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Introduction About R HUCOG PREFILLED SYRINGE(PFS)
R HUCOG PREFILLED SYRINGE(PFS) contains Chorionic Gonadotropin which belongs to the group of medicines called Gonadotropins. It helps in the growth and development of ovum (follicles or eggs) among women who undergo assisted reproductive techniques such as in vitro fertilization.
It also helps in the release of matured ovum (eggs) from the ovaries (ovulation) and increase the chances of pregnancy among women who do not ovulate or having problems in ovulation.
R HUCOG PREFILLED SYRINGE(PFS) is generally recommended after pre-management with certain medicines (such as follicle stimulating hormone or human menopausal gonadotropin) that stimulates ovarian follicles.
Prior to the management, your doctor may evaluate your and your partner’s fertility status thoroughly as a precaution. During management with R HUCOG PREFILLED SYRINGE(PFS), your doctor would monitor your health condition through several blood tests and ultrasounds to avoid the risk of side effects such as abnormally enlarged ovarian follicles or multiple pregnancies.
Before receiving R HUCOG PREFILLED SYRINGE(PFS) inform your doctor if you have unexplained vaginal bleeding, blood clot problems or any tumors in the brain, breast, uterus or ovaries. You must also inform your doctor if you have any damage in the fallopian tubes, as management with R HUCOG PREFILLED SYRINGE(PFS) may cause ectopic pregnancy (pregnancy outside of the womb) in such cases.
R HUCOG PREFILLED SYRINGE(PFS) may cause false positive pregnant result in women who take pregnancy test using their blood or urine. This effect may last up to 10 days even after discontinuing management with R HUCOG PREFILLED SYRINGE(PFS).
R HUCOG PREFILLED SYRINGE(PFS) should not be used in pregnant women after successful conception. It is also not recommended for use in breastfeeding women and in children or adolescents (below 18 years) due to lack of safety data.
The most common side effects of R HUCOG PREFILLED SYRINGE(PFS) are headache and injection site reactions (such as pain, redness and swelling). Consult your doctor if they worsen.
Uses Of R HUCOG PREFILLED SYRINGE(PFS)
It is used to:
- Stimulate the growth and maturation of ovarian follicles (eggs) among women undergoing assisted reproductive techniques
- Induce ovulation in women who do not ovulate or having problems in ovulation
How R HUCOG PREFILLED SYRINGE(PFS) Works
R HUCOG PREFILLED SYRINGE(PFS) is a synthetic hormone which is prepared artificially using recombinant DNA technology. It mimics the action of a naturally occurring hormone called luteinizing hormone that stimulates growth and ripening of ovarian follicles (eggs) and triggers ovulation. This helps in managing infertility and may increase the chances of pregnancy among infertile women.
How to use R HUCOG PREFILLED SYRINGE(PFS)
R HUCOG PREFILLED SYRINGE(PFS) should be used under proper medical supervision. It is either administered by the doctor or can be self-administered under the skin (subcutaneously). Your doctor would explain you how, when and where to inject the medicine. Inject R HUCOG PREFILLED SYRINGE(PFS) exactly as taught by your doctor.
Side Effects Of R HUCOG PREFILLED SYRINGE(PFS)
Common
- headache, tiredness
- injection site reactions (such as pain, redness or swelling)
Uncommon
- feeling depressed, irritated, or restless
- diarrhoea
- breast pain
Rare
Contact your doctor immediately if you experience any of the following side effects after receiving R HUCOG PREFILLED SYRINGE(PFS):
- signs of ovarian hyperstimulation syndrome (such as lower stomach pain, swollen stomach, rapid weight gain, nausea, vomiting, breast pain, difficulty in breathing, clearly enlarged ovaries in ultrasound, fluid accumulation in lungs with decreased urine production)
- signs of allergic reactions (such as skin rash, rapid or uneven pulse, swelling of the tongue and throat, sneezing, wheezing or serious difficulty in breathing)
- serious blood clotting problems which may cause chest pain, breathlessness, stroke or heart attack
How To Manage Side Effects
Diarrhea:
Drink lots of fluids, such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for managing diarrhea. Consult your doctor if the symptom worsens.
