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Introduction About PANOZ D TABLET
PANOZ D TABLET is used to manage peptic ulcers, gastroesophageal reflux disease (GERD) and reflux esophagitis. It is a combination of Domperidone and Pantoprazole which belongs to the group of medicines called Prokinetic Drugs and Proton pump inhibitors respectively. PANOZ D TABLET acts by reducing the production of gastric acid. It also speeds up the movement of food from the stomach to the intestines, thereby reducing the signs of nausea, vomiting and acid reflux. Due to these actions, it can also reduce the unpleasant signs of GI tract such as nausea, vomiting, indigestion, burping, bloating, acidity or heartburn.
It should be taken at least 15-30 minutes before meals. During management with PANOZ D TABLET your doctor will closely monitor your kidney functions, liver functions and blood magnesium levels to avoid the risk of unwanted side effects. Before taking PANOZ D TABLET inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have any blockage or tears in the gut or have weak bones.
PANOZ D TABLET is not recommended for use in patients bleeding from the gut. Consult your doctor before taking PANOZ D TABLET if you are pregnant or breastfeeding. The most common side effects are dryness of mouth, constipation and flatulence. Consult your doctor if any of these side effect bothers you. You must also inform your doctor immediately if you experience any signs of low magnesium levels in blood (such as tiredness, abnormal muscle movements, dizziness, confusion, disorientation, irregular heartbeat).
Uses Of PANOZ D TABLET
It is used to manage:
- Peptic ulcer
- Gastrointestinal Reflux disease (GERD)
- Reflux esophagitis (inflammation of the esophagus)
- Nausea and Vomiting
- Acidity, Heartburn
- Signs of indigestion (such as burping, bloating)
How PANOZ D TABLET Works
PANOZ D TABLET contains Domperidone and Pantoprazole. Domperidone is a prokinetic medicine with anti-emetic properties which works by blocking the actions of a chemical messenger called dopamine in the gut and across the brain and spinal cord. This action stimulates the gut, reduces acid reflux and speeds up the movements of food from the stomach into the intestines. It also blocks the transmission of nerve signals between the vomiting centers and brain which reduces the onset of nausea and vomiting. Pantoprazole reduces gastric acid secretion by the blocking the actions of a protein membrane called H+K+Atpase (proton pump) present in the lining of the stomach. By reducing stomach acid production, PANOZ D TABLET it manages the worsening of ulcers, heals the existing ulcers and esophageal lesions and provides relief from the unpleasant symptoms of GI tract (such as acidity, bloating, burping and indigestion).
How to use PANOZ D TABLET
- Take PANOZ D TABLET 15-30 minutes before meals or as advised by your physician
- Swallow the medicine with a glass of water. Do not crush or chew the medicine
- Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition
- Do not stop taking PANOZ D TABLET unless your doctor advice you to stop
Side Effects Of PANOZ D TABLET
Common side effects of PANOZ D TABLET:
- benign polyps in the stomach
- dry mouth
- headache, dizziness, drowsiness
- diarrhea, constipation, stomach pain, flatulence
Stop taking PANOZ D TABLET and inform your doctor immediately if you experience any of the following side effects such as:
- severe allergic reactions (such as skin rash, itching, swelling of the lips, face or body and difficulty in breathing or swallowing)
- signs of liver problems (yellowing of the skin and eyes, dark urine and tiredness)
- severe skin reactions (such as redness, blistering, peeling of skin and bleeding in the lips, eyes, mouth, nose and genitals with fever)
- signs of kidney problem (such as lower back pain, painful urination)
- signs of low magnesium levels in blood (such as tiredness, abnormal muscle movements, dizziness, confusion, disorientation, irregular heartbeat)
- severe, persistent diarrhea
- fast or irregular heartbeat, difficulty in breathing, feeling faint
- fits
- uncontrollable body movements (including eye and tongue), twisted neck and abnormal body posture
Warning & Precautions
Pregnancy
Monitoring requiredPANOZ D TABLET should be used in pregnant women only if it is considered necessary by the physician.
