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Introduction About RAMISAVE CH 10MG CAPSULE
RAMISAVE CH 10MG CAPSULE is a combination of Chlorthalidone and Ramipril which belongs to the group of medicines called Antihypertensive agents. It is used to manage hypertension (high blood pressure). It can also be used to manage heart failure and diabetes insipidus (a condition in which an individual produces large amounts of dilute urine and is constantly thirsty) and can reduce the chances of fluid retention (edema) in the body that occurs due to some kidney or liver diseases.
It also protects the function of kidneys particularly among diabetic patients who are in risk of developing kidney damage. Take this medicine preferably in the mornings with food. While taking RAMISAVE CH 10MG CAPSULE, avoid drinking alcohol or going for a low-salt diet, as they may make further reduce your blood pressure. Consult your doctor for the best diet that can suit your health condition.
Before taking RAMISAVE CH 10MG CAPSULE inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have diabetes, high blood cholesterol levels, dehydration, or very low blood sodium, potassium or magnesium levels as a precaution.
Do not take RAMISAVE CH 10MG CAPSULE if you are pregnant, think you may be pregnant or planning to have a baby or breastfeeding without consulting your doctor. The most common side effects of taking RAMISAVE CH 10MG CAPSULE are headache, dizziness, muscle cramps, stomach pain, constipation, diabetes, low blood potassium or sodium levels, impotence in men and low sex drive. Consult your doctor if any of these side effects trouble you.
Uses Of RAMISAVE CH 10MG CAPSULE
It is used to:
- Manage Hypertension (high blood pressure)
- Manage Heart failure
- Manage Diabetes insipidus (a condition causing excessive urination and thirst)
- Reduce Edema (fluid retention)
- Prevent kidney damage
How RAMISAVE CH 10MG CAPSULE Works
RAMISAVE CH 10MG CAPSULE contains two medicines namely chlorthalidone and ramipril. Chlorthalidone works by removing the excess fluids and electrolytes (sodium and water) from the body. This helps in reducing fluid retention (edema) from the body. It also reduces the thickness of the blood, which may help the heart to pump blood more smoothly across the body.
Ramipril causes relaxation of the blood vessels supplying the heart, kidneys and other parts of the body. It works by blocking the actions of certain enzymes (angiotensin-converting enzyme) in the body that causes narrowing of blood vessels and increase in blood pressure. Collectively, these actions improve blood flow, reduces the strain on the heart and helps the heart to pump more blood with less pressure.
How to use RAMISAVE CH 10MG CAPSULE
Always take RAMISAVE CH 10MG CAPSULE as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. RAMISAVE CH 10MG CAPSULE is preferably taken during the mornings with food.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and health condition. Do not stop taking RAMISAVE CH 10MG CAPSULE without consulting your doctor.
Side Effects Of RAMISAVE CH 10MG CAPSULE
Common
- low blood potassium levels causing muscle weakness, twitching or abnormal heartbeat
- high blood uric acid levels
- increased blood cholesterol levels
- low blood sodium levels (causing tiredness, confusion, muscle twitching, fits or fainting)
- low blood magnesium levels
- high blood sugar levels (causing tiredness, weakness or excessive thirst)
- skin rash
- low blood pressure which may make you feel dizzy while standing up
- dizziness, headache
- stomach pain, loss of appetite, diarrhea, indigestion
- impotence in men
- dry cough, inflammation of the sinuses, bronchitis, shortness of breath
- nausea, vomiting
- muscle cramps
Uncommon
- gout (join pain and swelling)
- sleep disorders
- spinning sensation (vertigo)
- paraesthesia (tingling and numbness of the skin)
- loss or changes in taste
- feeling depressed, anxious, nervous and restless
- nasal block, difficulty in breathing
- heartburn, constipation
- passing more urine than usual
- increased sweating
- edema (swollen arms and legs)
- flushing
- blurred vision, joint pain
- low sex drive
Rare
- high blood calcium levels (causing agitation, eye pain or inflammation, stomach pain)
- sugar in urine
- skin sensitivity
- fast or slow heartbeat
- pins and needles
- kidney problems
- inflammation of the blood vessels
- red swollen tongue
- confusion or shakiness
- loss of hearing or ringing sensation in ears
- nail problems (separation or loosening of nail from its bed)
- red, itchy, or watery eyes
- low RBC in blood (anemia)
Stop taking RAMISAVE CH 10MG CAPSULE and contact your doctor immediately if you experience any of the following side effects:
- severe allergic reactions (such as skin rash, itching, swelling of the face, lips, mouth, or throat which can lead to difficulty in breathing or swallowing)
- chest pain with faster heart rate, uneven or forceful heartbeat, chest tightness or more serious problems including heart attack and stroke
- breathing difficulties or a cough
- signs of blood or bone marrow problems (such as bruising very easily, bleeding for longer than normal, bleeding gums, purple spots under the skin, blotching on the skin or getting infections more easily than usual, fever, sore throat, feeling tired, faint, dizzy or having pale skin)
- sign of pancreatitis (such as severe stomach pain which may radiate towards your back)
- signs of liver problems (such as fever, chills, tiredness, loss of appetite, stomach pain, nausea, and yellowing of the skin or eyes)
How To Manage Side Effects
Nausea and vomiting:
Take RAMISAVE CH 10MG CAPSULE with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your nausea worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Warning & Precautions
Pregnancy
RAMISAVE CH 10MG CAPSULE is not recommended for use in pregnant women as it may cause serious harm to the growing foetus. Therefore, consult your doctor before taking it.
