Prolomet XL 12.5mg Tablet 10'S

Introduction About PROLOMET XL 12.5MG TABLET

Prolomet XL 12.5mg Tablet is an extended-release medicine containing Metoprolol, a cardioselective beta-blocker. It is commonly prescribed for the management of high blood pressure, chest discomfort due to angina, certain types of irregular heartbeat (arrhythmias), and as supportive therapy in heart failure. By slowing the heart rate and reducing the force of pumping, it helps decrease strain on the heart and improves long-term cardiovascular health. Its extended-release formulation ensures a steady effect throughout the day, making it convenient for once-daily dosing. 

This medicine is particularly useful for patients who need blood pressure control along with protection for the heart, such as those with a history of heart attack, chronic heart failure, or irregular heartbeat. It may also be recommended for patients who experience migraine headaches, as it helps reduce their frequency. Prolomet XL 12.5mg is generally taken once daily, preferably with or just after food, and should be swallowed whole with water. For best results, it should be taken at the same time each day without missing doses.

Certain precautions are necessary while using this medicine. It should not be stopped suddenly without medical advice, as this may worsen heart conditions. Patients with asthma, severe heart block, very low blood pressure, or certain lung problems should avoid its use. Prolomet XL 12.5mg is not recommended during pregnancy and breastfeeding, as it may affect the baby’s heart and breathing. Elderly patients and those with liver or kidney problems should use it with caution and under close supervision. 

Common side effects of Prolomet XL 12.5mg Tablet include tiredness, dizziness, slow heartbeat, cold hands and feet, and sometimes sleep disturbances. These effects are usually mild and improve with continued use. Patients are advised to avoid alcohol and limit caffeine while on this medicine, as these can interfere with its action. Regular monitoring of blood pressure, heart rate, and overall health is essential to ensure safe and effective use.    

Uses Of PROLOMET XL 12.5MG TABLET

• High blood pressure
• Angina pectoris (chest pain)
• Arrhythmias or palpitations
• Heart attack and heart failure
• Migraine

Benefits of PROLOMET XL 12.5MG TABLET

Prolomet XL 12.5mg for High Blood Pressure

Prolomet XL 12.5mg Tablet helps manage high blood pressure by relaxing blood vessels and reducing the workload on the heart. By lowering blood pressure, it decreases the risk of serious problems such as stroke, heart attack, or kidney damage. The extended-release action provides steady control throughout the day. For best results, it should be taken regularly as advised by your doctor, along with a healthy diet and lifestyle changes.

Prolomet XL 12.5mg for Angina Pectoris

This medicine is often prescribed to manage angina pectoris, a condition that causes chest discomfort due to reduced blood flow to the heart. Prolomet XL 12.5mg lowers the heart’s oxygen demand by slowing the heartbeat and reducing strain on the heart muscle. This helps prevent angina attacks and improves exercise tolerance. However, it should always be used under medical supervision and not for sudden chest pain relief.

Prolomet XL 12.5mg for Arrhythmia

Doctors may recommend Prolomet XL 12.5mg Tablet to control certain types of irregular heartbeats (arrhythmias). By slowing down the heart rate and stabilizing its rhythm, it helps the heart pump more efficiently. This reduces the risk of complications related to abnormal heart rhythms. Regular follow-up with your doctor is important to adjust the dose and monitor heart function.

Prolomet XL 12.5mg for Heart Function

Prolomet XL 12.5mg supports heart function in patients with heart conditions such as heart failure or after a heart attack. It protects the heart muscle from strain and helps improve long-term heart performance. By reducing stress on the heart, it enhances overall heart health and may improve quality of life in patients with weakened heart function. It should be taken consistently as prescribed for the best benefit.

Prolomet XL 12.5mg for Migraines

In some cases, doctors may prescribe Prolomet XL 12.5mg Tablet to help reduce the frequency of migraine headaches. It works by calming overactive blood vessels and nerves that trigger migraine attacks. While it is not a quick-relief medicine for migraine pain, it may help prevent future episodes when taken regularly. Always use it only under medical advice, as not all patients with migraines require beta-blockers.

