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Introduction About PIAT 15/10MG TABLET
PIAT 15/10MG TABLET is a combination of Atorvastatin and Pioglitazone which belongs to the group of medicines called Lipid-lowering drugs and Anti-diabetic agents respectively. It is used in the management of hyperlipidaemia and hyperglycaemia in adults when diet, exercise and management with single agents does not result in adequate results.
By reducing blood cholesterol levels, PIAT 15/10MG TABLET is also helpful in reducing the risk of heart and circulatory disorders. PIAT 15/10MG TABLET can be used both in adults and in children (aged 10 years or above).
Along with the management, you must follow a cholesterol-lowering diet, lifestyle changes and regular physical activity as instructed by your doctor to achieve better results. Avoid smoking and consumption of alcohol or grapefruit juice while taking PIAT 15/10MG TABLET as it may aggravate your existing condition.
Before taking PIAT 15/10MG TABLET inform your doctor if you have any lung, liver, kidney, or heart problems. You must also inform your doctor if you have thyroid problems, family history of muscle disorders, eye problems or menstrual problems (polycystic ovary syndrome).
Talk to your doctor before taking PIAT 15/10MG TABLET if you are already taking any antibiotics (such as fusidic acid) to manage any existing infections. Do not take PIAT 15/10MG TABLET if you are pregnant or breastfeeding without consulting your doctor.
One of the most common side effects of taking PIAT 15/10MG TABLET is hypoglycemia (low blood sugar levels) which can be identified by symptoms such as increased hunger, sweating, shakiness, weakness or an irregular heartbeat. To avoid this, your doctor will periodically monitor your blood sugar levels and adjust the dose of PIAT 15/10MG TABLET accordingly.
The most common side effects of taking PIAT 15/10MG TABLET are inflammation of nasal passage, throat pain, muscle ache, joint pain, back pain, constipation, nausea, headache, abnormal vision, dizziness, weight gain, numbness, joint pain, impotence, back pain, shortness of breath and anaemia. Consult your doctor if any of these side effect worsens.
Uses Of PIAT 15/10MG TABLET
- It is used in the management of hyperlipidaemia and hyperglycaemia
- Improves blood circulation to the heart and other body parts
How PIAT 15/10MG TABLET Works
PIAT 15/10MG TABLET contains two medicines namely, atorvastatin and pioglitazone. Atorvastatin is lipid lowering medicine. It works by blocking the action of an enzyme called HMG-CoA reductase that synthesizes cholesterol within the body. It also acts on the liver and improve the body’s ability to remove lipid particles from the blood. As a result, it helps in restoring blood lipid levels to normal.
Pioglitazone is a PPAR-gamma and PPAR-alpha agonist. Following administration, it activates certain receptors (PPAR-gamma and PPAR-alpha) in the body which are involved in metabolizing glucose. This makes our body utilize insulin for digesting the circulating blood glucose which in turn decreases blood sugar levels. Additionally, PIAT 15/10MG TABLET can also reduce the glucose produced by the liver.
How to use PIAT 15/10MG TABLET
Take PIAT 15/10MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. PIAT 15/10MG TABLET can be taken with or without meals.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and health condition. Do not stop taking PIAT 15/10MG TABLET without consulting your doctor.
Side Effects Of PIAT 15/10MG TABLET
Common
- inflammation of the nasal passages
- respiratory infection, sinus infection, sore throat, nose bleeds
- allergic reactions
- increase in blood creatine kinase
- nausea, constipation, indigestion, diarrhoea, flatulence
- joint pain, muscle pain and back pain
- liver problems
- hypoglycemia (low blood sugar levels causing dizziness, shakiness or hunger)
- headache, dizziness
- abnormal vision
- impotence
- shortness of breath, anaemia
- weight gain
- numbness
Uncommon
- changes in appetite (increased or decreased)
- having nightmares, insomnia
- tingling sensation, decreased sensation to pain or touch
- changes in sense of taste
- loss of memory
- blurring of vision
- ringing in the ears followed by vomiting
- abdominal pain
- neck pain, muscle fatigue
- fatigue, feeling unwell, weakness, chest pain
- swelling especially in the ankles (oedema)
- raised temperature
- difficulty in sleeping (insomnia)
- sugar in urine
- proteins in urine
- spinning sensation (vertigo)
- sweating
Rare
- visual disturbance
- unexpected bleeding or bruising
- cholestasis (yellowish discoloration of the skin and whites of the eyes)
- tendon injury
Stop taking PIAT 15/10MG TABLET and contact your doctor immediately if you experience any of the following side effects:
- severe allergic reactions (such as skin rash, blisters in the skin, severe peeling, blistering of the skin and swelling of the skin, mouth, eyes, face, lips, tongue and/or throat with difficulty in breathing or swallowing)
