Pregnistar Tablet 10'S

Introduction About PREGNISTAR TABLET

PREGNISTAR TABLET contains Niacinamide, Pyridoxine, and Thyroxine, which belong to the group of medicines called vitamins and thyroid hormones. It is used in the management of subclinical hypothyroidism.

PREGNISTAR TABLET is not recommended for use if you have unmanageed hyperthyroidism, unmanageed subclinical or overt thyrotoxicosis, unmanageed adrenal insufficiency or pituitary insufficiency, an active peptic ulcer, or arterial bleeding. Consult your doctor before taking it.

PREGNISTAR TABLET should be used with caution in patients with coronary heart disease such as acute myocardial infarction, acute myocarditis, acute pancarditis, angina pectoris, and hypertension. Consult your doctor before taking it.

Inform your doctor if you are pregnant or breastfeeding before taking this medication.

The most common side effects of taking PREGNISTAR TABLET are increased appetite, weight variations, headache, vomiting, diarrhea, changes in the menstrual cycle, fever, sensitivity to heat, cramps, and mood swings. Consult your doctor if any of the side effects worsen.

Uses Of PREGNISTAR TABLET

• To manage subclinical hypothyroidism

How PREGNISTAR TABLET Works

PREGNISTAR TABLET contains niacinamide, pyridoxine, and thyroxine. Niacinamide helps maintain healthy skin, nerves, and cholesterol levels. Pyridoxine helps in red blood cell formation and maintains brain function. Thyroxine is a synthetic form of a thyroid hormone that helps replace the thyroxine of your thyroid gland, which cannot produce it, and manages the symptoms of hypothyroidism. Thyroxine controls the entire metabolic activity of the body and is very important for the proper functioning of our body.

How to use PREGNISTAR TABLET

Take PREGNISTAR TABLET in the morning on an empty stomach at least half an hour before breakfast or as directed by the physician. Swallow the medicine with a glass of water. Do not chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition.

Side Effects Of PREGNISTAR TABLET

How To Manage Side Effects

Diarrhea

Drink lots of fluids, such as water or fruit juices, to keep yourself hydrated. Do not take any medicine on your own to manage diarrhea. Contact your doctor if your diarrhea does not improve.

Headache

Rest and relax. Drink plenty of fluids, such as water or ORS (Oral Rehydrating Solution), and apply a pain-relieving balm to the head if necessary. Contact your doctor if your headache does not improve.

Nausea And Vomiting

Take PREGNISTAR TABLET with a meal. Stick to simple meals. Avoid eating oily or spicy food. Contact your doctor if your vomiting does not improve.

Warning & Precautions

Pregnancy

Consult your doctor

Inform your doctor if you are pregnant or planning to become pregnant before taking PREGNISTAR TABLET.

Breastfeeding

Consult your doctor

Inform your doctor if you are breastfeeding before taking PREGNISTAR TABLET.

Driving and Using Machines

Use with Caution

PREGNISTAR TABLET does not have any influence on the ability to drive or operate any machine.

Alcohol

Consult your doctor

Avoid alcohol consumption while taking PREGNISTAR TABLET, as it may increase the risk of unwanted side effects.

Kidney

Consult your doctor

PREGNISTAR TABLET does not have any significant effect on patients with kidney disease. Consult your doctor before taking it.

Liver

Contraindicated

PREGNISTAR TABLET is not recommended for use in patients with active liver disease or unexplained liver dysfunction. Consult your doctor before taking it.

Allergy

Contraindicated

Do not take PREGNISTAR TABLET if you are allergic to niacinamide, pyridoxine, thyroxine, or any other ingredients in this medicine.

Heart Disease

Use with Caution

PREGNISTAR TABLET should be used with caution in patients with coronary heart disease such as acute myocardial infarction, acute myocarditis, acute pancarditis, angina pectoris, and hypertension. Consult your doctor before taking it.

Use In Pediatrics

Contraindicated

PREGNISTAR TABLET is not recommended for use in children and adolescents as safety and efficacy have not been established. Consult your doctor before taking it.

Use In Geriatrics

Use with Caution

PREGNISTAR TABLET should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before taking PREGNISTAR TABLET.

Interactions

A. Drug-Drug interactions:

Before taking PREGNISTAR TABLET, inform your doctor if you are taking any of the following medicines:

• cholestyramine, colestipol, clofibrate, simvastatin, and lovastatin (medicines used to manage high cholesterol levels in the blood)
• calcium, aluminium, magnesium, and iron supplements
• polystyrene sulfonates, kayexalate (used to manage high potassium levels in the blood),
• lanthanum, sevelamer (used to manage high phosphate levels in the blood)
• pantoprazole, rabeprazole, and sucralfate (medicines used to manage stomach ulcers)
• soya products and a high-fiber diet
• orlistat (a medicine used to reduce weight loss)
• propylthiouracil (used to manage hyperthyroidism)
• glucocorticoids (medicines used to manage inflammatory and autoimmune diseases) Ex. cortisone, prednisone
• lithium (used to manage mania)
• beta-receptor blockers (medicines used to manage heart problems) Ex. propranolol, atenolol, isosorbide dinitrate, amlodipine,
• amiodarone (used to manage irregular heartbeats)
• iodinated contrast media (used in imaging techniques)
• salicylates (used to manage pain, fever, and inflammation) Ex. aspirin
• furosemide (used to manage heart problems)
• anticonvulsants such as carbamazepine, phenytoin, and phenobarbital (used to manage fits)
• estrogen-based contraceptives (medicines used to manage fertilization) Ex. ethinylestradiol, norethindrone
• sertraline, amitriptyline, and imipramine (medicines used to manage depression)
• chloroquine or proguanil (used to manage malaria)
• tyrosine kinase inhibitors (Ex. imatinib and sunitinib)
• rifampicin, isoniazid (used to manage tuberculosis)
• St. John's Wort (Hypericum perforatum), an herbal medicine used to manage depression
• protease inhibitors, Ex. ritonavir (used to manage viral infections)
• methadone (used to manage pain)
• 5-flutouracil (used to manage cancer)
• coumarin derivatives (medicines used to manage blood clotting) Ex. warfarin
• digitalis (used to manage heart conditions)
• sympathomimetic agents (Ex. adrenaline), used to manage severe allergic reactions, cardiac arrest
• insulin or other anti-diabetic therapy Ex. metformin (used to manage diabetes mellitus)
• levodopa (a drug used in the management of Parkinson’s disease)
• penicillamine (used to manage arthritis and other conditions)