How PROLOMET XL 12.5MG TABLET Works

Prolomet XL 12.5mg Mechanism of Action

Prolomet XL 12.5mg Tablet contains metoprolol, which belongs to a group of medicines called beta-blockers. It works by blocking certain natural chemicals in the body, such as adrenaline, from acting on the heart and blood vessels. This slows down the heart rate, reduces the force of the heartbeat, and lowers blood pressure. By doing so, it decreases the oxygen demand of the heart and reduces strain on the heart muscle. The “XL” (extended release) form ensures that the medicine is released slowly, providing a steady effect throughout the day and improving heart health in conditions like high blood pressure, angina, arrhythmias, and heart failure.

How to use PROLOMET XL 12.5MG TABLET

How to Take Prolomet XL 12.5mg Tablet

• Take the tablet exactly as prescribed by your doctor, usually once daily.
• Swallow the tablet whole with a glass of water; do not crush, break, or chew it.
• It is best taken with food or just after a meal to avoid stomach discomfort.
• Try to take it at the same time every day for consistent results.
• Do not suddenly stop taking the medicine without medical advice, as it may worsen heart problems.
• If you miss a dose, take it as soon as you remember, but skip it if it’s nearly time for the next one never double the dose.

What if I forgot to take PROLOMET XL 12.5MG TABLET

• If you miss a dose, take it as soon as you remember.
• If it is almost time for your next scheduled dose, skip the missed one and continue with your regular timing.
• Do not take two tablets together to make up for a missed dose, as this may cause your blood pressure or heart rate to drop too low.
• Missing a single dose occasionally is not usually harmful but try to avoid frequent skips.
• To help remember, take your tablet at the same time each day or set a reminder.
• If you miss doses often, speak with your doctor for guidance on better ways to manage your schedule.

Overdose

If you or anyone else has accidentally taken too much of this medicine, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage are nausea, vomiting, bluish discolouration of the skin, severe bradycardia, low blood pressure (fatigue, dizziness), atrioventricular block, heart failure, bronchospasm or shortness of breath.

Side Effects Of PROLOMET XL 12.5MG TABLET

Common side effects of Prolomet XL 12.5mg tablet

• feeling faint on standing because of low blood pressure
• tiredness, drowsiness
• cold hands and feet
• palpitations
• dizziness, headache
• diarrhoea, constipation, abdominal pain
• fluid retention (swelling)
• muscle cramps
• weight gain, increased sweating
• depression, reduced concentration
• difficulty in sleeping
• shortness of breath
• skin rash

When to Seek Medical Attention?

Stop taking Prolomet XL 12.5mg tablet and contact your physician immediately if you experience any of the following side effects:

• symptoms of an allergic reaction such as skin rash, itching, flushing, swelling of the face, lips, tongue or throat, difficulty in breathing or swallowing

How To Manage Side Effects

Headache

• Rest in a Quiet Space: Lie down in a dark, calm room to reduce noise and light triggers
• Hydration: Drink enough water throughout the day to prevent dehydration, which can worsen headaches.
• Cold or Warm Compress: Apply a cold pack to the forehead or a warm compress to the neck and shoulders to relieve tension.
• Relaxation Techniques: Practice deep breathing, meditation, or gentle yoga to ease stress-related headaches.
• Posture Care: Sit and stand upright to avoid muscle strain that can trigger or worsen headaches.
• Limit Caffeine and Alcohol: Reduce intake as both can aggravate headache symptoms.
• Regular Sleep: Maintain a consistent sleep schedule to support overall well-being and reduce headache frequency.
• Light Physical Activity: Gentle walking or stretching improves blood circulation and eases tension.

Skin rash Or Itching

• Cold Compress: Apply a clean, cool, damp cloth to the affected area for 10–15 minutes to reduce redness, itching, and swelling.
• Aloe Vera Gel: Fresh aloe vera has cooling and anti-inflammatory properties that help soothe irritated skin.
• Oatmeal Bath: Adding finely ground oatmeal to lukewarm bath water can calm itching and irritation.
• Coconut Oil: Applying virgin coconut oil moisturizes the skin and may reduce dryness or mild inflammation.
• Chamomile Tea Wash: Washing the rash with cooled chamomile tea can help relieve itching naturally.
• Avoid Irritants: Use mild, fragrance-free soaps and detergents, and wear loose, cotton clothing to prevent further irritation.

Warning & Precautions

Pregnancy

Contraindicated

Prolomet XL 12.5mg Tablet should not be used during pregnancy, as it may affect the unborn baby.

Breastfeeding

Contraindicated

This medicine is not advised for breastfeeding women because metoprolol can pass into breast milk and may affect the infant.

