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Pevesca Plus SR 75mg Tablet 10'S

Neuropathic Pain
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    Introduction About PEVESCA PLUS SR 75MG TABLET

    PEVESCA PLUS SR 75MG TABLET is a combination of Folic Acid, Mecobalamin (Methylcobalamin), Pyridoxine, and Pregabalin which belongs to the group of medicines called Group B vitamins and Anticonvulsants respectively. It is used in adults to manage painful diabetic neuropathy.

    Diabetic neuropathy is a condition that occurs due to high blood sugar levels in which nerves get weakened and damaged throughout the body, but more often in the legs and feet. It is characterized by symptoms such as tingling sensations, numbness, pain, weakness, cramps, and extreme sensitivity to touch in the affected area.

    Do not take PEVESCA PLUS SR 75MG TABLET if you are allergic to folic acid, mecobalamin (methylcobalamin), pyridoxine, or pregabalin. Before taking this medicine, inform your doctor if you are suffering from a hepatic impairment, kidney impairment, congestive heart failure, or pre-existing ocular conditions (eye problems).

    PEVESCA PLUS SR 75MG TABLET is also not recommended for use in pregnant and breastfeeding women. It should be used with caution in children (aged 12 years or below) and elderly patients (aged 75 years or above). Consult your doctor before taking it.

    The common side effects associated with the use of PEVESCA PLUS SR 75MG TABLET are dizziness, sleepiness, ataxia (clumsy body movement), confusion, excessive weakness, abnormal thinking, and blurred vision. Contact your doctor or a nearby hospital if any of the conditions worsen.

    Uses Of PEVESCA PLUS SR 75MG TABLET

    • Manage painful diabetic neuropathy

    How PEVESCA PLUS SR 75MG TABLET Works

    PEVESCA PLUS SR 75MG TABLET helps in managing nerve health, where pregabalin lowers the abnormal nerve conduction and pain conduction in the brain and spinal cord, thereby lowering the sensation of pain. Folic acid and pyridoxine play a vital role in the growth, differentiation, and regeneration of nerves and the central nervous system, whereas methylcobalamin helps in the synthesis of a compound called myelin that covers and protects nerve fibers, thereby reversing nerve damage and lowering nerve pain.

    How to use PEVESCA PLUS SR 75MG TABLET

    Take PEVESCA PLUS SR 75MG TABLET as advised by your physician. Swallow the medicine with a glass of water, with or without food. Do not crush or chew the medicine. Your doctor will determine the correct dose and duration for you depending upon your age, body weight, and disease condition.

    Side Effects Of PEVESCA PLUS SR 75MG TABLET

    Common

    • dizziness
    • sleepiness
    • ataxia (clumsy body movement)
    • confusion
    • excessive weakness
    • abnormal thinking  abnormal
    • blurred vision
    • lack of coordination
    • peripheral oedema (swelling due to water retention)
    • dry mouth
    • abdominal pain
    • signs of an allergic reaction such as rashes, itching, shortness of breath, and noisy breathing
    • fever
    • increase in weight
    • gastroenteritis (inflammation of the stomach and intestines)
    • increased appetite
    • vomiting
    • nausea
    • constipation
    • diarrhoea
    • flatulence
    • abdominal distension (bloating and swelling in the stomach)
    • ecchymosis (skin discolouration due to underlying bleeding)
    • joint pain
    • leg cramps
    • muscle pain
    • muscle weakness
    • back pain
    • pain in the limb
    • cervical spasm
    • anxiety
    • depersonalisation
    • stiffness and immobility of muscles
    • decreased sense of touch or pain
    • loss of libido
    • uncontrolled eye movements
    • tingling and prickling sensations
    • sedation
    • state of being nearly unconscious
    • twitching
    • tremor
    • difficulty in speaking
    • loss of memory
    • memory impairment
    • disturbance in attention
    • lethargy
    • extreme happiness
    • confusion
    • irritability
    • disorientation
    • sleeplessness
    • balance disorder
    • itching
    • conjunctivitis (inflammation of the eye tissue)
    • diplopia (double vision)
    • otitis media (a middle ear infection)
    • ringing sensation in the ears
    • anorgasmia (impaired orgasms)
    • impotence
    • increased urinary frequency
    • urinary incontinence
    • nasopharyngitis (inflammation of the nose and throat)
    • falls
    • feeling drunk
    • feeling abnormal

