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Introduction About REST M TRIO SR 0.2MG TABLET
REST M TRIO SR 0.2MG TABLET is a combination of Gliclazide, Metformin, and Voglibose, which belongs to a group of medicines called Antidiabetic agents. It is used to manage type II diabetes in patients whose blood sugar level is not controlled by diet alone.
Type II diabetes, also known as non-insulin-dependent diabetes, is a disease condition that occurs when the body does not utilize insulin (a hormone that signals throughout the body to absorb glucose and regulate the blood sugar level), resulting in high blood sugar levels that are characterized by increased thirst, frequent urination, hunger, fatigue, and blurred vision.
Your doctor may advise you to take a blood and urine sugar level test before or along with the management.
Do not take REST M TRIO SR 0.2MG TABLET if you have severe liver, kidney, and heart problems. REST M TRIO SR 0.2MG TABLET is not recommended for use in pregnant and breast-feeding women. Consult your doctor before taking it.
REST M TRIO SR 0.2MG TABLET is not recommended for use in children, and it should be used with caution in elderly patients.
The common side effects of taking REST M TRIO SR 0.2MG TABLET are headache, nausea, constipation, indigestion, diarrhea, and abdominal pain. Consult your doctor if the side effects do not improve.
Uses Of REST M TRIO SR 0.2MG TABLET
- To manage type II diabetes mellitus
How REST M TRIO SR 0.2MG TABLET Works
REST M TRIO SR 0.2MG TABLET works effectively against diabetes, where Gliclazide acts by stimulating the secretion of insulin (a hormone that signals throughout the body to absorb glucose and regulate the blood sugar level) through beta-cell sulphonyl urea receptors. Metformin works by decreasing glucose production in the liver (gluconeogenesis) and increasing insulin sensitivity to absorb glucose. Voglibose inhibits the alpha-glucosidase in the intestine and manages the absorption of glucose from food, thereby reducing the blood sugar level.
How to use REST M TRIO SR 0.2MG TABLET
Take REST M TRIO SR 0.2MG TABLET as directed by your physician. Take this medicine with a glass of water before meals. Your doctor will decide the suitable dose and duration depending on your age, body weight, and disease condition.
Side Effects Of REST M TRIO SR 0.2MG TABLET
Common
- nausea, vomiting, diarrhoea, abdominal pain, indigestion, constipation
- loss of appetite
- altered taste sensation
- skin rashes, pale skin, redness, itching, and hives
- anemia, fever, or sore throat, or develop bruising or bleeding
- signs of low sodium levels like whole body dizziness, fatigue, lethargy, weakness, or thirst
Stop taking REST M TRIO SR 0.2MG TABLET and contact your doctor immediately if you experience any of the following side effects:
- allergic reaction like skin rash or angioedema (rapid swelling of tissues such as the eyelids, face, lips, mouth, tongue, or throat that may result in breathing difficulty)
- flu-like symptoms and a rash on the face, then an extended rash with a high temperature, the rash progressing to widespread blistering or peeling of the skin
- symptoms of low blood sugar level (hypoglycemia) such as sweating, clammy skin, trembling, weakness, double vision, palpitations, confusion, headache, hunger, feeling or being sick, sleep disorders, feeling agitated, unable to concentrate, drowsiness, loss of consciousness, slowed reactions, depression, trouble seeing or speaking, paralysis, numbness, dizziness, loss of self-control, sensing or seeing things that are not there, difficulty breathing, slowed or faster heartbeat, chest pains
- hepatitis or liver failure causing fatigue, excessive tiredness, weakness, loss of appetite, weight loss, fever, changes in liver enzymes, and jaundice (yellowing of the skin or whites of the eyes)
- lactic acidosis
How To Manage Side Effects
Diarrhea
To avoid dehydration in your body, drink plenty of fluids, such as water, fruit juices, or electrolytes. If the condition worsens, consult your physician immediately.
Headache
Apply a hot or cold water bag to your head. Try to take a rest in a quiet, dark room. Drink tea or coffee. Massage the scalp or head with mild pressure. Consult your doctor for advice.
Nausea And Vomiting
Take this medicine with, or just after, meals. Stick to simple meals. Avoid eating oil-rich or spicy foods. Consult your doctor if there is no improvement in symptoms.
Skin rash Or Itching
Try to avoid hot showers because they may cause skin irritation. Avoid frequent contact with and rubbing over the affected area. Use sunscreen and protective clothing when outdoors. If this symptom does not get better, speak to a doctor.
Warning & Precautions
Pregnancy
ContraindicatedREST M TRIO SR 0.2MG TABLET is not recommended for use by pregnant women. Consult your doctor before taking it.