Driving and Using Machines

Use with Caution

Avoid driving or operating heavy machines if you experience dizziness, tiredness, or slow reactions after taking this tablet.

Alcohol

Contraindicated

It is better to avoid alcohol while taking Prolomet XL 12.5mg Tablet, as it can increase dizziness and make you feel weaker.

Kidney

Use with Caution

Patients with kidney problems should use this medicine carefully and under medical supervision, as dose adjustments may be required.

Liver

Use with Caution

If you have liver disease, Prolomet XL 12.5mg Tablet should be taken only with caution, as the liver helps process this medicine.

Allergy

Contraindicated

Do not take this medicine if you are allergic to metoprolol or any of its ingredients, as it may cause serious allergic reactions.

Lungs

Contraindicated

This tablet is not suitable for people with breathing problems such as asthma or COPD, as it may worsen these conditions.

Heart Disease

Consult your doctor

Prolomet XL 12.5mg Tablet should not be used in patients with very slow heartbeat, very low blood pressure, severe heart block, shock due to heart failure, or severe heart failure without a pacemaker. It must be used carefully in patients with mild heart block, chest pain, heart valve disease, heart muscle enlargement, or after a heart attack.

Use In Pediatrics

Contraindicated

There is not enough safety information on the use of this medicine in children and adolescents, so it should be avoided.

Use In Geriatrics

Use with Caution

Older adults (65 years and above) may be more sensitive to the effects of this medicine and should use it only under medical guidance.

Other Warnings for PROLOMET XL 12.5MG TABLET

Before taking this medicine, inform your doctor if you have:

• major surgery or anaesthesia
• stroke
• diabetes or low blood sugar
• hyperthyroidism
• peripheral vascular disease
• psoriasis

Who should not take [GBNKEYWORD

PROLOMET XL 12.5MG TABLET is not recommended for use if you have:

• severe peripheral arterial disease
• metabolic acidosis
• unmanaged phaeochromocytoma

Safety Advice

• Surgery & Anaesthesia: Inform your doctor or anaesthetist before surgery, as the medicine can affect heart rate and blood pressure during procedures.
• Sports & Physical Activity: Athletes should be aware that this medicine may reduce exercise tolerance by lowering heart rate.
• Medication Interactions: Always share your medication list with your doctor, as Prolomet XL may interact with certain antidepressants, antihypertensives, or antiarrhythmics.
• Cold Extremities: It may sometimes cause cold hands and feet due to reduced blood circulation.
• Blood Sugar Monitoring: In diabetic patients, the medicine may mask signs of low blood sugar (like rapid heartbeat). Extra monitoring is advised.

Diet and Lifestyle Advice

• Balanced Diet: Include more fresh fruits, vegetables, whole grains, and lean proteins to support heart health.
• Limit Salt Intake: Reduce excess salt in your meals to help manage blood pressure effectively.
• Avoid Excess Caffeine: Minimize coffee, tea, and energy drinks, as they may interfere with blood pressure control.
• Regular Exercise: Engage in light to moderate activities such as walking, yoga, or cycling, as advised by your doctor. Avoid sudden, strenuous workouts.
• Weight Management: Maintain a healthy body weight to reduce strain on the heart.
• Quit Smoking: If you smoke, quitting can significantly improve cardiovascular health.
• Hydration: Drink adequate water unless your doctor restricts fluid intake.
• Stress Management: Practice relaxation techniques such as meditation, breathing exercises, or mindfulness to control stress.
• Sleep Routine: Ensure 7–8 hours of good-quality sleep to support heart and overall health.

1. Prolomet XL 12.5mg Tablet vs Atenolol

2.Prolomet XL 12.5mg vs Calcium Channel Blockers (CCBs) for Blood Pressure Control

Drug - Drug interaction

1. Other Blood Pressure Medicines (Calcium Channel Blockers like Verapamil, Diltiazem)

• Interaction: May cause very slow heartbeat, low blood pressure, or heart block.
• Management: Avoid combining without strict medical supervision. If used together, close monitoring of blood pressure and heart rhythm is required.

2. Antiarrhythmic Drugs (e.g., Amiodarone, Quinidine, Propafenone, Digoxin)

• Interaction: Can lead to dangerously slow heartbeat or irregular rhythm.
• Management: Use with caution under cardiologist supervision; ECG and heart rate monitoring are recommended.