Breastfeeding
RAMISAVE CH 10MG CAPSULE is not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.
Driving and Using Machines
Do not drive or handle any heavy tools or machines if you experience dizziness or drowsiness after taking RAMISAVE CH 10MG CAPSULE.
Alcohol
Avoid consumption of alcohol while taking RAMISAVE CH 10MG CAPSULE as it might make you feel dizzier and drowsier.
Kidney
RAMISAVE CH 10MG CAPSULE is not recommended for use in patients with severe kidney problems (such as kidney stones, renal artery stenosis, dialysis). It should be used with caution in patients with other kidney problems. Therefore, consult your doctor before taking it.
Liver
RAMISAVE CH 10MG CAPSULE is not recommended for use in patients with severe liver problems. It should be used with caution in patients with mild to moderate liver diseases. Therefore, consult your doctor before taking it.
Allergy
Do not take RAMISAVE CH 10MG CAPSULE if you are allergic to Chlorthalidone or Ramipril.
Others
RAMISAVE CH 10MG CAPSULE is not recommended for use if you:
- have diabetes related kidney problems
- have abnormally very low blood pressure
- are not passing urine at all
- have low blood potassium levels (hypokalemia)
- have low blood sodium levels (signs include tiredness, confusion, muscle twitching, fits or lack of consciousness)
- high blood calcium levels
- have gout
- have Addison’s disease (a problem in adrenal gland)
Before taking RAMISAVE CH 10MG CAPSULE, inform your doctor if you:
- are severely dehydrated (due to diarrhea, vomiting or excess sweating)
- are on a low-salt diet
- have diabetes
- have high blood cholesterol levels
- have primary hyperaldosteronism (problems in adrenal gland)
- are undergoing management for allergic reactions due to bee or wasp stings
- have hyperkalemia (high blood potassium levels)
- have collagen vascular disease such as scleroderma or lupus erythematosus
- are undergoing any surgery (including dental surgery)
Use in pediatrics:
RAMISAVE CH 10MG CAPSULE is generally not recommended for use in children and adolescents (aged below 18 years) due to lack of safety data. However, consult your doctor for advice before taking it.
Use in geriatrics:
RAMISAVE CH 10MG CAPSULE should be used with caution in elderly patients. Therefore, consult your doctor for advice before taking it.
