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Introduction About PERIDON DROPS
PERIDON DROPS contains Domperidone which belongs to the group of medicines called Dopamine antagonists. It is used to manage nausea (feeling sick) and vomiting (being sick).
Nausea and vomiting are not a disease but symptoms of different conditions such as infections, food poisoning, motion sickness, overeating, blocked intestine, migraine, indigestion and many more.
PERIDON DROPS is not recommended for use in patients having heart or moderate to severe liver diseases, bleeding in the stomach or intestines, blockage or tear in your intestines, and tumors in the pituitary gland (prolactinoma). PERIDON DROPS should be used with caution in patients having kidney diseases.
PERIDON DROPS should be used with caution in pregnant women and should be used in breastfeeding women only if considered clearly necessary by the doctor. Ask for your doctor’s advice before taking. PERIDON DROPS should be used with caution in elderly patients (above 60 years of age).
PERIDON DROPS should not be used in children below 12 years or weighing less than 35kgs. Consult with your child’s doctor. The common side effect of taking PERIDON DROPS includes dry mouth. Consult with your doctor if this worsens or doesn’t improve.
Uses Of PERIDON DROPS
- manages nausea and vomiting
How PERIDON DROPS Works
PERIDON DROPS has an anti-emetic property which acts by blocking a chemical messenger in the brain called dopamine, that transfers information through nerve endings. PERIDON DROPS functions by inhibiting the muscle contraction that occurs naturally in the digestive system and enhances the peristaltic movement in the food pipe which helps in facilitating the digestion time faster, this causes calming down effect, thereby relieving nausea or vomiting sensation.
How to use PERIDON DROPS
Take PERIDON DROPS as advised by your physician. Shake well before use. Your doctor will decide the appropriate dose and duration of PERIDON DROPS for you depending on your age, body weight and disease condition.
Side Effects Of PERIDON DROPS
Common
- dry mouth
Uncommon
- feeling anxious
- feeling drowsy
- headache
- diarrhoea
- itchy skin, rash
- unusual production of breast milk in men and women
- painful or tender breasts
- lowering of sexual desire in men
Rare
Stop taking PERIDON DROPS and consult your doctor immediately if you experience any of the following side effects
- severe reaction having symptoms such as swelling of the hands, feet, ankle, face, lips and throat which may cause difficulty in swallowing or breathing
- itchy lumpy rash (hives), nettle rash (urticaria)
- uncontrolled movements, which include irregular movements of eyes, an unusual movement of the tongue, abnormal posture (Ex. twisted neck)
- have a fast unusual heartbeat
- seizures (fits)
How To Manage Side Effects
Dry mouth:
Dry mouth can be managed by chewing sugar-free gum or sucking on sugar-free hard candies to stimulate the flow of saliva. Sip water at regular intervals of time. Do not use mouthwashes that contain alcohol because they can be drying. Consult your physician for advice.
Diarrhoea:
Drink lots of fluids, such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor. Ask for your doctor’s advice if diarrhoea doesn’t improve.
Headache:
Try to take rest and don’t involve yourself in exertive activities. Rest in a quiet and dark room. Apply a pain-relieving balm on your forehead. Ask for your doctor’s advice if the headache doesn’t improve
Drowsiness:
Take adequate sleep. Do not involve in rigorous activities. Do not interfere with your sleep cycle. Talk to your doctor if the drowsiness doesn’t improve.
Itchy skin:
Hot water makes your skin irritated, so avoid taking hot showers. Do not scratch the affected area. Use sunscreen and protective clothing when outdoors. To soothe and hydrate the irritated skin, apply moisturizers. Contact your doctor if itching worsens.
Warning & Precautions
Pregnancy
PERIDON DROPS should be used with caution in pregnant women. Consult your doctor before taking it.
Breastfeeding
PERIDON DROPS is not recommended for use in breastfeeding women as it may pass through breast milk. PERIDON DROPS may cause unwanted side effects affecting the heart in a breastfed baby. It should only be used only if considered clearly necessary by the doctor. Consult your doctor before taking PERIDON DROPS.
Driving and Using Machines
PERIDON DROPS does not affect the ability to drive or use machines.
Kidney
PERIDON DROPS should be taken with caution in patients with kidney problems such as kidney impairment or kidney failure. Your doctor might consider adjusting your dose. Consult your doctor before taking it.
Liver
PERIDON DROPS is not recommended for use in patients having moderate to severe liver diseases such as liver function impairment or liver failure. Consult your doctor before taking it.
Allergy
Do not take PERIDON DROPS if you are allergic to Domperidone or any other ingredients present in it.
Heart Disease
PERIDON DROPS is not recommended in patients suffering from heart problems such as prolonged QT corrected interval (reading in eco cardiogram (ECG) machine) or heart failure (heart cannot pump blood properly). Kindly consult a doctor before taking PERIDON DROPS.
Others
PERIDON DROPS is not recommended for use if you:
- tumor in the pituitary gland (prolactinoma)
- history of blockage or tear in the intestine
- hypokalemia (low level of potassium)
- hyperkalemia (increased levels of potassium in the blood)
- hypomagnesemia (decreased levels of magnesium in the blood)
- signs and symptoms of bleeding in the stomach or intestine (black tarry bowel motions or blood in your bowel motions)
Use in pediatrics:
PERIDON DROPS is not recommended for use in children below 12 years of age or weighing less than 35 kgs. Consult with your child’s doctor before giving PERIDON DROPS to your child.
Use in geriatrics:
PERIDON DROPS should be used with caution for use over 60 years of age, as PERIDON DROPS be associated with an increased risk of heart rhythm disorder and cardiac arrest. Consult your doctor before taking it.