    Uncommon

    • abscess (accumulation of pus)
    • cellulitis (a bacterial infection)
    • chills
    • malaise (a feeling of discomfort)
    • neck rigidity
    • pelvic pain
    • increased sensitivity to light
    • inflammation of deep blood vessels
    • congestive heart failure (impairment of the heart's ability to pump enough blood)
    • low blood pressure
    • postural hypotension (dip in blood pressure on changing the posture)
    • retinal vascular disorder (disease of the eye’s blood vessels)
    • transient loss of consciousness
    • pounding heart rate
    • first-degree atrioventricular block (heart block)
    • sinus bradycardia (slow heart rhythm)
    • cholecystitis (inflammation of the gall bladder)
    • cholelithiasis (stones in the gallbladder)
    • colitis (inflammation of the intestine)
    • dysphagia (difficulty swallowing)
    • oesophagitis (inflammation of the oesophagus)
    • gastritis (inflammation of the stomach)
    • gut bleeding
    • melaena (dark stools)
    • ulcers in the mouth
    • pancreatitis (inflammation of the pancreas)
    • rectal haemorrhage
    • tongue swelling
    • gastro-oesophageal reflux disease (disease-causing repeated flow back of acid)
    • overproduction of saliva
    • loss of sensation in the mouth
    • anaemia (decreased blood cell count)
    • eosinophilia (an increase in the count of a type of white blood cells)
    • hypochromic anaemia (decreased amount of haemoglobin)
    • leucocytosis (increased white blood cell count)
    • leukopenia (decreased white blood cell count)
    • lymphadenopathy (enlarged lymph nodes)
    • thrombocytopenia (decreased platelet count)
    • neutropenia (decreased white blood cell count)
    • anorexia (an eating disorder causing weight loss or weight gain)
    • reduced blood glucose levels
    • arthrosis (wearing of joints)
    • joint swelling
    • neck pain
    • muscle stiffness
    • abnormal dreams
    • agitation
    • apathy (lack of interest)
    • aphasia (impaired ability to communicate)
    • circumoral paraesthesia (reduced sensations around the mouth)
    • dysarthria (a brain disorder causing difficulty speaking)
    • hallucinations
    • hostility
    • hyperalgesia (increased ability to feel pain)
    • hyperkinesia (excessive restlessness)
    • hypokinesia (diminished motor strength)
    • hypotonia (decreased muscle tone)
    • increased libido
    • abnormal muscle jerks
    • neuralgia (pain in the nerves)
    • loss of consciousness
    • psychomotor hyperactivity (excess anxiety)
    • postural dizziness
    • intention tremor
    • cognitive disorder (disorder causing confusion)
    • mental impairment
    • speech disorder
    • hyporeflexia (decreased reflex responses)
    • burning sensation
    • loss of taste function
    • panic attack
    • restlessness
    • depression
    • elevated mood
    • mood swings
    • word-finding difficulty
    • dyskinesia (abnormal body movements)
    • shortness of breath
    • nose bleeding
    • cough
    • nasal congestion
    • swelling inside the nose
    • snoring
    • nasal dryness
    • loss of hair
    • excessive sweating
    • dry skin
    • eczema (inflamed and itchy rashes)
    • hirsutism (hair growth in a male pattern on the female body)
    • skin ulcers
    • urticaria (allergic reactions causing itchy welts)
    • vesiculobullous rash (rashes with fluid-filled cavities)
    • itching
    • abnormality of accommodation or vision
    • blepharitis (inflammation of the eyelids)
    • peripheral vision loss
    • reduced visual accuracy
    • eye pain
    • asthenopia (strain in the eyes)
    • photopsia (visuals of light)
    • increased lacrimation
    • irritation in the eyes
    • dry eyes
    • eye haemorrhage
    • eye swelling
    • visual field defect
    • hyperacusis (increased sensitivity to sounds)
    • photophobia (discomfort with bright lights)
    • retinal swelling
    • abnormal ejaculation
    • albuminuria (presence of albumin in the urine)
    • amenorrhoea (absence of menstruation)
    • dysmenorrhoea (painful periods)
    • dysuria (painful urination)
    • haematuria (blood in the urine)
    • kidney stones
    • leucorrhoea (abnormal discharge from the vagina)
    • menorrhagia (heavy bleeding)
    • metrorrhagia (abnormal bleeding between periods)
    • nephritis (inflammation of the kidney tissues)
    • oliguria (decreased urine volume)
    • urinary retention
    • urine abnormality
    • breast pain
    • high blood pressure
    • hot flushes
    • flushing
    • cold hands and feet
    • generalized swelling due to water retention
    • swelling in the face due to water retention
    • chest tightness
    • pain
    • very high fever
    • thirst

