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Introduction About PREGEB D 75/20 CAPSULE
PREGEB D 75/20 CAPSULE is used in the management of nerve pain (or neuropathy) caused by conditions like diabetes, spinal cord injury, or fibromyalgia. This medication helps reduce pain signals sent by damaged nerves and improves quality of life.
PREGEB D 75/20 CAPSULE can be taken with or without food, but it’s essential to take it at the same time daily to maintain consistent levels in the body. Always follow the dosage and duration recommended by your doctor, as this medicine is a habit-forming medicine. If you miss a dose, take it as soon as you remember. Avoid stopping the medication abruptly, as it can worsen your symptoms. Ensure you complete the full course of treatment even if you feel better.
Before starting PREGEB D 75/20 CAPSULE, inform your doctor if you have kidney or liver problems, a history of depression, mood changes, or suicidal thoughts. Let your doctor know if you are pregnant, planning to conceive, or breastfeeding.
Additionally, share details about any other medications you are taking to avoid interactions that may reduce the effectiveness of PREGEB D 75/20 CAPSULE PREGEB D 75/20 CAPSULE or cause side effects.
Regular follow-ups with your doctor are important to monitor your response to the medicine and manage any side effects. Avoid consuming alcohol while taking PREGEB D 75/20 CAPSULE as it may make you feel dizzier.
Some common side effects of PREGEB D 75/20 CAPSULE includes peripheral edema (swelling in the limbs), nausea, headache, dry mouth, tingling or numbness, constipation, reduced sex drive, blurred vision and difficulty concentrating. This medicine may cause drowsiness or dizziness, so avoid driving or operating machinery until you understand how it affects you. It may also lead to weight gain, which can be managed with a balanced diet and regular exercise.
Uses Of PREGEB D 75/20 CAPSULE
Benefits of PREGEB D 75/20 CAPSULE for nerve pain:
- Relieves Nerve Pain: Controls calcium channel activity in nerve cells to block pain signals and provide effective relief from burning, tingling, or stabbing pain.
- Improves Mood and Mental Balance: Enhances levels of certain brain chemicals such as serotonin and norepinephrine to reduce stress, anxiety, and depression often linked with chronic nerve pain.
- Dual-Action Therapy: Combines Pregabalin and Duloxetine to target both physical pain and emotional well-being for comprehensive relief.
- Boosts Quality of Life: Reduces nerve pain and improves sleep, mood, and daily functionality for individuals with conditions like diabetic neuropathy or fibromyalgia.
How PREGEB D 75/20 CAPSULE Works
PREGEB D 75/20 CAPSULE is a powerful medication designed to manage neuropathic pain. It combines two active ingredients, Pregabalin and Duloxetine, to provide relief from nerve pain and improve mental well-being. Here's how it works:
- Pregabalin: This component reduces nerve pain by controlling calcium channels in overactive nerve cells. It prevents the transmission of pain signals, effectively reducing the burning, tingling, or stabbing sensations caused by nerve damage.
- Duloxetine: It boosts the levels of serotonin and norepinephrine, which are chemical messengers in the brain. This action helps in maintaining mental balance, reducing anxiety, and relieving stress associated with chronic pain.
Together, these ingredients offer dual-action relief, targeting both the physical pain and emotional distress caused by nerve damage. PREGEB D 75/20 CAPSULE not only alleviates pain but also enhances mood, sleep quality, and overall quality of life.
How to use PREGEB D 75/20 CAPSULE
- Take PREGEB D 75/20 CAPSULE as advised by your physician.
- Swallow PREGEB D 75/20 CAPSULE with a glass of water. Do not crush or chew the medicine.
- PREGEB D 75/20 CAPSULE can be taken with or without food, but taking it at the same time every day ensures consistent levels of the medication in your body.
Dosage and Administration for PREGEB D 75/20 CAPSULE:
- Always start with the dose advised by your doctor, which may be adjusted based on your condition and response to treatment.
- Do not alter the dosage or stop taking the medicine without consulting your doctor, as sudden discontinuation may worsen your symptoms.
Missed Dose instructions for PREGEB D 75/20 CAPSULE:
- If you miss a dose, take it as soon as you remember.
- However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule.
- Do not double the dose to make up for the missed one.
Overdosage:
- Taking more than the prescribed dose can lead to serious side effects such as extreme drowsiness, confusion, or difficulty breathing.
- Symptoms of overdosage might include feeling sleepy, confused, agitated, or restless, fits, vomiting, fast heart rate or signs of serotonin syndrome (such as excitement, drowsiness, clumsiness, restlessness, feeling of being drunk, fever, sweating or rigid muscles).