Overdosage:

If you or anyone else accidentally took more PREGNISTAR TABLET, consult your doctor immediately or visit the nearby hospital. Overdosage may cause hyperthyroidism, and symptoms include agitation, confusion, irritability, hyperactivity, headache, sweating, mydriasis, fast heartbeat, irregular heartbeat, fast breathing, fever, increased bowel movements, and fits. Psychiatric symptoms associated with hyperthyroidism may also occur, including affectability, fatigue, anxiety, and nervousness. In severe cases, it causes a thyrotoxic crisis and leads to seizures, cardiac arrhythmias, heart failure, and coma.

Synopsis

More Information

• Keep PREGNISTAR TABLET out of the sight and reach of children
• Store PREGNISTAR TABLET below 25°C

FAQs About PREGNISTAR TABLET

Q: What if I forget to take PREGNISTAR TABLET?

A: If you forget to take a dose of PREGNISTAR TABLET, take another as soon as you remember. If it is almost time for your next dose, then do not take the missed dose at all. Do not take a double dose to make up for a forgotten tablet.

Q: Is PREGNISTAR TABLET safe in pregnancy?

A: Inform your doctor if you are pregnant, think you may be pregnant, or plan to become pregnant before taking this medicine.

Q: What are the side effects of taking PREGNISTAR TABLET?

A: The most common side effects of taking PREGNISTAR TABLET are increased appetite, weight variations, headache, vomiting, diarrhea, changes in the menstrual cycle, fever, sensitivity to heat, cramps, and mood swings. Consult your doctor if any of the side effects worsen.

Q: What is the best time to take PREGNISTAR TABLET?

A: Take PREGNISTAR TABLET in the morning on an empty stomach at least half an hour before breakfast or as directed by the physician. Swallow the medicine with a glass of water. Do not chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition.

Q: Who should not take PREGNISTAR TABLET?

A: PREGNISTAR TABLET is not recommended for use if you have unmanageed hyperthyroidism, unmanageed subclinical or overt thyrotoxicosis, unmanageed adrenal insufficiency or pituitary insufficiency, an active peptic ulcer, or arterial bleeding. Consult your doctor before taking it.

References

1. KD. Tripathi. Thyroid hormones and thyroid inhibitors. Essentials of medical pharmacology. Eight edition. 2019. Page – 273.

2. Mateo RCI, Hennessey JV. Thyroxine and treatment of hypothyroidism: seven decades of experience. Endocrine. 2019. [Accessed on 16th January 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794242/

3. Wockhardt Limited. Electronic Medicines Compendium (EMC) [Revised in March 2023] [Accessed on 16th January 2024] https://www.medicines.org.uk/emc/files/pil.1208.pdf

4. GlaxoSmithKline Pharmaceuticals Limited. Thyroxine. [Revised in June 2023] [Accessed on 16th January 2024] https://india-pharma.gsk.com/media/6368/eltroxin-tablets.pdf

5. Niacinamide. Daily Med: National Library of Medicine: National Institute of Health. [Revised in May 2019] [Accessed on 16th January 2024] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=04fb6cd5-3c21-433e-a053-623b73218bd6

6. EBEXID Tablet. Maneesh Pharmaceuticals Ltd. [Accessed on 16th January 2024] https://www.maneeshpharma.com/ace

7. Thyroxine sodium. Leeford Healthcare Ltd. [Accessed on 16th January 2024] https://www.leeford.in/product/1115/thyroactiv-50

8. Drug bank. Levothyroxine. [Accessed on 16th January 2024] https://go.drugbank.com/drugs/DB00451

Useful Diagnostic Tests

• Thyroid Stimulating Hormone (TSH)
• Basic Thyroid Care
• Advance Thyroid Care
• Comprehensive Thyroid Care
• Thyroid Profile-Total (T3,T4&Tsh)
• Thyroid Profile-Free (Ft3, Ft4 & Tsh)
• Netmeds Thyroid Package
• Healthians Full Body Checkup With Thyroid And Cbc
• Thyroid Profile-C
• Thyroid Profile-A
• Thyroid Panel-2
• Healthians Thyroid Test
• Thyroid Package-Advance
• Thyroid Package-Preventive
• Jaanch Thyroid Profile Advanced

Author Details

Written By Dr. N. Sai Swaroop - Pharm.D

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 18 Jan 2024 | 04:16 PM(IST)