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Introduction About RITROD INJECTION
RITROD INJECTION contains Ritodrine which belongs to a group of medicines called Tocolytics. It is indicated for the management of uncomplicated Premature labour.
Premature labour occurs when regular contractions result in the opening of the cervix after 20th week and before 37th week of pregnancy. It can result in premature birth. The earlier premature birth happens, the greater the health risks for the baby.
RITROD INJECTION is not recommended for use in patients with known hypersensitivity reactions, cardiac disease like myocardial ischaemia, antepartum haemorrhage, intra-uterine infection, intra-uterine fetal death, placenta praevia, abruptio placenta, threatened miscarriage, cord compression, eclampsia or severe pre-eclampsia.
Before receiving this medicine inform your doctor if you have cardiac diseases, hypertension, hyperthyroidism, hypokalaemia, diabetes mellitus, mild to moderate pre-eclampsia, blood pressure and pulse rate and avoid over-hydration while receiving this medicine.
There are no adequate and well controlled studies of effects in pregnant women before 20 weeks gestation. It should not be used before the 20th week of pregnancy. Studies in pregnant women from the 20th week of gestation onwards have not shown increased risk of fetal abnormalities. Therefore, it should be used only when clearly indicated by the physician.
The most common side effects of receiving are nausea, vomiting, flushing, sweating, tremor, hypokalaemia, tachycardia, palpitations, hypotension (left lateral position throughout infusion to minimize risk), uterine bleeding and pulmonary oedema. Consult your doctor if any of the above side effects worsen or persist for a long duration.
Uses Of RITROD INJECTION
- Used to manage uncomplicated premature labour
How RITROD INJECTION Works
RITROD INJECTION belongs to β2–adrenergic agonist which relaxes the uterus by stimulating the β2–adrenergic receptors of the uterine muscle, which causes a decrease in the intensity and frequency of uterine contractions. It eases the contraction of the uterus and helps relaxing it, thereby managing premature delivery.
How to use RITROD INJECTION
RITROD INJECTION will be administered intravenously or intramuscularly by your doctor or nurse. Your doctor will decide the right dose depends on your age, body weight and health condition.
Side Effects Of RITROD INJECTION
Common
- nausea, vomiting
- flushing
- sweating
- tremors
- hypokalaemia
- tachycardia, palpitations
- hypotension (left lateral position throughout infusion to minimize risk)
- uterine bleeding
- pulmonary oedema
- chest pain or tightness
- arrhythmias
- salivary gland enlargement
- leucopenia, agranulocytosis
- liver function abnormalities including increased transaminases and hepatitis
- headache
- nervousness
- anxiety
Rare
Stop receiving and contact your doctor immediately, if you experience the following:
- lung swelling
- severe allergic reactions
How To Manage Side Effects
Headache
Rest and relax. Drink plenty of fluids such as water and apply a pain-relieving balm on the head if necessary. Do not consume alcohol. Contact your doctor if headache worsens.
Nausea And Vomiting
Try to take this medicine with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food.
Warning & Precautions
Pregnancy
Consult your doctorThere are no adequate and well controlled studies of effects in pregnant women before 20 weeks gestation. It should not be used before the 20th week of pregnancy. Therefore, it will be administered only when clearly indicated by the physician. Consult your doctor for advice.
Breastfeeding
Use with CautionRITROD INJECTION should be used with caution in breastfeeding women. Consult your doctor before taking this medicine.
Allergy
ContraindicatedDo not receive if you are allergic to Ritodrine or any other ingredients of this medicine.
Lungs
Use with CautionRITROD INJECTION should be used with caution in patients suffering from lung disease such as bronchial asthma. Consult your doctor for advice before receiving.
Heart Disease
Consult your doctorRITROD INJECTION is not recommended in patients with heart diseases such as myocardial ischaemia. It should be used with caution in patients suffering from myocardial insufficiency, arrhythmias. Before receiving, discuss the risks and benefits with your doctor.
