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Introduction About QUALINOR 400 TABLET
QUALINOR 400 TABLET is used to manage urinary tract infections and gonococcal infections. It contains Norfloxacin which belongs to the group of medicines called Fluoroquinolone antibiotics that works by inhibiting the activity of the bacterial enzyme DNA-gyrase, which helps to manage the bacteria from multiplying and thus effectively manages the bacterial infection.
Always take QUALINOR 400 TABLET exactly as directed by your doctor. Before taking this medicine, inform your doctor if you have or had seizures, tendon problems, liver, kidney or heart problems. Drink plenty of liquids during management with QUALINOR 400 TABLET (such as water or juice) to avoid potential side effects (such as crystalluria). QUALINOR 400 TABLET should be taken at least 1 hour before or 2 hours after taking products containing calcium such as dairy products (milk or liquid milk products such as yoghurt), including iron, zinc or multivitamin supplements.
QUALINOR 400 TABLET is not recommended for use in pregnant and breast-feeding women. QUALINOR 400 TABLET is not recommended for use in children and adolescents (aged under 18 years). Also, it should be used with caution in elderly patients (aged 60 years and above) due to increased risk of pain and swelling in the joints and inflammation or rupture of tendons. The common side effects of taking QUALINOR 400 TABLET are headache, dizziness, light-headedness stomach pain and nausea. Consult your doctor if any of the side effect worsens or persist for a long period of time.
Uses Of QUALINOR 400 TABLET
- It is used to manage urinary tract infections and gonococcal infections
How QUALINOR 400 TABLET Works
QUALINOR 400 TABLET works by inhibiting the activity of the bacterial enzyme DNA-gyrase, which helps to manage the bacteria from multiplying and thus effectively manages the bacterial infection.
How to use QUALINOR 400 TABLET
Take QUALINOR 400 TABLET exactly as advised by your doctor. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of the management for you based on the age, body weight and disease condition.
Side Effects Of QUALINOR 400 TABLET
Common
- Headache
- Dizziness, light-headedness, drowsiness
- Abdominal pain and spasms
- Nausea
- Rash
Uncommon
- Crystalluria
- Tiredness
- Mood swings
- Difficulty sleeping, sleep disorders
- Anxiety, nervousness
- Irritability, euphoria, disorientation
- Hallucination, confusion
- Polyneuropathy
- Fits
- Myasthenia gravis
- Disturbed vision
- Increased lacrimation (tear production)
- Tinnitus (ringing in the ears)
- Palpitation (feeling your heartbeat)
- Heartburn, vomiting
- Diarrhea
- Loss of appetite
- Skin reactions and photosensitivity (increased sensitivity to sunlight)
- Pain or inflammation in joints
- Muscle pain, inflamed tendons
- Vaginal candidiasis
Rare
- Pseudomembranous colitis (inflammation of the bowel causing fever, abdominal pain or diarrhoea
- Inflammation of the Achilles (pain and swelling in the backside of your heel when you walk or run)
Stop taking QUALINOR 400 TABLET and consult your doctor immediately if you experience any of the following side effects:
- Symptoms of angio-oedema (such as swollen face, tongue or throat, difficulty in swallowing, hives and difficulty breathing)
- Severe skin reaction
- Symptom of an inflammation of the liver (hepatitis) or liver failure (such as yellow discoloration of the eye whites or skin)
- Pain or inflammation of a tendon (in your ankle, wrist, elbow, shoulder or knee)
- Symptoms of nerve damage (neuropathy) such as pain, burning, tingling, numbness and/or weakness especially in the feet and legs or hands and arms
- Pseudomembranous colitis (infection causing inflammation of the large intestine, severe and persistent diarrhoea)
How To Manage Side Effects
Diarrhea
Drink lot of fluids such as water to keep yourself hydrated. Avoid eating high-fat or spicy foods. Consult your doctor if the symptom gets worse.
Headache
Drink ample amount of water and avoid skipping meals. Get adequate rest. Try to be relaxed and stress free. Apply pain relieving balm on your forehead if necessary. Consult your doctor if the symptom does not improve.
Nausea And Vomiting
Stick to simple meals while taking QUALINOR 400 TABLET. Avoid eating oily rich, fried or spicy foods. Do not lie down or sleep immediately after eating. Inform your doctor if the symptom does not improve.
