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Introduction About R CIN SYRUP
R CIN SYRUP contains Rifampicin which belongs to the group of medicines called Antibacterial. It is used in the management of serious bacterial infections such as tuberculosis (affects the lungs), legionnaires disease (lung inflammation), brucellosis (infection spreading from animal to people), leprosy (causes skin lesions and nerve damage) along with other medicines and also manages haemophilus influenzae.
It is also used to stop meningitis (inflammation of the membranes and fluid surrounding the brain and spinal cord) and haemophilus influenzae (in children aged 4 years or younger). Your doctor may ask you to take blood tests and liver function tests before the management with R CIN SYRUP. R CIN SYRUP is not recommended for use if you have yellowing of the skin and eyes (jaundice).
Before taking R CIN SYRUP, it is recommended to inform your doctor if you have liver, kidney problems, diabetes, feel numb or weak in your arms and legs (peripheral neuropathy), are underweight or malnourished. Also, inform your doctor if you have a rare blood problem (porphyria), bleeding or a tendency to bruise easily, symptoms of tuberculosis return/get worse or are wearing contact lenses.
R CIN SYRUP should be used with caution in pregnant women. It is not recommended for use in breastfeeding women. R CIN SYRUP should be used with caution in children under 2 years of age and elderly patients above 65 years of age. The most common side effects seen are nausea, vomiting, chills, fever. Consult your doctor if symptoms do not improve.
Uses Of R CIN SYRUP
- it is used to manage tuberculosis, leprosy, brucellosis, legionnaires along with other medicines
- manages haemophilus influenzae and other serious bacterial infections
- prevents the development of meningitis
- prevents haemophilus Influenzae in children less than 4 years
How R CIN SYRUP Works
R CIN SYRUP works by managing protein synthesis and interferes with the enzymes present in the bacteria causing its death. This results in the reduction in the count of infection-causing bacteria, thereby managing bacterial infections.
How to use R CIN SYRUP
Take R CIN SYRUP as advised by your physician. Shake well before use. It is recommended to take R CIN SYRUP on an empty stomach. Your doctor will decide the correct dose and duration for you depending on your age, body weight and severity of infection.
Side Effects Of R CIN SYRUP
Common
- yellow orange and brown discoloration of teeth, urine, sweat, phlegm, saliva, tears
- thrombocytopenia with or without purpura (low platelet level)
- headache, dizziness
- nausea and vomiting
- pyrexia (fever)
- chills
Rare
Stop taking R CIN SYRUP and consult your doctor immediately if you experience any of the following:
- mental problems such as visions, hallucinations and unusual thoughts
- severe watery, frequent loose stools along with weakness and/or fever (Pseudomembranous Colitis)
- flu like symptoms like chills, fever, headache and bone pain
- swelling (oedema) of face, stomach, arms, legs due to water retention
- dizziness, light-headedness and fainting due to a drop in blood pressure while changing posture
- weakness and pain of muscles and loss of its reflexes
- inability to focus and concentrate
- feeling irritated, anxious, depressed, tired and having difficulty in sleeping
- short term memory loss
- wasting of muscles of body
- loss of weight
- night sweats and fever
- irregular monthly periods
- stomach discomfort
- blisters on skin and mucosal surfaces that peel and form painful raw areas. (Stevens-Johnson syndrome, toxic epidermal necrolysis)
- flu- like symptoms along with the appearance of a rash which are widespread in nature, along with increased temperature and enlarged lymph nodes which are characteristic of DRESS (Drug Reaction with Eosinophilia and Systemic symptoms)
- sudden development of rash, blisters and pustules all over the body especially in folds of skin, trunk and upper extremities along with onset of fever (Acute Generalized Exanthematous Pustulosis (AGEP))
- a rash, swallowing or breathing problems, wheezing, swelling of your lips, face, throat or tongue
- fever and yellowing of the skin or whites of the eyes, feel tired, weak or generally
- unwell, loss of appetite (anorexia), feeling sick (nausea), being sick (vomiting) (early signs of liver problems)
- severe bleeding (hemorrhage)
- tendency to get bruised frequently
- painful red rash under the skin (purpura)
- severe bleeding (hemorrhage)
- chills, tiredness, unusually pale skin color, shortness of breath, fast heartbeat or dark colored urine (signs of a serious type of anemia)
- blood in your urine or an increase or decrease in amount of urine you produce, swelling, especially of the legs, ankles or feet (serious kidney problems)
- sudden severe headache (sign of bleeding in the brain)
- return of previous symptoms after initial improvement (Paradoxical Drug Reaction) along with experiencing pain, swollen lymph nodes, headaches, loss of appetite and weight, shortness of breath, fast and rapid heartbeat)
- cold-clammy skin along with confusion and sleepiness.