- unexplained muscle pain or weakness, especially if accompanied by fever, weakness, or reddish-brown urine (rhabdomyolysis)
- unexpected bleeding or bruising
- severe skin rash with joint disorders and changes in blood counts (Lupus-like disease syndrome)
- symptoms of heart failure (such as unusual shortness of breath or trouble in breathing, rapid increase in weight or localised swelling (oedema), especially in the ankles or legs, unusual tiredness)
- signs and symptoms of bladder cancer (such as blood in your urine, pain while urinating or urgent need to pee)
- increased risk of fractures (especially in the bones of hand, upper arm, or foot in women)
- blurred vision due to swelling at the back of the eye or worsening of existing blurred vision
- signs of liver problems (such as nausea or vomiting, stomach pain, unusual or unexplained tiredness, loss of appetite, dark urine, yellowing of the skin or the whites of the eyes)
How To Manage Side Effects
Bloating
To manage flatulence, consider dietary adjustments and lifestyle changes. Identify and limit gas-producing foods such as beans, cabbage, and carbonated drinks. Chew food thoroughly to aid digestion and reduce the likelihood of swallowing air. Introduce probiotics through yogurt or supplements to promote a healthy gut flora. Regular physical activity can also aid digestion. If persistent, consult a healthcare professional to rule out underlying issues and discuss potential solutions, such as medications or further dietary modifications.
Dizziness Or Drowsiness
Managing dizziness involves addressing potential underlying causes and making lifestyle adjustments. If you experience sudden or severe dizziness, it's important to sit or lie down to manage the risk of falling. Ensure proper hydration and maintain a balanced diet to regulate blood sugar levels. Avoid sudden movements and try to rise slowly from a seated or lying position. If dizziness persists, it's advisable to consult with a healthcare professional to rule out any serious medical conditions.
Headache
Stay well-hydrated, as dehydration can contribute to headaches. Get adequate rest and maintain a regular sleep schedule. Practice stress-management techniques, such as deep breathing or meditation, to alleviate tension. Over-the-counter pain relievers like acetaminophen or ibuprofen can provide relief, but it's essential to follow recommended dosages. Applying a cold or warm compress to the forehead may also ease discomfort. If headaches persist or worsen, seek medical advice to rule out underlying issues and receive appropriate> management.
Nausea And Vomiting
To manage nausea and vomiting, it is essential to focus on hydration, rest, and dietary adjustments. Stay well-hydrated by sipping on clear fluids like water or ginger tea. Opt for small, frequent meals to ease the digestive process, avoiding strong-smelling or heavy foods. Ginger, known for its anti-nausea properties, can be consumed through tea or candies. Adequate rest is crucial for recovery, allowing your body to heal. If symptoms persist, consult a healthcare professional who may recommend medications or other interventions tailored to the underlying cause of nausea and vomiting.
Warning & Precautions
Pregnancy
ContraindicatedPIAT 15/10MG TABLET is not recommended for use in pregnant women. Therefore, consult your doctor before taking it. Women of childbearing age must use a reliable contraceptive method to avoid pregnancy while undergoing therapy with PIAT 15/10MG TABLET. However, if you accidentally become pregnant while taking PIAT 15/10MG TABLET, stop taking it and consult your doctor immediately.
Breastfeeding
ContraindicatedPIAT 15/10MG TABLET is not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.
Driving and Using Machines
Use with CautionDo not drive or operate any heavy tools or machines if you feel dizzy or sleepy after taking PIAT 15/10MG TABLET.
Alcohol
Consult your doctorIt is advisable to avoid alcohol consumption while taking PIAT 15/10MG TABLET to achieve maximum benefits.
Kidney
Use with CautionPIAT 15/10MG TABLET should be used with caution in patients with kidney problems. Therefore, consult your doctor before taking it.
Liver
Consult your doctorPIAT 15/10MG TABLET is not recommended for use in patients with severe liver diseases. It should be used with caution in patients with a history of liver problems. Therefore, consult your doctor before taking it.
Allergy
ContraindicatedDo not take PIAT 15/10MG TABLET if you are allergic to Atorvastatin or Pioglitazone.
Lungs
Use with CautionPIAT 15/10MG TABLET should be used with caution in patients with lung diseases (such as severe respiratory failure). Therefore, consult your doctor before taking it.
Heart Disease
Consult your doctorPIAT 15/10MG TABLET is not recommended for use in patients with severe heart problems (such as heart failure). It should be used with caution in patients with other heart problems. Therefore, consult your doctor before taking it.
