Regestrone CR 10mg Tablet 10'S

Introduction About REGESTRONE CR 10MG TABLET

Regestrone CR 10mg Tablet is commonly used when there are menstrual cycle concerns such as irregular periods, heavy menstrual bleeding, delayed periods, or abnormal uterine bleeding related to hormonal imbalance. It contains Norethisterone, a synthetic form of the natural female hormone progesterone, which helps support hormonal balance and regulates the growth and shedding of the uterine lining. This helps maintain better menstrual control and supports overall reproductive health.

This tablet is considered suitable for women who experience irregular or prolonged menstrual cycles, excessive bleeding, or delayed menstruation due to low progesterone levels or hormonal imbalance. It may be particularly helpful for those needing short-term hormonal support to regulate menstrual patterns and improve cycle predictability. By stabilizing the uterine lining and supporting progesterone levels, it helps improve menstrual comfort and daily well-being.

Regestrone CR 10mg Tablet should be taken exactly as directed by the doctor, with or without food, and preferably at the same time each day for better hormonal balance. The dosage and duration depend on the patient’s condition, treatment goals, and medical history. Swallow the tablet whole with water and do not crush or chew it. Regular follow-up may be advised during treatment to monitor response and ensure safe use.

Before using Regestrone CR 10mg Tablet, inform your doctor if you have liver disease, kidney problems, heart conditions, a history of blood clots, or allergies to hormonal medicines. It is not recommended during pregnancy and should be used with caution during breastfeeding only under medical advice. Common side effects may include nausea, headache, bloating, breast tenderness, mood changes, or mild vaginal spotting, which are usually temporary. Seek medical advice if symptoms persist or if unusual bleeding, severe pain, or chest discomfort occurs.

Uses Of REGESTRONE CR 10MG TABLET

• To manage female reproductive health

Benefits of REGESTRONE CR 10MG TABLET

Regestrone CR 10mg Tablet for Menstrual Cycle Regulation

Regestrone CR 10mg Tablet contains norethisterone, a synthetic hormone that helps support the balance of hormonal changes related to the menstrual cycle. It is commonly used when periods are irregular, delayed, or heavier than usual. By helping maintain proper hormonal levels, it supports better cycle control and menstrual comfort. This may help improve daily routine and well-being. Use the tablet only as advised by your doctor.

Regestrone CR 10mg Tablet for Effective Control of Heavy Menstrual Bleeding

Regestrone CR 10mg Tablet helps reduce excessive menstrual bleeding by supporting the normal lining of the uterus and controlling hormone-related changes. It is often included in care plans for women experiencing heavy or prolonged periods. This may help reduce discomfort, weakness, and inconvenience caused by heavy flow. Regular use as prescribed supports better menstrual balance. Follow your doctor’s instructions for safe use.

How REGESTRONE CR 10MG TABLET Works

Mechanism of Action of Regestrone CR 10mg Tablet (Norethisterone)

Regestrone CR 10mg Tablet contains norethisterone, a synthetic form of the natural female hormone progesterone. It helps support hormonal balance in women when the body does not produce enough progesterone. This medicine is commonly used to manage irregular periods, heavy bleeding, delayed menstruation, and certain menstrual-related concerns. By maintaining hormonal stability, it helps support normal menstrual function and uterine health. 

Action of Norethisterone on Hormonal Balance

Norethisterone works by acting like progesterone in the body and helping regulate the growth and shedding of the uterine lining. It supports proper hormonal signals during the menstrual cycle, which helps in controlling irregular or heavy bleeding. This action helps maintain a more balanced menstrual pattern and improves cycle regularity.

Support for Uterine Lining Stability

Norethisterone helps stabilize the lining of the uterus (endometrium), preventing excessive thickening or irregular shedding. This is especially helpful in women experiencing heavy menstrual flow or abnormal uterine bleeding. By supporting controlled shedding of the uterine lining, it helps reduce discomfort and supports menstrual health.