- bleeding from your nose, ear, gums, throat, skin or stomach (feeling of tenderness and swelling in your stomach, purple spots on your skin and black or tar like stools)
How To Manage Side Effects
Nausea and Vomiting:
Stick to simple meals. Avoid eating oil-rich or spicy foods, sugary snacks and drinks. Avoid drinking too much liquid along with your meals, drink slowly in between meals. Inform your doctor if the condition worsens.
Headache:
Take some rest, in a quiet place and avoid using mobile phones and other electronic devices for a while. Drinking water as inadequate hydration may worsen your headache. If symptoms persist, contact your doctor.
Warning & Precautions
Pregnancy
R CIN SYRUP must be used with caution in women who are pregnant and/or planning pregnancy. Also, R CIN SYRUP may result in the ineffectiveness of oral contraception, hence using physical methods of contraception like condoms and coils are recommended. Always consult your doctor before taking R CIN SYRUP.
Breastfeeding
R CIN SYRUP is not recommended to be taken by nursing women since it may pass to the baby through mother’s milk. Consult your doctor before taking R CIN SYRUP.
Driving and Using Machines
Do not drive and use heavy machinery after taking R CIN SYRUP as it might make you feel dizzy, faint and can adversely affect the vision. Consult your doctor before taking R CIN SYRUP.
Kidney
R CIN SYRUP must be taken with caution if you are diagnosed with any kidney disease. Consult your doctor before taking R CIN SYRUP.
Liver
R CIN SYRUP must be taken with caution if you are diagnosed with liver disease. Consult your doctor before taking R CIN SYRUP.
Allergy
Do not take R CIN SYRUP if you are allergic to Rifampicin and/or any other constituents present in the medicine.
Others
R CIN SYRUP is not recommended for use if you:
- have yellowish tinge to eyes and skin which may be indicative of jaundice
Before taking R CIN SYRUP, inform your doctor if you:
- have diabetes (elevated level of sugar in blood)
- have peripheral neuropathy which is characterized by feeling of weakness and numbness in feet and hands
- are underweight and/or malnourished
- are diagnosed with a blood disorder called Porphyria characterized by the appearance of purple colored rash on skin.
- are prone to bleeding and/or bruising easily
- wear contact lens
- notice worsening and/or return of your initial symptoms of tuberculosis
Use in Pediatrics:
R CIN SYRUP must be taken in caution in children below 2 years of age. Consult your doctor before taking it as they can decide the correct and required dosage, frequency and strength of R CIN SYRUP based on age, disease condition and body weight of the child.
Use in Geriatrics:
R CIN SYRUP must be taken with caution in elderly patients (above the age of 65 years). Consult your doctor before taking R CIN SYRUP.
Interactions
A. Drug-Drug Interactions:
Before taking R CIN SYRUP, inform your doctor if you are taking any of the following medicine:
- medicines used to manage HIV infection (Ex. saquinavir, ritonavir)
- medicines used to manage indigestion such as antacids (Ex. aluminium hydroxide, magnesium carbonate)
- other medicines used to manage tuberculosis (Ex. P-Aminosalicylic Acid)
- medicines used to thin the blood (Ex. clopidrogel, warfarrin)
- medicines used to lower cholesterol (Ex. atorvastatin, rosuvastatin)
- medicines for heart problems or to control your heartbeat (Ex. atenolol, bisprolol), lower the blood pressure (Ex. diuretics like eplerenone)
- medicines used to manage thought disorders (Ex. antipsychotics like haloperidol), reduce anxiety (Ex. hypnotics-lorazepam), to induce sleep (Ex. barbiturates-phenobarbital), manage depression (Ex. amitriptyline)
- medicines used to manage epilepsy (Ex. phenytoin), disease of motor neurons (Ex. riluzole)
- medicines used to manage various viral infections (Ex. indinavir, telaprevir, amprenavir, nelfinavir, atazanavir, lopinavir, neviparine, daclatasvir, simeprevir, sofosbuvir and telaprevir)
- medicines used to manage fungal diseases (Ex. ketoconazole, clotrimazole), bacterial infections (Ex. amoxicillin, cephalosporin), tapeworm infections (Ex. praziquantel)
- medicines used to lower the immune system response (Ex. ciclosporin, tacrolimus, sirolimus)
- medicines used to manage pneumonia (Ex. atovaquone)
- medicines used for contraception (Ex. estrogen, progestogens)
