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Introduction About RETOL DT 650MG TABLET
RETOL DT 650MG TABLET contains Paracetamol which belongs to the group of medicines called Analgesics and Antipyretics. It is used to relieve mild to moderate pain (including headaches, backache, toothache, severe nerve pain, sore throat, period pain, low back and leg pain, muscle, connective tissue and joint pain, symptomatic relief of sprains, strain, joint swelling and stiffness). It is also used to lower fever (high body temperature) and relieve cold or flu symptoms.
Before taking RETOL DT 650MG TABLET, inform your doctor if you or your child have liver or kidney problems or any allergies. It should be used with caution in patients with liver problems due to alcohol to manage the risk of liver damage.
RETOL DT 650MG TABLET should be used with caution in pregnant women only if clearly advised by the doctor and can be used in breastfeeding women. RETOL DT 650MG TABLET is not recommended for use in children less than 10 years of age and should be used with caution in elderly patients.
Consult your doctor if you experience any side effects or unusual effects during management with RETOL DT 650MG TABLET.
Uses Of RETOL DT 650MG TABLET
- relieves mild to moderate pain (such as headache, toothache, joint pain)
- lowers fever and relieves the symptoms of cold or flu
How RETOL DT 650MG TABLET Works
RETOL DT 650MG TABLET relieves pain by increasing the pain threshold by inhibiting certain enzymes (COX-1 and COX-2) involved in the synthesis of chemicals responsible for inducing pain (prostaglandins). It reduces fever by directly acting on heat-regulating centers in the brain, resulting in vessel relaxation, sweating and loss of body heat.
How to use RETOL DT 650MG TABLET
Take RETOL DT 650MG TABLET as advised by your physician. RETOL DT 650MG TABLET should be dispersed in a glass of water and then drink the whole glass of fluid to ensure the correct dose is taken. Your doctor will decide the correct dose and duration for you based upon your age, body weight and disease condition.
Side Effects Of RETOL DT 650MG TABLET
Rare
- reduced white blood cells (infections are more likely to occur)
Stop taking RETOL DT 650MG TABLET and contact your doctor immediately if you experience any of the following side effects:
- allergic reaction (swelling of the hands, feet, ankles, face, lips or throat which may cause trouble swallowing or breathing, an itchy, lumpy rash or nettle rash, runny nose)
Warning & Precautions
Pregnancy
RETOL DT 650MG TABLET should be used with caution in pregnant women only if considered clearly necessary. Your doctor may use the lowest possible dose to reduce the pain and fever only for a shorter duration in pregnant women. Consult your doctor before taking RETOL DT 650MG TABLET.
Breastfeeding
RETOL DT 650MG TABLET should be used with caution in breastfeeding women. Consult your doctor before taking it.
Driving and Using Machines
RETOL DT 650MG TABLET has no influence on the ability to drive and operate machinery.
Alcohol
RETOL DT 650MG TABLET should be used with caution in patients with chronic alcoholism. Consult your doctor before taking it.
Kidney
RETOL DT 650MG TABLET should be used with caution in patients with severe kidney problems. Consult your doctor before taking it.
Liver
RETOL DT 650MG TABLET should be used with caution in patients with severe liver problems or liver problems due to alcohol. Consult your doctor before taking it.
Allergy
Do not take RETOL DT 650MG TABLET if you are allergic to Paracetamol or any other ingredients of this medicine.
Others
Before taking RETOL DT 650MG TABLET, inform your doctor if you:
- have sepsis (circulation of bacteria and their toxins in the blood leading to organ damage)
- are malnourished
Use in pediatrics:
RETOL DT 650MG TABLET is not recommended for use in children less than 10 years of age. It can be used in children and adolescents aged above 10 and your child’s doctor may adjust the dose based on the child’s age and body weight. Consult your child’s doctor for advice.
Use in geriatrics:
RETOL DT 650MG TABLET should be used with caution in elderly patients. Consult your doctor before taking it.
