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Introduction About REZART S TABLET
REZART S TABLET contains Artesunate which belongs to the group of medicines called Antimalarials. It is used to manage uncomplicated malaria due to Plasmodium falciparum (a particular type of malaria parasite).
Malaria is mosquito-borne acute febrile disease caused by a protozoan named Plasmodium falciparum. It is characterized by symptoms such as high fever, chills, sweating, headache, muscle pain, nausea, vomiting, body aches, weakness, agitation, confusion, fainting on standing up and anaemia (reduced red blood cell count).
REZART S TABLET is not recommended for use in patients with complicated malaria or malaria caused by other types of parasites such as Plasmodium vivax, Plasmodium malariae or Plasmodium ovale and it is not recommended to manage malaria.
Before taking REZART S TABLET inform your doctor if you have liver or kidney problems, special hereditary disorders of blood (called thalassaemia, sickle cell anaemia and G6PD deficiency).
REZART S TABLET should be used in pregnant women only if advised by the doctor and breast feeding may be continued during therapy with REZART S TABLET. It should be used with caution in children, consult your child’s doctor for advice.
This medicine may cause side effects such as slow heart rate and mild abdominal disturbances. Consult your doctor if any of the side effects worsens or if you experience any unusual effects.
Uses Of REZART S TABLET
- Manage uncomplicated malaria
How REZART S TABLET Works
REZART S TABLET helps in managing malaria where Artesunate works by transforming into a metabolite and binds with iron component of blood and forms free radicals which inhibit the synthesis of protein and nucleic acid in Plasmodium parasites and manages it from invading red blood cells, thus managing the malaria effectively.
How to use REZART S TABLET
Take REZART S TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. REZART S TABLET should not be taken with a high-fat meal. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of REZART S TABLET
Uncommon
- slow heart rate
- mild abdominal disturbances
Rare
- severe allergic reactions
Warning & Precautions
Pregnancy
REZART S TABLET should be used in pregnant women only if advised by the doctor. Consult your doctor before taking it.
Breastfeeding
Breast feeding may be continued during therapy with REZART S TABLET. Consult your doctor before taking it.
Driving and Using Machines
Do not drive or operate any machines if you feel dizzy after taking REZART S TABLET.
Kidney
REZART S TABLET can be used in patients with kidney problems with no dose adjustment. Consult your doctor for advice.
Liver
REZART S TABLET can be used in patients with liver problems with no dose adjustment. Consult your doctor for advice.
Allergy
Do not take REZART S TABLET if you are allergic to artesunate or any other ingredients of this medicine.
Others
REZART S TABLET is not recommended for use if you:
- have complicated malaria
- have malaria due to other types of parasites such as Plasmodium vivax, Plasmodium malariae or Plasmodium ovale
- have to manage malaria
- have experienced rash or urticarial reaction (during management with this medicine in the past)
Before taking REZART S TABLET, inform your doctor if you:
- have special hereditary disorders of blood called thalassaemia, sickle cell anaemia and G6PD deficiency
Use in Paediatrics:
REZART S TABLET should be used with caution in children. Consult your child’s doctor for advice.
Interactions
A. Drug-Drug Interactions:
Before taking REZART S TABLET, inform your doctor, if you are taking any of the following medicines:
- amodiaquine (used to manage malaria)
- efavirenz (used to manage HIV-infection)
Overdosage:
If you or anyone else accidentally takes too much of REZART S TABLET, consult your doctor immediately or visit the nearby hospital.
Synopsis
| Drug | : | Artesunate |
| Pharmacological Category | : | Artemisinin derivative |
| Therapeutic Indication | : | Uncomplicated malaria including falciparum malaria |
| Dosage Forms | : | Injection, Infusion, Tablet |
More Information
- Keep REZART S TABLET out of reach of children
- Store at room temperature
FAQs About REZART S TABLET
What is REZART S TABLET used for?
REZART S TABLET is used to manage uncomplicated malaria including falciparum malaria due to Plasmodium falciparum (a particular type of malaria parasite). Malaria is mosquito-borne acute febrile disease caused by a protozoan named Plasmodium falciparum. Consult your doctor before taking this medicine.
Who should avoid taking REZART S TABLET?
Do not take REZART S TABLET if you are allergic to artesunate. It is not recommended for use in patients with complicated malaria or malaria caused by other types of parasites such as Plasmodium vivax, Plasmodium malariae or Plasmodium ovale and it is not recommended to manage malaria. Consult your doctor before taking this medicine.
Is REZART S TABLET safe to use in pregnant women?
REZART S TABLET should be used with caution in pregnant women only if advised by the doctor. Consult your doctor before taking this medicine if you are pregnant or planning to get pregnant.
How does REZART S TABLET work?
REZART S TABLET helps in managing malaria where Artesunate works by transforming into a metabolite and binds with iron component of blood and forms free radicals which inhibit the synthesis of protein and nucleic acid in Plasmodium parasites and manages it from invading red blood cells, thus managing the malaria effectively.
What if I forget to take a dose of REZART S TABLET?
If you forget to take REZART S TABLET dose, take it as early as possible when you remember. Avoid doubling up the dose to make up for the missed one. Consult your doctor if you have doubts on missed dosage.
When to stop taking REZART S TABLET?
Do not stop taking REZART S TABLET on your own without the advice of the doctor, even if you start feeling better. This is because if you stop taking it sooner, the infection may remain unmanaged which may relapse the malaria symptoms.
References
1. KD. Tripathi. Antimalarial drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 830.
2. Michael T Hawkes, Sarah Forgie, Jason Brophy, Maryanne Crockett. Artesunate treatment of severe pediatric malaria: A review of parasite clearance kinetics and clinical implications. NIH. National Library of Medicine. National Centre for Biotechnology Information. PubMed Central (PMC). October 2015. [Accessed on 8th November 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644001/
3. Bethesda, National Library of Medicine (US). NIH. National Library of Medicine. National Centre for Biotechnology Information. Drugs and Lactation Database (LactMed) [Internet]. March 2021. [Accessed on 8th November 2022] https://www.ncbi.nlm.nih.gov/books/NBK501473/
4. Guilin Pharmaceutical Co. Ltd. Artesunate. [Revised in June 2017] [Accessed on 8th November 2022] https://extranet.who.int/pqweb/sites/default/files/MA044part3v1.pdf
Useful Diagnostic Tests
- Malarial Falciparum & Vivax Antigen
- Malarial Parasite Identification
- Peripheral Smear for Malaria
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