REEPAG MF 1 Tablet 10's

Introduction About REEPAG MF 1 TABLET

REEPAG MF 1 TABLET is a combination of Repaglinide and Metformin which belongs to the group of medicines called Anti-diabetic agents. It is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus who are already managed with Meglitinide and Metformin or who have inadequate glycemic control on a Meglitinide alone or Metformin.    

During course of the management your doctor might regularly monitor your blood glucose level and kidney function test at regular intervals to avoid any untoward side effects. Avoid consumption of alcohol while taking REEPAG MF 1 TABLET.  

REEPAG MF 1 TABLET is not recommended for use in patients with cardiac, kidney or respiratory failure, impaired liver or kidney function, diabetic ketoacidosis, type-1 diabetes mellitus and if you are dehydrated. Before taking REEPAG MF 1 TABLET, inform your doctor if you have any planned major surgery.  

REEPAG MF 1 TABLET should not be used in pregnant women and breastfeeding women. This medicine is not recommended for use in children and adolescents (aged below 18 years) and it should be used with caution in elderly patients (aged 65 years and above).

The most common side effect of taking REEPAG MF 1 TABLET are diarrhea, nausea, vomiting, stomach pain and taste disturbances. Consult your doctor if any of the side effects worsen.

Uses Of REEPAG MF 1 TABLET

• Manage type 2 diabetes mellitus as an adjunct to diet and exercise to improve glycemic control

How REEPAG MF 1 TABLET Works

REEPAG MF 1 TABLET is a combination of Repaglinide and Metformin where Repaglinide is a meglitinide analogue which increases the amount of insulin released by the pancreas. This manages blood glucose from rising very high after the meals. Metformin is a biguanide which decreases the production and absorption of sugar in your body and allows better use of existing insulin. 

How to use REEPAG MF 1 TABLET

Take REEPAG MF 1 TABLET as advised by your physician. Swallow the medicine with a glass of water immediately before or up to 30 minutes before the meal. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Side Effects Of REEPAG MF 1 TABLET

How To Manage Side Effects

Diarrhea

Drink lot of fluids such as water to keep yourself hydrated. Avoid eating high-fat foods, dairy products and spicy foods. Do not consume any medicine on your own without consulting your doctor to manage diarrhea.

Nausea And Vomiting

Stick to simple meals while taking this medicine. Avoid eating oily, fried or spicy food. Do not perform any strenuous activities immediately after eating and do not lie down or sleep immediately after eating. If the symptom does not improve, consult your doctor.

Stomach Pain

Try to rest and relax. Eat and drink slowly or try to have smaller meals more frequently. Keep a heat pad on your stomach. If the symptom does not improve, consult your doctor.

Warning & Precautions

Pregnancy

Consult your doctor

REEPAG MF 1 TABLET is not recommended for use in pregnant women, as it is not known if it causes any potential harm to the unborn baby. Consult your doctor before taking it.

Breastfeeding

Contraindicated

REEPAG MF 1 TABLET is not recommended for use in breast-feeding women. Consult your doctor before taking it.

Driving and Using Machines

Use with Caution

Your ability to drive or use a machine may be affected if your blood sugar is low. Do not drive or operate any machines if you experience any unusual reactions.

Alcohol

Contraindicated

Consumption of alcohol is not recommended during management with REEPAG MF 1 TABLET since it may increase the risk of lactic acidosis.

Kidney

Contraindicated

REEPAG MF 1 TABLET is not recommended for use in patients with renal failure or renal dysfunction. Consult your doctor before taking it.

Liver

Contraindicated

REEPAG MF 1 TABLET is not recommended for use in patients with hepatic insufficiency. Consult your doctor before taking it.

Allergy

Contraindicated

Do not take REEPAG MF 1 TABLET if you are allergic to Repaglinide and Metformin.

Lungs

Contraindicated

REEPAG MF 1 TABLET is not recommended for use in patients with respiratory failure. Consult your doctor before taking it.

Heart Disease

Contraindicated

REEPAG MF 1 TABLET is not recommended for use in patients with acute or chronic disease which may cause tissue hypoxia such as cardiac failure or recently had myocardial infarction. Consult your doctor before taking it.

Use In Pediatrics

Contraindicated

REEPAG MF 1 TABLET is not recommended for use in children and adolescents (aged below 18 years). Consult your child’s doctor for advice.

Use In Geriatrics

Use with Caution

REEPAG MF 1 TABLET should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before taking it.