How to use REGESTRONE CR 10MG TABLET

How to Take Regestrone CR 10mg Tablet

•  Take the tablet exactly as prescribed by your doctor
•  Swallow the tablet whole with water; do not crush or chew it
•  It may be taken with or without food, as advised by your doctor
•  Try to take it at the same time each day for better results
• Do not skip doses or stop the medicine suddenly without medical advice
•  Do not exceed the recommended dose or duration of use
•  Continue the treatment for the full period advised by your healthcare professional

What if I forgot to take REGESTRONE CR 10MG TABLET

•  Take the missed dose as soon as you remember
•  If it is almost time for your next dose, skip the missed dose
•  Continue with your regular dosing schedule
•  Do not take a double dose to make up for the missed one
•  Taking the tablet at the same time each day helps maintain better results
•  Consult your doctor if you miss doses frequently

Overdose

If you or someone else takes more than the prescribed dose of Regestrone CR 10mg Tablet, seek medical attention immediately. Contact your doctor or visit the nearest hospital without delay. Symptoms of overdose may include nausea, vomiting, breast enlargement, and vaginal bleeding. Prompt medical care is important, especially if the symptoms become severe.

Side Effects Of REGESTRONE CR 10MG TABLET

Common side effects of Regestrone CR 10mg Tablet:

• irregular bleeding, heavy menstruation
• spotting between menstrual cycles
• delayed or not having a menstrual cycle
• stomach discomfort, nausea, vomiting
• breast tenderness
• headache and dizziness

When to Seek Medical Attention?

Stop taking Regestrone CR 10mg Tablet and contact your doctor immediately if you experience any of the following side effects

• yellowing of the skin or white area of the eyes (jaundice)
• migraine headache for the very first time (a headache that usually restricts itself to one side of your head)
• high blood pressure
• symptoms of severe allergic reaction such as itchy skin rash, swelling of the face or tongue, hands or feet causing wheezing, difficulty breathing or feeling faint
• symptoms of a blood clot in the lungs include a sudden, severe, sharp pain in the chest, coughing up blood, shortness of breath, rapid heartbeats
• symptoms of a blood clot in the brain (stroke) include unusually severe or long headache, change in sight, difficulty speaking, collapsing, or fainting and weakness or paralysis of any part of your body
• symptoms of a deep-vein thrombosis such as severe pain, tenderness or swelling in your calf, ankle or foot, purplish discolouration of the skin of the leg and red or warmth skin

How To Manage Side Effects

Dizziness Or Drowsiness

• Sit or Lie Down Immediately: If you feel dizzy, sit or lie down right away to avoid falls or imbalance. Rest until the feeling passes.
• Stay Hydrated: Drink plenty of fluids such as water, coconut water, or lemon water. Dehydration is a common cause of dizziness.
• Eat Small, Frequent Meals: Low blood sugar may trigger dizziness. Eat balanced meals with complex carbs, proteins, and fruits.
• Avoid Sudden Movements: Stand up slowly from sitting or lying positions to prevent a drop in blood pressure that can cause light-headedness.
• Get Fresh Air: Step outside or open a window to improve oxygen flow and reduce feelings of giddiness.
• Reduce Caffeine and Alcohol: Both can cause dehydration or affect blood circulation, increasing dizziness episodes.
• Deep Breathing or Relaxation: Gentle breathing exercises can calm your nervous system and improve oxygen flow.
• Monitor Medications: Some medicines can cause dizziness as a side effect if it occurs often, consult your healthcare professional for guidance.

Warning & Precautions

Pregnancy

Contraindicated

Regestrone CR 10mg Tablet is not recommended during pregnancy. It should also be avoided in women with a history of pregnancy-related jaundice, pemphigoid gestationis (itchy rash with blisters during pregnancy), or certain pregnancy complications. Consult your doctor before use.

Breastfeeding

Use with Caution

This medicine should be used carefully during breastfeeding, as it may pass into breast milk. Medical advice is recommended before taking it.

Driving and Using Machines

Use with Caution

Regestrone CR 10mg Tablet generally does not affect alertness or the ability to drive or operate machinery.

Kidney

Use with Caution

Use cautiously in patients with kidney problems. A doctor’s guidance is advised before starting this medicine.

Liver

Consult your doctor

Patients with liver disease should take this medicine only under medical supervision.

