Rozagold 20mg Capsule 10'S

Introduction About ROZAGOLD 20MG CAPSULE

Rozagold 20mg Capsule contains Rosuvastatin, Clopidogrel and Aspirin which belongs to the group of medicines called HMG-CoA reductase inhibitors, Antiplatelet agents, and Non-Steroidal Anti-Inflammatory Agents respectively. It is used to manage high cholesterol and reduce the risk of serious heart problems such as heart attack, stroke, and angina. Rosuvastatin lowers bad cholesterol (LDL) and triglycerides, Clopidogrel and Aspirin work together to reduce blood clots, and this combination helps keep blood vessels clear, supporting overall heart and vascular health.  

Rozagold 20mg Capsule should be taken with food to help reduce stomach upset. Take it at the same time each day as prescribed by your doctor, and follow the dosing schedule carefully without skipping or stopping the medication on your own, even if you start to feel better. Swallow the capsule whole with water, do not cut, crush, or chew it. Your doctor will determine the appropriate dose and duration based on your specific condition. To enhance the effectiveness of Rozagold 20mg Capsule, adopt healthy lifestyle habits such as following a low-fat diet, exercising regularly, and avoiding smoking and alcohol.

Common side effects of this medicine include mild digestive discomfort, muscle pain, headache, increased bleeding tendency, stomach pain, indigestion, diarrhea, dizziness, constipation, nausea, and bruising. Inform your doctor immediately if you notice gastrointestinal bleeding, yellowing of the eyes or skin, severe muscle pain and allergic reactions.

Before taking Rozagold 20mg Capsule, inform your doctor if you have liver or kidney problems or history of bleeding disorders such as hemophilia or thrombocytopenia, or if you have ulcers or active bleeding from any part of the body. Let your doctor know if you are pregnant, planning to become pregnant, or breastfeeding, as this medicine is not recommended during pregnancy or lactation. You should also tell your doctor about all other medicines you are taking, including prescription, over-the-counter, and herbal products, as Rozagold 20mg Capsule can interact with several medications and increase the risk of side effects or reduce effectiveness.

Uses Of ROZAGOLD 20MG CAPSULE

• High cholesterol
• Reduce the risk of serious heart problems such as heart attack, stroke, and angina

Benefits of ROZAGOLD 20MG CAPSULE

1)Cardiovascular Support: Rozagold 20mg Capsule combines Rosuvastatin, Clopidogrel, and Aspirin to provide comprehensive cardiovascular protection. This combination helps maintain a healthy heart and circulatory system by lowering cholesterol and lowering blood clots, thereby reducing the risk of heart attack, stroke, and other cardiovascular events.

2)Cholesterol Management: Rosuvastatin, a statin, effectively lowers LDL (bad) cholesterol and triglycerides while increasing HDL (good) cholesterol. This supports a balanced lipid profile and helps prevent the buildup of plaques in the arteries, reducing the risk of atherosclerosis and its complications.

3)Blood Flow Maintenance: Aspirin and Clopidogrel are antiplatelet agents that work synergistically to inhibit platelet aggregation. This action helps keep blood flowing smoothly by reducing the likelihood of clot formation, which is crucial for preventing heart attacks and strokes.

4)Multi-Ingredient Synergy: The fixed-dose combination of a statin and two antiplatelet agents addresses multiple risk factors in cardiovascular disease. This multi-pronged approach offers enhanced protection compared to using any of the components alone, making it especially beneficial for high-risk patients.

5)Post-Procedure Support: Rozagold 20mg Capsule is often recommended after cardiovascular procedures such as stent placement or bypass surgery. It helps maintain vessel patency by lowering clot formation around the stent or surgical site, supporting long-term heart health, and reducing the risk of recurrent events.

