PYRESTAT MR Tablet 10's

Introduction About PYRESTAT MR TABLET

PYRESTAT MR TABLET contains Nimesulide, which belongs to the group of medicines called Non-steroidal anti-inflammatory drugs (NSAIDs). It is used to manage inflammatory conditions, including joint disorders such as rheumatoid arthritis, posttraumatic and postoperative painful conditions, and fever. PYRESTAT MR TABLET is also used to manage acute pain in orthopaedic, ENT, dental, and mild to moderate pain of osteoarthritis and rheumatoid arthritis.

Your doctor might advise regular liver function tests during management with PYRESTAT MR TABLET.

PYRESTAT MR TABLET is usually advised as a second line of management for a short duration of time in order to relieve symptoms.

PYRESTAT MR TABLET is not recommended in cases of active stomach or duodenal ulcers, alcoholism, drug addiction, cerebrovascular bleeding or bleeding disorders, severe clotting disorders, severe heart, kidney, or liver impairment, fever and/or flu-like symptoms, a history of recurrent ulceration, or gastrointestinal bleeding.

PYRESTAT MR TABLET is not recommended during the third trimester of pregnancy and in breast-feeding women.

PYRESTAT MR TABLET is not given to children and adolescents below 12 years of age. It should be used with caution in elderly patients.

The most common side effects of taking PYRESTAT MR TABLET are vomiting, diarrhea or nausea, and changes in the level of liver enzymes. Consult your doctor if the above side effects do not improve.

Uses Of PYRESTAT MR TABLET

It is used to manage inflammatory conditions, including joint disorders such as:

• rheumatoid arthritis
• post traumatic
• postoperative painful condition and
• fever

How PYRESTAT MR TABLET Works

PYRESTAT MR TABLET works by blocking the enzyme involved in the production of certain chemical substances during inflammation, which are responsible for causing pain, redness, swelling, and fever in the body. Hence decreasing the fever, pain, and swelling caused after injuries.

How to use PYRESTAT MR TABLET

Take PYRESTAT MR TABLET as advised by your physician. It can be taken with or without meals.

For Tablet, Capsule: Swallow PYRESTAT MR TABLET with a glass of water. Do not crush or chew the medicine.

For Dispersible Tablet: Disperse PYRESTAT MR TABLET in the specified quantity of water as mentioned in the label. Consume the mixture immediately after reconstitution.

Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight, and disease condition. Continue to take PYRESTAT MR TABLET for the stipulated duration prescribed by your doctor to achieve better results.

Side Effects Of PYRESTAT MR TABLET

How To Manage Side Effects

Diarrhea

Drink lots of fluids, like water and fruit juice, to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor. If the diarrhea does not improve, contact your doctor.

Nausea And Vomiting

Take this medicine just after meals. Stick to simple meals. Avoid eating oil-rich or spicy foods. If the nausea and vomiting do not improve, contact your doctor.

Warning & Precautions

Pregnancy

Monitoring required

PYRESTAT MR TABLET is not recommended for use in the third trimester of pregnancy and women planning to have a baby because it may cause many malformations in neonates. If needed, the dose will be adjusted by your doctor. Consult your doctor before taking.

Breastfeeding

Contraindicated

PYRESTAT MR TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking it.

Driving and Using Machines

Use with Caution

Do not drive or operate machinery if you feel dizzy, have a head spinning sensation, or have excessive sleepiness after taking PYRESTAT MR TABLET.

Alcohol

Contraindicated

Consumption of alcohol is not recommended while taking PYRESTAT MR TABLET.

Kidney

Contraindicated

PYRESTAT MR TABLET is not recommended for use in patients with severe impairment in kidney function. Consult your doctor before taking it.

Liver

Contraindicated

PYRESTAT MR TABLET is not recommended for use in patients with severe impaired liver function and liver failure. Consult your doctor before taking it.

Allergy

Contraindicated

Do not take PYRESTAT MR TABLET if you are allergic to Nimesulide or any history of hypersensitivity reactions (Ex. bronchospasm, rhinitis, urticarial, nasal polyps) or any ingredients of this medicine.

Heart Disease

Consult your doctor

PYRESTAT MR TABLET is not recommended for use in patients with severe heart failure. It should be used with caution in patients with impaired heart function, uncontrolled hypertension, established ischaemic heart disease, peripheral arterial disease, and/or cerebrovascular disease. Consult your doctor before taking it.

Use In Pediatrics

Contraindicated

PYRESTAT MR TABLET is not recommended for children and adolescents below 12 years of age. Consult your doctor before taking it.

Use In Geriatrics

Use with Caution

PYRESTAT MR TABLET should be used with caution in elderly patients as they are more susceptible to the adverse effects. Consult your doctor before taking it.

Interactions

A. Drug-Drug interactions:

Before taking PYRESTAT MR TABLET, inform your doctor if you are taking any of the following medicine:

• other medicine used to reduce inflammation (Ex. methylprednisolone)
• medicine used to manage blood clots (Ex. warfarin)
• medicine used in management of arthritis (Ex. methotrexate)
• medicines used in the management of mental disorders (Ex. lithium)
• diuretics (Ex. furosemide) to rid the body of salt and water

Overdosage:

If you or anyone else accidentally takes too much PYRESTAT MR TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are drowsiness, sluggishness, nausea, vomiting, and abdominal discomfort.

Synopsis

More Information

FAQs About PYRESTAT MR TABLET

Q: What is the use of PYRESTAT MR TABLET?

A: PYRESTAT MR TABLET is used for pain relief, headache, muscle pain, dental pain, joint pain, back pain, menstrual pain, sprains, strains, sports injuries, and other forms of painful conditions.