Breastfeeding
Monitoring requiredPANOZ D TABLET may pass through breast milk. Therefore, it should be used in breastfeeding women only if it is considered necessary by the physician.
Driving and Using Machines
Use with CautionPANOZ D TABLET does not affect your ability in driving or handling heavy tools or machines. However, do not drive or handle heavy tools or machines if your ability is affected by the medicine.
Alcohol
Consult your doctorAvoid consumption of alcohol while taking PANOZ D TABLET, as it could aggravate your existing condition.
Kidney
Use with CautionPANOZ D TABLET should be used with caution in patients with kidney problems.
Liver
Consult your doctorPANOZ D TABLET is not recommended for use in patients with moderate or severe liver impairment. It should be used with caution in patients with other mild liver problems.
Allergy
ContraindicatedDo not take PANOZ D TABLET if you are allergic to Domperidone, Pantoprazole or to any other ingredients of this medicine.
Heart Disease
ContraindicatedPANOZ D TABLET is not recommended for use in patients with heart problems such as prolongation of QT interval or congestive heart failure.
Use In Pediatrics
ContraindicatedPANOZ D TABLET is not recommended for use in children and adolescents (aged below 18 years).
Use In Geriatrics
Use with CautionPANOZ D TABLET should be used with caution in elderly patients (aged 65 years and above).
Others
PANOZ D TABLET is not recommended for use if you:
- have bloody stools or bleeding in the gut
- have blockage or tear in the intestines
- have severe fluid or electrolyte disturbances
- have prolactinoma (a non-cancerous tumor of pituitary gland)
- have low blood potassium or magnesium levels
Before taking PANOZ D TABLET inform your doctor if you:
- have osteoporosis
- have vitamin B12 deficiency (sore tongue, mouth ulcers, pale skin, depression)
- are going to test Chromogranin A level
Interactions
A. Drug-Drug interactions:
Before taking PANOZ D TABLET inform your doctor if you are taking any of the following medicines such as:
- Aminobenzamides (Ex. cisapride, dolasetron, prucalopride, diphemanil)
- Cardiac glycosides (Ex. digoxin, apomorphine, disopyramide, hydroquinidine, quinidine, amiodarone, dofetilide, dronedarone, ibutilide, sotalol, diltiazem or verapamil)
- Anti-viral agents (Ex. atazanavir, nelfinavir, saquinavir, telaprevir)
- Antifungal (Ex. ketoconazole, itraconazole, posaconazole)
- Anti-coagulants (Ex. warfarin, phenprocoumon)
- Antipsychotics (Ex. haloperidol, pimozide, sertindole)
- Antidepressants (Ex. escitalopram or citalopram, fluvoxamine, St John’s wort)
- Antibiotics (Ex. moxifloxacin, erythromycin, levofloxacin, clarithromycin, telithromycin or amoxicillin)
- Phenanthrene class (Ex. halofantrine, lumefantrine)
- Antihistamines (Ex. mizolastine, mequitazine)
- Anti-cancer agents (Ex. toremifene, vandetanib, vincamine, erlotinib, dasatinib, nilotinib)
- Antimetabolites (Ex. methotrexate)
- Anti-arrhythmic (Ex. bepridil)
- Opiate (narcotic) analgesics (Ex. methadone)
- Iron salts
- Immunosupressants (Ex. tacrolimus or mycophenolate mofetil)
- Anti-infective (Ex. pentamidine)
- Anti-TB agents (Ex. rifampicin)
Overdosage:
If you or anyone else accidentally took more PANOZ D TABLET, contact your doctor immediately or go to a hospital straight away. Symptoms of overdosage might include sleepiness, confusion, uncontrollable body movements (including eye and tongue), twisted neck and abnormal body posture.
Synopsis
| Drug | : | Domperidone, Pantoprazole |
| Pharmacological Category | : | Dopamine D2 antagonists, Proton-pump inhibitors |
| Therapeutic Indication | : | Peptic ulcer, GERD, Reflux esophagitis |
| Dosage Forms | : | Tablet, Capsule |
More Information
FAQs About PANOZ D TABLET
Q: What is PANOZ D TABLET used for?