    Rare

    • signs of an anaphylactic reaction such as shortness of breath, chest tightness, and wheezing
    • ascites (abnormal retention of fluid in the abdomen)
    • granuloma (small areas of inflammation)
    • hangover effect
    • intentional injury
    • retroperitoneal fibrosis (an extensive scar in the back of the abdominal cavity)
    • shock (sudden drop in blood pressure)
    • heart problems such as st depression, ventricular fibrillation, qt prolongation, and sinus arrhythmia
    • painful swelling in the mouth
    • ulcer in the food pipe
    • pus formation near the tooth sockets
    • myelofibrosis (bone marrow cancer)
    • polycythaemia (increased blood haemoglobin levels)
    • decreased prothrombin levels
    • purpura (pinpoint bleeding below the skin)
    • thrombocythemia (unusual bleeding)
    • decreased glucose tolerance levels
    • urate crystalluria (deposition of uric acid in soft tissue)
    • chondrodystrophy (abnormal cartilage development)
    • generalised spasm
    • rhabdomyolysis (breakdown of muscle tissue)
    • addiction
    • cerebellar syndrome (a brain disorder)
    • cogwheel rigidity (muscle rigidity causing repeated jerks)
    • coma (complete loss of consciousness)
    • delirium (disturbed mental abilities)
    • delusions (false beliefs)
    • dysautonomia (loss of nervous system function)
    • abnormal muscle contractions
    • involuntary muscle contractions
    • encephalopathy (a brain disease)
    • extrapyramidal syndrome (brain disorder causing abnormal body movements)
    • guillain-barré syndrome (a condition in which the immune system damages healthy nerves)
    • hypoalgesia (decreased ability to feel pain)
    • intracranial hypertension (increased blood pressure in the brain)
    • manic reaction (extreme mood changes)
    • paranoid reaction (irrational thoughts)
    • torticollis (abnormal head twisting)
    • trismus (decreased mouth opening)
    • convulsions
    • parosmia (abnormal sensation of smell)
    • dysgraphia (loss of ability to write)
    • disinhibition (lack of restraint)
    • peripheral neuritis (nerve damage outside the brain and spinal cord)
    • personality disorder
    • schizophrenic reaction (a mental disorder)
    • atelectasis (loss of a lung lobe)
    • bronchiolitis (inflammation of the lung tissue)
    • hiccup
    • laryngismus (abnormal spasms in the throat)
    • lung swelling
    • lung fibrosis (scarring of lung tissue)
    • yawn
    • water retention in lung tissue
    • throat tightness
    • signs of angioedema (a serious allergic reaction) such as swelling of the face
    • exfoliative dermatitis (inflammation and peeling of the skin)
    • lichenoid dermatitis (a type of skin swelling)
    • melanosis (increased skin pigmentation)
    • nail disorders
    • petechial rash (rashes with purple-red spots)
    • purpuric rash (rashes with dark skin patches)
    • pustular rash (rashes with pus formation)
    • skin atrophy (decreased skin thickness)
    • skin necrosis (death of skin cells due to a lack of oxygen supply)
    • formation of skin nodules
    • signs of stevens-johnson syndrome (a serious allergic reaction) such as blistering and peeling of skin
    • subcutaneous nodule (nodule formation below the skin)
    • anisocoria (unequal pupil size)
    • blindness
    • corneal ulcer
    • exophthalmos (protrusion of eyeballs)
    • extraocular palsy (paralysis of an eye muscle)
    • iritis (inflammation of an eye tissue)
    • keratitis (inflammation of an eye tissue)
    • oscillopsia (illusions)
    • altered visual depth perception
    • strabismus (an aligning disorder in the eyes)
    • visual brightness
    • keratoconjunctivitis (inflammation of an eye tissue)
    • miosis (excessive contraction of the pupils of the eye)
    • mydriasis (over-dilatation of the pupils of the eye)
    • night blindness
    • ophthalmoplegia (weakening of eye muscles)
    • optic atrophy (a disorder of the optic nerve)
    • papilloedema (swelling of an eye tissue)
    • ptosis (drooping of the upper eyelid)
    • uveitis (inflammation of an eye tissue)
    • acute kidney failure, balanitis
    • cancer of the bladder
    • inflammation of the cervix
    • dyspareunia (genital pain)
    • epididymitis (inflammation of the male genital area)
    • female lactation
    • glomerulitis (inflammation of kidney tissue)
    • ovarian disorder
    • pyelonephritis (inflammation of kidney tissue)
    • breast discharge
    • breast enlargement
    • breast enlargement in males