Use In Pediatrics
ContraindicatedPIAT 15/10MG TABLET is not recommended for use in children and adolescents (aged below 18 years). Therefore, contact your doctor before taking it.
Use In Geriatrics
Use with CautionPIAT 15/10MG TABLET should be used with caution in elderly patients (aged 70 years or older). Therefore, consult your doctor for advice before taking it.
Others
PIAT 15/10MG TABLET is not recommended for use if you:
- have diabetic ketoacidosis (increased levels of ketone bodies in the blood)
- have bladder cancer
- pass bloody urine
Before taking PIAT 15/10MG TABLET, inform your doctor if you:
- have an unexplained muscle pain
- had any muscle problems in the past
- have improper functioning of thyroid gland
- have personal or family history of muscle problems
- are alcoholic
- are overweight
- have a previous history of stroke with bleeding the brain
- have small holes or pockets in the brain due to previous stroke
- have fluid retention and swelling
- have any urinary problems
- smoke
- have special type of diabetic eye disease called macular oedema (swelling of the back of the eye with worsening of your vision)
- have cysts on your ovaries (polycystic ovary syndrome)
- have anemia (low RBC in blood)
- have any bone problems or at risk of developing bone fractures
- are a premenopausal woman
Interactions
A. Drug-Drug interactions:
Before taking PIAT 15/10MG TABLET, inform your doctor if you are taking any of the following medicines such as:
- Immunosuppressants (Ex. cyclosporine)
- Antibiotics (such as fusidic acid, erythromycin, clarithromycin, telithromycin)
- Antifungal agents (such as ketoconazole, itraconazole, voriconazole, fluconazole, posaconazole)
- other lipid lowering agents (such as gemfibrozil, fenofibrate, colestipol or ezetimibe)
- cardiovascular drugs (Ex. amlodipine, diltiazem, digoxin, verapamil, amiodarone)
- antiviral agents (Ex. letermovir, ritonavir, lopinavir, atazanavir, indinavir, darunavir, the combination of tipranavir/ritonavir, telaprevir, boceprevir and the combination of elbasvir/grazoprevir, ledipasvir/sofosbuvir)
- warfarin (an anticoagulant)
- oral contraceptives (Ex. levonorgestrel)
- stiripentol (a medicine used to control epilepsy)
- medicines used to manage stomach ulcers (such as cimetidine)
- antacids (used to neutralize stomach acid and to reduce heartburn) Ex. aluminium hydroxide or magnesium hydroxide
- phenazone (a medicine used for pain relief)
- colchicine (a medicine used to manage gout)
- St John’s wort (a herbal preparation used for depression)
- non-steroidal anti-inflammatory medicines (used for pain relief) such as celecoxib or etoricoxib
- anti-TB drugs (such as rifampicin and rifampin)
B. Drug-Food interactions:
Avoid consumption of grapefruit while taking PIAT 15/10MG TABLET as it may reduce its effectiveness.
Overdosage:
If you or anyone else accidentally took more PIAT 15/10MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage might include hypoglycemia which may cause increased hunger, sweating, shakiness, weakness, or an irregular heartbeat.
Synopsis
| Drug | : | Atorvastatin, Pioglitazone |
| Pharmacological Category | : |
HMG-CoA reductase inhibitors, PPAR-gamma and PPAR-alpha agonists |
| Therapeutic Indication | : |
Controls blood sugar and blood cholesterol levels |
| Dosage Forms | : | Tablet |
More Information
- Keep PIAT 15/10MG TABLET out of reach of children
- Store PIAT 15/10MG TABLET at room temperature
FAQs About PIAT 15/10MG TABLET
Q: What are the uses of PIAT 15/10MG TABLET?
A: PIAT 15/10MG TABLET is used in the management of hyperlipidaemia and hyperglycaemia in adults when diet, exercise and management with single agents does not result in adequate results. It also improves blood circulation to the heart and other body parts.
Q: What is the best time to take PIAT 15/10MG TABLET?
A: Take PIAT 15/10MG TABLET as advised by your physician. Your doctor will decide the best time for you to take PIAT 15/10MG TABLET. Try to take this medicine at the same time each day. It can be taken with or without food.
Q: What are the side effects of taking PIAT 15/10MG TABLET?
A: The most common side effects of taking PIAT 15/10MG TABLET are hypoglycemia, inflammation of nasal passage, throat pain, muscle ache, joint pain, back pain, constipation, nausea, headache, abnormal vision, dizziness, weight gain, numbness, joint pain, impotence, back pain, shortness of breath and anaemia. Consult your doctor if any of these side effect worsens.
Q: Can I consume alcohol along with PIAT 15/10MG TABLET?
A: PIAT 15/10MG TABLET should be used with caution in patients who consume large amounts of alcohol. Therefore, it is advisable to avoid alcohol consumption while taking this medicine to achieve maximum benefits.