Interactions
A. Drug - Drug interactions:
Before taking RETOL DT 650MG TABLET, inform your doctor if you are taking any of the following medicines:
- other medicines containing paracetamol
- medicines to manage nausea and vomiting (Ex. metoclopramide, domperidone)
- cholestyramine (used to control blood lipid levels)
- warfarin (used for managing blood clots)
- medicines used to manage bacterial infections (Ex. rifampicin, flucloxacillin, chloramphenicol)
Overdosage:
If you or anyone else accidentally takes too much of RETOL DT 650MG TABLET, consult your doctor immediately or visit the nearby hospital, even if you feel well, as it can cause delayed, serious liver damage.
Synopsis
| Drug | : | Paracetamol |
| Pharmacological Category | : | Para aminophenol derivative |
| Therapeutic Indication | : | Pain, Fever |
| Dosage Forms | : |
Tablet, Dispersible tablet, Drops, Syrup, Oral suspension, Liquid, Oral solution, Suppositories, Infusion, Injection |
More Information
- Keep RETOL DT 650MG TABLET out of reach of children
- Store below 25°C
FAQs About RETOL DT 650MG TABLET
What if I forget to take a dose of RETOL DT 650MG TABLET?
If you forget to take a dose of RETOL DT 650MG TABLET, take it as soon as you remember. However, omit the missed dose if it is almost time for the next one. Do not take the medicine twice to make up for the missed dose.
Can RETOL DT 650MG TABLET be used during pregnancy?
RETOL DT 650MG TABLET should be used with caution in pregnant women only if considered clearly necessary. Your doctor may use the lowest possible dose to reduce the pain and fever only for a shorter duration in pregnant women. Consult your doctor before taking RETOL DT 650MG TABLET.
How does RETOL DT 650MG TABLET work?
RETOL DT 650MG TABLET relieves pain by increasing the pain threshold by inhibiting certain enzymes (COX-1 and COX-2) involved in the synthesis of chemicals responsible for inducing pain (prostaglandins). It reduces fever by directly acting on heat-regulating centers in the brain, resulting in vessel relaxation, sweating and loss of body heat.
Can RETOL DT 650MG TABLET be used in children?
RETOL DT 650MG TABLET is not recommended for use in children less than 10 years of age. It can be used in children and adolescents aged above 10 and your child’s doctor may adjust the dose based on the child’s age and body weight. Consult your child’s doctor for advice.
Is RETOL DT 650MG TABLET safe to use in patients with liver problems?
RETOL DT 650MG TABLET should be used with caution in patients with severe liver problems or liver problems due to alcohol. Your doctor may monitor your liver function test before and during management with this medicine to manage the risk of liver damage. Consult your doctor before taking RETOL DT 650MG TABLET.
References
1. Tilo Grosser, Emer Smyth and Garret A. FitzGerald. Anti-inflammatory, Antipyretic and Analgesic agents; Pharmacotherapy of gout. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 693.
2. KD. Tripathi. NSAIDs and Antipyretic-Analgesics. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 206.
3. Ulderico Freo, Chiara Ruocco, Alessandra Valerio, Irene Scagnol and Enzo Nisoli. Paracetamol: A Review of Guideline Recommendations. NIH National Library of Medicine, National center for biotechnology information. PubMed Central. August 2021. [Accessed on 12th August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347233/
4. Ohashi N and Kohno T. Analgesic Effect of Acetaminophen: A Review of Known and Novel Mechanisms of Action. Pharmacology. Frontiers. November 2020. [Accessed on 12th August 2022] https://www.frontiersin.org/articles/10.3389/fphar.2020.580289/full
5. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in April 2022] [Accessed on 12th August 2022] https://www.medicines.org.uk/emc/files/pil.1958.pdf
6. Zentiva Pharma UK Limited. Electronic Medicines Compendium (EMC). [Revised in May 2022] [Accessed on 12th August 2022] https://www.medicines.org.uk/emc/files/pil.4195.pdf
7. GlaxoSmithKline Asia Private Limited. Crocin 500 mg and Crocin 650 mg (Paracetamol). [Accessed on 12th August 2022] https://www.crocin.com/content/dam/cf-consumer-healthcare/panadol/en_in/adult/productshots/pdfs/Crocin-650-mg-Product-Info.pdf
Useful Diagnostic Tests
- Complete blood count
- Liver function test
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