    Stop taking PEVESCA PLUS SR 75MG TABLET and contact your doctor if you experience any of the following side effects:   

    • signs of anaphylactoid reaction such as shortness of breath, chest tightness, and wheezing
    • signs of angioedema (a serious allergic reaction) such as swelling of the face
    • signs of allergic reactions such as skin redness, blisters, hives, rash, shortness of breath, and wheezing
    • diseases of muscles
    • markedly elevated creatine kinase levels in the blood

    How To Manage Side Effects

    Constipation

    Try to eat more high-fiber foods, such as fresh fruit, vegetables, and cereals, and drink plenty of water. Try doing exercise regularly (going for a daily walk or run). If this does not help, inform your doctor about receiving alternate managements for constipation.

    Diarrhea

    Drink lots of fluids, such as water, to keep yourself hydrated. Try to avoid taking any medicine on your own to manage diarrhoea, and consult your doctor if the symptom gets worse.

    Dizziness Or Drowsiness

    Lie down until the dizziness passes, and then get up slowly. Do not bend down suddenly. Get a lot of rest. Walk slowly and carefully. Take plenty of fluids. Avoid drinking coffee, alcohol, or smoking. Consult your doctor if the condition persists for a long time or gets worse.

    Nausea And Vomiting

    Try to take PEVESCA PLUS SR 75MG TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptom gets worse.

    Warning & Precautions

    Pregnancy

    Monitoring required

    PEVESCA PLUS SR 75MG TABLET is not recommended to be used in pregnant women unless considered necessary. Consult your doctor before taking it.

    Breastfeeding

    Contraindicated

    PEVESCA PLUS SR 75MG TABLET is not recommended to be used in breastfeeding women. Either breastfeeding should be discontinued or this medicine. Consult your doctor before taking it.

    Driving and Using Machines

    Use with Caution

    Do not drive or operate any machine if you feel dizziness and sleepiness after taking PEVESCA PLUS SR 75MG TABLET.

    Alcohol

    Consult your doctor

    Avoid regular consumption of alcohol while taking PEVESCA PLUS SR 75MG TABLET. Consult your doctor before taking it.