How ROZAGOLD 20MG CAPSULE Works

How Rozagold 20mg Capsule Works in the Body

Rozagold 20mg Capsule acts by combining three agents such as Rosuvastatin, Aspirin, and Clopidogrel to lower cholesterol levels and reduce the formation of blood clots, thereby supporting heart health and reducing the risk of heart attacks, strokes, and other cardiovascular events.

Mechanism of Action: Rosuvastatin, Aspirin, and Clopidogrel

• Rosuvastatin is an HMG-CoA reductase inhibitor (statin) that lowers cholesterol by blocking the enzyme responsible for cholesterol synthesis in the liver, resulting in reduced LDL (bad cholesterol) and triglycerides, and increased HDL (good cholesterol).
• Aspirin works by inhibiting the cyclo-oxygenase (COX) enzyme, which decreases the production of thromboxane A2, a substance that promotes platelet aggregation and blood clot formation.
• Clopidogrel is another antiplatelet drug that blocks the P2Y12 component of ADP receptors on the platelet surface, lowering platelet activation and aggregation, further reducing the risk of clot formation.

Role of Rosuvastatin in Cholesterol Management

Rosuvastatin primarily targets the liver to inhibit HMG-CoA reductase, the key enzyme in cholesterol biosynthesis. This action lowers LDL cholesterol and triglycerides, while modestly increasing HDL cholesterol, helping to maintain a favorable lipid profile and slow the progression of atherosclerosis.

How Aspirin and Clopidogrel Support Healthy Blood Flow

Aspirin and Clopidogrel both act as antiplatelet agents but through different mechanisms. Aspirin inhibits COX-1, reducing thromboxane A2 and thus platelet aggregation. Clopidogrel blocks ADP-mediated platelet activation. Together, they significantly decrease the risk of harmful blood clot formation, ensuring smoother blood flow and reducing the risk of heart attack and stroke.

Synergistic Effects of the Rozagold 20mg Capsule Combination

The combination of Rosuvastatin, Aspirin and Clopidogrel provides a comprehensive approach: It simultaneously manages cholesterol and reduce blood clots. This synergy offers enhanced cardiovascular protection, especially for patients at high risk of heart attack, stroke, or those who have undergone cardiac procedures.

Understanding the Lipid-Lowering and Antiplatelet Actions

• Lipid-lowering: Rosuvastatin reduces the liver's ability to produce cholesterol, lowering blood levels of LDL and triglycerides, and raising HDL, which helps prevent plaque buildup in arteries.
• Antiplatelet: Aspirin and Clopidogrel inhibit different pathways of platelet aggregation, minimizing the risk of clot formation that can block arteries and lead to heart attacks or strokes.

Together, these actions help maintain open blood vessels, support healthy circulation, and significantly lower the risk of major cardiovascular events.

How to use ROZAGOLD 20MG CAPSULE

Follow your doctor's instructions regarding the exact dosage. Do not exceed the recommended daily dosage.

Recommended Dosage and Administration Guidelines

• Take Rozagold 20mg Capsule exactly as prescribed by your doctor, usually once daily with food to help reduce stomach irritation.
• Swallow the capsule whole with a glass of water; do not cut, crush, or chew it.
• Your doctor will determine the appropriate dose and duration based on your specific condition and response to management.

How to Take Rozagold 20mg Capsule Safely

• Always take Rozagold 20mg Capsule at the same time each day to maintain consistent levels in your body.
• Follow your doctor’s instructions carefully, and do not alter the dose or stop the medication without consulting your doctor, as this may worsen your condition or increase the risk of heart events.

Tips for Incorporating Rozagold 20mg Capsule into Your Routine

• Take Rozagold 20mg Capsule with a meal, preferably at the same time each day, to help remember your dose and minimize stomach upset.
• Set a daily alarm or reminder to help you take your medication consistently.
• Maintain healthy lifestyle habits such as a low-fat diet, regular exercise, and avoiding smoking and alcohol to enhance the effectiveness of the medicine.
• Store the medicine as per the instructions on the label and keep it out of reach of children.
• Attend regular follow-up appointments and blood tests as advised by your doctor to monitor your response and adjust the dose if needed.

