Panlipase 25000 Capsule 10'S

Introduction About PANLIPASE 25000IU CAPSULE

PANLIPASE 25000IU CAPSULE contains Pancreatin which belongs to the group of medicines called Gastrointestinal agents. It is used to manage exocrine pancreatic enzyme insufficiency, pancreatitis (swelling of pancreas), flatulence, cystic fibrosis, moderate indigestion in diabetes and irritable bowel syndrome (intestinal disorder). The medicine is also indicated for use as digestive aid, and in pancreas removal.

PANLIPASE 25000IU CAPSULE is not recommended if you are allergic to Pancreatin. Before taking PANLIPASE 25000IU CAPSULE, inform your doctor if you have kidney problems (such as renal impairment), and/or liver problems (such as hepatic impairment). It should be used with caution during pregnancy and in women planning for pregnancy. It is safe to use in breastfeeding women.

The medicine should be used with caution in children and adolescents (aged below 18 years) and in elderly patients (aged above 65 years) after consulting the doctor. Common side effects of taking PANLIPASE 25000IU CAPSULE are stomach pain, bloating, nausea, vomiting, diarrhea, and/or constipation.

Uses Of PANLIPASE 25000IU CAPSULE

Used in:

• People with insufficient pancreatic enzyme production
• Individuals with cystic fibrosis or pancreatic disorders
• Patients requiring digestive support after gastrointestinal surgeries

Benefits of PANLIPASE 25000IU CAPSULE

• Supports Digestion: Helps break down dietary fats, proteins, and carbohydrates in individuals with pancreatic enzyme deficiency, improving nutrient absorption.
• Manages Pancreatic Enzyme Insufficiency: Aids in managing symptoms related to insufficient pancreatic enzymes due to conditions like chronic pancreatitis, cystic fibrosis, or pancreas removal.
• Enhances Nutritional Status: By improving digestion, it helps reduce malabsorption-related issues like weight loss, nutrient deficiencies, and fatigue.
• Relieves Digestive Symptoms: Can help alleviate bloating, indigestion, flatulence, and fatty stools associated with enzyme deficiency.
• Improves Quality of Life: Supports better overall digestive health, allowing individuals to eat a more normal diet with less discomfort.

How PANLIPASE 25000IU CAPSULE Works

• Provides Digestive Enzymes: Contains pancreatin, which is a mixture of natural digestive enzymes including lipase, protease, and amylase.
• Breaks Down Fats, Proteins, and Carbohydrates: These enzymes catalyze the hydrolysis of fats into glycerol and fatty acids, proteins into amino acids, and starch into dextrins and sugars.
• Facilitates Nutrient Absorption: By breaking down food into simpler molecules, it aids in their absorption in the intestine.
• Replenishes Deficient Enzymes: Acts as a replacement therapy in conditions where the pancreas fails to produce enough enzymes, such as cystic fibrosis, chronic pancreatitis, or after pancreatic surgery.
• Supports Proper Digestion: Ensures proper digestion of fats, proteins, and carbohydrates, thereby reducing symptoms like bloating, diarrhea, or malnutrition related to enzyme deficiency.

How to use PANLIPASE 25000IU CAPSULE

How to Use the Capsule Correctly

• Take the capsule during or immediately after a meal or snack with plenty of water.
• Swallow the capsule whole; do not crush or chew it as this may reduce effectiveness and cause irritation.
• If using granules, do not crush; they can be mixed with acidic foods like apple sauce or orange juice and consumed right away.

Dosage Guidelines

• The exact dose depends on your condition, body weight, and doctor's prescription.

• Typical dosing is based on pancreatic enzyme insufficiency severity, frequently requiring adjustment over time.
• Continue taking the medicine regularly as advised by your healthcare provider, even if symptoms improve.

When to Take Panlipase: Timing with Meals and Snacks

• Always take Panlipase with meals or snacks to ensure enzymes mix well with food for optimal digestion.
• Avoid taking on an empty stomach to stop irritation and reduce effectiveness.
• Maintain consistent timing relative to food intake to maximize benefits.