A: PANOZ D TABLET is used to manage peptic ulcers, GERD and reflux esophagitis. It can also be used to manage nausea, vomiting, bloating, burping, acidity and heartburn.
Q: How and when to take PANOZ D TABLET?
A: Take PANOZ D TABLET at least 15-30 minutes before meals. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Q: How long should I take PANOZ D TABLET?
A: You need to take PANOZ D TABLET for the stipulated duration prescribed by your doctor. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Q: What is the best time to take PANOZ D TABLET?
A: PANOZ D TABLET must be taken before meals to avoid gastrointestinal side effects.
Q: What to do if I forgot to take a dose of PANOZ D TABLET?
A: If you forgot to take a dose of PANOZ D TABLET, take it as soon as you remember. However, if it is time for the next dose of PANOZ D TABLET, skip the missed dose and take the next one regularly.
Q: What are the most common side effects of taking PANOZ D TABLET?
A: The most common side effects are dryness of mouth, constipation and flatulence. Consult your doctor if any of these side effect bothers you.
Q: Will taking a higher dose of PANOZ D TABLET be more effective?
A: No, taking a higher dose of PANOZ D TABLET will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
Q: What precautions do I need to follow while taking PANOZ D TABLET?
A: Make sure to take PANOZ D TABLET 30 minutes before meals. Before taking PANOZ D TABLET inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have any blockage or tears in the gut or have weak bones.
Q: Can I take medication for high blood pressure along with PANOZ D TABLET?
A: It is not advisable to take medicines to control blood pressure while taking PANOZ D TABLET without consulting your doctor as they have known interactions with the medicine.
Q: Can PANOZ D TABLET be used in pregnant women?
A: PANOZ D TABLET should be used in pregnant women only if it is considered necessary by the physician.
Q: Can PANOZ D TABLET cause constipation?
A: Yes. Constipation is a common side effect of using PANOZ D TABLET. Eat plenty of fiber rich foods such as fresh fruits, vegetables, cereals as well as drink plenty of water and exercise more regularly when taking this medicine. Contact your doctor if this side effect bothers you.
Q: Can PANOZ D TABLET cause dry mouth?
A: Yes. Dry mouth is a common side effect of using PANOZ D TABLET. Contact your doctor if this side effect bothers you.
References
1. KD. Tripathi. Antiemetic, Prokinetic and Digestant drugs & Drugs for Peptic Ulcer and Gastroesophageal Reflux Disease. Essentials of medical pharmacology. Seventh edition. 2013. Page – 666 & 653.
2. Nur Fathurah Zamani, Afifah Sjamun Sjahid, Tuan Hairulnizam Tuan Kamauzaman, Yeong Yeh Lee and Md Asiful Islam. Efficacy and Safety of Domperidone in Combination with Proton Pump Inhibitors in Gastroesophageal Reflux Disease: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. Journal of Clinical Medicine. August 2022. [Accessed on 21st October 2022] click here
3. Cipla Ltd. NEW PANTOSEC D SR Capsules (Pantoprazole Gastro-resistant + Domperidone Prolonged Release Capsules IP). Ciplamed.com. [Revised in April 2020] [Accessed on 21st October 2022] click here
4. Panacea Biotec Limited. OD-PEP-D CAPSULES. [Revised in July 2019]. [Accessed on 21st October 2022] click here
5. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in March 2021]. [Accessed on 21st October 2022] click here
6. Takeda GmbH. Electronic Medicines Compendium (EMC). [Revised in April 2022]. [Accessed on 21st October 2022] click here
7. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in November 2021]. [Accessed on 21st October 2022] click here
8. Leeford Healthcare Ltd. Pantafol-D. [Accessed on 21st October 2022] click here
9. Hetero Healthcare Ltd. Pantin RD Tablet. [Accessed on 21st October 2022] click here
10. Central Drugs Standard Control Organization. Pantoprazole+Domperidone SR. [Revised in December 2004] [Accessed on 21st October 2022] click here
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