Proentra Sachet 1gm
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Introduction About PROENTRA SACHET
PROENTRA SACHET contains Saccharomyces boulardi which belongs to the group of medicines called Probiotics. PROENTRA SACHET is used to manage acute infectious diarrhoea in adults and children (aged below 18 years) which is also used to manage antibiotic associated colitis (inflammatory bowel disease) and diarrhoea in affected individuals.
PROENTRA SACHET is also used in addition to vancomycin/metronidazole (antibiotic) medicines to manage recurrent Clostridium difficile diseases (colon infection) and manage tube-feeding associated diarrhoea. The medicine is also indicated for use to manage irritable bowel syndrome (intestinal disorder) in affected individuals.
PROENTRA SACHET is not recommended for use in patients allergic to Saccharomyces boulardii. It is also not recommended for use in patients with central venous catheter (long flexible tube inserted into the vein of neck, chest, arm, and/or groin), and in patients who are immunocompromised/hospitalised (due to serious illness, and/or altered/weakened immune system).
Before taking PROENTRA SACHET, inform you had undergone liver transplantation. PROENTRA SACHET is not recommended for use in pregnant and breastfeeding women.
PROENTRA SACHET should be used with caution in children and adolescents (aged below 18 years) and is advised to be used in elderly patients (aged 65 years and above) after consulting the doctor.
The most common side effects of taking PROENTRA SACHET are constipation, bloating, and/or faecal incontinence. Consult your doctor if any of these symptoms worsens.
Uses Of PROENTRA SACHET
- Manage acute infectious diarrhoea in adults and children (aged below 18 years)
- Manage and manage antibiotic associated colitis (inflammatory bowel disease) and diarrhoea
- Manage recurrent Clostridium difficile diseases (colon infection) and manages tube-feeding associated diarrhoea
- Manage irritable bowel syndrome (intestinal disorder) in affected individuals
How PROENTRA SACHET Works
PROENTRA SACHET works by inhibiting protease enzyme (responsible for protein breakdown) which helps to manage development of bacterial overgrowth, host cell adherence, and provides a protective effect to the normal healthy gut flora thus managing inflammation of gut and reducing frequency of passing stool and tiredness in individuals affected with diarrhoea.
How to use PROENTRA SACHET
Always take PROENTRA SACHET as advised by your physician. Pour the contents of the sachet in a little amount of water/ sweetened drink or mix it with food. Avoid mixing it with very cold/hot liquids/food and consume the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight, and disease condition.
Side Effects Of PROENTRA SACHET
Common
- constipation
- bloating
- faecal incontinence
Rare
- flatulence
Stop taking PROENTRA SACHET and contact your doctor if you experience any of the following side effects:
- deterioration of health after 2 days of management
- fever, vomiting
- presence of blood/mucus in stools
- signs of dehydration such as intense thirst, and/or dryness of tongue
How To Manage Side Effects
Constipation:
Try to eat high-fiber foods such as vegetables, cereals, fresh fruit, and drink plenty of water. Involve in regular exercise (such as going for a daily walk or run) and if this does not help, consult and inform your doctor for receiving alternate managements for constipation.
Warning & Precautions
Pregnancy
PROENTRA SACHET is generally not recommended for use during pregnancy. Consult your doctor before taking the medicine.
Breastfeeding
PROENTRA SACHET should be used with caution in breastfeeding women. Consult your doctor before taking the medicine.
Liver
PROENTRA SACHET should be used with caution in patients who had undergone hepatic transplant. Consult a doctor before taking PROENTRA SACHET.
Allergy
Do not take PROENTRA SACHET if you are allergic to Saccharomyces boulardii, and/or any other ingredients of this medicine.
Others
PROENTRA SACHET is not recommended for use if you:
- have central venous catheter (long flexible tube inserted into the vein of neck, chest, arm, and/or groin to receive drugs, fluids or blood in emergency or long-term management)
- are immunocompromised/hospitalised (due to serious illness, and/or altered/weakened immune system)
- have fructose intolerance
- suffer from congenital galactosemia (inability to break down galactose sugar), glucose and galactose malabsorption syndrome, and/or lactose intolerance
Use in Pediatrics:
PROENTRA SACHET should be used with caution in children and adolescents (aged below 18 years). Consult your doctor before taking the medicine.
Use in Geriatrics:
PROENTRA SACHET should be used with caution in elderly patients (aged 65 and above). Consult your doctor before taking PROENTRA SACHET.