- If you suspect an overdose, seek immediate medical attention or contact a poison control center.
Misuse, Abuse and Drug Dependence:
- PREGEB D 75/20 CAPSULE contains Pregabalin, which has the potential for misuse or abuse.
- Avoid sharing this medication with others, especially individuals with a history of substance abuse or addiction.
- Use the medicine only as prescribed to minimize the risk of dependence.
- Long-term or improper use of PREGEB D 75/20 CAPSULE may lead to physical or psychological dependence.
- To avoid dependence, your doctor may gradually reduce the dosage when stopping the medication.
Side Effects Of PREGEB D 75/20 CAPSULE
Like all medicines, PREGEB D 75/20 CAPSULE may cause certain side effects, although not everybody gets them.
Some of the most common side effects of PREGEB D 75/20 CAPSULE are:
- dizziness, drowsiness, headache
- increased appetite, weight gain
- Dry mouth, nausea, constipation
- increased mood, difficulty in concentration
- tingling or numbness, sedation, lethargy
- blurred vision, double vision
- weight gain, increased sweating
- muscle cramps, joint or back pain, pain in limbs
- sore throat
- difficulties with erection, inability to reach orgasm, decreased sexual drive, delayed ejaculation
- painful urination, frequent urination
When to Consult your doctor?
Stop taking PREGEB D 75/20 CAPSULE and contact your doctor immediately if you experience any of the following side effects:
- suicidal thoughts and behaviour
- serious skin reaction involving reddish non-elevated, target-like, or circular patches on the trunk, often with central blisters, skin peeling, ulcers of mouth, throat, nose, genitals and eyes (Stevens-Johnson syndrome, toxic epidermal necrolysis)
- feeling restless, urge to move, increased irritation
- signs of serotonin syndrome (feeling agitated, hallucinations, confusion, loss of consciousness, fast heartbeat, feeling dizzy, increased sweating, flushing, tremors, stiff muscles, or muscle twitching, loss of coordination, nausea, vomiting, diarrhea or seizures)
- signs of allergic reactions (such as skin rash, itching, swellling of the face, lips, tongue and throat which causes difficulty in breathing or swallowing)
To know more about the safety of this medicine, refer
How To Manage Side Effects
Constipation
- Increase Fiber Intake: Eat more fiber-rich foods like fruits, vegetables, and whole grains to help prevent constipation.
- Stay Hydrated: Drinking plenty of fluids, especially water, helps keep your stool soft and easier to pass.
- Exercise Regularly: Physical activity can help stimulate bowel movements and reduce constipation.
- Consider a Stool Softener: If constipation persists, your doctor may recommend a stool softener or laxative to relieve symptoms.
Dizziness Or Drowsiness
- Avoid Driving or Operating Machinery: If you feel drowsy or dizzy, avoid activities that require full attention until you know how the medication affects you.
- Take the Medication at Night: If dizziness or drowsiness is a concern, consider taking PREGEB D 75/20 CAPSULE before bed, as this can minimize daytime drowsiness.
- Stay Hydrated: Drink plenty of water to stay alert and avoid dehydration, which can worsen dizziness.
- Move Slowly: When standing up, do so slowly to prevent sudden dizziness from a change in position (orthostatic hypotension).
Dry Mouth
- Stay Hydrated: Drink plenty of water throughout the day to help soothe dry mouth.
- Chew Sugar-Free Gum or Mints: This can help stimulate saliva production and relieve dry mouth.
- Use Mouthwash or a Humidifier: Alcohol-free mouthwashes or using a humidifier at night can help moisturize the mouth.
- Avoid Caffeine and Tobacco: These can contribute to dry mouth, so try to reduce or eliminate their use.
Warning & Precautions
Pregnancy
Monitoring requiredAccording to clinical studies, there have been no large-scale trials in pregnant women to firmly establish the safety of PREGEB D 75/20 CAPSULE during pregnancy. As such, it is important to consult with a healthcare provider before using this medication during pregnancy. In cases where the benefits outweigh the risks, the doctor may recommend a careful monitoring plan.
PREGEB D 75/20 CAPSULE is generally not recommended for use in pregnant women unless considered necessary by the physician. Therefore, consult your doctor before taking it. Women of childbearing age must use a suitable contraceptive method (non-hormonal methods) to avoid pregnancy while undergoing therapy with PREGEB D 75/20 CAPSULE.
Breastfeeding
Consult your doctorClinical studies have shown that both Pregabalin and Duloxetine are present in breast milk, but the effects on infants are not fully established. A few studies have reported mild sedation or withdrawal symptoms in infants, though these are rare. Therefore, breastfeeding should only be done under medical supervision if no alternative treatment is available.
