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Introduction About PEPTIRAN
PEPTIRAN contains Ranitidine which belongs to the group of medicines called H2 receptor antagonists. It is used in adults and children (3 to 18 years old) to heal and stop ulcers in the stomach or duodenum (part of the gut it empties into) and indigestion, dyspepsia or heartburn (problems caused by acid in the food pipe or too much acid in the stomach, causing pain or discomfort).
PEPTIRAN is also used in adults to help clear up any stomach infection when taken with antibiotics, to stop stomach ulcers when they are a side effect of some medicines, to stop ulcers from bleeding and to stop acid reflux from the stomach while under anaesthetic during an operation.
Avoid smoking during management with PEPTIRAN. Before taking PEPTIRAN, inform your doctor if you have stomach cancer, liver, kidney, lung or immunity problems, acute porphyria (a rare blood disorder) or diabetes.
PEPTIRAN is not recommended for use in pregnant or breastfeeding women unless your doctor finds it essential. For children (3 to 11 years old), your doctor will determine a proper dose depending on your child’s age, body weight and disease condition.
The most common side effects of taking PEPTIRAN are nausea, vomiting, diarrhea, constipation, stomach pain and headache. Call your doctor if the symptoms do not improve or worsen.
Uses Of PEPTIRAN
Used in adults and children (3 to 18 years old) to heal and stop
- ulcers in the stomach or duodenum
- indigestion, dyspepsia or heartburn
Used in adults to
- help clear up any stomach infection when taken with antibiotics
- stop stomach ulcers when they are a side effect of certain medicines
- stop ulcers from bleeding
- stop acid reflux from the stomach while under anaesthetic during an operation
How PEPTIRAN Works
PEPTIRAN contains ranitidine that effectively manages and heals stomach ulcers by reducing the secretion of stomach acid via inhibition of histamine (H2) receptors present in the stomach walls.
How to use PEPTIRAN
Take PEPTIRAN as advised by your physician. Shake well before use. Your doctor will decide a proper dose and duration of PEPTIRAN for you according to your age, body weight and disease condition. Do not stop taking PEPTIRAN unless your doctor advises you to stop.
Side Effects Of PEPTIRAN
Common
- headache
- constipation, diarrhea
- nausea, vomiting, stomach pain
Rare
- skin rashes
- increase in serum creatinine levels
- changes in the liver function
Stop taking PEPTIRAN and contact your doctor immediately if you experience any of the following side effects:
- allergic reactions (rash, itching, hives, swelling of the face, lips, tongue or other body parts, chest pain, wheezing or breathing difficulties, feeling faint especially when standing up, unexplained fever)
- kidney problems (changes in the amount and colour of urine you pass leading to back pain, fever, pain when urinating, blood in urine and changes in the blood test)
- pancreatitis (severe stomach pain)
- irregular or slow heartbeat
- liver problems (Ex. hepatocellular, cholestatic or mixed hepatitis), with or without yellowing of skin or eyes
How To Manage Side Effects
Diarrhoea:
Drink lots of fluids such as water or fruit juices so that you are sufficiently hydrated. If symptom persists, contact your doctor.
Nausea:
Take PEPTIRAN with or just after meals. Stick to simple meals. Avoid eating oily or spicy foods. If symptom persists, contact your doctor.
Vomiting:
Get adequate rest. Drink lots of fluids, especially water. Have small sips if you feel sick. Eat when you feel like it – no need to eat or avoid any specific foods. If symptom persists, contact your doctor.
Constipation:
Have enough fiber rich foods like fresh fruits, vegetables, cereals and drink ample amount of water. Exercise more regularly. If symptom persists, contact your doctor.
Stomach pain:
Try to rest and relax. Try to eat smaller meals in small breaks or eat and drink slowly. Keep a heat pad on your stomach. If symptom persists, contact your doctor.
Skin rash:
Avoid hot showers as it can further irritate your skin. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin. If symptom persists, contact your doctor.
Warning & Precautions
Pregnancy
PEPTIRAN is not recommended for use in pregnant women unless considered clearly necessary. Consult your doctor before taking it.
Breastfeeding
PEPTIRAN is not recommended for use in breastfeeding women unless considered clearly necessary. Consult your doctor before taking it.
Driving and Using Machines
PEPTIRAN might affect your ability to drive or use machines. Consult your doctor if you feel any side effect during management with PEPTIRAN that may stop you from driving or using machines.
Kidney
PEPTIRAN should be used with caution in patients having impaired kidney function. Consult your doctor before taking it.
Liver
PEPTIRAN should be used with caution in patients having liver dysfunction. Consult your doctor before taking it.
Allergy
Do not take PEPTIRAN if you are allergic to Ranitidine or any other ingredients of this medicine.
Lungs
PEPTIRAN should be taken with caution in patients having lung disease. Consult your doctor before taking it.