Allergy

Contraindicated

Do not use this medicine if you are allergic to norethisterone, similar hormonal medicines, or any of its ingredients.

Lungs

Contraindicated

Not recommended for patients with current or past pulmonary embolism (blood clot in the lungs). Use carefully in people with asthma.

Heart Disease

Contraindicated

This medicine is not advised for patients with active or recent angina or heart attack. Consult your doctor before use.

Other Warnings for REGESTRONE CR 10MG TABLET

Before taking Regestrone CR 10mg Tablet tell your doctor if you have

• epilepsy
• migraine headache
• are very overweight
• systemic lupus erythematosus.
• a blood clot in the veins
• are unable to move for long periods (Ex. after an operation)
• serious injury
• have major surgery or are going to have an operation (particularly abdominal or orthopaedic surgery to the lower limbs)
• blood tests (for liver function, thyroid function, and coagulation).
• vision impairment, bulging eyes, double vision
• depression

Who should not take REGESTRONE CR 10MG TABLET

Regestrone CR 10mg Tablet is not recommended for use if you have

• blood disorders like porphyria
• clotting disorders like deep vein thrombosis or a family history of the same
• pruritis (a condition with severe generalised itching of the body)
• undiagnosed vaginal bleeding (not a period)

Safety Advice

•  Dose accuracy: Take Regestrone CR 10mg Tablet exactly as prescribed by your doctor. Do not increase, decrease, or skip doses without medical advice.
•  Timing consistency: Take the tablet at the same time each day to maintain steady hormone levels and improve effectiveness. Irregular timing may affect results.
•  Short-term use awareness: This medicine is often used for a specific duration depending on the condition. Do not continue longer than advised without consulting your doctor.
•  Avoid abrupt changes: Do not stop or restart the tablet suddenly without medical guidance, as this may disturb hormonal balance and menstrual patterns.
•  Label check before use: Always check the medicine strip and dosage strength before use, especially if you are taking other hormonal medicines.
•  Missed dose handling: If you miss a dose, take it as soon as you remember. If it is close to the next dose, skip the missed one. Do not double the dose.
•  Symptom monitoring: Watch for unusual bleeding, severe abdominal pain, swelling, or changes in mood, and report any unusual symptoms to your doctor.
•  Avoid unnecessary combinations: Do not combine with other hormonal medicines or supplements without medical advice, as this may affect how the medicine works.

Diet and Lifestyle Advice

•  Maintain a balanced diet: Eat nutritious foods rich in iron, calcium, fruits, vegetables, and whole grains to support hormonal health and overall well-being.
•  Stay well hydrated: Drink enough water throughout the day to help reduce bloating and maintain general body balance.
•  Prefer light, regular meals: Eating meals on time may help reduce nausea or stomach discomfort sometimes associated with hormonal medicines.
•  Limit excess salt and processed foods: Reducing salty and highly processed foods may help manage bloating and water retention.
•  Moderate caffeine intake: Too much tea, coffee, or caffeinated drinks may increase restlessness or discomfort in some individuals. Consume in moderation.
•  Rest adequately: Proper sleep and stress management help support hormonal balance and improve overall menstrual health.
•  Maintain healthy body weight: Regular light exercise such as walking or yoga may support better hormonal regulation and menstrual comfort.
•  Avoid smoking and alcohol: These may interfere with hormonal balance and may worsen certain symptoms, so limiting them is advisable.
•  Track your cycle: Keeping a record of your menstrual cycle and symptoms may help your doctor better monitor your progress and adjust treatment if needed.

1. Regestrone CR 10mg Tablet vs Primolut N Tablet – irregular periods

Drug - Drug interaction

 1. Anticoagulants (e.g., Warfarin)

• Interaction: Norethisterone may affect the action of blood thinners and may increase the risk of bleeding or clot-related complications in some patients.
• Management: Use only under medical supervision. Regular monitoring of blood clotting levels may be required. Inform your doctor if you notice unusual bleeding or bruising. 

