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Introduction About PERITO 500MG TABLET
PERITO 500MG TABLET contains Lanthanum which belongs to the group of medicines called Phosphate binders. It is used to manage hyperphosphatemia (high levels of phosphate in the blood) in patients with chronic kidney disease.
PERITO 500MG TABLET is not recommended for use in patients with low levels of phosphate (hypophosphatemia), bowel obstruction, ileus, faecal impaction, and severe constipation. PERITO 500MG TABLET should be used with caution in patients with liver or kidney disease. PERITO 500MG TABLET is not recommended for use by pregnant and breastfeeding women as it is not known if it can pass through breast milk. PERITO 500MG TABLET is not recommended for use by children and adolescents under 18 years of age, as its safety and efficacy are not established.
PERITO 500MG TABLET should be used with caution in elderly patients aged 65 years or above. Contact your doctor before taking PERITO 500MG TABLET. The most common side effects of taking PERITO 500MG TABLET are nausea, vomiting, diarrhoea, stomach pain, headache, itching, and rash. Contact your physician if any of the side effects worsen.
Uses Of PERITO 500MG TABLET
- Used to manage hyperphosphatemia (high levels of phosphate in the blood) in patients with chronic kidney disease
How PERITO 500MG TABLET Works
PERITO 500MG TABLET is a phosphate binder that works by binding to dietary phosphorus released from food during digestion, by which it inhibits the absorption of phosphorus by the formation of highly insoluble lanthanum phosphate complexes that cannot easily pass through the gastrointestinal tract wall and are excreted in the faeces. Thus, decreasing phosphate levels in the blood.
How to use PERITO 500MG TABLET
Take PERITO 500MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your physician will decide the correct dose and duration for you depending upon your age, body weight, and disease condition.
Side Effects Of PERITO 500MG TABLET
Common
- nausea, vomiting
- diarrhoea
- stomach pain
- headache
- itching, rash
- heartburn
- flatulence
- hypocalcaemia
Uncommon
- tiredness
- chest pain
- weakness
- swollen hands and feet
- body pains
- dizziness
- belching, indigestion
- inflammation of the stomach and intestines
- irritable bowel syndrome
- dry mouth, thirst
- tooth disorders
- inflammation of the mouth
- loose stools
- increases in certain liver enzymes
- abnormal phosphate level in the blood
- joint pain, muscle pain
- increase in sweat
- weakening and degeneration of bones
- lack of appetite or increased appetite
- laryngitis (inflammation of the larynx)
- decrease in weight
- change in taste
- increased white blood cells
- hair loss
Stop taking PERITO 500MG TABLET and contact your physician immediately if you experience any of the following side effects:
- rupture in the intestinal wall (signs include sudden severe stomach pain, bloating, chills, fever, nausea, vomiting, or tenderness in the abdomen)
- blockage in the intestine, abdominal bloating, abdominal pain, swelling or cramps, severe constipation and vomiting
How To Manage Side Effects
Constipation
Eat fiber-rich foods such as fresh fruits, vegetables, and cereals. Drink more water and exercise regularly. Contact your doctor if your symptom does not improve.
Diarrhea
Drink lots of fluids, such as water or fruit juices, to keep yourself hydrated. Do not take any medicine on your own to manage diarrhoea. Contact your doctor if your symptom does not improve.
Dizziness Or Drowsiness
Try to rest and relax. Get enough sleep. Avoid driving or operating machines if you feel dizzy. Do not drink alcohol, as it can aggravate your dizziness. Contact your doctor if your dizziness does not improve.
Headache
Rest and relax. Drink plenty of fluids to keep yourself hydrated. Apply a pain-relieving balm on the head if necessary. Contact your doctor if your headache does not improve.
Nausea And Vomiting
Take the medicine with or just after a meal. Stick to simple meals. Avoid eating oily or spicy foods. Contact your doctor if your symptoms do not improve.
Stomach Pain
Try to rest and relax. Eat small meals but take them frequently. Keep a heating pad on your stomach. Contact your doctor if the stomach pain gets worse.
Warning & Precautions
Pregnancy
ContraindicatedPERITO 500MG TABLET is not recommended for use by pregnant women. Contact your doctor before taking PERITO 500MG TABLET.
Breastfeeding
ContraindicatedPERITO 500MG TABLET is not recommended for use by breastfeeding mothers. Contact your doctor before taking PERITO 500MG TABLET.
Driving and Using Machines
Use with CautionDo not drive or operate any machines if you feel dizzy or have vertigo (spinning sensation in the head) after taking PERITO 500MG TABLET.
Kidney
Use with CautionPERITO 500MG TABLET should be used with caution in patients with kidney diseases. Contact your doctor before taking PERITO 500MG TABLET.
Liver
Use with CautionPERITO 500MG TABLET should be used with caution in patients with reduced liver function. Contact your doctor before taking PERITO 500MG TABLET.
Allergy
ContraindicatedDo not take PERITO 500MG TABLET if you are allergic to Lanthanum or other ingredients in this medicine.
Use In Pediatrics
ContraindicatedPERITO 500MG TABLET is not recommended for use in children and adolescents under 18 years of age as safety and efficacy are not established. Contact your doctor before taking PERITO 500MG TABLET.
Use In Geriatrics
Use with CautionPERITO 500MG TABLET should be used with caution in elderly patients aged 65 years or above. Contact your doctor before taking PERITO 500MG TABLET.