What if I forgot to take ROZAGOLD 20MG CAPSULE

• If you miss a dose, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double the dose to make up for the missed one.

Side Effects Of ROZAGOLD 20MG CAPSULE

Like all medicines, Rozagold 20mg Capsule may cause certain side effects in some individuals, although not everybody gets them.

The most common side effects of taking Rozagold 20mg Capsule are:

• Mild digestive discomfort
• Muscle pain
• Headache
• Increased bleeding tendency
• Stomach pain
• Indigestion
• Diarrhea
• Dizziness
• Constipation
• Nausea
• Bruising

When to consult your doctor?

• Allergic reaction symptoms such as swelling of the face, lips, tongue, or throat, difficulty breathing or swallowing, or severe skin rash
• Serious muscle damage (rhabdomyolysis) symptoms such as unexplained muscle pain, tenderness, or weakness
• Liver problems symptoms such as yellowing of the skin or eyes (jaundice), pale stools, or dark urine
• Gastrointestinal bleeding symptoms such as severe stomach pain, persistent vomiting, vomiting blood or passing black stools
• Stroke symptoms such as sudden weakness, numbness, difficulty speaking, or loss of coordination

How To Manage Side Effects

Headache

• Rest in a Quiet, Dark Room: Find a calm, quiet space away from bright lights and loud noises. Lie down and close your eyes.
• Hydrate: Dehydration can contribute to headaches, so drink plenty of water.
• Apply a Cold or Warm Compress: A cold pack on your forehead may reduce pain, or a warm compress on your neck or shoulders can relieve tension.
• Over-the-Counter Pain Relief: You can take over-the-counter pain relievers like acetaminophen or ibuprofen if appropriate for you. Follow the recommended dosage.
• Practice Relaxation Techniques: Deep breathing exercises, meditation, or gentle stretching can help reduce stress and alleviate headache symptoms.

Nausea And Vomiting

• Eat Small, Frequent Meals: Avoid heavy or greasy foods. Opt for bland foods like crackers, toast, or bananas.
• Stay Hydrated: Sip on clear fluids like water, ginger tea, or electrolyte drinks, Avoid caffeinated and carbonated beverages.
• Ginger: Ginger is a natural remedy for nausea. Try ginger tea, ginger candies, or ginger ale (ensure it contains real ginger).
• Avoid Strong Odors: Minimize exposure to smells that might trigger nausea, such as perfumes or cooking odors.

Warning & Precautions

Pregnancy

Contraindicated

Rozagold 20mg Capsule is not recommended for use during pregnancy. It should not be used by pregnant women, and women of child-bearing potential must use effective contraception while taking this medicine. Consult your doctor before taking this medication.

Breastfeeding

Contraindicated

Rozagold 20mg Capsule is not recommended for use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. Consult your doctor before taking this medication.

Driving and Using Machines

Use with Caution

Rozagold 20mg Capsule generally does not affect your ability to drive or operate machinery. However, if you experience dizziness or reduced alertness, avoid such activities.

Alcohol

Consult your doctor

Avoid alcohol consumption while taking this medicine as it increases the risk of stomach bleeding and can worsen certain side effects.

Kidney

Consult your doctor

Rozagold 20mg Capsule is not recommended for use in patients having moderate-to-severe kidney disease and should be used with caution in patients with kidney problems. Consult your doctor before taking this medication.

Liver

Consult your doctor

Rozagold 20mg Capsule is not recommended for use in patients with severe or active liver disease, including persistent elevations of liver enzymes and should be used with caution in patients with history of liver disease. Consult your doctor before taking this medication.

Allergy

Contraindicated

Do not take Rozagold 20mg Capsule if you are allergic to Rosuvastatin or Clopidogrel or Aspirin or other NSAIDs/prostaglandin synthetase inhibitors or any other ingredients of this medicine.