    Kidney

    Use with Caution

    PEVESCA PLUS SR 75MG TABLET should be used with caution in patients with renal impairment. Consult your doctor before taking it.

    Liver

    Use with Caution

    PEVESCA PLUS SR 75MG TABLET should be used with caution in patients with hepatic impairment. Consult your doctor before taking it.

    Allergy

    Contraindicated

    Do not take PEVESCA PLUS SR 75MG TABLET if you are allergic to any of the ingredients of this medicine. Consult your doctor before taking it.

    Heart Disease

    Use with Caution

    PEVESCA PLUS SR 75MG TABLET should be used with caution in patients with congestive heart failure. Consult your doctor before taking it.

    Use In Pediatrics

    Use with Caution

    PEVESCA PLUS SR 75MG TABLET should be used with caution in children (aged 12 years or below). Consult your doctor before taking it.

    Use In Geriatrics

    Use with Caution

    PEVESCA PLUS SR 75MG TABLET should be used with caution in elderly patients (aged 75 years or above). Consult your doctor before taking it.

    Others

    Before taking PEVESCA PLUS SR 75MG TABLET, inform your doctor if you:    

    • have pre-existing ocular conditions (eye problems)

    Interactions

    A. Drug-Drug Interactions:

    Before taking PEVESCA PLUS SR 75MG TABLET, inform your doctor, if you are taking any of the following medicine:

    • gabapentin (a medicine used to manage seizures)
    • oral contraceptives (medicines used to manage conception) Ex. oestrogen preparations
    • lorazepam (a medicine used to manage anxiety)
    • oxycodone (a medicine used to manage pain and inflammation)
    • anti-epileptic drugs (medicines used to manage epilepsy) Ex. phenytoin, phenobarbital, topiramate, carbamazepine, carbamazepine, epoxide, valproic acid, lamotrigine
    • antidiabetic agents (medicines used to manage diabetes) Ex. glyburide, insulin, metformin
    • furosemide (a medicine used to lower blood pressure)

    Overdosage:

    If you or anyone else accidentally takes too much of PEVESCA PLUS SR 75MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage dizziness and sleepiness.

    Synopsis

    Drug :   Folic Acid, Mecobalamin (Methylcobalamin), Pyridoxine, and Pregabalin
    Pharmacological Category :   Group B vitamins and Anticonvulsants
    Therapeutic Indication :   Painful diabetic neuropathy
    Dosage Forms :   Tablet

    More Information

    • Keep the medicine out of reach of children
    • Store PEVESCA PLUS SR 75MG TABLET below 30°C

    FAQs About PEVESCA PLUS SR 75MG TABLET

    Q: What is PEVESCA PLUS SR 75MG TABLET used for?

    A: PEVESCA PLUS SR 75MG TABLET is used in adults to manage painful diabetic neuropathy, which is a condition that occurs due to high blood sugar levels in which nerves get weakened and damaged throughout the body but more often in the legs and feet. It is characterized by symptoms such as tingling sensations, numbness, pain, weakness, cramps, and extreme sensitivity to touch in the affected area.

    Q: What side effects are seen with PEVESCA PLUS SR 75MG TABLET?

    A: The common side effects associated with the use of PEVESCA PLUS SR 75MG TABLET are dizziness, sleepiness, ataxia (clumsy body movement), confusion, excessive weakness, abnormal thinking, and blurred vision. Contact your doctor or a nearby hospital if any of the conditions worsen.

    Q: What happens if you take more PEVESCA PLUS SR 75MG TABLET than your required dose?

    A: If you or anyone else accidentally takes too much PEVESCA PLUS SR 75MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage include dizziness and sleepiness.

    Q: Who should avoid taking PEVESCA PLUS SR 75MG TABLET?

    A: Do not take PEVESCA PLUS SR 75MG TABLET if you are allergic to folic acid, mecobalamin (methylcobalamin), pyridoxine, or pregabalin. It is also not recommended for use in pregnant or breastfeeding women to ensure the safety of the mother and baby. Consult your doctor before taking PEVESCA PLUS SR 75MG TABLET.