Interactions
A. Drug-Drug interactions:
Before taking PERIDON DROPS, inform your doctor if you are taking any of the following medicines:
- medicines to manage fungal infections (Ex. ketoconazole, fluconazole, and voriconazole)
- medicines to manage bacterial infections (Ex. erythromycin, clarithromycin, telithromycin, moxifloxacin, pentamidine)
- medicine to manage heart problems or high blood pressure (Ex. amiodarone, dronedarone, quinidine, disopyramide, bepridil, dofetilide, sotalol, diltiazem, verapamil)
- medicines to manage psychoses (Ex. haloperidol, pimozide, sertindole), medicine to manage depression (Ex. citalopram, escitalopram)
- medicines to manage gastrointestinal disorders (such as cisapride, diphemanil, dolasetron, prucalopride)
- medicines to manage allergies (Ex. mequitazine, mizolastine)
- medicine to manage malaria (specifically halofantrine)
- medicines to manage AIDS/HIV (Ex. ritonavir, atazanavir)
- medicine to manage cancer (Ex. toremifene, vandetanib, vincamine)
- medicine used to manage drug addiction (Ex. methadone)
Overdosage:
If you or anyone else accidentally took too much of this medicine, consult your doctor immediately. The symptoms might include feeling sleepy, confused, uncontrolled movements of the eye and tongue and abnormal posture (like a twisted neck).
Synopsis
| Drug | : | Domperidone |
| Pharmacological Category | : | Dopamine antagonists |
| Therapeutic Indication | : | Nausea and Vomiting |
| Dosage Forms | : |
Tablets, Capsules, Dispersible tablets, Rapitab, Suspension, Oral Suspension, Syrup, Oral Drops, Drops |
More Information
- Keep PERIDON DROPS out of reach of children
- Store PERIDON DROPS at room temperature below 30°C
FAQs About PERIDON DROPS
What is PERIDON DROPS and why is it prescribed?
PERIDON DROPS contains Domperidone which belongs to the group of medicines called Dopamine antagonists. It is used in managing nausea and vomiting.
How long can I take PERIDON DROPS?
It is recommended that PERIDON DROPS be taken for the shortest period and at the lowest dose. This is because PERIDON DROPS can cause an irregular heartbeat when taken for a longer period or at a high dose. Ask for your doctor’s advice.
Can I take PERIDON DROPS with antibiotics?
Use of PERIDON DROPS with antibiotics like erythromycin, levofloxacin, and some antifungals is not recommended as this can cause interaction. Please consult your doctor for advice before using any antibiotics with PERIDON DROPS.
Does PERIDON DROPS increase milk secretion?
Yes, PERIDON DROPS can increase milk secretion also known as galactorrhoea. This is an uncommon side effect of using PERIDON DROPS. Talk to your doctor if you are experiencing this side effect while taking this medicine.
Does PERIDON DROPS cause heart problems?
PERIDON DROPS may be associated with an increased risk of heart problems (like an irregular heartbeat) and heart attacks. The risk also increases when PERIDON DROPS is given together with other medicines. Inform the doctor of your medication history when taking PERIDON DROPS.
Does PERIDON DROPS cause dry mouth?
Yes, PERIDON DROPS can cause dry mouth. Dry mouth can be managed by chewing sugar-free gum or sucking on sugar-free hard candies to stimulate the flow of saliva. Sip water at regular intervals of time. Do not use mouthwashes that contain alcohol because they can be drying. Consult your physician for advice.
What is the best time to take PERIDON DROPS?
It is recommended to take PERIDON DROPS before meals. If taken after meals, absorption of the medicine is somewhat delayed. Patients should try to take each dose of PERIDON DROPS at a scheduled time to avoid missing a dose.
References
1. KD Tripathi. Antiemetics. Essentials of Medical Pharmacology. Eighth edition. 2019. Page - 414.
2. Rhew K, Han N, Oh JM. Impact of Safety Warning on Domperidone Prescribing for Geriatric Patients in South Korea: Analysis of National Insurance Claim Data. NIH National Library of Medicine, National Centre for Biotechnology Information. Pubmed Central. August 2019. [Accessed on 3rd November 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719182/
3. NIH National Library of Medicine, National Centre for Biotechnology Information. Pubchem. Domperidone. [Accessed on 3rd November 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Domperidone
4. Savio C Reddymasu, Irfan Soykan, Richard W McCallum. Domperidone: review of pharmacology and clinical applications in gastroenterology. NIH National Library of Medicine, National Centre for Biotechnology Information. Pubmed.gov. September 2007. [Accessed on 3rd November 2022] https://pubmed.ncbi.nlm.nih.gov/17488253/
5. Sofarimex - Industria Quimica e Farmacêutica Lda. Electronic Medicines Compendium (EMC). [Revised in March 2021] [Accessed on 03rd November 2022] https://www.medicines.org.uk/emc/files/pil.3188.pdf
6. Torrent Pharmaceuticals Ltd. Domstal Baby (Domperidone). [Revised in February 2022] [Accessed on 3rd November 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2518.pdf
7. Medley Pharmaceuticals Ltd. Motinorm drops (Domperidone). [Accessed on 3rd November 2022] https://www.medleylab.com/product/suprakare/anti-emetic.html
8. Torque Pharmaceuticals Pvt. Ltd. Peridon Drops (Domperidone). [Accessed on 3rd November 2022] https://www.torquepharma.com/peridon-drops/
9. Aristo Pharma Ltd. Apuldon (Domperidone). [Accessed on 3rd November 2022]. https://aristopharma.com/upload/product_pdf/1649581141.pdf
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