Lungs

Use with Caution

Rozagold 20mg Capsule should be used with caution in patients with interstitial lung disease or severe respiratory failure. Consult your doctor before taking it.

Heart Disease

Contraindicated

Rozagold 20mg Capsule is not recommended for use in patients with recent ischemic stroke and should be used caution in other heart problems. Consult your doctor before taking this medication.

Use In Pediatrics

Monitoring required

Rozagold 20mg Capsule is not recommended for children and adolescents under 18 years unless specifically prescribed by a physician due to increased risk of bleeding. Consult your pediatrician before giving it.

Use In Geriatrics

Use with Caution

Rozagold 20mg Capsule should be administered cautiously in elderly patients aged 70 years or older due to increased risk of gastrointestinal bleeding and perforation, especially with prolonged use. Regular review is advised if long-term therapy is necessary. Consult your doctor before taking this medication.

Other Warnings for ROZAGOLD 20MG CAPSULE

Before taking Rozagold 20mg Capsule, inform your doctor if you have:

• upcoming planned surgery (including dental surgery)

Who should not take [GBNKEYWORD

Rozagold 20mg Capsule is not recommended for use if you:

• have or had any repeated or unexplained muscle pains
• have family history of hereditary muscular disorders
• have family history of muscle problems following management with cholesterol-lowering medicines
• have an underactive thyroid gland
• have gastrointestinal problems (such as peptic ulcer, or bleeding in the gut)
• have bleeding disorders (Ex. bleeding in the brain, hemophilia, or others)
• have thrombocytopenia (decreased platelet count)
• have gout
• have lactose intolerance
• have diabetes
• have dehydration
• have menorrhagia (abnormally heavy bleeding during menstruation)

Drug - Drug interaction

Inform your physician if you are taking any of the following medicine before taking Rozagold 20mg Capsule:

1) Cyclosporine

• Interaction: Cyclosporine significantly increases the plasma concentration of rosuvastatin.
• Effects: Increased risk of myopathy and rhabdomyolysis; potential renal impairment.
• Management: Avoid concomitant use if possible. If necessary, limit rosuvastatin to 5 mg/day. Consider switching to an alternative statin not metabolized by the same pathway.

2) Gemfibrozil (or other fibrates)

• Interaction: Increases the risk of muscle-related side effects.
• Effects: Elevated risk of myopathy and rhabdomyolysis.
• Management: Avoid combination if possible. If necessary, monitor closely for muscle symptoms and check creatine kinase (CK) levels regularly.

3) Protease Inhibitors (e.g., Ritonavir, Lopinavir)

• Interaction: These can significantly increase rosuvastatin levels by inhibiting its metabolism.
• Effects: Higher chance of muscle toxicity and liver enzyme elevations.
• Management: Use with caution, and limit rosuvastatin dose to maximum 10 mg/day depending on the specific protease inhibitor.

4) Warfarin

• Interaction: Rosuvastatin can enhance the anticoagulant effect of warfarin.
• Effects: Increased risk of bleeding.
• Management: Monitor INR (International Normalized Ratio) more frequently when starting or changing the dose of rosuvastatin.

5) Antacids containing aluminum and magnesium

• Interaction: These reduce the absorption of rosuvastatin.
• Effects: Decreased efficacy of rosuvastatin.
• Management: Administer rosuvastatin at least 2 hours before or after taking the antacid.

6) Erythromycin

• Interaction: May increase gastrointestinal motility, potentially reducing rosuvastatin absorption.
• Effects: Reduced plasma levels and efficacy.
• Management: Monitor lipid levels; no routine dose adjustment but consider alternatives if lipid control is inadequate.

7) Colchicine

• Interaction: Combined use may increase the risk of muscle toxicity.
• Effects: Potential for myopathy and rhabdomyolysis.
• Management: Monitor for signs of muscle pain, weakness, or elevated CK levels. Use with caution, especially in the elderly or those with renal impairment.