Interactions

A. Drug-Drug interactions:

Before taking REEPAG MF 1 TABLET, inform your doctor if you are taking any of the following medicines:

• gemfibrozil (used to lower increased fat levels in the blood)
• thiazide diuretics such as hydrochlorothiazide, angiotensin-converting enzyme (ACE) inhibitors (used to manage high blood pressure) Ex. captopril, enalapril
• corticosteroids such as cortisone, hydrocortisone and prednisone (used to manage inflammation)
• anabolic steroids such as nandrolone (used in the management of anemia of renal insufficiency)
• oral contraceptives such as mifepristone (used for termination of pregnancy)
• danazol (used to manage breast cysts and endometriosis)
• thyroid hormones such as levothyroxine (used to manage underactive thyroid gland)
• clarithromycin, trimethoprim, rifampicin (used to manage bacterial infections)
• itraconazole, ketoconazole (used to manage fungal infections)
• ciclosporin (used to suppress the immune system)
• aspirin, clopidogrel (used to manage blood clots)
• phenytoin, carbamazepine, phenobarbital (used to manage epilepsy)
• St. john’s wort (herbal medicine) (used to manage depression)

Overdosage:

If you or anyone else accidentally take too much of REEPAG MF 1 TABLET, consult your doctor immediately or visit the nearby hospital. Overdosage symptom of REEPAG MF 1 TABLET includes lactic acidosis and low blood sugar levels with symptoms such as dizziness, sweating, tremor, headache and in severe cases it may cause seizures and loss of consciousness. 

Synopsis

More Information

• Keep REEPAG MF 1 TABLET out of reach of children
• Store at room temperature

FAQs About REEPAG MF 1 TABLET

Q: Is REEPAG MF 1 TABLET safe during pregnancy?

A: REEPAG MF 1 TABLET is not recommended for use during pregnancy as it is not known if it causes any potential harm to the unborn baby. If you are pregnant, think you may be pregnant or are planning to get pregnant, inform your doctor before taking REEPAG MF 1 TABLET.

Q: Can REEPAG MF 1 TABLET be stopped on my own?

A: Continue taking REEPAG MF 1 TABLET until your doctor tells you to stop. This is to help keep your blood sugar under normal levels. If you have any further doubts regarding the use of REEPAG MF 1 TABLET, contact your doctor.

Q: What precautions do I need to follow while taking REEPAG MF 1 TABLET?

A: Patients taking REEPAG MF 1 TABLET must inform their doctor about their pre-existing disease conditions like kidney, liver or heart problems. Contact your doctor immediately if you have any unusual symptoms.

Q: Can REEPAG MF 1 TABLET be used in patients with heart problems?

A: REEPAG MF 1 TABLET is not recommended for use in patients with acute or chronic disease which may cause tissue hypoxia such as cardiac failure or recently had myocardial infarction. Consult your doctor before taking it.

Q: What are the common side effect of REEPAG MF 1 TABLET?

A: The most common side effect of taking REEPAG MF 1 TABLET are diarrhea, nausea, vomiting, stomach pain, loss of appetite and taste disturbances. Consult your doctor if any of the side effects worsen.

References

1. KD. Tripathi. Insulin, Oral Antidiabetic Drugs and Glucagon. Essentials of medical pharmacology. Eighth edition. 2019. Page – 299 & 296-297.

2. Novo Nordisk A/S. Efficacy and Safety of Repaglinide and Metformin Combination Therapy in Type 2 Diabetes Failing on Oral Anti-diabetic Drugs. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in March 2016] [Accessed on 11th April 2022] https://clinicaltrials.gov/ct2/show/NCT00491725

3. Novo Nordisk A/S. Comparison of Repaglinide and Metformin Combination Tablet Versus Repaglinide and Metformin as Separate Tablets in Healthy Volunteers. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in March 2015] [Accessed on 11th April 2022] https://clinicaltrials.gov/ct2/show/NCT00959101

4. Torrent Pharmaceuticals Ltd. Eurepa MF (Repaglinide and Metformin Hydrochloride Tablets). [Revised in August 2016] [Accessed on 11th April 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/1718.pdf

Useful Diagnostic Tests

• Glucose-Fasting Blood
• Glucose-Postprandial Blood
• Glycosylated Hemoglobin

Author Details

Written By Dr. R. Dinesh John Rajkumar - Pharm.D

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 21 Oct 2023 | 04:08 PM(IST)