Breastfeeding
ContraindicatedREST M TRIO SR 0.2MG TABLET is not recommended for use by breastfeeding women. Consult your doctor before taking it.
Driving and Using Machines
Use with CautionREST M TRIO SR 0.2MG TABLET does not affect your ability to drive or operate any machinery. Take special care while driving or operating machines since it may cause difficulty in concentration.
Alcohol
Consult your doctorDo not consume alcohol while taking REST M TRIO SR 0.2MG TABLET, as it may increase the risk of side effects.
Kidney
ContraindicatedREST M TRIO SR 0.2MG TABLET is not recommended for use in patients with severe kidney problems. Consult your doctor before taking REST M TRIO SR 0.2MG TABLET.
Liver
ContraindicatedREST M TRIO SR 0.2MG TABLET is not recommended for use in patients with severe liver problems. Consult your doctor before taking REST M TRIO SR 0.2MG TABLET.
Allergy
ContraindicatedDo not take REST M TRIO SR 0.2MG TABLET if you are allergic to Gliclazide, Metformin, Voglibose, or any ingredients of this medicine.
Lungs
ContraindicatedREST M TRIO SR 0.2MG TABLET is not recommended for use in patients with lung or bronchial infections. Consult your doctor before taking REST M TRIO SR 0.2MG TABLET.
Heart Disease
ContraindicatedREST M TRIO SR 0.2MG TABLET is not recommended for use in patients with acute heart failure or who have recently had a heart attack. Consult your doctor before taking REST M TRIO SR 0.2MG TABLET.
Use In Pediatrics
ContraindicatedREST M TRIO SR 0.2MG TABLET is not recommended for use with children. Consult your doctor for advice before taking REST M TRIO SR 0.2MG TABLET.
Use In Geriatrics
Use with CautionREST M TRIO SR 0.2MG TABLET should be used with caution with elderly patients. Consult your doctor for advice.
Others
REST M TRIO SR 0.2MG TABLET is not recommended for use if you:
- have porphyria (a disorder of red blood cells)
- have diabetes ketoacidosis
- have type 1 diabetes
- have to undergo any operation or have previously suffered from severe trauma or infection
- have severe hyperglycemia (high blood glucose).
- have dehydration problems
- have gastrointestinal obstruction
Before taking REST M TRIO SR 0.2MG TABLET, inform your doctor if you:
- have an inherited condition where your red blood cells don’t produce enough of the enzyme G6PD (glucose-6 phosphate dehydrogenase)
- have hormone-induced disorders such as functional disorders of the thyroid gland, pituitary gland, or adrenal cortex
- have low blood sugar (hypoglycaemia)
- have lactic acidosis
Interactions
A. Drug-Drug interactions:
Before taking REST M TRIO SR 0.2MG TABLET, inform your doctor if you are taking any of the following medicines:
- medicines used to manage high blood sugar (Ex. glimepiride, liraglutide, or insulin)
- antibiotics (Ex. sulphonamides, clarithromycin)
- medicines to manage high blood pressure, such as beta blockers (Ex. propranolol, atenolol), ACE inhibitors (Ex. captopril), angiotensin-II antagonists (Ex. losartan), nifedipine, and diazoxide
- medicines used to manage infections, such as co-trimoxazole, fluconazole, rifampicin, chloramphenicol, and oral forms of miconazole (sulphonamides such as sulfafurazole or tetracycline compounds, tetracycline, sulfonamides, and clarithromycin)
- medicines used to manage blood clotting (Ex. warfarin)
- medicines used to manage depression, such as monoamine oxidase inhibitors (Ex. moclobemide)
- medicines used to manage mental health problems, such as lithium and phenothiazine derivatives (Ex. prochlorperazine)
- prednisolone, glucocorticoids, and tetracosactrin (medicines used to reduce inflammation in the body)
- medicines used to manage pain like phenylbutazone, azapropazone, and other NSAIDs like ibuprofen, celecoxib, and salicylates like aspirin
- bendroflumethiazide, hydrochlorothiazide, and furosemide (medicines used to manage fluid retention)
- oral contraceptives (medicines used to manage female reproductive health) Ex. levonorgestrel
- sulfinpyrazone (medicine used for gout)
- aminoglutethimide (a medicine used to manage breast or prostate cancer)
- hormones like testosterone, octreotide, or thyroid hormones (Ex. thyroxine)
- cimetidine (a medicine used to manage stomach ulcers)
- clofibrate (a medicine used to manage high cholesterol in the blood)
- disopyramide (medicine used to manage irregular heartbeats)
- laxatives (medicine used to manage constipation)
- chlorpromazine (a medicine used to manage disorders of the central nervous system)
- medicines to manage asthma or used during labour (Ex. intravenous salbutamol, ritodrine, and terbutaline)
- danazol (medicine used to manage breast disorders, heavy menstrual bleeding, and endometriosis)
- St. John’s Wort (a herbal medicine used to manage depression)
Overdosage:
If you or anyone else accidentally used too much of REST M TRIO SR 0.2MG TABLET, consult your doctor immediately or visit any nearby hospital. Symptoms of an overdose are low blood sugar, such as sweating, trembling, weakness, double vision, palpitations, confusion, and symptoms of lactic acidosis that are non-specific, such as vomiting, abdominal pain with muscle cramps, a feeling of being unwell with severe tiredness, and difficulty breathing.