Headache:
Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the head if required. Do not consume too much of alcohol. Consult your doctor if the symptom worsens.
Injection site reactions (such as pain, swelling or redness):
Apply an ice pack on the affected area. Do not move or shake the affected site frequently. Do not inject the medicine at the same site each time. Instead, alter the site. Consult your doctor if the symptom worsens.
Warning & Precautions
Pregnancy
R HUCOG PREFILLED SYRINGE(PFS) is not recommended for use in pregnant women. Although, it may increase the chances of pregnancy among infertile women by inducing ovulation, it should not be used once after successful pregnancy has been established. Therefore, consult your doctor for advice.
Breastfeeding
R HUCOG PREFILLED SYRINGE(PFS) is generally not recommended for use in breastfeeding women. Therefore, consult your doctor before receiving it.
Driving and Using Machines
Do not drive or operate any heavy tools or machines if your ability is affected by R HUCOG PREFILLED SYRINGE(PFS).
Alcohol
Avoid consumption of alcohol while receiving R HUCOG PREFILLED SYRINGE(PFS).
Allergy
Do not receive R HUCOG PREFILLED SYRINGE(PFS) if you are allergic to Chorionic Gonadotropin.
Lungs
R HUCOG PREFILLED SYRINGE(PFS) should be used with caution in patients who have or ever had blood clot in lungs (Ex. pulmonary embolism). Therefore, consult your doctor before receiving it.
Heart Disease
R HUCOG PREFILLED SYRINGE(PFS) should be used with caution in patients who have or ever had heart attack or stroke. Therefore, consult your doctor before receiving it.
Others
R HUCOG PREFILLED SYRINGE(PFS) is not recommended for use if you have:
- any form of tumors in hypothalamus or pituitary gland (Ex. pituitary adenoma)
- an enlarged ovaries or polycystic ovarian disease (numerous fluids filled sacs on top of ovaries)
- unexplained bleeding from vagina
- cancers in the breasts, uterus or ovaries
- problems affecting veins (such as severe inflammation or blood clot in veins)
- underlying conditions that causes difficulty in getting pregnant (such as malformations of sexual organs, menopause or early menopause)
- uncontrollable thyroid or adrenal dysfunction
Before receiving R HUCOG PREFILLED SYRINGE(PFS), inform your physician if you:
- have damaged fallopian tubes
- have a history of blood clots in the legs (Ex. deep vein thrombosis)
- are going to have a blood/urine test to detect pregnancy
Use in pediatrics:
R HUCOG PREFILLED SYRINGE(PFS) is not indicated for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before administration.
Use in geriatrics:
There is no proper information regarding the use of R HUCOG PREFILLED SYRINGE(PFS) in the elderly patients. Therefore, consult your doctor for advice.
Interactions
A. Drug-Drug interactions:
Inform your doctor if you are taking or have recently taken any other medicines while taking R HUCOG PREFILLED SYRINGE(PFS) as a precaution.
Overdosage:
If you or anyone else accidentally injected more R HUCOG PREFILLED SYRINGE(PFS), contact your doctor immediately or go to a hospital straight away. Symptoms of overdosage might include signs of ovarian hyperstimulation syndrome (such as lower stomach pain, swollen stomach, rapid weight gain, nausea, vomiting, breast pain, difficulty in breathing, fluid accumulation in the chest or difficulty in passing urine).
Synopsis
| Drug | : | Chorionic Gonadotropin |
| Pharmacological Category | : | Gonadotropins |
| Therapeutic Indication | : | Infertility in Women |
| Dosage Forms | : | Prefilled syringe, Injection |
More Information
- Keep R HUCOG PREFILLED SYRINGE(PFS) out of reach of children
- Store R HUCOG PREFILLED SYRINGE(PFS) in a refrigerator (2-8°C)
- Do not use R HUCOG PREFILLED SYRINGE(PFS) if you notice any signs of deterioration or if the liquid is not clear
- Immediately dispose the used needle safely
FAQs About R HUCOG PREFILLED SYRINGE(PFS)
Can R HUCOG PREFILLED SYRINGE(PFS) help in getting pregnant?