Driving and Using Machines
Use with CautionDo not drive or operate any heavy tools or machines if you feel dizzy or sleepy after taking PREGEB D 75/20 CAPSULE.
Alcohol
Consult your doctorAvoid consumption of alcohol while taking PREGEB D 75/20 CAPSULE as it could increase your dizziness.
Kidney
Consult your doctorPREGEB D 75/20 CAPSULE is not recommended for use in patients with severe kidney diseases. It should be used with caution in patients with other mild kidney problems (such as decreased urination). Dose adjustments may be needed in such patients. Therefore, consult your doctor before taking it.
Liver
ContraindicatedPREGEB D 75/20 CAPSULE is not recommended for use in patients with severe liver diseases. Therefore, consult your doctor before taking it.
Allergy
ContraindicatedDo not take PREGEB D 75/20 CAPSULE if you are allergic to the Pregabalin or Duloxetine.
Lungs
Use with CautionPREGEB D 75/20 CAPSULE should be used with caution in patients having respiratory problems. Therefore, consult your doctor before taking it.
Heart Disease
Use with CautionPREGEB D 75/20 CAPSULE should be used with caution in patients who have a history of heart disease (Ex. high or low blood pressure). Therefore, consult your doctor before taking it.
Use In Pediatrics
ContraindicatedPREGEB D 75/20 CAPSULE is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before taking it.
Use In Geriatrics
Use with CautionPREGEB D 75/20 CAPSULE should be used with caution in elderly patients (aged above 65 years). Therefore, consult your doctor before taking it. Proper dose adjustments and careful monitoring are required in such patients.
Others
Before taking PREGEB D 75/20 CAPSULE, inform your doctor if you:
- have or had constipation
- have a history of drug abuse
- have had seizures
- have mania (sudden extreme sense of excitement and hyperactivity)
- have or previously had bipolar disorder (alternative episodes of excitement and sadness)
- have glaucoma
- have or previously had any bleeding disorders
- are taking diuretic medications (water pills)
- have diabetes
Safety Advice
Expert tips to maximize the effects of PREGEB D 75/20 CAPSULE:
- Follow the Prescribed Dosage: Always take PREGEB D 75/20 CAPSULE as prescribed by your healthcare provider. Do not adjust the dose or frequency without consulting your doctor to ensure optimal results and minimize side effects.
- Take Consistently at the Same Time Daily: For best results, take PREGEB D 75/20 CAPSULE at the same time every day. This helps maintain steady levels of the medication in your body and enhances its effectiveness.
- Avoid Alcohol and Sedatives: Minimize alcohol consumption and avoid other CNS depressants (e.g., sedatives, benzodiazepines) while using PREGEB D 75/20 CAPSULE to prevent excessive drowsiness and ensure proper treatment.
- Monitor Side Effects: Keep track of any side effects, such as dizziness or dry mouth, and report them to your doctor. Your healthcare provider may adjust the dosage or recommend additional measures to help manage these effects.
- Maintain a Healthy Lifestyle: Exercise regularly and eat a balanced diet to help reduce potential weight gain and manage constipation, both of which may be side effects of PREGEB D 75/20 CAPSULE.
- Consult Your Doctor Before Stopping: Do not suddenly stop taking PREGEB D 75/20 CAPSULE, as this may worsen your symptoms. Always consult your healthcare provider for a gradual reduction in dosage if discontinuation is necessary.
Interactions
A. Drug – Drug interactions:
- Central Nervous System Depressants (e.g., benzodiazepines, opioids, sedatives):
- Effect: Taking PREGEB D 75/20 CAPSULE with other central nervous system depressants can enhance sedative effects, leading to increased drowsiness, dizziness, and difficulty concentrating.
- Monoamine Oxidase Inhibitors (MAOIs) (e.g., phenelzine, tranylcypromine):
- Effect: Combining Duloxetine with MAOIs can lead to dangerous increases in serotonin levels, a condition called serotonin syndrome, which can cause symptoms like agitation, hallucinations, fever, rapid heartbeat, and muscle rigidity.
- Blood Pressure Medications (e.g., antihypertensives):
- Effect: Duloxetine present in the medicine may increase blood pressure, especially when taken in high doses or in combination with certain antihypertensive drugs.
- Alcohol:
- Effect: Alcohol can increase the sedative effects of PREGEB D 75/20 CAPSULE, leading to excessive drowsiness, dizziness, and impaired coordination. It may also worsen depression and anxiety symptoms.
- Antidiabetic Medications (e.g., insulin, metformin):
- Effect: The Duloxetine present in the medicine may lower blood sugar levels, which could interact with diabetes medications and lead to hypoglycemia (low blood sugar).