8) Niacin (Nicotinic Acid)

• Interaction: Increases the risk of myopathy when used with rosuvastatin.
• Effects: Elevated risk of rhabdomyolysis, especially at high doses.
• Management: Use with caution; monitor for muscle symptoms and consider dose reduction.

Drug - Food interaction

1) Grapefruit Juice

• Interaction: Unlike other statins (like simvastatin), rosuvastatin is minimally affected by grapefruit juice.
• Effects: Clinically insignificant effect on rosuvastatin blood levels.
• Management: No specific dietary restriction needed regarding grapefruit juice. However, it is best to moderate intake as a general precaution.

2) High-Fat Meals

• Interaction: Rosuvastatin absorption is not significantly affected by food.
• Effects: The presence of food may slightly delay the peak concentration but does not reduce bioavailability.
• Management: Rosuvastatin can be taken with or without food.

3) Alcohol

• Interaction: Alcohol does not directly interact with rosuvastatin, but both can affect liver function.
• Effects: Increased risk of liver damage (elevated liver enzymes, hepatotoxicity).
• Management: Advise limiting or avoiding alcohol intake, especially in patients with liver disease or elevated liver enzymes.

4) St. John’s Wort (Herbal Supplement)

• Interaction: Can induce certain enzymes (CYP3A4), but rosuvastatin is not primarily metabolized by CYP3A4.
• Effects: Possible reduction in effectiveness of rosuvastatin (though less significant than with other statins).
• Management: Use with caution, monitor lipid levels if used together. Prefer avoiding herbal supplements unless cleared by a doctor.

5) Foods High in Cholesterol/Saturated Fat

• Interaction: Diet rich in saturated fats and cholesterol counteracts the lipid-lowering effects of rosuvastatin.
• Effects: Reduced effectiveness in lowering LDL cholesterol and total cholesterol.
• Management: Encourage patients to follow a low-cholesterol, low-saturated fat diet as advised in dyslipidemia management.

Synopsis

More Information

1) Why Rozagold 20mg Capsule is prescribed and how it can help manage cardiovascular health, cholesterol, and blood flow? 

Rozagold 20mg Capsule is prescribed for the management of serious cardiovascular conditions such as acute coronary syndrome, myocardial infarction (heart attack), angina (chest pain), and stroke. It contains a combination of three key medications:

• Rosuvastatin: A statin that lowers "bad" cholesterol (LDL) and triglycerides while increasing "good" cholesterol (HDL), thereby reducing plaque buildup in arteries.
• Clopidogrel: An antiplatelet agent that prevents platelets from clumping together, reducing the risk of blood clot formation.
• Aspirin: Another antiplatelet and NSAID that further inhibits platelet aggregation and reduces inflammation, helping to prevent blood clots and improve blood flow.

How Rozagold 20mg Capsule Helps Manage Cardiovascular Health, Cholesterol, and Blood Flow: 

• Cholesterol Management: Rosuvastatin lowers LDL and triglycerides, slowing the progression of atherosclerosis (narrowing of arteries due to plaque), which is a major risk factor for heart attacks and strokes.
• Blood Clot Prevention: Clopidogrel and aspirin work together to prevent platelets from forming clots, ensuring smoother blood flow through arteries and veins.
• Improved Blood Flow: By preventing clots and reducing plaque, the medication helps maintain uninterrupted blood supply to the heart, brain, and other organs, lowering the risk of heart attacks, strokes, and peripheral vascular disease.
• Cardiovascular Protection: Regular use of Rozagold 20mg Capsule, combined with lifestyle changes such as a healthy diet and regular exercise, provides comprehensive protection against cardiovascular events.

Rozagold 20mg Capsule is prescribed to improve heart health, manage cholesterol, and ensure proper blood flow, thereby reducing the risk of life-threatening cardiovascular events.