Others
PERITO 500MG TABLET is not recommended for use if you have:
- low levels of phosphate (hypophosphatemia)
- bowel obstruction (blockage in the intestine)
- ileus, and faecal impaction
- severe constipation
Before taking PERITO 500MG TABLET inform your doctor if you have:
- stomach or intestinal cancer
- inflammatory bowel disease ex. crohn’s disease and ulcerative colitis
- biliary obstruction
- infection or inflammation of the abdomen (peritonitis)
- stomach or intestinal ulcers
- blockage of the intestine (bowel obstruction)
- gastrointestinal perforation
- slow movement in the intestine (ex. constipation and stomach complications like ileus, sub ileus, diabetic gastroparesis)
- x-ray of the stomach
- bone diseases like osteoporosis
- gastrointestinal endoscopy
- diverticular disease (infection or inflammation in the intestine)
Interactions
A. Drug-Drug interactions:
Before taking PERITO 500MG TABLET inform your doctor if you are taking any of the following medicine:
- chloroquine, halofantrine (a medicine used for malaria)
- hydroxychloroquine (a medicine used for rheumatoid arthritis and malaria)
- ketoconazole (a medicine used to manage fungal infections)
- tetracycline, doxycycline, ciprofloxacin, ampicillin (medicines used to manage bacterial infections)
- levothyroxine (a medicine used for hypothyroidism)
- benazepril, captopril (medicines used for high blood pressure)
- antacids (medicines used for indigestion)
Overdosage:
If you or anyone else have accidentally taken too much of PERITO 500MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage include headache, nausea, and vomiting.
Synopsis
| Drug | : | Lanthanum |
| Pharmacological Category | : | Phosphate binders |
| Therapeutic Indication | : | Hyperphosphatemia |
| Dosage Forms | : | Tablet |
More Information
- Keep PERITO 500MG TABLET out of sight and reach from children
- Store PERITO 500MG TABLET at room temperature
FAQs About PERITO 500MG TABLET
Q: How does PERITO 500MG TABLET work?
A: PERITO 500MG TABLET is a Phosphate binder that works by binding to dietary phosphorus released from food during digestion, by which it inhibits the absorption of phosphorus by the formation of highly insoluble lanthanum phosphate complexes that cannot easily pass through the gastrointestinal tract wall and are excreted in the faeces. Thus, decreasing phosphate levels.
Q: What is PERITO 500MG TABLET used for?
A: PERITO 500MG TABLET is used to manage high levels of phosphate in the blood (hyperphosphatemia) in patients with chronic kidney disease. Contact your doctor before taking PERITO 500MG TABLET.
Q: Who should not take PERITO 500MG TABLET?
A: PERITO 500MG TABLET is not recommended for use in patients with allergic history to lanthanum carbonate or glucose or other sugars, low levels of phosphate (hypophosphatemia), bowel obstruction, ileus, faecal impaction, severe constipation, pregnancy, breastfeeding women, and children and adolescents under 18 years of age. Contact your doctor before taking PERITO 500MG TABLET.
Q: What are the side effects of taking PERITO 500MG TABLET?
A: The most common side effects of taking PERITO 500MG TABLET are nausea, vomiting, diarrhoea, stomach pain, headache, itching, and rash. Contact your physician if any of the side effects worsen.
Q: Can PERITO 500MG TABLET cause gastrointestinal perforation?
A: Yes. PERITO 500MG TABLET may cause gastrointestinal perforation. Stop taking PERITO 500MG TABLET and contact your doctor if you experience any unusual symptoms like sudden severe stomach pain, bloating, chills, fever, nausea, vomiting, or tenderness in the abdomen.
Q: Does PERITO 500MG TABLET cause constipation?
A: Yes. PERITO 500MG TABLET may cause constipation. Stop taking PERITO 500MG TABLET and contact your doctor if your symptom gets worse or persists for a longer duration.
References
1. Stuart M. Sprague, Hanna Abboud, Ping Qiu, Mattheew Dauphin, Pinggao Zhang and William Finn. Uses of Lanthanum carbonate. National Institute of Health. NLM. National Centre for Biotechnology Information. Pubmed.gov. January 2009. [Accessed on 28th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615694/
2. RB NL Brands B.V. Electronic Medicines Compendium (EMC). [Revised in January 2022] [Accessed on 28th June 2022] https://www.medicines.org.uk/emc/files/pil.323.pdf
3. Shire US Inc. U.S. Food & Drug Administration. [Revised in February 2016] [Accessed on 28th June 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021468s020,204734s001lbl.pdf
4. Lupin Pharmaceuticals, Inc. Lanthanum carbonate. [Revised in September 2021] [Accessed on 28th June 2022] https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=91556a42-5e16-4f86-bae9-a8cdd6b182a6
5. Takeda Canada Inc. Lanthanum carbonate. [Revised in January 2021] [Accessed on 28th June 2022] https://www.takeda.com/48f58f/siteassets/en-ca/home/what-we-do/our-medicines/product-monographs/fosrenol/fosrenol-pm-en.pdf
6. Lanthanum carbonate. Mims.com. [Accessed on 28th June 2022] https://www.mims.com/malaysia/drug/info/lanthanum%20carbonate?mtype=generic
Useful Diagnostic Tests
- Bilirubin Profile
- Kidney Function Test (KFT)
- Liver Function Test (LFT)
- Creatinine, Serum
- Uric Acid, Serum
- Albumin, Serum
- Alkaline Phosphatase, Serum
- Bilirubin Direct, Serum
- Bilirubin Total, Serum
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