Drug-Food Interactions
- High-Fat Meals:
- Effect: High-fat meals can slow the absorption of PREGEB D 75/20 CAPSULE, which may delay its effectiveness.
- Caffeine:
- Effect: Caffeine may increase nervousness or anxiety, counteracting some of the calming effects of Duloxetine.
- Grapefruit Juice:
- Effect: Grapefruit juice may interfere with the metabolism of certain medications, including Duloxetine. This could increase the drug's concentration in the body and heighten the risk of side effects.
- Alcoholic Beverages:
- Effect: Alcohol can enhance the side effects of PREGEB D 75/20 CAPSULE, especially its sedative effects, leading to excessive drowsiness and impaired judgment.
Synopsis
| Drug | : | Pregabalin and Duloxetine |
| Pharmacological Category | : | Selective serotonin and norepinephrine reuptake inhibitors, GABA Analogs |
| Therapeutic Indication | : | |
| Dosage Forms | : | Capsule |
More Information
Is PREGEB D 75/20 CAPSULE addictive or habit-forming?
Yes, PREGEB D 75/20 CAPSULE has the potential to be habit-forming, particularly due to the Pregabalin component. Pregabalin can lead to physical dependence if used for a prolonged period or at higher doses than prescribed. While it is effective for managing neuropathic pain, it’s important to follow the prescribed dosage and avoid misuse.
If the medication is discontinued suddenly, it may cause withdrawal symptoms or worsen pain, so it should only be stopped under the supervision of a healthcare provider, who may recommend a gradual reduction in dosage to minimize withdrawal effects.
Always take PREGEB D 75/20 CAPSULE exactly as prescribed, and consult your doctor if you have concerns about dependence or misuse.
FAQs About PREGEB D 75/20 CAPSULE
Q: What is PREGEB D 75/20 CAPSULE?
A: PREGEB D 75/20 CAPSULE is a combination medication containing Pregabalin + Duloxetine, commonly used for the management of neuropathic pain and anxiety disorders. This medicine works by affecting the brain's chemical balance, helping to reduce pain signals and improve mood.
Q: What are the uses and Benefits of PREGEB D 75/20 CAPSULE?
A: PREGEB D 75/20 CAPSULE is effective in managing pain caused by nerve damage, such as diabetic neuropathy or post-herpetic neuralgia. It also helps manage generalized anxiety disorder (GAD), providing a calming effect and improving mood. By reducing pain and alleviating anxiety, PREGEB D 75/20 CAPSULE enhances daily functioning and overall well-being. The combination of Pregabalin and Duloxetine offers a comprehensive solution for both pain and anxiety, targeting multiple symptoms
Q: What are the Dosage Instructions for PREGEB D 75/20 CAPSULE?
A: Follow your doctor’s prescribed dosage. Typically, PREGEB D 75/20 CAPSULE is taken once or twice a day, with or without food. Your doctor may start you on a low dose and gradually increase it based on your response and tolerance. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. Do not double the dose to make up for the missed one.
Q: What are the possible Side Effects of PREGEB D 75/20 CAPSULE?
A: The most common side effects of PREGEB D 75/20 CAPSULE are drowsiness, dizziness, dry mouth, weight gain, blurred vision, and constipation. In rare cases, it may cause changes in mood or behavior, including suicidal thoughts, and severe allergic reactions. Contact your doctor if you experience severe side effects or symptoms that worsen.
Q: What precautions to Take While Using PREGEB D 75/20 CAPSULE?
A: Before taking PREGEB D 75/20 CAPSULE inform your doctor if you have liver or kidney problems. Avoid consumption of alcohol as it could make you drowsier. Avoid concomitant usage of PREGEB D 75/20 CAPSULE with CNS depressants without consulting your doctor. If you notice any mood changes or signs of depression, inform your healthcare provider immediately.
Q: Who Should Avoid PREGEB D 75/20 CAPSULE?
A: PREGEB D 75/20 CAPSULE should only be used during pregnancy if clearly needed. Consult your doctor about potential risks. Pregabalin and Duloxetine are excreted in breast milk. It's advised to avoid breastfeeding or consult your doctor. PREGEB D 75/20 CAPSULE has the potential for dependency, and should be avoided by individuals with a history of drug misuse. Individuals with severe renal or hepatic impairment may need dosage adjustments or alternative treatment options.
Q: How to Take PREGEB D 75/20 CAPSULE Safely?