Q: When can I notice pain relief after using PYRESTAT MR TABLET?

A: You may notice that your pain subsides within 1 hour of using PYRESTAT MR TABLET. It may take a day to show significant effects. However, this period can vary from person to person based on their health condition.

Q: Can PYRESTAT MR TABLET be taken for a longer duration?

A: No, PYRESTAT MR TABLET is not recommended for a long period of time as it can lead to serious symptoms like ulcers and bleeding in the stomach. It is also known to cause kidney problems if taken for a long period of time. Therefore, take this medicine only for the duration specified by your physician.

Q: Can PYRESTAT MR TABLET be taken along with food?

A: PYRESTAT MR TABLET is usually taken with food to avoid gastrointestinal side effects. It should not be taken with an empty stomach, as it can lead to discomfort and irritation in the stomach along with pain. Consult your doctor before taking it.

Q: Is PYRESTAT MR TABLET good for stomach pain?

A: No. Do not take PYRESTAT MR TABLET if you have stomach pain. As it could generally increase your stomach acid secretion, it could worsen your existing condition. Therefore, check with your doctor for managing stomach pain.

Q: What are the long-term side effects of using PYRESTAT MR TABLET?

A: PYRESTAT MR TABLET should be used only for short-term periods. Long-term usage is more likely to cause liver damage. If you are using PYRESTAT MR TABLET based on a doctor's advice, such unnecessary side effects can be avoided.

Q: Can I take PYRESTAT MR TABLET daily?

A: PYRESTAT MR TABLET can be taken daily if requested by your doctor. However, please note that it should be followed only for a short period of time (not more than 4 weeks).

Q: Does PYRESTAT MR TABLET damage your liver?

A: prolonged or overdosage of PYRESTAT MR TABLET has been reported to cause liver damage. Hence, use this medicine for the exact duration as advised by your doctor and stop it.

Q: Is PYRESTAT MR TABLET banned for use in children?

A: PYRESTAT MR TABLET is not recommended for use in children under 12 years of age. Therefore, consult your doctor for advice.

Q: Does PYRESTAT MR TABLET have side effects?

A: The most common side effects of PYRESTAT MR TABLET are dizziness, excess sleepiness, stomach upset, nausea, abdominal discomfort, diarrhea, and/or peripheral oedema (swelling in the legs and arms). Consult your doctor if any of the symptoms worsen.

Q: Can PYRESTAT MR TABLET be used in pregnant women?

A: Consult your doctor before taking PYRESTAT MR TABLET if you are pregnant, as it is not known how this medicine reacts with an unborn baby.

Q: Who should not take PYRESTAT MR TABLET?

A: Do not take PYRESTAT MR TABLET if you are allergic to Nimesulide or other NSAIDS, or if you have severe kidney disease and/or analgesic nephropathy, liver disease, peptic ulcer, and/or gastrointestinal bleeding. Consult your doctor before taking it.

Q: Does PYRESTAT MR TABLET make you dizzy?

A: Yes, PYRESTAT MR TABLET can make you feel dizzy. Therefore, it is not advised to not drive or do any tiring work if you feel these symptoms, as it may cause great harm. If you feel this symptom is disturbing, consult your doctor for advice.

Q: Does PYRESTAT MR TABLET cause diarrhea?

A: Yes, PYRESTAT MR TABLET cause diarrhea. Drink lots of fluids, like water and fruit juice, to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor. If the diarrhea does not improve, contact your doctor.

References

1. KD Tripathi. Nonsteroidal Anti-inflammatory Drugs and Antipyretic-Analgesics. Essentials of Medical Pharmacology. Seventh Edition, 2013. Page - 203-204.

2. H G Kress, A Baltov, A Basinski, F Berghea, J Castellsague, C Codreanu, E Copaciu, M A Giamberardino, M Hakl, L Hrazdira, M Kokavec, J Lejcko, L Nachtnebl, R Stancík, A Švec, T Tóth, M V Vlaskovska, J Woron. Acute pain: a multifaceted challenge—the role of nimesulide. NIH: National Library of Medicine, National Center of Biotechnology Information Pubmed.gov. 2016. [Accessed on 10th August 2024] https://pubmed.ncbi.nlm.nih.gov/26414386/

3. A K Singla, M Chawla, A Singh. Nimesulide: some pharmaceutical and pharmacological aspects—an update. NIH: National Library of Medicine, National Center of Biotechnology Information Pubmed.gov. 2000. [Accessed on 10th August 2024] https://pubmed.ncbi.nlm.nih.gov/10864134/

4. Magis Farmaceutici. Isodol. (Nimesulide 100 mg). [Revised in July 2022] [Accessed on 10th August 2024] https://www.magispharma.it/media/isodol/download/en/15700031575d9458d58342b.pdf

5. Pharm Evo Pvt Ltd. PYRESTAT MR TABLET (Nimesulide 100mg). [Revised on May 2016] [Accessed on 10th August 2024] https://pharmevo.biz/wp-content/uploads/2021/03/Nise.pdf

Useful Diagnostic Tests

• Complete Blood Count (CBC)/ Hemogram
• Liver Function Test (LFT)
• Kidney Function Test (KFT)
• Rheumatoid Factor (RF)/RA Test Rheumatoid Arthritis Factor, Qualitative
• Basic Arthritis Care
• Advance Bone Care
• Esr Automated
• Extended Arthritis Care Plan
• Bone Strength Package
• Autoimmune Arthritis Panel

Author Details

Written By Dr. N. Sai Swaroop - Pharm.D

Reviewed For Accuracy By Dr. Sankara Babu Gorle - MBBS, MD (Pharmacology)

Last updated on 13 Aug 2024 | 05:04 PM(IST)