2.  Antidiabetic Medicines (e.g., Metformin, Insulin)

• Interaction: Regestrone CR 10mg Tablet may affect blood sugar control and may reduce the effectiveness of some diabetes medicines.
• Management: Blood sugar levels should be monitored regularly. Your doctor may adjust the dose of antidiabetic medicines if needed.

3. Antiepileptic Medicines (e.g., Phenytoin, Carbamazepine)

• Interaction: These medicines may reduce the effectiveness of norethisterone by increasing its breakdown in the body.
• Management: Inform your doctor if you are using seizure medicines. Dose adjustment or alternative treatment may be considered.

4. Rifampicin and Rifabutin

• Interaction: These antibiotics may lower the effectiveness of Regestrone CR 10mg Tablet by speeding up hormone metabolism.
• Management: Medical supervision is important. Your doctor may suggest an alternative option if needed.

5. Cyclosporine

• Interaction: Norethisterone may increase the levels of cyclosporine in the body, which may raise the risk of side effects.
• Management: Careful monitoring may be required. Inform your doctor if you are taking medicines for immune-related conditions.

 6. Herbal Products (e.g., St. John’s Wort)

• Interaction: Some herbal supplements may reduce the effectiveness of hormonal medicines like norethisterone.
• Management: Avoid self-medication with herbal products without consulting your doctor. Always share details of supplements you use.

 7. Other Hormonal Medicines

• Interaction: Combining with other hormonal tablets may increase the risk of side effects or disturb hormone balance.
• Management: Do not combine hormonal medicines without medical advice. Your doctor will decide the safest combination if required.

 8. Herbal Supplements (e.g., Ashwagandha, Ginseng)

• Interaction: Some herbal products may interfere with hormone balance or affect how norethisterone works in the body.
• Management: Inform your doctor about any herbal supplements before starting the medicine to avoid unwanted interactions.

Drug - Food interaction

 1. Alcohol

• Interaction: Alcohol does not directly interact with norethisterone, but excessive intake may worsen side effects like nausea, dizziness, or headache.
• Management: Limit alcohol consumption while taking Regestrone CR 10mg Tablet to reduce discomfort.

 2. Heavy or Oily Meals

• Interaction: Food does not significantly affect absorption, but very heavy meals may increase stomach discomfort in some people.
• Management: The tablet can be taken with or without food. Taking it after a light meal may help if you experience nausea.

 3. Caffeinated Beverages (Tea, Coffee, Energy Drinks)

• Interaction: Excess caffeine may worsen bloating, breast tenderness, or mood changes in some individuals using hormonal medicines.
• Management: Consume caffeine in moderation and monitor how your body responds.

Synopsis

More Information

FAQs About REGESTRONE CR 10MG TABLET

References

1. K D Tripathi. Hormones and Related Drugs. Essentials of Medical Pharmacology. 7th Edition. Page 309-310.

2. Arun Madhab Boruah, Dibyendu Banerjee, Farendra Bhardwaj, Subash Mallya, Rajat Singal, Sugandha Sharma, Ashutosh Gautam. Effect of norethisterone dose and duration in the management of abnormal uterine bleeding: a narrative review and case report. PubMed. NIH. National Library of Medicine. [Revised in 4th July 2024] [Accessed on 21st May 2026]        

3. Bayer Limited. Primolut N 5 mg Tablets (Norethisterone). Health Products Regulatory Authority (HPRA). [Revised in December 2018] [Accessed on 21st May 2026]

4. Leeford Health Care Ltd. Rethrowel-10 CR (Norethisterone) [Accessed on 21st May 2026]

Useful Diagnostic Tests

• Complete Blood Count (CBC)/ Hemogram
• Thyroid Stimulating Hormone (TSH)
• Free Thyroxine (Ft4)
• Free Triiodothyronine (Ft3)
• Total Thyroxine(T4)
• Healthy Midlife Checkup
• Complete Women Checkup
• Senior Citizen Checkup – Female
• Women Health Checkup - Essential
• Full Body Checkup - Gold
• Elderly Checkup – Female

Author Details

Written By Dr. N. Sai Swaroop - Pharm.D

Reviewed For Accuracy By Dr. M N Himaja - MBBS

Last updated on 04 Apr 2024 | 10:46 AM(IST)