Q: Can the use of PIAT 15/10MG TABLET make me feel more tired?
A: Yes. The use of PIAT 15/10MG TABLET can make you feel more tired, because it acts by reducing the supply of energy to the muscles present in your body. However, you may also feel tired due to other reasons such as severe liver damage. Consult your doctor if you experience excessive tiredness with muscle pain.
Q: What are the dietary restrictions that I need to follow while taking PIAT 15/10MG TABLET?
A: While taking PIAT 15/10MG TABLET, follow a low-cholesterol diet as instructed by your doctor and avoid excessive alcohol intake. Avoid eating oil rich or deep-fried foods. Limit your sugar intake by avoid eating biscuits, cakes, soft drinks, or pastries. Stick to a simple nutritious diet. Avoid consumption of grapefruit while taking PIAT 15/10MG TABLET as it may reduce its effectiveness.
Q: What should I do if I forget to take a dose of PIAT 15/10MG TABLET?
A: If you forget to take a dose of PIAT 15/10MG TABLET, take it as soon as you remember. However, if it is time to take the next dose of PIAT 15/10MG TABLET, skip the missed dose and take the next one at regular times. Do not take a double dose of PIAT 15/10MG TABLET to compensate the missed dose, as it could lead to toxicity.
Q: Does PIAT 15/10MG TABLET cause muscle pain?
A: PIAT 15/10MG TABLET may cause a rare but serious side effect of unexplained muscle pain or weakness called rhabdomyolysis. It might be an early sign of a potentially serious muscle degradation. Therefore, consult your doctor if you experience any signs of muscle problems after taking PIAT 15/10MG TABLET. Also, talk to your doctor before taking PIAT 15/10MG TABLET if you already have weak muscles or have a family history of any muscle disorders.
Q: Can PIAT 15/10MG TABLET be taken by pregnant or breast-feeding women?
A: PIAT 15/10MG TABLET is not recommended for use in pregnant or breast-feeding women. Therefore, consult your doctor before taking it. Women of childbearing age must use a reliable contraceptive method to avoid pregnancy while undergoing therapy with this medicine. However, if you accidentally become pregnant while taking this medicine, stop taking it and consult your doctor immediately.
Q: Does PIAT 15/10MG TABLET cause bone fractures?
A: Yes. PIAT 15/10MG TABLET may cause bone fractures in some individuals. Therefore, it is important for you to inform your doctor before taking PIAT 15/10MG TABLET if you have any bone problems or at risk of developing any bone fractures (such as menopause).
Q: Does PIAT 15/10MG TABLET cause weight gain?
A: Yes. PIAT 15/10MG TABLET may cause weight gain in some individuals. To avoid this, follow a healthy diet and regular physical activity as advised by your physician. However, if you experience any weight gain due to swelling of body parts (such as in face, legs, or hands), consult your doctor immediately.
References
1. KD. Tripathi. Insulin, Hypolipidemic Drugs and Plasma Expanders. Essentials of medical pharmacology. Seventh edition. 2013. Page – 637.
2. K.D. Tripathi. Insulin, oral hypoglycaemic drugs, and glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 277.
3. Vishwanath Pattan, Sandeep Seth, Waqas Jehangir, Balram Bhargava, and Subir Kumar Maulik. Effect of Atorvastatin and Pioglitazone on Plasma Levels of Adhesion Molecules in Non-Diabetic Patients With Hypertension or Stable Angina or Both. National Library of Medicine. National Center for biotechnology Information. PMC. Pubmed Central. June 2015. [Accessed on 27th January 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471748/
4. Gerard Laboratories. Electronic Medicines Compendium (EMC). [Revised in August 2020] [Accessed on 27th January 2024] https://www.medicines.org.uk/emc/files/pil.8836.pdf
5. Sun Pharmaceutical Industries. Electronic Medicines Compendium (EMC). [Revised in September 2023] [Accessed on 27th January 2024] https://www.medicines.org.uk/emc/files/pil.4339.pdf
6. Zentiva Pharma UK Limited. Electronic Medicines Compendium (EMC). [Revised in May 2023] [Accessed on 27th January 2024] https://www.medicines.org.uk/emc/files/pil.11753.pdf
Useful Diagnostic Tests
- HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin
- Blood Glucose Fasting (FBS)
- Post Prandial Blood Sugar (PPBS)
- Netmeds Diabetic Checkup
- Advance Diabetes Monitoring (Senior Female)
- Lipid Profile Test/Cholesterol-Total
- Serum Ldl Cholesterol -Direct
- Hdl Cholesterol Direct
- Cholesterol-Total, Serum
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