Important Administration Tips

• Do not mix granules with non-acidic liquids or food, which can cause irritation or alter effectiveness.
• Avoid inhaling powder from crushed capsules as it can cause respiratory irritation.
• Inform your doctor about other medications you take to avoid interactions.

Duration and Frequency of Use

• Use this medicine for as long as your doctor recommends; this could be long-term or lifelong in some cases.
• Regular medical follow-up is essential to assess dosage adequacy and effectiveness.

Panlipase Capsule and Food: What You Should Know

• Avoid oily, spicy foods, and sugary snacks to reduce digestive discomfort.
• Maintain a balanced diet with frequent small meals if advised by your healthcare provider.
• Hydration is important; drink plenty of water along with medication to facilitate digestion

What if I forgot to take PANLIPASE 25000IU CAPSULE

• Take the missed dose as soon as you remember if it is close to meal time. 
• If it is almost time for the next dose, skip the missed one.
• Do not double the dose to make up for a missed one.

Overdose

If you or anyone else accidentally take too much of PANLIPASE 25000IU CAPSULE, consult your doctor immediately or visit the nearby hospital. Symptoms include hyperuricosuria (condition marked by increased excretion of uric acid in urine) and hyperuricemia (high uric acid level in blood).

Side Effects Of PANLIPASE 25000IU CAPSULE

Common

• Stomach pain
• bloating
• Nausea
• Vomiting
• Diarrhea
• constipation

When to consult a doctor?

• Severe abdominal pain, unusual abdominal symptoms
• Signs of allergic reaction such as rash, wheezing, breathlessness, swollen eyelids, face/lips

How To Manage Side Effects

Constipation

• Stay Hydrated: Drink plenty of water daily to help soften stools and support bowel movements.
• Increase Fiber Intake: Include more high-fiber foods such as fruits, vegetables, and whole grains in your diet to promote regularity.
• Exercise Regularly: Physical activity encourages intestinal motility and can reduce constipation.
• Use Laxatives if Needed: If constipation persists, talk to your healthcare provider about safe over-the-counter laxatives or stool softeners.
• Do Not Ignore the Urge: Responding promptly to bowel urges helps to control constipation buildup.
• Consult Your Doctor: Persistent or severe constipation should be reported to your doctor, as dosage adjustment or additional interventions may be necessary.

Nausea And Vomiting

• Stay Hydrated: Drink plenty of water throughout the day to stay hydrated, which can ease nausea.
• Eat Small, Frequent Meals: Instead of large meals, opt for smaller, more frequent meals to reduce nausea and maintain energy.
• Avoid Strong Odors and Greasy Foods: These can trigger or worsen nausea and should be limited.
• Rest and Relax: Resting in a comfortable position and avoiding sudden movements may help reduce nausea symptoms.
• Consult Your Doctor: If nausea is persistent, severe, or accompanied by other symptoms like vomiting or abdominal pain, inform your healthcare provider promptly. They might adjust your dose or suggest anti-nausea medications.

Warning & Precautions

Pregnancy

Use with Caution

PANLIPASE 25000IU CAPSULE should be used with caution during pregnancy and in women planning for pregnancy.

Breastfeeding

Consult your doctor

PANLIPASE 25000IU CAPSULE is safe to use in breastfeeding women. Consult your doctor before taking the medicine.

Driving and Using Machines

Use with Caution

PANLIPASE 25000IU CAPSULE is unlikely to affect your ability to drive or operate machines. Consult your doctor before taking PANLIPASE 25000IU CAPSULE.

Kidney

Use with Caution

PANLIPASE 25000IU CAPSULE should be used with caution in patients with kidney problems such as renal impairment. Consult your doctor before taking the medicine.

Liver

Use with Caution

PANLIPASE 25000IU CAPSULE should be used with caution in patients with liver problems such as hepatic impairment. Consult your doctor before taking the medicine.