Stomach Pain
Try to rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heating pad on your stomach. If the symptom does not improve, consult your doctor.
Warning & Precautions
Pregnancy
ContraindicatedQUALINOR 400 TABLET is not recommended for use in pregnant women and those who are planning to become pregnant. If you become pregnant while taking this medicine inform your doctor immediately. You must use effective contraceptive methods while you are taking this medicine. Consult your doctor before taking it.
Breastfeeding
ContraindicatedQUALINOR 400 TABLET is not recommended for use in breast-feeding women. Consult your doctor before taking it.
Driving and Using Machines
Use with CautionDo not drive or handle machines while taking QUALINOR 400 TABLET, since it may cause dizziness or light-headedness.
Alcohol
ContraindicatedConsumption of alcohol is not recommended during management with QUALINOR 400 TABLET.
Kidney
Use with CautionQUALINOR 400 TABLET should be used with caution in patients with kidney disease or problems. Consult your doctor before taking it.
Liver
Use with CautionQUALINOR 400 TABLET should be used with caution in patients with liver disease. Consult your doctor before taking it.
Allergy
ContraindicatedDo not take QUALINOR 400 TABLET if you are allergic (hypersensitive) to Norfloxacin or other ingredients of this medicine.
Heart Disease
Use with CautionQUALINOR 400 TABLET should be used with caution in patients with an enlargement or bulge of a large blood vessel (aortic aneurysm or large vessel peripheral aneurysm), experienced a previous episode of aortic dissection (a tear in the aorta wall), very slow heart rhythm, weak heart (heart failure), history of heart attack, have a family history of prolonged QT interval, aortic aneurysm or aortic dissection or predisposing conditions (such as connective tissue disorders such as Marfan syndrome, vascular disorders such as Takayasu arteritis, high blood pressure or known atherosclerosis). Consult your doctor before taking it.
Use In Pediatrics
ContraindicatedQUALINOR 400 TABLET is not recommended for use in children and adolescents (aged under 18 years). Consult your child’s doctor for advice.
Use In Geriatrics
Use with CautionQUALINOR 400 TABLET should be used with caution in elderly patients (aged 60 years and above) due to increased risk of pain and swelling in the joints and inflammation or rupture of tendons. Consult your doctor before taking it.
Others
QUALINOR 400 TABLET is not recommended for use if you:
- Have a history of inflamed (tendonitis) or ruptured tendons related to management with fluoroquinolones
Before taking QUALINOR 400 TABLET, inform your doctor if you:
- Have a surgical history of organ transplant recently
- Epilepsy or convulsions (fits)
- Mental disorders such as hallucination or confusion
- Disorders of the central nervous system such as reduced blood flow to the brain or a stroke
- Glucose-6-phosphate dehydrogenase enzyme deficiency
- Myasthenia gravis
Interactions
A. Drug-Drug Interactions:
- Skeletal muscle relaxants (Ex. Tizanidine)
- Antibiotics (Ex. Nitrofurantoin, erythromycin and clarithromycin)
- Antigout drugs (Ex. Probenecid)
- Bronchial Asthma drugs (Ex. theophylline)
- Immunosuppressive agents (Ex. cyclosporine)
- Anticoagulant drugs (Ex. warfarin)
- Non-steroidal anti-inflammatory drug (Ex. Fenbufen)
- Anti-arrhythmics drugs (Ex. quinidine, hydroquinidine, disopyramide, amiodarone, sotalol, dofetilide, ibutilide)
- Antidepressants (Ex. amitriptyline)
- Antipsychotics drugs (Ex. risperidone, ziprasidone)
- Oral contraceptives (Ex. ethinylestradiol and norethindrone)
- Multivitamins
- Antacids (Ex. aluminum hydroxide, magnesium hydroxide and sucralfate)
- CNS Stimulants drugs (Ex. caffeine)
B. Drug-Food interaction:
QUALINOR 400 TABLET should be taken at least 1 hour before or 2 hours after taking products containing calcium such as dairy products (milk or liquid milk products such as yoghurt). Consult your doctor before taking QUALINOR 400 TABLET.
Overdosage:
If you or anyone else accidentally takes too much of QUALINOR 400 TABLET, consult your doctor immediately or visit the nearby hospital.