3. Other Beta-Blockers or Clonidine

• Interaction: May cause excessive lowering of blood pressure and severe slowing of heart rate. Stopping clonidine suddenly while on Prolomet can cause a rebound rise in blood pressure.
• Management: Avoid duplication of beta-blockers. If used with clonidine, taper clonidine gradually under medical guidance.

4. Anti-Diabetic Medicines (Insulin, Sulfonylureas, Metformin)

• Interaction: Prolomet may mask warning signs of low blood sugar (like fast heartbeat) and may increase the risk of hypoglycaemia.
• Management: Monitor blood sugar levels closely; adjust diabetes medicines if needed. Inform your doctor if you notice unusual sweating, dizziness, or confusion.

5. Anaesthesia Medicines (General Anaesthetics like Halothane, Propofol, Isoflurane)

• Interaction: Can increase the risk of very low blood pressure and slow heart rate during surgery.
• Management: Inform the anaesthesiologist if you are taking Prolomet. Dose adjustment or special monitoring during surgery may be required.

6. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs, e.g., Ibuprofen, Diclofenac, Naproxen)

• Interaction: May reduce the blood pressure-lowering effect of Prolomet.
• Management: Limit long-term NSAID use. If needed, monitor blood pressure regularly and discuss alternative pain relief options with your doctor.

7. Antidepressants (SSRIs like Paroxetine, Fluoxetine; MAOIs; Tricyclics)

• Interaction: May increase blood levels of metoprolol, leading to stronger side effects such as very slow heartbeat or low blood pressure.
• Management: Doctor may lower the Prolomet dose and monitor for side effects.

8. Asthma and COPD Medicines (Theophylline, Beta-agonists like Salbutamol, Formoterol)

• Interaction: Prolomet may reduce the effect of these inhalers, making breathing problems worse.
• Management: Use with caution; doctor may choose an alternative or adjust doses. Inform your doctor if you notice worsening wheezing or shortness of breath.

9. Ergot Derivatives (for migraine, e.g., Ergotamine)

• Interaction: May increase the risk of poor blood flow to hands and feet.
• Management: Avoid combination if possible; doctor may recommend alternative migraine medicines.

Drug - Food interaction

1. Food (General Meals)

• Interaction: Taking Prolomet XL with food increases its absorption, which helps in steady blood levels.
• Management: Always take this tablet with or just after meals for better effect and reduced stomach irritation.

2. Caffeine (Tea, Coffee, Energy Drinks, Chocolates)

• Interaction: Caffeine may reduce the calming effect of Prolomet on the heart and may cause faster heartbeat or reduced blood pressure control.
• Management: Limit caffeine-rich foods and drinks to avoid reduced effectiveness of the medicine.

3. Grapefruit and Grapefruit Juice

• Interaction: Grapefruit may increase the blood levels of metoprolol in some people, leading to stronger side effects like slow heartbeat or dizziness.
• Management: It is safer to avoid grapefruit and its juice while taking Prolomet XL.

4. High-Salt Foods (Pickles, Chips, Processed Meats)

• Interaction: Excess salt can counteract the blood pressure–lowering benefit of Prolomet XL.
• Management: Reduce salt intake and follow a low-sodium diet to support blood pressure control.

5. High-Fat Meals

• Interaction: Very fatty meals may delay the absorption of the medicine, making it act more slowly
• Management: Prefer balanced meals with moderate fat when taking your dose.

Synopsis

More Information

FAQs About PROLOMET XL 12.5MG TABLET

References

1. K D Tripathi. Cardiovascular drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page - 523, 545, 564.

2. Jason Morris; Ayoola O. Awosika; Alexis Dunham. Metoprolol. National Institute of Health. NLM. National Centre for Biotechnology Information. [Revised in 29th February 2024]. [Accessed on 10th  September 2025] 

3. DailyMed. NIH. National Library of Medicine. Metoprolol Succinate ER Tablet. [Revised in 7th  April 2016] [Accessed on 10th September 2025] 

4. STADA Arzneimittel AG. Metoprolol. [Accessed on 10th September 2025] 

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Useful Diagnostic Tests

• Kidney function test (KFT)
• Cardiac Risk Profile

Author Details

Written By Srilekha. R - B.Pharm

Reviewed For Accuracy By Dr. Thamada Manikanta Praveen - MBBS, MD (General Medicine)

Last updated on 20 Nov 2024 | 12:06 PM(IST)