Heart Disease
PEPTIRAN should be used with caution in patients having heart failure or surgery. Consult your doctor before taking it.
Others
Before taking PEPTIRAN, inform your doctor if you have:
- a history of stomach ulcers
- stomach cancer
- acute porphyria (a rare genetic condition)
- diabetes (high blood sugar)
- problems with your immune system
Use in paediatrics:
Your doctor will prescribe the right dose of PEPTIRAN depending on age, body weight and health condition of your child (3 to 11 years old). Safety and effectiveness of PEPTIRAN in babies (below 1 month of age) have not been established. Consult your child’s doctor for advice.
Use in geriatrics:
PEPTIRAN should be used with caution in elderly patients (aged above 65 years). Consult your doctor before taking it.
Interactions
A. Drug - Drug interactions:
Before taking PEPTIRAN, inform your doctor if you are taking any of the following medicines:
- medicines used to reduce pain and inflammation (Ex. aspirin, ibuprofen, naproxen)
- lidocaine (used to make you feel insensitive to pain)
- medicines used to manage heart problems (Ex. propranolol, procainamide, n-acetylprocainamide)
- diazepam (used for worrying or anxiety problems)
- phenytoin (used to manage fits)
- theophylline (used to manage breathing problems)
- warfarin (used to manage blood clots)
- glipizide (used to control blood glucose levels)
- medicines used to manage HIV infection (Ex. atazanavir, delavirdine)
- gefitinib (used in lung cancer management)
- ketoconazole (used to manage thrush)
- sucralfate (used to manage intestinal ulcers)
- medicines used to produce sleepiness and drowsiness during surgeries or to manage insomnia (Ex. midazolam, triazolam)
Overdosage:
If you or anyone else accidentally took too much of PEPTIRAN, consult your doctor immediately or visit any nearby hospital. Symptoms of overdose include low blood pressure and abnormal walking pattern (gait).
Synopsis
| Drug | : | Ranitidine |
| Pharmacological Category | : | H2 receptor antagonist |
| Therapeutic Indication | : | Peptic ulcer, Indigestion |
| Dosage Forms | : | Tablet, Capsule, Injection, Liquid, Oral solution, Syrup |
More Information
- Keep PEPTIRAN out of reach of children
- Store PEPTIRAN below 25°C
FAQs About PEPTIRAN
Is PEPTIRAN good for acid reflux?
Yes. PEPTIRAN heals and stops problems caused by acid in the food pipe or too much acid in the stomach and thus relieves acid reflux or heartburn. Consult your doctor for further queries.
Can I take PEPTIRAN before an operation?
Before undergoing any operation, inform your doctor if you are taking PEPTIRAN. This is because the doctor or surgeon can give you midazolam to make you fall asleep before operation and it can interact with PEPTIRAN. Consult your doctor for further queries.
What if I forget to take a dose of PEPTIRAN?
If you forgot a dose of PEPTIRAN, try to take it as soon as you notice. However, if the time for next dose is closer, skip the missed dose and do not take double dose.
Can PEPTIRAN cause erectile dysfunction?
Certain acid reflux medicines (H2 blockers) can also affect histamine and cause erectile dysfunction. Whereas some medicines of this class have the highest risk for ED, PEPTIRAN have a lower risk. Consult your doctor for further queries.
Can I stop taking PEPTIRAN on my own?
If you suddenly stop taking PEPTIRAN, the pain and discomfort that existed before the management may return. It is always better to consult your physician before stopping the medicine, even if you feel better.
References
Is PEPTIRAN good for acid reflux?
Yes. PEPTIRAN heals and stops problems caused by acid in the food pipe or too much acid in the stomach and thus relieves acid reflux or heartburn. Consult your doctor for further queries.
Can I take PEPTIRAN before an operation?
Before undergoing any operation, inform your doctor if you are taking PEPTIRAN. This is because the doctor or surgeon can give you midazolam to make you fall asleep before operation and it can interact with PEPTIRAN. Consult your doctor for further queries.
What if I forget to take a dose of PEPTIRAN?
If you forgot a dose of PEPTIRAN, try to take it as soon as you notice. However, if the time for next dose is closer, skip the missed dose and do not take double dose.
Can PEPTIRAN cause erectile dysfunction?
Certain acid reflux medicines (H2 blockers) can also affect histamine and cause erectile dysfunction. Whereas some medicines of this class have the highest risk for ED, PEPTIRAN have a lower risk. Consult your doctor for further queries.
Can I stop taking PEPTIRAN on my own?
If you suddenly stop taking PEPTIRAN, the pain and discomfort that existed before the treatment may return. It is always better to consult your physician before stopping the medicine, even if you feel better.
Useful Diagnostic Tests
- Urea breath test
- Upper GI endoscopy
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