necessary by the physician.
Breastfeeding
RYNAZMA INJECTION is not recommended for use in breastfeeding women. Therefore, consult your doctor before receiving it.
Driving and Using Machines
RYNAZMA INJECTION does not affect your ability to drive or operate machines. However, do not drive or handle any heavy tools or machines if your ability is affected by RYNAZMA INJECTION.
Kidney
RYNAZMA INJECTION should be used with caution in patients with kidney problems. Therefore, consult your doctor before receiving it.
Liver
RYNAZMA INJECTION should be used with caution in patients with liver diseases. Therefore, consult your doctor before receiving it.
Allergy
Talk to your doctor before receiving RYNAZMA INJECTION if you are allergic to Doxofylline or to any other similar medicines (such as etophylline, aminophylline).
Heart Disease
RYNAZMA INJECTION is not recommended for use in patients with heart problems (such as heart attack or myocardial infarction). It should be used with caution in patients with congestive heart failure. Therefore, consult your doctor before receiving it.
Others
RYNAZMA INJECTION is not recommended for use if you:
- have severe hypotension (low blood pressure)
Before receiving RYNAZMA INJECTION tell your doctor if you:
- have concomitant infections
- have hypertension (high blood pressure)
- have severe hypoxemia (low oxygen levels in blood)
- have hyperthyroidism
- have chronic cor pulmonale (right side of the heart fails to function properly)
- have peptic ulcer
Use in Pediatrics:
There is no adequate information regarding the use of RYNAZMA INJECTION in children and adolescents (aged below 18 years). Therefore, consult your doctor for advice before administration.
Use in Geriatrics:
RYNAZMA INJECTION should be used with caution in elderly patients (aged 65 years or above). Therefore, consult your doctor before receiving it.
Interactions
A. Drug-Drug Interactions:
Before receiving RYNAZMA INJECTION, inform your doctor if you are taking any of the following medicines such as:
- other methylxanthines (used to manage respiratory problems) Ex. etophylline, aminophylline
- medicines used to manage bacterial infections (such as erythromycin, troleandomycin, lincomycin, clindamycin)
- allopurinol (a medicine used to manage gout)
- cimetidine (a medicine used to manage stomach ulcers)
- influenza vaccine
- propranolol (a medicine used to manage heart problems)
- phenytoin (a medicine used to manage fits)
- sympathomimetic drugs (medicines used to increase heart rate and hypertension) Ex. ephedrine
B. Drug-Food Interactions:
Limit the consumption of foods and beverages rich in caffeine (such as coffee) while receiving RYNAZMA INJECTION.
Overdosage:
RYNAZMA INJECTION will be administered to you only by a doctor or a nurse and so it is unlikely to receive an overdose. However, consult your doctor if you experience any unpleasant symptoms after receiving RYNAZMA INJECTION.
Synopsis
| Drug | : | Doxofylline |
| Pharmacological Category | : | Methylxanthines |
| Therapeutic Indication | : | Bronchial Asthma, Chronic Obstructive Pulmonary Disease, Apnea |
| Dosage Forms | : | Tablet, Syrup, Injection |
More Information
- Keep RYNAZMA INJECTION out of reach of children
- Store RYNAZMA INJECTION at room temperature
FAQs About RYNAZMA INJECTION
How RYNAZMA INJECTION works?
RYNAZMA INJECTION is a bronchodilator. It relaxes the smooth muscles of the airways by blocking the release of certain enzymes (phosphodiesterase) in the respiratory tract that triggers narrowing. As a result, it widens the airways, allows the air to pass through more freely and makes breathing easier.
What is the use of RYNAZMA INJECTION?
RYNAZMA INJECTION is used to manage asthma and chronic obstructive pulmonary disease (COPD). It can also be used to reduce apnea (lack of breathing) and other respiratory diseases associated with bronchospasm (tightening of airways).
Is RYNAZMA INJECTION effective?
Yes. RYNAZMA INJECTION effectively controls the symptoms of asthma, COPD and other breathing problems, by relaxing the smooth muscles of the airways. As a result, it widens the airways, allows the air to pass through more freely and makes breathing easier.
What will happen if I received a higher dose of RYNAZMA INJECTION?
RYNAZMA INJECTION will be administered to you only by a doctor or a nurse and so it is unlikely to receive an overdose. However, consult your doctor if you experience any unpleasant symptoms after receiving RYNAZMA INJECTION.
Is RYNAZMA INJECTION safe?
RYNAZMA INJECTION is considered safe at doses prescribed by the physician. However, it may cause few side effects such as stomach pain, headache, nausea, vomiting, irritability, lack of sleep or fast breathing or heart rate in some individuals. Contact your doctor if they bother you.
Will receiving a higher dose of RYNAZMA INJECTION be more effective?
No. Do not take a higher dose of RYNAZMA INJECTION than prescribed by your doctor, as it could lead to toxicity. Always consume the dose prescribed by your doctor. If you feel that the prescribed dose is not working for you, consult your doctor for advice.
I’m pregnant. Can I receive RYNAZMA INJECTION?
RYNAZMA INJECTION should be used in pregnant women only if it is considered necessary by the physician. Your doctor will prescribe you with RYNAZMA INJECTION after evaluating the risks and benefits of the therapy.
Can RYNAZMA INJECTION be used in children?
There is no adequate information regarding the use of RYNAZMA INJECTION in children and adolescents (aged below 18 years). Therefore, consult your doctor for advice before receiving it.
Can I stop therapy with RYNAZMA INJECTION once my symptoms subside?
No. Continue to receive RYNAZMA INJECTION as long as your doctor prescribes it to you. Do not stop receiving this medicine suddenly without consulting your doctor as it may make it less effective.
Can RYNAZMA INJECTION be used on an asthma attack?
No. RYNAZMA INJECTION is only used to manage or manage the symptoms of asthma. If your asthma or breathing gets worse suddenly, contact your doctor immediately or go to the hospital straight away to avoid further exacerbation of the attack. Meanwhile use a fast-acting rescue inhaler for managing your condition.
How RYNAZMA INJECTION is administered?
RYNAZMA INJECTION will be administered to you only by a doctor or a nurse into the vein (intravenously).
What are the side effects of receiving RYNAZMA INJECTION?
The most common side effects of receiving RYNAZMA INJECTION are nausea, vomiting, upper stomach pain, irritability, lack of sleep and fast heartbeat or breathing. Consult your doctor if any of these side effect worsens.
References
1. KD. Tripathi. Drugs for Cough and Bronchial Asthma. Essentials of Medical Pharmacology. Page - 227.
2. Maria Gabriella Matera, Clive Page and Mario Cazzola. Doxofylline is not just another theophylline! NIH. National Library of Medicine. National Center for biotechnology Information. PMC. PubMed Central. December 2015. [Accessed on 15th November 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723117/
3. A.B.C Farmaceutici S.P.A. Doxofylline. [Revised in March 2011] [Accessed on 14th November 2022] https://www.abcfarmaceutici.it/uploads/news/40_file3_en.pdf
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