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Introduction About RIFALIN I 450/300MG TABLET
RIFALIN I 450/300MG TABLET is a combination of Isoniazid and Rifampicin which belongs to the group of medicines called Antitubercular agents. It is used to manage tuberculosis and bacterial infection of membranes covering the brain, and spinal cord. It is also used to manage contagious disease of skin, nerves, mucous membrane, and other conditions in affected individuals.
RIFALIN I 450/300MG TABLET is not recommended for use in patients allergic to Isoniazid, and/or Rifampicin. Before taking RIFALIN I 450/300MG TABLET, inform your doctor if you are scheduled for any upcoming surgery, and/or suffering from pre-existing diseases, liver problems (such as cirrhosis of liver)/kidney problems (such as renal insufficiency).
RIFALIN I 450/300MG TABLET should be used with caution during pregnancy and in women planning for pregnancy. It is also advised to be used with caution in breastfeeding women as it may pass through breast milk.
RIFALIN I 450/300MG TABLET should be used with caution in children and adolescents (aged below 18 years) and is advised to be used with caution in elderly patients (aged 65years and above) after consulting the doctor.
The most common side effects of taking RIFALIN I 450/300MG TABLET are hypersensitivity reaction (associated with signs such as skin rash, red itchy welt, and/or shortness of breath), loss of vision/hearing, flu-like syndrome, and/or arthralgia (joint stiffness). Consult your doctor if any of these symptoms worsens.
Uses Of RIFALIN I 450/300MG TABLET
- Manage tuberculosis and bacterial infection of membranes covering the brain, and spinal cord
- Manage contagious disease of skin, nerves, mucous membrane, and other conditions in affected individuals
How RIFALIN I 450/300MG TABLET Works
RIFALIN I 450/300MG TABLET manages tuberculosis infection, where Rifampicin works by inactivating bacterial enzyme (RNA-polymerase) resulting in its destruction and Isoniazid works by managing the bacteria to form its own protective covering leading to its death thus managing tuberculosis in affected individuals.
How to use RIFALIN I 450/300MG TABLET
Tablet, Capsule:
Take RIFALIN I 450/300MG TABLET as advised by your physician. Swallow RIFALIN I 450/300MG TABLET with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of the medicine depending upon your age, body weight and disease condition.
Side Effects Of RIFALIN I 450/300MG TABLET
Common
- signs of hypersensitivity (immune & inflammatory response) reactions such as skin rash, red itchy welt, shortness of breath, and/or wheezing
- loss of vision/hearing
- flu-like syndrome
- haemolytic anaemia (blood disorder)
- arthralgia (joint stiffness)
Rare
Stop taking RIFALIN I 450/300MG TABLET and contact your doctor immediately if you experience any of the following side effects:
- signs of severe thrombocytopenia (low platelet count) such as excessive bruising, prolonged bleeding (from cuts), bleeding from gums, and/or blood in urine/stools
Warning & Precautions
Pregnancy
Use with CautionRIFALIN I 450/300MG TABLET is advised to be used with caution during pregnancy and in women planning for pregnancy. Consult your doctor before taking the medicine.
Breastfeeding
Use with CautionRIFALIN I 450/300MG TABLET should be used with caution in breastfeeding women since the medicine may pass through breast milk. Consult your doctor before taking the medicine.
Kidney
Use with CautionRIFALIN I 450/300MG TABLET should be used with caution in patients with kidney problems such as renal insufficiency. Consult your doctor before taking the medicine.
Liver
Use with CautionRIFALIN I 450/300MG TABLET should be used with caution in patients with liver problems such as cirrhosis of liver. Consult your doctor before taking the medicine.
Allergy
ContraindicatedDo not take RIFALIN I 450/300MG TABLET if you are allergic to Isoniazid, Rifampicin, and/or any other ingredients of this medicine.
Others
Before taking RIFALIN I 450/300MG TABLET, inform your doctor if you:
- are suffering from pre-existing diseases
- are scheduled for upcoming surgery
Use in Paediatrics:
RIFALIN I 450/300MG TABLET should be used with caution in children and adolescents (aged below 18 years). Consult your doctor before taking the medicine.
Use in Geriatrics:
RIFALIN I 450/300MG TABLET should be used with caution in elderly patients (aged 65years and above). Consult your doctor before taking the medicine.
Interactions
A. Drug-Drug interactions:
- oral contraceptive medicines (used to manage pregnancy) Ex. desogestrel, ethinyl estradiol
Overdosage:
If you or anyone else accidentally takes too much of RIFALIN I 450/300MG TABLET, consult your doctor immediately or visit the nearby hospital to manage overdose symptoms.
Synopsis
| Drug | : | Isoniazid, Rifampicin |
| Pharmacological Category | : | Anti-tubercular agents |
| Therapeutic Indication | : | Tuberculosis, Bacterial infection of membranes (covering the brain, and spinal cord), Contagious disease of skin, nerves, mucous membrane, and other conditions |
| Dosage Forms | : | Tablet, Dispersible tablet, Capsule, Powder, Pouch, Suspension |
More Information
- Keep RIFALIN I 450/300MG TABLET out of reach of children
- Store RIFALIN I 450/300MG TABLET at room temperature
FAQs About RIFALIN I 450/300MG TABLET
Q. What is RIFALIN I 450/300MG TABLET used for?
A. RIFALIN I 450/300MG TABLET is used to manage tuberculosis and bacterial infection of membranes covering brain, and spinal cord which is also used to manage contagious disease of skin, nerves, and mucous membrane in affected individuals.
Q. How RIFALIN I 450/300MG TABLET works?
A. RIFALIN I 450/300MG TABLET manages tuberculosis infection, where Rifampicin works by inactivating bacterial enzyme (RNA-polymerase) resulting in its destruction and Isoniazid works by managing the bacteria to form its own protective covering leading to its death thus managing tuberculosis in affected individuals.
Q. What are the common side effects of taking RIFALIN I 450/300MG TABLET?
A. The most common side effects of taking RIFALIN I 450/300MG TABLET are hypersensitivity reaction (associated with signs such as skin rash, red itchy welt, and/or shortness of breath), loss of vision/hearing, flu-like syndrome, and/or arthralgia (joint stiffness). Consult your doctor if any of these symptoms worsens.
Q. How RIFALIN I 450/300MG TABLET should be taken?
A. Take RIFALIN I 450/300MG TABLET as advised by your physician. Swallow the medicines with a glass of water. Do not crush or chew the medicine. Your physician will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Q. Can RIFALIN I 450/300MG TABLET be used in pregnant and breastfeeding women?
Yes, RIFALIN I 450/300MG TABLET can be used but with caution in pregnant and breastfeeding women. Consult your doctor before taking the medicine.
References
1. K.D. Tripathi. Antitubercular Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 767, 766.
2. Fatih Yakar, Namsan Yildiz, Aysun Yakar, Zeki Kiliçaslan. Isoniazid- and rifampicin-induced thrombocytopenia. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. February 2013. [Accessed on 14th January 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660205/
3. Wellona Pharma. Riwell-IS. [Accessed on 14th January 2023] https://wellonapharma.com/product/finished/rifampicin-and-isoniazid-tablets
Useful Diagnostic Tests
- Mantoux test
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