Yes. R HUCOG PREFILLED SYRINGE(PFS) is used to improve the growth and development of egg follicles in women who have problem with egg growth. It can also be used to stimulate the release of the completely matured egg from the ovaries in women who do not produce eggs or produce very few eggs. Because of its ovulatory effects, it helps infertile women to release well developed ripened ovarian follicles which are required for getting pregnant.
Can I try to become pregnant while receiving R HUCOG PREFILLED SYRINGE(PFS)?
Yes. R HUCOG PREFILLED SYRINGE(PFS) is generally used among women who are facing difficulties in getting pregnant. It is mostly used along with certain assisted reproductive techniques (such as in vitro fertilization) or hormonal medicine that can increase the chances of getting pregnant in an infertile woman. Before receiving R HUCOG PREFILLED SYRINGE(PFS) your doctor would completely evaluate your fertility status and decide your management interventions.
Can R HUCOG PREFILLED SYRINGE(PFS) be self-administered?
Yes. R HUCOG PREFILLED SYRINGE(PFS) can be self-administered by patients. It is usually administered beneath the skin as subcutaneous injection. Your doctor or nurse will explain you how, when, and where R HUCOG PREFILLED SYRINGE(PFS) should be administered. Kindly inject R HUCOG PREFILLED SYRINGE(PFS) exactly as doctor or nurse taught you. Consult your doctor if you have any doubts regarding the administration of R HUCOG PREFILLED SYRINGE(PFS).
Can R HUCOG PREFILLED SYRINGE(PFS) be used in men?
No. R HUCOG PREFILLED SYRINGE(PFS) is not suitable for use in men. It exerts its effects only on the growth and development of ovarian follicles. Consult your doctor if you are a man who wish to use HCG hormone for hormonal disorders. Your doctor will prescribe you a suitable medicine with a higher dose.
Can R HUCOG PREFILLED SYRINGE(PFS) be used to manage PCOD?
R HUCOG PREFILLED SYRINGE(PFS) is not recommended for use in patients with polycystic ovarian disease (PCOD). However, consult your doctor before receiving it. Your doctor will decide whether you can use R HUCOG PREFILLED SYRINGE(PFS) or not based on your disease condition.
Can management with R HUCOG PREFILLED SYRINGE(PFS) cause twin pregnancy?
Yes. Usage of R HUCOG PREFILLED SYRINGE(PFS) has a higher risk of becoming pregnant with more than one child at the same time (twin pregnancy or multiple pregnancy) than if conceived naturally. The risk further increases if management with R HUCOG PREFILLED SYRINGE(PFS) is combined with assisted reproductive techniques. To avoid this, your doctor will carefully monitor you through several blood tests (for estradiol levels) and ultrasounds.
Where to inject R HUCOG PREFILLED SYRINGE(PFS)?
R HUCOG PREFILLED SYRINGE(PFS) is usually injected beneath the skin as subcutaneous injection. Your doctor or nurse will explain you how, when, and where R HUCOG PREFILLED SYRINGE(PFS) should be administered. Consult your doctor if you have any doubts regarding the administration of R HUCOG PREFILLED SYRINGE(PFS).
Will the use of R HUCOG PREFILLED SYRINGE(PFS) cause breast pain or tenderness?
R HUCOG PREFILLED SYRINGE(PFS) may cause breast pain or tenderness in some individuals. It is caused due to overstimulation of ovaries. If the symptom worsens, consult your doctor immediately.
Why I’m experiencing positive result in pregnancy kit after taking R HUCOG PREFILLED SYRINGE(PFS) even though I’m not pregnant?
It is because, R HUCOG PREFILLED SYRINGE(PFS) contains a medicine called Chorionic Gonadotropin which is similar to an endogenous hormone called ‘human chorionic gonadotropin’ (HCG). HCG is a hormone that can only be produced in the body of pregnant women during the early stages of pregnancy. Because pregnancy kits are designed in such a way to capture the levels of naturally produced HCG hormone from the urine of pregnant women, they tend to show a false positive result after receiving R HUCOG PREFILLED SYRINGE(PFS), even if you are not pregnant.
