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Introduction About PALOTRON INJECTION
GBNKEYWORD] contains Palonosetron which belongs to a group of medicines called Serotonin antagonists. It is used to control nausea and vomiting that occurs as a result of chemotherapy (management of cancer). PALOTRON INJECTION is also used for Postoperative nausea and vomiting following surgery.
Inform your doctor before receiving PALOTRON INJECTION if you have or had heart diseases or a family history of heart diseases such as QT prolongation (changes in heartbeat) or congestive heart failure, slow heartbeat or conduction disturbances, acute bowel obstruction or chronic constipation or unmanageed electrolyte imbalances like potassium and magnesium in the blood.
PALOTRON INJECTION is not recommended for use in pregnancy unless clearly necessary as it is not known whether it may cause harm to the unborn baby. Contact your doctor before receiving it.
PALOTRON INJECTION should be used with caution as it is not known whether it may pass through the breast milk. Contact your doctor before receiving PALOTRON INJECTION.
PALOTRON INJECTION should not be used in children below 1 month of age for managing nausea and vomiting due to chemotherapy and safety and effectiveness have not been established in children under 18 years of age for managing postoperative nausea and vomiting after surgery. Contact your doctor before receiving PALOTRON INJECTION.
PALOTRON INJECTION should be used with caution in elderly patients aged above 65 years of age. Contact your doctor before receiving it.
The most common side effect of receiving PALOTRON INJECTION is a headache. Contact your physician if the symptoms worsen.
Uses Of PALOTRON INJECTION
Used:
- to control nausea and vomiting that occurs as a result of chemotherapy (management of cancer)
- for postoperative nausea and vomiting following surgery
How PALOTRON INJECTION Works
PALOTRON INJECTION blocks the action of serotonin, which induces nausea and vomiting (serotonin is a chemical that carries messages between nerve cells in the brain and throughout the body).
How to use PALOTRON INJECTION
PALOTRON INJECTION will be injected intravenously into your body only by your doctor or nurse. Your doctor will administer the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of PALOTRON INJECTION
Common
- headache (both in adults and children)
- dizziness
- constipation
- diarrhoea
- heart rhythm changes (QT prolongation) or slow heartbeat
Uncommon
- changes in blood pressure
- irregular heart rate or lack of blood flow to the heart
- widening or change in colour of veins
- changes in potassium levels in the blood
- increased levels of sugar in blood or urine
- low calcium levels in the blood
- increased bilirubin
- increased levels of liver enzymes
- anxiety
- difficulty sleeping
- loss of appetite
- weakness, tiredness and fever or flu-like symptoms
- skin numbness, burning, prickling, tingling, itchy skin or rashes
- eye irritation or impaired vision
- motion sickness
- tinnitus (ringing in the ear)
- hiccups, flatulence, dry mouth, indigestion, stomach ache
- difficulty in passing urine
- aching joints
- dizziness, jerky body movements, abnormal heart rate, cough and shortness of breath, nosebleed, hives, fever, pain at the injection site (in children)
Rare
Stop receiving PALOTRON INJECTION and contact your doctor immediately if you experience any of the following side effects:
- severe allergic reactions such as hives, swollen face, difficulty breathing, chest pain
How To Manage Side Effects
Constipation:
Eat plenty of fibre-rich foods such as fresh fruits, vegetables and cereals. Drink water and exercise regularly. Contact your doctor if constipation persists.
Headache:
Rest and relax. Drink plenty of water and electrolytes. Apply a pain-relieving balm on the head if needed. Do not consume alcohol. Contact your doctor if your headache worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating machinery if you feel dizziness. Avoid alcohol consumption as it aggravates dizziness. Contact your doctor if the dizziness worsens.
Stomach pain:
Try to rest and relax. Eat small meals but take them frequently. Keep a heating pad on your stomach. Contact your doctor if the stomach pain does not improve.
Indigestion:
Eat small meals but take them frequently. Eat and exercise regularly. Contact your doctor if indigestion persists.
Itchy skin:
Avoid hot showers because hot water can irritate the skin. Do not scratch the affected area. Use sunscreen and protective clothing when outdoors. Use moisturizers to soothe and hydrate the affected skin area. Contact your doctor if the itching worsens.
Diarrhoea:
Drink plenty of water or fruit juices to keep you hydrated. Do not take any medicine on your own to manage diarrhoea. Contact your doctor if diarrhoea worsens.
Warning & Precautions
Pregnancy
PALOTRON INJECTION is not recommended for use in pregnancy unless clearly necessary as it is not known whether it may cause harm to the unborn baby. Contact your doctor before receiving PALOTRON INJECTION.
Breastfeeding
It is not known whether PALOTRON INJECTION passes through breast milk, hence consult your doctor before receiving this medicine.
Driving and Using Machines
Do not drive or operate any machines if you feel dizziness or tiredness after receiving PALOTRON INJECTION.
Allergy
Do not receive PALOTRON INJECTION if you are allergic to Palonosetron or any other constituents of this medicine.
Heart Disease
PALOTRON INJECTION should be used with caution in patients with heart diseases or a family history of heart diseases such as QT prolongation (changes in heartbeat) or congestive heart failure, slow heartbeat and conduction disturbances. Contact your doctor before receiving PALOTRON INJECTION.