Interactions
A. Drug–Drug interactions:
Before taking PROENTRA SACHET, inform your doctor if your taking any of the following medicines:
- oral antifungal agents (medicines used to manage fungal infections) Ex. Ketoconazole, clotrimazole, amphotericin
B. Drug–Food interactions:
Avoid taking too hot/cold food items while taking PROENTRA SACHET since it may reduce the effect of medicine.
Overdosage:
If you or anyone else accidentally takes too much of PROENTRA SACHET, then consult your doctor immediately or visit the nearby hospital to manage overdose symptoms.
Synopsis
| Drug | : | Saccharomyces |
| Pharmacological Category | : | Probiotics |
| Therapeutic Indication | : | Acute infectious diarrhoea, Recurrent Clostridium difficile diseases, and irritable bowel syndrome,Prevents antibiotic associated colitis & diarrhoea, Tube-feeding associated diarrhoea |
| Dosage Forms | : | Capsule, Syrup, Powder, Sachet |
More Information
- Keep PROENTRA SACHET out of reach for children
- Do not store PROENTRA SACHET above 25°C
FAQs About PROENTRA SACHET
Q. What is PROENTRA SACHET used for?
A. PROENTRA SACHET is used to manage acute infectious diarrhoea in adults and children (aged below 18 years) which is also used to manage antibiotic associated colitis (inflammatory bowel disease) and diarrhoea in affected individuals. It is also used in addition to vancomycin/metronidazole (antibiotic) medicines to manage recurrent Clostridium difficile diseases (colon infection) and manage tube-feeding associated diarrhoea. The medicine is also indicated for use to manage irritable bowel syndrome (intestinal disorder) in affected individuals.
Q. What are the common side effects of taking PROENTRA SACHET ?
A. The most common side effects of taking PROENTRA SACHET are constipation, bloating, and/or faecal incontinence. Consult your doctor if any of these symptoms worsens.
Q. How PROENTRA SACHET should be taken?
A. Always take PROENTRA SACHET as advised by your physician. Pour the contents of the sachet in a little amount of water/ sweetened drink or mix it with food. Avoid mixing it with very cold/hot liquids/food and consume the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight, and disease condition.
Q. What happens if PROENTRA SACHET is taken more than its required dosage?
A. If you or anyone else accidentally takes too much of PROENTRA SACHET, then consult your doctor immediately or visit the nearby hospital to manage overdose symptoms.
Q. How PROENTRA SACHET works?
A. PROENTRA SACHET works by inhibiting protease enzyme (responsible for protein breakdown) which helps to manage development of bacterial overgrowth, host cell adherence, and provides a protective effect to the normal healthy gut flora thus managing inflammation of gut and reducing frequency of passing stool and tiredness in individuals affected with diarrhoea.
References
1. K.D Tripathi. Drugs for Constipation and Diarrhoea. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 683.
2. Karolina Kazmierczak-Siedlecka, Jakub Ruszkowski, Mateusz Fic, Marcin Folwarski, Wojciech Makarewicz. Saccharomyces boulardii CNCM I-745: A Non-bacterial Microorganism Used as Probiotic Agent in Supporting Treatment of Selected Diseases. NIH National Library of Medicine. National center for biotechnology information. PMC PubMed Central. May 2020. [Accessed on 6th January 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415030/
3. Ener Cagri Dinleyici, Ates Kara, Metehan Ozen, Yvan Vandenplas. Saccharomyces boulardii CNCM I-745 in different clinical conditions. NIH National Library of Medicine. National center for biotechnology information. PubMed.gov. July 2014. [Accessed on 6th January 2023] https://pubmed.ncbi.nlm.nih.gov/24995675/
4. C. Pothoulakis. Review article: Anti-inflammatory mechanisms of action of Saccharomyces boulardii. NIH National Library of Medicine. National center for biotechnology information. PMC PubMed Central. July 2008. [Accessed on 6th January 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761627/
5. S J Lewis, L F Potts, R E Barry. The lack of therapeutic effect of Saccharomyces boulardii in the prevention of antibiotic-related diarrhoea in elderly patients. NIH National Library of Medicine. National center for biotechnology information. PubMed.gov. March 1998. [Accessed on 6th January 2023] https://pubmed.ncbi.nlm.nih.gov/9570649/
6. BIOCODEX. Ghana Food and Drugs Authority. [Revised in January 2019] [Accessed on 6th January 2023] https://fdaghana.gov.gh/img/pils/Bioflor%20250mg%20sachet.pdf
Useful Diagnostic Tests
- Blood culture
- Stool culture
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