A: Always take PREGEB D 75/20 CAPSULE as prescribed, without altering the dosage or stopping the medication abruptly. If discontinuing the medication, your doctor will guide you on a gradual reduction to prevent withdrawal symptoms. Drink plenty of water to avoid dry mouth or constipation. Visit your healthcare provider regularly to monitor the drug's effectiveness and side effects.
Q: What are the Common Conditions Treated by PREGEB D 75/20 CAPSULE?
A: PREGEB D 75/20 CAPSULE is a combination medication containing Pregabalin + Duloxetine, commonly used for the management of neuropathic pain.
Q: Can PREGEB D 75/20 CAPSULE Be Taken During Pregnancy?
A: PREGEB D 75/20 CAPSULE should only be used during pregnancy if the benefits outweigh the risks. It is important to consult your healthcare provider before taking this medication during pregnancy, as animal studies show potential risks to the fetus
Q: Why Choose PREGEB D 75/20 CAPSULE for Nerve Pain Relief?
A: PREGEB D 75/20 CAPSULE combines the pain-relieving effects of Pregabalin and the mood-stabilizing effects of Duloxetine, offering comprehensive relief from neuropathic pain and anxiety. Clinical studies have demonstrated the effectiveness of Duloxetine+pregabalin combination in managing nerve pain conditions, including diabetic neuropathy and post-herpetic neuralgia.
Q: Can PREGEB D 75/20 CAPSULE cause weight gain?
A: Yes. Weight gain is one of the common side effects of taking PREGEB D 75/20 CAPSULE. If this side effect bothers you, contact your doctor.
Q: What to do if I forget to take a dose of PREGEB D 75/20 CAPSULE?
A: If you forget to take a dose of PREGEB D 75/20 CAPSULE, take it as soon as you remember. However, if it is time to take the next dose, skip the missed dose and take the next one at regular times. Do not take a double dose of PREGEB D 75/20 CAPSULE to compensate a missed dose, as it could lead to toxicity.
Q: Can I stop taking PREGEB D 75/20 CAPSULE once my symptoms subside?
A: No. Do not stop taking PREGEB D 75/20 CAPSULE without consulting your doctor even if you feel better during the mid-way of the therapy. You may feel better after 2 weeks of therapy with PREGEB D 75/20 CAPSULE, but it might take several weeks for you to experience complete benefits. Also, sudden discontinuation of therapy may cause withdrawal symptoms such as nausea, vomiting, sweating, lack of sleep, anxiety and abnormal dreams.
Q: How long does it take for PREGEB D 75/20 CAPSULE to work?
A: It may take several weeks for PREGEB D 75/20 CAPSULE to heal your condition. Therefore, continue to take PREGEB D 75/20 CAPSULE for the stipulated duration recommended by your doctor without any interruption.
Q: How Does PREGEB D 75/20 CAPSULE work?
A: PREGEB D 75/20 CAPSULE is a pain-relieving medication. It reduces pain sensation by altering the activity of certain brain chemicals (dopamine, serotonin and adrenaline) within the nervous system. As a result, it reduces the transmission of pain signals from the damaged nerves to the brain and vice versa.
References
- KD. Tripathi. Antiepileptic Drugs. Drugs Used in Mental Illness: Antidepressant and Antianxiety Drugs. Essentials of Medical Pharmacology. 7th Edition. Page – 420 & 462.
- Robert J. Tanenberg, Gordon A. Irving, Richard C. Risser, Jonna Ahl, Michael J. Robinson, Vladimir Skljarevski and Sandra K. Malcolm. Duloxetine, Pregabalin, and Duloxetine Plus Gabapentin for Diabetic Peripheral Neuropathic Pain Management in Patients with Inadequate Pain Response to Gabapentin: An Open-Label, Randomized, Noninferiority Comparison. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. July 2011. [Accessed on 3rd February 2023] click here
- Pharmadox Healthcare Ltd. Duloxetine 30mg gastro-resistant capsules, hard Duloxetine 60mg gastro-resistant capsules, hard Duloxetine. Electronic Medicines Compendium. [Revised in May 2021]. [Accessed on 3rd February 2023] click here
- Milpharm Limited. Pregabalin. Electronic Medicines Compendium (EMC). [Revised in September 2022] [Accessed on 3rd February 2023] click here
- Torrent Pharmaceuticals Ltd. Pregab-D/PREGEB D 75/20 CAPSULE/Pregalin-D. [Revised in October 2021]. [Accessed on 3rd February 2023] click here
- Pbren-D Pregabalin+Duloxetine. 50mg+20mg, 75mg+20mg, 75mg +30mg. December 2013. [Accessed on 3rd February 2023] click here
- Leeford Healthcare Pvt Ltd. Pregabanyl-DX. [Accessed on 3rd February 2023] click here
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