Others
Before receiving PALOTRON INJECTION tell your doctor if you have:
- acute bowel obstruction or chronic constipation
- improper balance of minerals such as potassium and magnesium in the blood (unmanageed)
Use in pediatrics:
PALOTRON INJECTION should not be used in children below 1 month of age for managing nausea and vomiting due to chemotherapy. Safety and effectiveness in children and adolescents below the age of 18 years have not been established for managing postoperative nausea and vomiting after surgery. Your doctor will administer the right dose depending on your child’s age and body weight and disease condition.
Use in geriatrics:
PALOTRON INJECTION should be used with caution in elderly patients aged above 65 years of age. Contact your doctor before receiving PALOTRON INJECTION.
Interactions
A. Drug-Drug Interactions:
Before taking this medicine, inform your doctor if you are taking any of the following medicine:
- medicines used to manage depression and anxiety (fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram, escitalopram, venlafaxine, moclobemide, mirtazapine duloxetine)
- medicines used in cardiac disorders (amiodarone, nicardipine, quinidine)
- moxifloxacin, lithium, erythromycin (medicines used for bacterial infections)
- medicines used for serious mental disorders (haloperidol, chlorpromazine, quetiapine, thioridazine)
- domperidone (used for managing nausea and vomiting)
- fentanyl, tramadol (medicines used for severe pain)
- intravenous methylene blue (medicines used to manage methemoglobinemia)
Overdosage:
PALOTRON INJECTION will be administered intravenously into your body by the doctor only so there is minimal chance of overdose. Symptoms of overdose are fits, gasping, pallor, cyanosis and collapse.
Synopsis
| Drug | : | Palonosetron |
| Pharmacological Category | : | Serotonin antagonist |
| Therapeutic Indication | : |
Nausea and vomiting in patients undergoing chemotherapy, Postoperative nausea and vomiting after surgery |
| Dosage Forms | : |
Tablet, Capsule, Injection |
More Information
- Keep PALOTRON INJECTION out of the sight and reach of children
- Store at room temperature
FAQs About PALOTRON INJECTION
What is PALOTRON INJECTION used for?
It is used in adults, adolescents and children (more than 1 month of age) to control nausea and vomiting that occurs as a result of chemotherapy (management of cancer). Contact your doctor before receiving PALOTRON INJECTION.
Does PALOTRON INJECTION cause constipation?
Yes, PALOTRON INJECTION may cause constipation. Eat fibre-rich foods such as vegetables, fresh fruits and cereals. Drink adequate water and exercise regularly. Contact your doctor if constipation persists.
Is PALOTRON INJECTION a steroid?
No, it is a selective 5-HT3 receptor antagonist prescribed for the management of nausea and vomiting caused due to cancer chemotherapy and postoperative nausea and vomiting after surgery.
What are the side effects of PALOTRON INJECTION?
The most common side effect of receiving PALOTRON INJECTION is a headache. Contact your physician if the symptoms worsen.
How do you give a PALOTRON INJECTION?
It is injected intravenously into your body only by your doctor or nurse. Your doctor will administer the correct dose depending on your age, body weight and disease condition.
References
1. KD Tripathi. Antiemetic, Prokinetic and Digestant Drugs. Essentials of Medical Pharmacology. Seventh Edition.2013 Page 669.
2. Matti S Aapro. Palonosetron as an anti-emetic and anti-nausea agent in oncology. Therapeutics and Clinical Risk Management. National Institute of Health. NLM. National Center for Biotechnology Information. PubMed Central. December 2007. [Accessed on August 4th 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2387285/
3. Bethesda (MD). Palonosetron. Drugs and Lactation Database (Lactmed). National Library of Medicine. 2006. [Revised in February 2015] [Accessed on August 5th 2022] https://www.ncbi.nlm.nih.gov/books/NBK567877/
4. Accord Healthcare Limited. UK. Electronic Medicines Compendium (EMC) Palonosetron Accord. [Revised on Apr 2021] [Accessed on 4th Aug 2022] https://www.medicines.org.uk/emc/files/pil.7235.pdf
5. Seacross Pharmaceuticals Limited. UK. Electronic Medicines Compendium (EMC). Palonosetron. [Revised on Jan 2021] [Accessed on 4th Aug 2022] https://www.medicines.org.uk/emc/files/pil.12627.pdf
6. Helsinn Birex Pharmaceuticals Ltd. Ireland. Aloxi 250mcg European Medical Agency (EMA). [Revised in March 2010] [Accessed on 4th Aug 2022] https://www.ema.europa.eu/en/documents/product-information/aloxi-epar-product-information_en.pdf
7. Fresenius Kabi. Austria. Palonosetron. U.S. Food & Drug Administration [Revised on Dec 2018] [Accessed on 4th Aug 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/208109s001lbl.pdf
8. Themiset 75mcg (Palonosetron). Themis medicare. [Accessed on 4th August 2022] https://www.themismedicare.com/products/therapeutic-products
Useful Diagnostic Tests
- Complete blood count
- ECG
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