What can be done if I forget to take a dose of R HUCOG PREFILLED SYRINGE(PFS)?
Consult your doctor if you missed a dose of R HUCOG PREFILLED SYRINGE(PFS). Do not take a double dose to compensate the missed one.
What precautions need to be followed while taking R HUCOG PREFILLED SYRINGE(PFS)?
Before receiving R HUCOG PREFILLED SYRINGE(PFS) inform your doctor if you have any other problems in reproductive organs like a tumor or cancers, unexplained vaginal bleeding, PCOD, or damage in fallopian tubes. Regularly monitor your health condition through blood tests and ultrasounds as instructed by your doctor. Regularly receive R HUCOG PREFILLED SYRINGE(PFS) as instructed by your physician. If you become pregnant during therapy with R HUCOG PREFILLED SYRINGE(PFS) inform your doctor immediately.
Can R HUCOG PREFILLED SYRINGE(PFS) be used to induce periods?
R HUCOG PREFILLED SYRINGE(PFS) is a hormone which is primarily used to improve the chances of getting pregnant in infertile women. Only failure in fertilization or over stimulation of ovaries during therapy can cause miscarriage or menstruation. R HUCOG PREFILLED SYRINGE(PFS) is not a first line medicine to induce periods among patients who have amenorrhea (lack of periods). Consult your doctor for some alternative therapy.
References
1. Keith L. Parker and Bernard P. Schimmer. Introduction to Endocrinology: The Hypothalamic-Pituitary Axis. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 1123-1124
2. Peter Chang, Ph.D., Susan Kenley, Ph.D., Tammy Burns, Gary DeVane, M.D., Louis O’Dea. Recombinant human chorionic gonadotropin (rhCG) in assisted reproductive technology: results of a clinical trial comparing two doses of rhCG (OvidrelR) to urinary hCG (ProfasiR) for induction of final follicular maturation in in vitro fertilization–embryo transfer. Fertility and Sterility. American Society for Reproductive Medicine. March 2001. [Accessed on 21st September 2022] https://www.fertstert.org/article/S0015-0282(01)01851-9/fulltext#relatedArticles
3. Meng-Han Yan, Jing-Xian Cao, Jin-Wei Hau, Wen Jing Jiang, Dan-Dan Wang, Zhen-Gao Sun, Jing-Yan Song. GnRH Agonist and hCG (Dual Trigger) Versus hCG Trigger for Final Oocyte Maturation in Expected Normal Responders with a High Immature Oocyte Rate: Study Protocol for a Randomized, Superiority, Parallel Group, Controlled Trial. Frontiers in Endocrinology. March 2022. [Accessed on 21st September 2022] https://www.frontiersin.org/articles/10.3389/fendo.2022.831859/full
4. Merck Serono S.p.A. Electronic Medicines Compendium (EMC). [Revised in November 2021] [Accessed on 20th April 2022] https://www.medicines.org.uk/emc/files/pil.2806.pdf
5. Merck Serono S.p.A. Electronic Medicines Compendium (EMC). [Revised in October 2020] [Accessed on 20th April 2022] https://www.medicines.org.uk/emc/files/pil.5527.pdf
6. Ovitrelle (choriogonadotropin alfa). European Medicines Agency. [Revised in December 2020]. [Accessed on 20th April 2022]. https://www.ema.europa.eu/en/documents/overview/ovitrelle-epar-medicine-overview_en.pdf
7. Bharat Serums and Vaccines Ltd. R-HUCOG. Recombinant Human Chorionic Gonadotropin for Injection. 6500 IU/0.5 ml Prefilled syringe. [Revised in January 2019] [Accessed on 22nd April 2022]. https://www.bharatserums.com/assets/pdf/products/r-HUCOG-6500-IU-(Liquid)-PFS-Pack-Insert-for-Domestic-08-01-19.pdf
8. Mims.com. Ovidrel. choriogonadotropin alfa. [Accessed on 20th April 2022]. https://www.mims.com/singapore/drug/info/ovidrel/mechanism-of-action
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