Allergy

Contraindicated

Do not take PANLIPASE 25000IU CAPSULE if you are allergic to Pancreatin or any other ingredients of this medicine.

Use In Pediatrics

Use with Caution

PANLIPASE 25000IU CAPSULE should be used with caution children and adolescents (aged below 18 years). Your doctor will decide the correct dose and duration for the child depending on child’s age, body weight and disease condition.

Use In Geriatrics

Use with Caution

PANLIPASE 25000IU CAPSULE should be used with caution in elderly patients (aged above 65 years).  Consult your doctor before taking it.

Safety Advice

• Avoid taking this medicine simultaneously with antacids; maintain proper timing around meals.
• Inform your healthcare provider of all current medications to avoid drug interactions.
• Stop use and seek medical attention if you experience severe abdominal pain, allergic reactions (rash, swelling, breathing difficulties), or other unusual symptoms.
• Do not use if allergic to pancreatin or any capsule ingredients, including animal-derived components.
• Avoid alcohol or consult your doctor as safety with alcohol is uncertain.

Diet and Lifestyle Advice

Diet Tips

• Eat small, frequent meals to ease digestion and optimize enzyme effectiveness.
• Include easily digestible foods low in fat and avoid greasy, fried, and spicy items that can worsen symptoms.
• Incorporate enough fruits, vegetables, and fiber to support gut health, but introduce fiber gradually.
• Stay well-hydrated by drinking plenty of water throughout the day to aid digestion.
• Avoid excessive sugar and alcohol, which may irritate the digestive system or interfere with medication.

Lifestyle Tips

• Follow a consistent medication schedule, taking it with every meal or snack requiring enzyme support.
• Maintain a healthy weight through balanced nutrition and regular physical activity.
• Manage stress with relaxation techniques like meditation, yoga, or deep breathing, as stress can affect digestive functions.
• Avoid smoking, as it can impair pancreatic function and worsen digestive issues.
• Schedule regular medical check-ups to monitor your digestive health and adjust therapy as needed.

Drug - Drug interaction

• Multivitamins and Folic Acid: Panlipase may decrease the absorption of folic acid and iron. Avoid taking these supplements simultaneously without medical advice.
• Antiplatelet Drugs: Use caution when taking with drugs like aspirin, clopidogrel, as interactions may alter effectiveness.
• Proton Pump Inhibitors (PPIs): Medicines such as omeprazole and pantoprazole may interact; consult your healthcare provider for monitoring and dose adjustments.
• Inform Healthcare Providers: Always inform your doctor about all medications, supplements, and herbal products you are using to avoid potential interactions.
• Safety in Special Conditions: Use caution if you have kidney or liver problems, and consult your doctor regarding safety during pregnancy and breastfeeding.
• Avoid Simultaneous Use with Antacids: To maximize effectiveness, avoid taking antacids at the same time as Panlipase.

Synopsis

More Information

Did you know these interesting facts about Panlipase 25000IU Capsule?

• Panlipase contains pancreatin, a natural blend of digestive enzymes like lipase, protease, and amylase derived from pork pancreas.
• It was developed to help individuals with pancreatic enzyme insufficiency caused by diseases like cystic fibrosis, chronic pancreatitis, or pancreas removal.
• Panlipase was approved as an enzyme replacement therapy to aid digestion when the pancreas does not produce enough enzymes.
• The enzymes in Panlipase break down fats, proteins, and carbohydrates into simpler molecules for easier nutrient absorption.
• Long-term use may be necessary for chronic conditions to ensure proper digestion and nutrient uptake.
• It may reduce absorption of folic acid and iron, so they should be taken with an appropriate gap.
• Proper use can significantly improve quality of life for patients with enzyme deficiency by reducing digestive symptoms and improving nutrition.

Alternatives to Panlipase 25000IU Capsule

• CREON 25000 CAPSULE
• Pankreoflat Tablet

FAQs About PANLIPASE 25000IU CAPSULE

Q: What does Panlipase 25000IU Capsule help with?