2) What lifestyle modifications, including diet, physical activity, and health monitoring, can help enhance the effectiveness of Rozagold 20 mg Capsule?

Following these tips will help you maximize the effectiveness of Rozagold 20mg Capsule and support your overall cardiovascular health.

3) How does Rozagold 20 mg compare to other commonly prescribed statins? What makes Rozagold 20 mg stand out compared to other statins?

a) Rozagold 20mg Capsule vs. Single-Ingredient Statins

b) Rosuvastatin (as in Rozagold) vs. Other Statins

Why Rozagold 20mg Stands Out:

• Comprehensive Protection: Combines three powerful agents—statin for cholesterol, and two antiplatelets for clot prevention—providing multi-faceted cardiovascular protection.
• Targeted for High-Risk Patients: Ideal for those with recent heart attacks, stents, strokes, or peripheral arterial disease, as it addresses both cholesterol and clotting risks.
• Potent Cholesterol Reduction: Rosuvastatin component is among the most effective statins for lowering LDL cholesterol.
• Dual Antiplatelet Therapy: Offers superior clot prevention compared to statin-only therapy, significantly reducing the risk of recurrent cardiovascular events.
• Synergistic Effect: The combination works together to prevent atherosclerosis progression and maintain blood flow to vital organs.

Rozagold 20mg Capsule stands out by offering a unique, comprehensive approach for patients needing both cholesterol control and enhanced protection against blood clots.

FAQs About ROZAGOLD 20MG CAPSULE

References

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2. Jeffery I. Weitz. Blood coagulation and Anticoagulant, Fibrinolytic and Antiplatelet Drugs. Thomas P. Bersot. Drug therapy for hypercholesterolemia and dyslipidemia. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 868-870 & 892-898.

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4. Susan Smyth. Early Use of Rosuvastatin in Acute Coronary Syndromes: Targeting Platelet-Leukocyte Interactions. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in March 2017] [Accessed on 2nd July 2025]

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7. Travis R. Sexton, Eric L. Wallace, Tracy E. Macaulay, Richard J. Charnigo, Virgilio Evangelista, Charles L. Campbell, Alison L. Bailey and Susan S. Smyth. The effect of rosuvastatin on thrombo inflammation in the setting of acute coronary syndrome. NCBI; PMC US National Library of Medicine, National Institute of Health. October 2014. [Accessed on 2nd July 2025]

8. Ke An, Rong Huang, Sai Tian, Dan Guo, Jiaqi Wang, Hongyan Lin, and Shaohua Wang. Statins significantly reduce mortality in patients receiving clopidogrel without affecting platelet activation and aggregation: a systematic review and meta-analysis. NCBI; PMC US National Library of Medicine, National Institute of Health. May 2019. [Accessed on 2nd July 2025]

9. P. Maggi, G. V. De Socio, S. Cicalini, M. D’Abbraccio, G. Dettorre, A. Di Biagio, C. Martinelli, G. Nunnari, S. Rusconi, L. Sighinolfi, V. Spagnuolo, and N. Squillace. Statins and aspirin in the prevention of cardiovascular disease among HIV-positive patients between controversies and unmet needs: review of the literature and suggestions for a friendly use. NCBI; PMC US National Library of Medicine, National Institute of Health. May 2019. [Accessed on 2nd July 2025]

10. Torrent Pharmaceuticals Ltd. Unistar Gold / Rozucor Gold. Torrentian.com. [Revised in March 2021] [Accessed on 2nd July 2025]

11. Cipla Ltd. Rosulip Gold Capsules (Rosuvastatin calcium + Clopidogrel + Aspirin). Ciplamed.com. [Revised in January 2019] [Accessed on 2nd July 2025]

Useful Diagnostic Tests

• Cardiac Risk Profile

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Venkatesh Poludasu - MBBS

Last updated on 02 Jul 2025 | 02:52 PM(IST)