    Q: Is PEVESCA PLUS SR 75MG TABLET safe to use in children or elderly patients?

    A: PEVESCA PLUS SR 75MG TABLET should be used with caution in children (aged 12 years or below) and elderly patients (aged 75 years or above). Consult your doctor before taking PEVESCA PLUS SR 75MG TABLET.

    Q: How does PEVESCA PLUS SR 75MG TABLET work?

    A: PEVESCA PLUS SR 75MG TABLET helps in managing nerve health, where pregabalin lowers the abnormal nerve conduction and pain conduction in the brain and spinal cord, thereby lowering the sensation of pain. Folic acid and pyridoxine play a vital role in the growth, differentiation, and regeneration of nerves and the central nervous system, whereas methylcobalamin helps in the synthesis of a compound called myelin that covers and protects nerve fibers, thereby reversing nerve damage and lowering nerve pain.

    Q: What is the method of taking PEVESCA PLUS SR 75MG TABLET?

    A: Take PEVESCA PLUS SR 75MG TABLET as advised by your physician. Swallow the medicine with a glass of water, along with or without food. Do not crush or chew the medicine. Your doctor will determine the correct dose and duration for you depending upon your age, body weight, and disease condition.

    Q: Is PEVESCA PLUS SR 75MG TABLET safe for pregnant women to use?

    A: According to animal studies, PEVESCA PLUS SR 75MG TABLET is not recommended for use in pregnant women unless clearly necessary because it may cause foetal structural abnormalities or developmental toxicity, including lethality, growth retardation, and functional impairment of the nervous and reproductive systems. Consult your doctor before taking PEVESCA PLUS SR 75MG TABLET.

    Q: Is PEVESCA PLUS SR 75MG TABLET safe to use in kidney patients?

    A: PEVESCA PLUS SR 75MG TABLET should be used with caution in patients with renal impairment (complete or partial loss of kidney function). The dosage must be adjusted according to the disease status of such patients. Consult your doctor before taking PEVESCA PLUS SR 75MG TABLET.

    Q: Is PEVESCA PLUS SR 75MG TABLET safe to use in heart patients?

    A: PEVESCA PLUS SR 75MG TABLET should be used with caution in patients with congestive heart failure (complete or partial loss of heart function). The dosage must be adjusted according to the disease status of such patients. Consult your doctor before taking PEVESCA PLUS SR 75MG TABLET.

    Q: Is it safe to drive while taking PEVESCA PLUS SR 75MG TABLET?

    A: Do not drive or operate any machine if you feel dizziness and sleepiness after taking PEVESCA PLUS SR 75MG TABLET. Consult your doctor before driving if you need to take this medicine.

    References

    1. KD Tripathi. Drugs Acting on Central Nervous System. Essentials of medical pharmacology. Seventh edition. 2013. Page - 420.

    2. Yasmin U Dongre, Onkar C Swami. Sustained-release pregabalin with methylcobalamin in neuropathic pain: an Indian real-life experience. NIH National Library of Medicine. National Centre for Biotechnology Information. PMC PubMed Central. May 2013. [Assessed on 3rd October 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674019/

    3. Panacea Biotec Limited (INDIA). MYELOGEN PG 75. [Revised in February 2019] [Assessed on 3rd October 2022] https://media.panaceabiotec.com/documents/2019/7/27/ProductMonograph-MyelogenPG-MethylB12FAB6-Pregabalin-Feb2014.pdf

    Useful Diagnostic Tests

    • Complete blood count
    • Blood sugar test

    Author Details

    Written By Dr. Dhivakaran R - BDS
    Reviewed For Accuracy By Dr. Sankara Babu Gorle - MBBS, MD (Pharmacology)
    Last updated on 16 Mar 2023 | 04:37 PM(IST)
    Lab updated