- medicines used to manage cancer (Ex. imatinib, irinotecan, ethinyloestradiol, levonorgestrel or dydrogesterone), for breast cancer or endometriosis (Ex. tamoxifen, gestrinone, toremifene)
- medicines used to manage thyroid gland problems (Ex. levothyroxine)
- medicines used to manage gout and other pains (Ex. aspirin, etoricoxib, codeine, morphine, fentanyl, pethidine, etoricoxib, aspirin and indomethacin)
- medicines used to manage inflammation in the body such as corticosteroids (Ex. hydrocortisone, betamethasone and prednisolone)
- medicines used during withdrawal from heroin (Ex. methadone)
- medicines used to manage diabetes (Ex. metformin)
- medicines used before surgery to relax the mind and body (Ex. halothane)
- medicines used for nausea (Ex. ondansetron, aprepitant)
- medicines used for malaria (Ex. quinine)
- medicines used to manage difficulty breathing and wheezing sound (Ex. theophylline)
Overdosage:
If you or anyone else accidentally took more of R CIN SYRUP, visit the nearby hospital or consult your doctor immediately. The symptoms of overdosage are nausea, vomiting, stomachache, itch and headache. The patient may also experience tiredness, sleepiness and dizziness, along with swelling of face and eyes, difficult breathing and fast, uneven heartbeat, heart attack and fits.
Synopsis
| Drug | : | Rifampicin |
| Pharmacological Category | : | Antibacterial |
| Therapeutic Indication | : | Serious Bacterial Infections |
| Dosage Forms | : | Syrup, Suspension, Capsule, Tablet |
More Information
- Keep R CIN SYRUP out of reach of children
- Keep R CIN SYRUP safe from light and humidity
- Keep it below 25°C
FAQs About R CIN SYRUP
What is R CIN SYRUP used for?
R CIN SYRUP s used in the management of serious bacterial infections such as tuberculosis (affects the lungs), legionnaires diseases (lung inflammation), brucellosis (infection spreading from animal to people), leprosy (causes skin lesions and nerve damage) along with other medicines and haemophilus influenzae. It is also used to stop meningitis (inflammation of the membranes and fluid surrounding brain and spinal cord) and haemophilus influenzae (in children aged 4 years or younger).
Can I take R CIN SYRUP in pregnancy?
R CIN SYRUP must be used with caution in women who are pregnant and/or planning pregnancy. Also, R CIN SYRUP may result in the ineffectiveness of oral contraception, hence using physical methods of contraception like condoms and coils are recommended. Always consult your doctor before taking R CIN SYRUP.
How does R CIN SYRUP work?
R CIN SYRUP works by managing the protein synthesis and interferes with the enzymes present in the bacteria causing its death. This results in the reduction in the count of infection causing bacteria, thereby managing bacterial infections.
Can I take antacids while taking R CIN SYRUP?
No, it is not recommended to take R CIN SYRUP and antacids such as Aluminium hydroxide and magnesium carbonate together as antacids may affect its absorption. It is recommended to take R CIN SYRUP at least 1 hour before taking antacids.
Can R CIN SYRUP be taken with Vitamin D?
Taking R CIN SYRUP with Vitamin D will decrease the effect of Vitamin D. Inform your doctor if you are taking this medicine as the dose will be adjusted accordingly.
References
1. KD. Tripathi. Antitubercular Drugs. Essentials of medical pharmacology. Seventh edition. Page- 675.
2. KD. Tripathi. Antileprotic Drugs. Essentials of medical pharmacology. Seventh edition. Page- 685.
3. Niemi, M., Backman, J.T., Fromm, M.F., Neuvonen, P.J. and Kivistö, K.T. Pharmacokinetic interactions with rifampicin. Clinical pharmacokinetics. Springer link. 2003 [Accessed on 10th September 2022] https://link.springer.com/article/10.2165/00003088-200342090-00003
4. McClure, W.R. and Cech, C.L. On the mechanism of rifampicin inhibition of RNA synthesis. Journal of Biological Chemistry. December 1978 [Accessed on 10th September 2022] https://www.sciencedirect.com/science/article/pii/S0021925817342692
5. Sanofi S.P.A. Electronic Medicines Compendium (EMC). [Revised in August 2021] [Accessed on 10th September 2022] https://www.medicines.org.uk/emc/files/pil.6383.pdf , https://www.medicines.org.uk/emc/product/6383/smpc
Useful Diagnostic Tests
- Complete Blood Count
- Liver Function Tests
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