Perfalgan 500mg Injection 50ml
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Introduction About PERFALGAN 500MG INJECTION
PERFALGAN 500MG INJECTION contains Paracetamol which belongs to the group of medicines called Analgesics and Antipyretics. It is used for short-term management of moderate pain (especially after surgery) and fever when administered by the intravenous route is clinically justified.
Before receiving PERFALGAN 500MG INJECTION, inform your doctor if you have heart, lung, liver or kidney problems or if you suffer from alcoholism or alcohol abuse, malnourishment and severely low blood volume due to dehydration or blood loss.
PERFALGAN 500MG INJECTION should be used with caution in pregnant and breastfeeding women only if clearly advised by the doctor. PERFALGAN 500MG INJECTION should be used with caution in children and elderly patients.
The most common side effects of receiving PERFALGAN 500MG INJECTION are nausea, vomiting, headache, sleep problems and itching. Inform your doctor if any of these side effect worsens.
Uses Of PERFALGAN 500MG INJECTION
For short-term management of moderate pain (especially after surgery) and fever
How PERFALGAN 500MG INJECTION Works
PERFALGAN 500MG INJECTION relieves pain by increasing the pain threshold by inhibiting certain enzymes (COX-1 and COX-2) involved in the synthesis of chemicals responsible for inducing pain (prostaglandins). It reduces fever by directly acting on heat-regulating centers in the brain, resulting in vessel relaxation, sweating and loss of body heat.
How to use PERFALGAN 500MG INJECTION
PERFALGAN 500MG INJECTION will be given to you only by a doctor or a nurse into the vein as an intravenous infusion. Your doctor will decide the correct dose and duration for you based upon your age, body weight and disease condition.
Side Effects Of PERFALGAN 500MG INJECTION
Common
- nausea, vomiting, constipation
- headache
- sleep problems
- itching
Rare
- feeling generally unwell
- drop in blood pressure
- abnormal levels of liver enzymes
Inform your doctor immediately if you experience any of the following side effects while receiving PERFALGAN 500MG INJECTION:
- serious allergic reaction or skin rash
How To Manage Side Effects
Nausea or vomiting:
Stick to simple meals while receiving this medicine. Avoid eating oily rich, fried or spicy foods. Do not lie down or sleep immediately after eating. Inform your doctor if the symptom does not improve.
Constipation:
Try to eat more high-fibre foods such as fresh fruit, vegetables, cereals and drink plenty of water. If this does not help, inform your doctor to receive alternate management for constipation.
Headache:
Drink ample amount of water and avoid skipping meals. Get adequate rest. Try to be relaxed and stress-free. Apply pain relieving balm on your forehead if necessary. Inform your doctor if the symptom does not improve.
Warning & Precautions
Pregnancy
PERFALGAN 500MG INJECTION should be used with caution in pregnant women only if considered clearly necessary. Your doctor may use the lowest possible dose to reduce the pain and fever only for shorter duration in pregnant women. Consult your doctor before receiving it.
Breastfeeding
PERFALGAN 500MG INJECTION can be used in breastfeeding women only if considered clearly necessary. Consult your doctor before receiving it.
Alcohol
PERFALGAN 500MG INJECTION should be used with caution in patients with alcoholism or those who suffer from alcohol abuse.
Kidney
PERFALGAN 500MG INJECTION should be used with caution in patients with kidney disease. Consult your doctor before receiving it.
Liver
PERFALGAN 500MG INJECTION is not recommended for use in patients with severe liver disease. It should be used with caution in patients with liver disease. Consult your doctor before receiving it.
Allergy
Do not receive PERFALGAN 500MG INJECTION if you are allergic to Paracetamol, propacetamol or any other ingredients of this medicine.
Lungs
Repeated use of PERFALGAN 500MG INJECTION is not recommended for use in patients with lung disease. Consult your doctor before receiving it.
Others
PERFALGAN 500MG INJECTION is not recommended for use if you:
- have anaemia
Before receiving PERFALGAN 500MG INJECTION, inform your doctor if you:
- have severe hypovolemia (low blood volume due to dehydration or blood loss)
- have chronic malnutrition
Use in pediatrics:
PERFALGAN 500MG INJECTION should be used with caution in children and your child’s doctor may adjust the dose depending upon the child’s age and body weight. Consult your child’s doctor for advice before administration of PERFALGAN 500MG INJECTION.
Use in geriatrics:
PERFALGAN 500MG INJECTION should be used with caution in elderly patients. Consult your doctor before receiving it.
