PICICLIB 125 Capsule 21's

Introduction About PICICLIB 125 CAPSULE

PICICLIB 125 CAPSULE contains Palbociclib which belongs to the group of medicines called Kinase inhibitors. It is used to manage men and women with certain types of breast cancer (hormone receptor-positive, human epidermal growth factor receptor 2-negative) which have spread beyond the original tumour or to other organs. Also, for women, it is given together with aromatase inhibitors or flustering who have received prior endocrine therapy.

In pre- or perimenopausal women, endocrine therapy should be combined with a luteinizing hormone-releasing hormone (LHRH) agonist. Breast cancer is defined as a malignancy (abnormal cells divide without control and can invade nearby tissues) originating from breast tissue, with symptoms like a painless lump and swelling, redness, warmth, and hardening of the skin.

Before taking PICICLIB 125 CAPSULE, inform your doctor if you have liver, lung, heart, or kidney problems. PICICLIB 125 CAPSULE is not recommended for use during pregnancy and breastfeeding; therefore, consult your doctor before taking it. PICICLIB 125 CAPSULE is not recommended in children and adolescents (below the age of 18 years).

The most common side effects of taking PICICLIB 125 CAPSULE are infections, tiredness, rash, hair loss, decreased appetite, inflammation of the mouth and lips, nausea, vomiting, diarrhoea, weakness, fever, and dry skin. Contact your doctor if any of your symptoms get worse or persist.

Uses Of PICICLIB 125 CAPSULE

• Manage certain types of breast cancer (hormone receptor-positive, human epidermal growth factor receptor 2-negative) that have spread beyond the original tumour or to other organs

How PICICLIB 125 CAPSULE Works

PICICLIB 125 CAPSULE blocks certain proteins (cyclin-dependent kinase 4 and 6) that regulate cell growth and division. Blocking these proteins can slow down the growth of cancer cells and delay the advancement of your cancer.

How to use PICICLIB 125 CAPSULE

Take PICICLIB 125 CAPSULE as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will determine the correct dose and duration for you depending on your age, body weight, and disease condition. Do not stop taking PICICLIB 125 CAPSULE unless your doctor advises you to stop.

Side Effects Of PICICLIB 125 CAPSULE

How To Manage Side Effects

Diarrhea

Drink lots of fluids, such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor.

Nausea And Vomiting

Take PICICLIB 125 CAPSULE with, or just after meals. Stick to simple meals. Avoid eating oily or spicy foods. Get adequate rest. Drink lots of fluids, especially water. Have small sips if you feel sick. Eat when you feel like it, you do not need to eat or avoid any specific foods. Do not take any medicine for vomiting without asking your doctor.

Warning & Precautions

Pregnancy

Contraindicated

PICICLIB 125 CAPSULE is not recommended for use in pregnant women. Women of childbearing potential taking this medicine or their male partners should use adequate contraceptives. Consult your doctor before taking it.

Breastfeeding

Contraindicated

PICICLIB 125 CAPSULE is not recommended during breastfeeding, as it is not known if it is excreted in breast milk. Consult your doctor before taking it.

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if you experience tiredness after taking PICICLIB 125 CAPSULE.

Kidney

Use with Caution

PICICLIB 125 CAPSULE should be taken with caution in patients with kidney impairment. Consult your doctor before taking it.

Liver

Use with Caution

PICICLIB 125 CAPSULE should be taken with caution in patients with liver impairment. Consult your doctor before taking it.

Allergy

Contraindicated

Do not take PICICLIB 125 CAPSULE if you are allergic to Palbociclib.

Use In Pediatrics

Contraindicated

PICICLIB 125 CAPSULE is not recommended for use in children and adolescents (under 18 years of age). Consult your doctor before taking it.