A: Panlipase 25000IU Capsule is a pancreatic enzyme supplement that helps individuals who have a deficiency of natural pancreatic enzymes digest fats, proteins, and carbohydrates more effectively. It is used in conditions like pancreatic insufficiency, chronic pancreatitis, cystic fibrosis, and after pancreatic surgery.

Q: How does Panlipase 25000IU Capsule work?

A: It provides digestive enzymes (lipase, protease, amylase) that break down food into simpler molecules that the body can absorb, supporting proper digestion and nutrient absorption.

Q: How should I take Panlipase 25000IU Capsule?

A: Take the capsule during or immediately after meals or snacks with plenty of water. Do not crush or chew the capsule. If you have difficulty swallowing capsules, granules inside the capsule can be mixed with acidic foods like apple sauce or juice without chewing.

Q: What are the common side effects?

A: Some common side effects include stomach pain, bloating, nausea, vomiting, diarrhea, and constipation. If any side effects worsen or are persistent, consult your doctor.

Q: Are there any precautions?

A: Inform your doctor if you have allergies, gout, asthma, diabetes, or other medical conditions. Do not take Panlipase simultaneously with antacids. Discuss usage if pregnant or breastfeeding.

Q: What if I miss a dose?

A: Take the missed dose as soon as you remember if it is close to mealtime. If it is almost time for your next dose, skip the missed one. Do not double the dose.

Q: Can Panlipase 25000IU Capsule be used long term?

A: Yes, many patients require long-term or lifelong enzyme supplementation. Regular medical follow-up is needed for dosage adjustment and monitoring.

Q: Can Panlipase interfere with other medications?

A: Panlipase may reduce absorption of folic acid and iron, so maintain a gap when taking these supplements. Always inform your healthcare provider about all medicines you are taking.

References

1. K.D. Tripathi. Antiemetic, Prokinetic and Digestant Drugs. Seventh edition. 2013. Page – 670.

2. Priyanka Venkatesh, Anup Kasi. Pancrelipase Therapy. NIH National Library of Medicine. National Center for Biotechnology Information. StatPearls [Internet].  July 2022.  [Accessed on 7th November 2025] 

3. Didier Rémond, Danit R. Shahar, Doreen Gille, Paula Pinto, Josefa Kachal, Marie-Agnès Peyron, Claudia Nunes Dos Santos, Barbara Walther, Alessandra Bordoni, Didier Dupont, Lidia Tomás-Cobos, and Guy Vergères. Understanding the gastrointestinal tract of the elderly to develop dietary solutions that prevent malnutrition. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. June 2015. [Accessed on 7th November 2025] 

4. Abbott Laboratories GmbH. Electronic Medicines Compendium (EMC). [Revised in November 2021] [Accessed 7th November 2025] 

5. INNOVATIVE PHARMACEUTICALS PVT LTD. Panzide 300 mg Capsules. [Accessed on 7th November 2025] 

6. Nutraceutical Corporation. Pancreatin Tablets 350 mg. [Accessed on 7th November 2025] 

7. Daxin Pharma Pvt. Ltd. PANKRIODAX TAB. [Accessed on 7th November 2025] 

8. Hetero Healthcare Limited. PANMATE CAPSULES. [Accessed on 7th November 2025] 

9. Piramal Pharma Solutions. Digeplex-T. [Accessed on 7th November 2025] 

10. Tidal Laboratories Pvt. Ltd. Enzox Plus. [Accessed on 7th November 2025] 

11. Torrent pharmaceuticals Ltd. ENZAR. [Revised on March 2020] [Accessed on 7th November 2025] 

Useful Diagnostic Tests

• Blood test
• Stool evaluation test
• Pancreatic Function test

Author Details

Written By Dr. Janet.C - Pharm.D

Reviewed For Accuracy By Dr. Vrushabhakumar Jitendra Shah. - MBBS

Last updated on 23 Jul 2024 | 11:51 AM(IST)