Interactions
A. Drug - Drug interactions:
Before receiving PERFALGAN 500MG INJECTION, inform your doctor if you are taking any of the following medicines:
- other medicines containing paracetamol or propacetamol
- probenecid (used to manage gout)
- medicines used for blood thinning (Ex. warfarin)
Overdosage:
PERFALGAN 500MG INJECTION will be administered to you only by a doctor or a nurse in a hospital and so it is unlikely to receive an overdose. However, consult your doctor if you experience any unusual symptoms such as nausea, vomiting, anorexia (eating disorder), paleness, stomach pain and a risk of liver injury.
Synopsis
| Drug | : | Paracetamol |
| Pharmacological Category | : | Para aminophenol derivative |
| Therapeutic Indication | : | Pain, Fever |
| Dosage Forms | : |
Tablet, Dispersible tablet, Drops, Syrup, Oral suspension, Liquid, Oral solution, Suppositories, Infusion, Injection |
More Information
Store below 25°C
FAQs About PERFALGAN 500MG INJECTION
What is PERFALGAN 500MG INJECTION used for?
PERFALGAN 500MG INJECTION is used for short-term management of moderate pain (especially after surgery) and fever and when administered by the intravenous route is clinically justified. Consult your doctor for advice before administration of PERFALGAN 500MG INJECTION.
What should I tell my doctor before receiving PERFALGAN 500MG INJECTION?
Patients receiving PERFALGAN 500MG INJECTION must inform their doctor about pre-existing conditions like heart, lung, liver or kidney problems, alcoholism, malnourishment or dehydration. Patients should also inform the doctor if they are pregnant, breastfeeding or allergic to anything. Inform your doctor if you experience any unusual symptoms during management with this medicine.
Can PERFALGAN 500MG INJECTION be used during pregnancy?
PERFALGAN 500MG INJECTION should be used with caution in pregnant women only if clearly advised by the doctor. Your doctor may use the lowest possible dose to reduce the pain and fever only for a shorter duration in pregnant women. Consult your doctor before receiving PERFALGAN 500MG INJECTION.
How does PERFALGAN 500MG INJECTION work?
PERFALGAN 500MG INJECTION relieves pain by increasing the pain threshold by inhibiting certain enzymes (COX-1 and COX-2) involved in the synthesis of chemicals responsible for inducing pain (prostaglandins). It reduces fever by directly acting on heat-regulating centers in the brain, resulting in vessel relaxation, sweating and loss of body heat.
Is PERFALGAN 500MG INJECTION safe to use in patients with liver disease?
PERFALGAN 500MG INJECTION is not recommended for use in patients with severe liver disease. It should be used with caution in patients with liver disease. Your doctor may monitor your liver function test before and during management with this medicine to manage the risk of liver damage. Consult your doctor before receiving PERFALGAN 500MG INJECTION.
References
1. Tilo Grosser, Emer Smyth and Garret A. FitzGerald. Anti-inflammatory, Antipyretic and Analgesic agents; Pharmacotherapy of gout. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 693.
2. KD. Tripathi. NSAIDs and Antipyretic-Analgesics. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 206.
3. Ulderico Freo, Chiara Ruocco, Alessandra Valerio, Irene Scagnol and Enzo Nisoli. Paracetamol: A Review of Guideline Recommendations. NIH National Library of Medicine, National center for biotechnology information. PubMed Central. August 2021. [Accessed on 16th August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347233/
4. Olivier Malaise, Olivier Bruyere and Jean-Yves Reginster. Intravenous paracetamol: A review of efficacy and safety in therapeutic use. ResearchGate. November 2007. [Accessed on 16th August 2022] https://www.researchgate.net/publication/247872458_Intravenous_paracetamol_A_review_of_efficacy_and_safety_in_therapeutic_use
5. Altan Pharmaceutical. Electronic Medicines Compendium (EMC). [Revised in December 2021] [Accessed on 16th August 2022] https://www.medicines.org.uk/emc/files/pil.13649.pdf
6. B. Braun Medical Inc. U.S. Food & Drug Administration. [Revised in February 2021] [Accessed on 16th August 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/204957s000lbl.pdf
7. Therapeutic Pharmaceuticals. Aeknil injection (Paracetamol). [Revised in May 2016] [Accessed on 16th August 2022] https://aeknil.com/pi/aekinj.pdf
8. Central Drugs Standard Control Organization (CDSCO). Paracetamol. [Accessed on 16th August 2022] https://cdscoonline.gov.in/CDSCO/Drugs
Useful Diagnostic Tests
- Complete blood count
- Liver function test
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