Others
Do not receive RITROD INJECTION, if you have:
- antepartum haemorrhage
- intra-uterine infection
- intra-uterine fetal death
- placenta praevia
- abruptio placenta
- threatened miscarriage
- cord compression
- eclampsia or severe preeclampsia
Before receiving RITROD INJECTION, inform your doctor if you have:
- hypertension
- hyperthyroidism
- hypokalaemia
- diabetes mellitus
- mild to moderate preeclampsia
- pulmonary oedema
Interactions
A. Drug-Drug interactions:
Before receiving RITROD INJECTION inform your doctor if you are taking the following medicines:
- corticosteroids
- diuretics (acetazolamide, loop diuretics and thiazides)
- theophylline (used for breathing problems)
- sympathomimetic medicines
- β–adrenergic blocking medicines
- anesthetics (used for surgery)
- neuromuscular blockers such as pancuronium, vecuronium
- potassium-depleting medicines
Overdosage:
Your doctor or nurse will administer the RITROD INJECTION, so it is unlikely to cause overdosage. If you experience any unusual side effects after receiving RITROD INJECTION, consult your doctor immediately. Symptoms of overdose includes tachycardia (maternal and fetal), palpitation, cardiac arrhythmia, hypotension, nervousness, tremor, nausea, and vomiting.
Synopsis
| Drug | : | Ritodrine |
| Pharmacological Category | : | Tocolytics |
| Therapeutic Indication | : | Uncomplicated premature labour |
| Dosage Forms | : | Tablet, Injection |
More Information
- Keep out of reach of children
- Store at room temperature
FAQs About RITROD INJECTION
Q: How RITROD INJECTION will be administered?
A: RITROD INJECTION will be administered intravenously or intramuscularly by your doctor or nurse. Your doctor will decide the right dose depends on your age, body weight and health condition.
Q: Does RITROD INJECTION cause headache?
A: Yes, this medicine may cause headache in some individuals. Rest and relax. Drink plenty of fluids such as water and apply a pain-relieving balm on the head if necessary. Do not consume alcohol. Contact your doctor if headache worsens.
Q: Is this medicine safe in diabetic patients?
A: This medicine may increase blood glucose levels. So, it should be used with caution in pregnant women with diabetes mellitus. In addition, this medicine is not recommended to use in pregnant women with uncontrolled diabetes.
Q: Does RITROD INJECTION manage high blood pressure during pregnancy?
A: No, it doesn’t manage high blood pressure during pregnancy. Consult your doctor for advice before taking this medicine.
Q: Is RITROD INJECTION safe?
A: Yes, it is safe if used in the dose and duration advised by your doctor. Consult your doctor for advice before taking this medicine.
References
1. KD. Tripathi. Oxytocin and Other Drugs Acting on Uterus. Essentials of medical pharmacology. Seventh edition. 2013. Page –333.
2. Yukari Yaju 1, Takeo Nakayama. Effectiveness and safety of ritodrine hydrochloride for the treatment of preterm labour: a systematic review. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. Nov 2006. [Accessed 15 Nov 2021] https://pubmed.ncbi.nlm.nih.gov/16981213/
3. Ritodrine. [Accessed on 15 Nov 2021] https://www.just.edu.jo/DIC/AZLibrary/Ritodrine.pdf
4. ACI Limited. [Accessed on 15 Nov 2021] https://medex.com.bd/brands/15672/ritopar-50mg
5. ACI Limited. [Accessed on 15 Nov 2021] https://www.aci-bd.com/Brand/Ritopar.pdf
6. Michael G Ross. Preterm Labor. [Accessed on 15 Nov 2021] https://emedicine.medscape.com/article/260998-overview
7. Pubchem, Ritodrine, US National Library of Medicines, National Institutes of Health. [Accessed on 15 Nov 2021] https://pubchem.ncbi.nlm.nih.gov/compound/Ritodrine#section=Metabolism-Metabolites
8. Drugs update. Ritodrine. [Accessed on 15 Nov 2021] https://www.drugsupdate.com/generic/view/449/Ritodrine-
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