Interactions
A. Drug-Drug interactions:
Before taking RAMISAVE CH 10MG CAPSULE, inform your doctor if you are taking any of the following medicines such as:
- other medicines used to reduce elevated blood pressure and other heart problems (Ex. atenolol, propranolol, enalapril, lisinopril, amlodipine, nifedipine, diltiazem, verapamil, methyldopa, guanethidine)
- corticotropin (a medicine used to correct hormone problems)
- non-steroidal anti-inflammatory drugs (used for pain relief) such as indomethacin, celecoxib, ibuprofen, aspirin
- sacubitril/valsartan (a combination used to manage chronic heart failure)
- noradrenaline, ephedrine, or adrenaline (used to manage low blood pressure, asthma, or heart failure)
- medicines used for cancer (Ex. temsirolimus, cyclophosphamide, methotrexate)
- medicines to manage graft rejection (Ex. cyclosporin, tacrolimus, sirolimus)
- diuretics (used to manage edema and hypertension) such as furosemide
- potassium supplements or potassium-sparing diuretics such as spironolactone, triamterene or amiloride (used to retain or increase potassium levels)
- procainamide, digoxin (medicines used to manage irregular heartbeat)
- medicines used to manage asthma (such as salbutamol, formoterol)
- amphotericin B (a medicine used to manage fungal infections)
- carbenoxolone (a medicine used to manage mouth ulcers)
- anticholinergics (used to manage stomach muscle spasms) such as atropine, hyoscine
- heparin (a medicine used for blood thinning)
- corticosteroids (used to manage pain and inflammation) Ex. prednisolone, betamethasone
- allopurinol (a medicine used to manage gout)
- medicines used to manage diabetes (such as insulin, metformin, glimepiride, glibenclamide, vildagliptin)
- medicines used to reduce blood cholesterol levels (such as cholestyramine, colestipol)
- amantadine (a medicine used for parkinsonism or viral infections)
- racecadotril (a medicine used to stop diarrhea)
- aliskiren (a medicine used to reduce blood pressure)
- lithium (a medicine used to manage various mental health problems)
- anesthetics (used to create loss of sensations before surgery) Ex. proparacaine, lignocaine
- calcium and vitamin D supplements
Overdosage:
If you or anyone else accidentally took more RAMISAVE CH 10MG CAPSULE, consult your doctor immediately or visit the nearby hospital straight away. Overdosage may cause side effects such as dizziness, nausea, drowsiness, slow heart rate, kidney problems and electrolyte disturbances.
Synopsis
| Drug | : | Chlorthalidone, Ramipril |
| Pharmacological Category | : | Thiazide Diuretics, ACE inhibitors |
| Therapeutic Indication | : | Hypertension, Heart failure, Diabetes insipidus, Edema, Kidney damage |
| Dosage Forms | : | Capsule |
More Information
- Keep RAMISAVE CH 10MG CAPSULE out of reach of children
- Store RAMISAVE CH 10MG CAPSULE at room temperature
FAQs About RAMISAVE CH 10MG CAPSULE
Q: Is RAMISAVE CH 10MG CAPSULE safe to use in diabetic patients?
A: RAMISAVE CH 10MG CAPSULE may alter the blood sugar levels in your body. It can also hide the symptoms of low blood sugar. Therefore, it is necessary to inform your doctor if you have diabetes before taking RAMISAVE CH 10MG CAPSULE as a precaution. Your doctor will closely monitor you blood sugar levels to avoid the risk of side effects.
Q: What precautions should be followed while taking RAMISAVE CH 10MG CAPSULE?
A: Before taking RAMISAVE CH 10MG CAPSULE inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have diabetes, high blood cholesterol, electrolyte imbalance or are severely dehydrated. Regularly visit your doctor and take all the necessary tests which your doctor recommends to you without fail. Do not take RAMISAVE CH 10MG CAPSULE if you are pregnant or breastfeeding.
Q: Can RAMISAVE CH 10MG CAPSULE causes electrolyte imbalance?
A: Yes. RAMISAVE CH 10MG CAPSULE may alter the levels of certain electrolytes (sodium or potassium) in the body. To avoid this, your doctor will closely monitor the electrolytes levels in the blood periodically. However, if you experience any unusual symptoms such as chest pain, muscle weakness, irregular heartbeat, confusion, drowsiness, nausea, or vomiting, consult your doctor for advice.
Q: How long will it take for RAMISAVE CH 10MG CAPSULE to show the results?
A: It may take around 3-6 weeks for RAMISAVE CH 10MG CAPSULE to show the results. However, this period may vary from person-to-person depending upon their health condition. Therefore, consult your doctor for advice.
Q: Can I consume alcohol while taking RAMISAVE CH 10MG CAPSULE?
A: Avoid consumption of alcohol while taking RAMISAVE CH 10MG CAPSULE as it might make you feel dizzier and drowsier.
Q: What happens if I accidentally take more RAMISAVE CH 10MG CAPSULE?
A: If you or anyone else accidentally took more RAMISAVE CH 10MG CAPSULE, consult your doctor immediately or visit the nearby hospital straight away. Overdosage may cause side effects such as dizziness, nausea, drowsiness, slow heart rate, kidney problems and electrolyte disturbances.