Synopsis
| Drug | : | Gliclazide, Metformin, Voglibose |
| Pharmacological Category | : |
Sulfonylureas, biguanides, and alpha-glucosidase inhibitors |
| Therapeutic Indication | : | Type II diabetes mellitus |
| Dosage Forms | : | Tablet |
More Information
- Keep REST M TRIO SR 0.2MG TABLET out of reach of children
- Store at normal temperature
FAQs About REST M TRIO SR 0.2MG TABLET
Q: What is REST M TRIO SR 0.2MG TABLET and why is it given?
A: REST M TRIO SR 0.2MG TABLET contains Gliclazide, Metformin, and Voglibose, which are collectively used to manage type II diabetes (noninsulin-dependent diabetes) in patients whose blood sugar level is not controlled by diet alone.
Q: Can I drink alcohol while taking REST M TRIO SR 0.2MG TABLET?
A: Avoid consumption of alcohol while taking REST M TRIO SR 0.2MG TABLET, as it may increase the risk of side effects. Consult your doctor for advice.
Q: Is REST M TRIO SR 0.2MG TABLET safe for pregnant and breast-feeding women?
A: REST M TRIO SR 0.2MG TABLET is not recommended for use in pregnant women, if you are planning to become pregnant, or in breast-feeding women. Consult your doctor before taking it.
Q: Is REST M TRIO SR 0.2MG TABLET safe for use by children?
REST M TRIO SR 0.2MG TABLET is not recommended for use with children. Your physician will prescribe you any other suitable medicine. Consult your doctor for advice before taking REST M TRIO SR 0.2MG TABLET.
Q: Does REST M TRIO SR 0.2MG TABLET cause skin rashes?
A: Yes, it may cause skin rash in some individuals. Try to avoid hot showers because they may cause skin irritation. Avoid frequent contact with and rubbing over the affected area. Use sunscreen and protective clothing when outdoors. If this symptom does not get better, speak to a doctor.
References
1. KD. Tripathi. Oral Antidiabetic drugs. Essentials of medical pharmacology. Eighth edition. 2019. Page – 294.
2. Yi-Wei Wang, Si-Jia He, Xiao Feng, Jin Cheng, Yun-Tao Luo, Ling Tian, and Qian Huang. Metformin: a review of its potential indications. NIH National Library of Medicine, National Center for Biotechnology Information PubMed Central. August 2011. [Accessed on 22nd January 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574599/
3. Gijs W. D. Landman,Geertruide H. de Bock,Kornelis J. J. van Hateren, Peter R. van Dijk, Klaas H. Groenier, Rijk O. B. Gans, Sebastiaan T. Houweling, Henk J. G. Bilo, and Nanne Kleefstra. Safety and Efficacy of Gliclazide as Treatment for Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Trials. NIH National Library of Medicine, National Center for Biotechnology Information PubMed Central. February 2014. [Accessed on 22nd January 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922704/
4. Accord, Barnstaple. Electronic Medicines Compendium (EMC). [Revised in March 2021] [Accessed on 22nd January 2024] https://www.medicines.org.uk/emc/files/pil.5883.pdf
5. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in June 2020] [Accessed 22nd January 2024] https://www.medicines.org.uk/emc/files/pil.594.pdf
6. Biocon Limited. [Accessed 22nd January 2024] https://www.biocon.com/docs/prescribing_information/diabetology/volicose_pi.pdf
Useful Diagnostic Tests
- HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin
- Blood Glucose Fasting (FBS)
- Random Blood Sugar (RBS)
- Post Prandial Blood Sugar (PPBS)
- Insulin-Fasting
- Insulin Postprandial (PP)
- Vital Diabetes Care
- Extended Diabetes Care
- Advance Diabetes Care
- Comprehensive Diabetes Care
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