Synopsis
| Drug | : | Norfloxacin |
| Pharmacological Category | : | Fluoroquinolone antibiotics |
| Therapeutic Indication | : | Used to manage Urinary tract and Gonococcal infections |
| Dosage Forms | : | Tablet |
More Information
Storage
- Keep QUALINOR 400 TABLET out of reach of children
- Store QUALINOR 400 TABLET at room temperature
FAQs About QUALINOR 400 TABLET
Q: What is QUALINOR 400 TABLET used for?
A: QUALINOR 400 TABLET is used to manage urinary tract infections (infection in any part of the urinary system, the kidneys, bladder or urethra) and gonococcal infections (sexually transmitted infection that infects both male and female).
Q: Can QUALINOR 400 TABLET be used in elderly patients?
A: QUALINOR 400 TABLET should be used with caution in elderly patients (aged 60 years and above) due to increased risk of pain and swelling in the joints and inflammation or rupture of tendons. Consult your doctor before taking QUALINOR 400 TABLET.
Q: Can I stop taking QUALINOR 400 TABLET when my symptoms are relieved?
A: Do not stop taking QUALINOR 400 TABLET abruptly even if your symptoms may get better quickly. You should continue to take your medicine for as long as your doctor recommends, otherwise the infection may reoccur again.
Q: Is QUALINOR 400 TABLET safe to use in pregnant women?
A: QUALINOR 400 TABLET is not recommended for use in pregnant women and those who are planning to become pregnant. If you become pregnant while taking this medicine inform your doctor immediately. You must use effective contraceptive methods while you are taking this medicine. Consult your doctor before taking QUALINOR 400 TABLET.
Q: Can QUALINOR 400 TABLET be taken with foods containing calcium?
A: QUALINOR 400 TABLET should be taken at least 1 hour before or 2 hours after taking products containing calcium such as dairy products (milk or liquid milk products such as yoghurt). Consult your doctor before taking QUALINOR 400 TABLET.
Q: What should I do if I forget to take a dose of QUALINOR 400 TABLET?
A: If you forget to take a dose of QUALINOR 400 TABLET, take it as soon as you remember. However, if it is time to take the next dose of QUALINOR 400 TABLET, skip the missed dose and take the next one at regular times. Do not take a double dose of QUALINOR 400 TABLET to compensate the missed dose, as it could lead to toxicity.
Q: Can I consume alcohol along with QUALINOR 400 TABLET?
A: Consumption of alcohol is not recommended during management with QUALINOR 400 TABLET.
Q: How does QUALINOR TABLET works?
A: QUALINOR TABLET works by inhibiting the activity of the bacterial enzyme DNA-gyrase, which helps to manage the bacteria from multiplying and thus effectively manages the bacterial infection.
Q: How to take QUALINOR TABLET?
A: Take QUALINOR TABLET exactly as advised by your doctor. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of the management for you based on the age, body weight and disease condition.
Q: Where can I purchase QUALINOR TABLET conveniently?
A: You can buy QUALINOR TABLET online through platforms like Netmeds, an online pharmacy, which offers a hassle-free way to get your medications delivered to your doorstep.
References
1. KD. Tripathi. Sulfonamides, cotrimoxazole and quinolones. Essentials of medical pharmacology. Seventh edition. 2013. Page-713.
2. OBS Pakistan. Noroxin Efficacy and Safety Trial (NEST). NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in April 2018] [Accessed on 3rd June 2024] https://clinicaltrials.gov/ct2/show/NCT03506256
3. T Matsuura, T Kurita. [Clinical studies of norfloxacin in urinary tract infections]. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. November 1985. [Accessed on 3rd June 2024] https://pubmed.ncbi.nlm.nih.gov/4091145/
4. Teva Pharma (New Zealand) Limited. Norfloxacin 400 mg Tablets. [Revised in April 2017] [Accessed on 3rd June 2024] https://medsafe.govt.nz/consumers/cmi/a/arrow-norfloxacin.pdf
5. Norfloxacin STADA (Norfloxacin 400 mg Tablet). [Revised in March 2019] [Accessed on 3rd June 2024] https://file.wuxuwang.com/hma/DE_H_0173_001_FinalPI_2of3.pdf
Useful Diagnostic Tests
- Complete Blood Count (CBC)/ Hemogram
- Total IGE
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