Q: Can I take RAMISAVE CH 10MG CAPSULE daily?
A: Take RAMISAVE CH 10MG CAPSULE as advised by your physician. Your doctor will evaluate your health condition and suggests whether can you take RAMISAVE CH 10MG CAPSULE every day or not.
Q: What to do if I forgot to take a dose of RAMISAVE CH 10MG CAPSULE?
A: If you have missed a dose of RAMISAVE CH 10MG CAPSULE, take it as soon as you remember. However, if it is time for the next dose, skip the missed one and take the next one at regular times. Do not take a double dose of RAMISAVE CH 10MG CAPSULE to compensate the missed ones.
Q: Can I stop taking RAMISAVE CH 10MG CAPSULE if my blood pressure reduces?
A: Do not stop taking RAMISAVE CH 10MG CAPSULE without consulting your doctor as your blood pressure may raise once again. Make sure to take RAMISAVE CH 10MG CAPSULE for the stipulated duration recommended by your doctor to achieve maximum results.
Q: Can the use of RAMISAVE CH 10MG CAPSULE affect my sexual life?
A: Yes. RAMISAVE CH 10MG CAPSULE may cause impotence in men and low sex drive in both men and women. Consult your doctor if they trouble you.
Q: What are the side effects of RAMISAVE CH 10MG CAPSULE?
A: The most common side effects of taking RAMISAVE CH 10MG CAPSULE are headache, dizziness, muscle cramps, stomach pain, constipation, diabetes, low blood potassium or sodium levels, impotence in men and low sex drive. Consult your doctor if any of these side effects trouble you.
Q: Can RAMISAVE CH 10MG CAPSULE be taken during pregnancy?
A: RAMISAVE CH 10MG CAPSULE is not recommended for use in pregnant women as it may harm the growing baby. Therefore, consult your doctor before taking it.
Q: Is RAMISAVE CH 10MG CAPSULE safe to use in kidney disease?
A: RAMISAVE CH 10MG CAPSULE is not recommended for use in patients with severe kidney problems (such as kidney stones, renal artery stenosis, dialysis). It should be used with caution in patients with other kidney problems. Therefore, consult your doctor before taking it.
Q: Can the use of RAMISAVE CH 10MG CAPSULE affect the liver?
A: Yes. RAMISAVE CH 10MG CAPSULE may affect the way your liver work. It can elevate the levels of certain liver enzymes in your body. Therefore, it should be used with caution in patients with liver problems. Consult your doctor before taking it.
Q: Does RAMISAVE CH 10MG CAPSULE cause frequent urination?
A: Yes. RAMISAVE CH 10MG CAPSULE may cause frequent urination. It is because RAMISAVE CH 10MG CAPSULE contains a medicine called chlorthalidone which is a diuretic (water pill). It excretes the excess water from the body in the form of urine. Therefore, it is advised to take RAMISAVE CH 10MG CAPSULE at least 5 hours before bedtime to avoid the urge at night to urinate.
Q: Can I take potassium supplements along with RAMISAVE CH 10MG CAPSULE?
A: Yes. Potassium supplements can be taken along with RAMISAVE CH 10MG CAPSULE. However, consult your doctor before taking it.
References
1. KD. Tripathi. Drugs Affecting Renin-Angiotensin System and Plasma Kinins. Antihypertensive Drugs. Diuretics. Essentials of Medical Pharmacology. 7th Edition. 2013. Page – 503, 559 & 583.
2. Connor C. Kerndt; Jayesh B. Patel. Chlorthalidone. StatPearls [Internet]. NIH. National Library of Medicine, National Center for biotechnology information. PMC. PubMed Central. November 2022. [Accessed on 2nd January 2023] https://www.ncbi.nlm.nih.gov/books/NBK553174/
3. Atlantic Pharma. Electronic Medicines Compendium (EMC). [Revised in September 2020] [Accessed on 2nd January 2023] https://www.medicines.org.uk/emc/files/pil.11982.pdf
4. Accord-UK Limited. Electronic Medicines Compendium (EMC). [Revised in May 2022] [Accessed on 2nd January 2023] https://www.medicines.org.uk/emc/files/pil.5900.pdf
Useful Diagnostic Tests
- Kidney function test
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