Interactions

A. Drug-Drug interactions:

Before taking PICICLIB 125 CAPSULE, inform your doctor if you are taking any of the following medicine:

• medicines used to manage viral infections (Ex. lopinavir, indinavir, nelfinavir, ritonavir, telaprevir, saquinavir)
• medicines used to manage bacterial infections (Ex. clarithromycin and telithromycin)
• medicines used to manage fungal infections (Ex. voriconazole, itraconazole, ketoconazole, posaconazole)
• nefazodone (used to manage depression)
• quinidine (used to manage irregular heartbeat)
• colchicine (used to manage gout)
• medicines used to lower blood cholesterol levels (Ex. pravastatin, rosuvastatin)
• sulfasalazine (used to manage ulcerative colitis)
• medicines used to manage severe pain (Ex. alfentanil, fentanyl)
• medicines used after organ transplant (Ex. cyclosporine, everolimus, tacrolimus, sirolimus)
• medicines used to manage migraine (Ex. dihydroergotamine and ergotamine)
• pimozide (used to manage motor or verbal tics)
• digoxin (used to manage heart insufficiency)
• dabigatran (used to manage blood clots)
• medicines used to manage fits (Ex. carbamazepine and phenytoin)
• enzalutamide (used to manage prostate cancer)
• rifampin (used to manage tuberculosis)
• St. John’s Wort (used to manage depression)

B. Drug-Food interaction:

Avoid drinking grapefruit juice while taking PICICLIB 125 CAPSULE as it may increase the risk of side effects.

Overdosage:

If you or anyone else accidentally take too much of PICICLIB 125 CAPSULE, consult your doctor immediately or visit the nearby hospital.

Synopsis

More Information

• Keep PICICLIB 125 CAPSULE out of reach of children
• Store below 30°C

FAQs About PICICLIB 125 CAPSULE

Q: Can PICICLIB 125 CAPSULE be used by men?

A: Yes. PICICLIB 125 CAPSULE is used by men to manage certain types of breast cancer that have spread beyond the original tumour or to other organs. If you have any questions about how this medicine works or why it has been given to you, ask your doctor.

Q: Can PICICLIB 125 CAPSULE increase the risk of infections?

A: PICICLIB 125 CAPSULE may cause a drop in the number of white blood cells and weaken your immune system. Therefore, you may be at greater risk of getting infected while you are taking it. You will have regular blood tests during the management to check if PICICLIB 125 CAPSULE affects your blood cells. Inform your doctor if you get any signs or symptoms of an infection, like a fever.

Q: Can PICICLIB 125 CAPSULE cause diarrhoea?

A: Yes. Diarrhoea is a common side effect of PICICLIB 125 CAPSULE. Drink lots of fluids, such as water or fruit juice, to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor. If you experience persistent diarrhoea, consult your doctor.

Q: Can I take PICICLIB 125 CAPSULE on an empty stomach?

A: Take PICICLIB 125 CAPSULE as advised by your physician. It may be taken with food, preferably a meal, to ensure consistent exposure to the medicine. Avoid drinking grapefruit juice while taking PICICLIB 125 CAPSULE as it may increase the risk of side effects.

Q: Can I plan to have a baby while taking PICICLIB 125 CAPSULE?

You should avoid having a baby while taking PICICLIB 125 CAPSULE. Women of childbearing potential taking this medicine or their male partners should use adequate contraceptives. These methods should be used during management and for at least 3 weeks after completing therapy for females and for at least 14 weeks for males. Discuss contraception with your doctor while you are taking this medicine.

Q: Does PICICLIB 125 CAPSULE affect male fertility?

A: PICICLIB 125 CAPSULE may decrease fertility in men. Therefore, men may consider sperm preservation before taking this medicine. Consult your doctor regarding any further queries.

Q: What if I forget to take a dose of PICICLIB 125 CAPSULE?

If you forget to take a dose of PICICLIB 125 CAPSULE or vomit, take it as soon as you remember. Do not take the medicine twice to make up for the forgotten dose.

References

1. Barbara G. Wells, Joseph T. DiPiro, Terry L. Shwinghammer, Cecily V. DiPiro. Breast Cancer. Pharmacotherapy Handbook. Ninth edition. Page-619.

2. M/s. Pfizer Manufacturing Deutschland GmbH Betriebsstatte. Palbociclib. [Revised in October 2021] [Accessed on 14th May 2022] https://labeling.pfizer.com/ShowLabeling.aspx?id=16265

3. Palbociclib. Chemocare. [Accessed on 14th May 2022] https://chemocare.com/chemotherapy/drug-info/palbociclib.aspx

Useful Diagnostic Tests

• Mammography
• Ultrasound of the breast
• HER2 test

Author Details

Written By Dr. Dhivakaran R - BDS

Reviewed For Accuracy By Dr. Rajnikant - MBBS, MD (Physiology)

Last updated on 04 Apr 2023 | 04:00 PM(IST)