Pacitane 2mg Tablet 30'S

Introduction About PACITANE 2MG TABLET

Pacitane 2mg Tablet is a commonly prescribed medicine containing Trihexyphenidyl, which belongs to the class of anticholinergic agents. It is often considered in situations where individuals experience involuntary body movements, muscle stiffness, or tremors, either due to certain neurological conditions or as side effects of psychiatric medications. Pacitane helps by restoring the balance of specific brain chemicals involved in motor control, offering support in managing physical discomforts that interfere with daily movement and coordination.

Pacitane 2mg is usually recommended for patients dealing with extrapyramidal symptoms such as rigidity, spasms, or tremors associated with Parkinsonism or due to certain antipsychotic therapies. It may also be beneficial in helping users improve body coordination and reduce stiffness caused by nervous system imbalances. The medicine is typically taken once or twice a day, preferably at the same time each day, and may be taken with or without meals, depending on individual tolerance. Taking it after food may help reduce the chances of stomach discomfort.

While taking Pacitane 2mg, patients are advised to follow a fixed dosing schedule and avoid abrupt discontinuation unless guided by a healthcare provider. Common precautions include staying hydrated, especially in hot weather, and being cautious during activities like driving, due to the possibility of drowsiness or blurred vision. Individuals with glaucoma, urinary retention, or certain heart conditions should inform their doctor before using this medicine. Monitoring is also important if taken alongside other neurological or psychiatric medications.

Use of Pacitane 2mg in pregnancy and breastfeeding should only be considered under the supervision of a medical professional. Some of the frequently observed side effects may include dry mouth, dizziness, blurred vision, or mild constipation. If these symptoms persist or worsen, a healthcare provider should be consulted for advice. This medicine is part of a carefully managed care plan, and patients are encouraged to maintain good hydration, a balanced diet, and a consistent physical activity routine to support better results during its use.

Uses Of PACITANE 2MG TABLET

• Reduce muscle stiffness and improve muscle control in patients with Parkinson’s disease
• Manage drug-induced abnormal involuntary muscle movements (such as extreme restlessness or muscle spasms)

Benefits of PACITANE 2MG TABLET

Pacitane 2mg for Stiffness

Pacitane 2mg may be advised to help reduce muscle stiffness linked to certain neurological or medicine-related conditions. It works by balancing specific brain chemicals that control muscle tone and movement. This can help improve flexibility and ease difficulty in body movement, especially when stiffness interferes with daily tasks. It is commonly included in long-term care plans involving neuromuscular coordination support.

Pacitane for Involuntary Body Movements

In some cases, Pacitane is used when individuals experience uncontrolled or jerky movements because of other medicines, such as antipsychotics. It helps manage these involuntary muscle movements by modifying nerve signals in the brain. This action helps in regaining better control over motor responses and reducing discomfort caused by sudden muscle activity.

Pacitane 2mg for Poor Muscle Coordination

Pacitane 2mg may be included in neurological care routines to support better coordination in people who have trouble with smooth, purposeful movements. It helps by relaxing overactive muscles and easing tension that interferes with controlled physical actions. As muscle control improves, patients may find better balance, posture, and coordination in regular movements like walking or writing.

How PACITANE 2MG TABLET Works

Pacitane 2mg Mechanism of Action

Pacitane 2mg contains Trihexyphenidyl, which belongs to a class of medicines called anticholinergics. It works by blocking the action of a natural chemical called acetylcholine in the brain. Acetylcholine plays a key role in regulating muscle movement. By reducing its effect, Pacitane helps restore the balance between brain chemicals, supporting smoother and more controlled muscle activity.

Role of Pacitane 2mg in Muscle Control

Pacitane 2mg is often included in care plans where individuals experience muscle stiffness, spasms, or tremors, particularly due to certain neurological conditions or medication effects. It supports muscle control by relaxing overly tense muscles and minimizing involuntary movements. This can lead to improved mobility and more coordinated motor function during daily activities.

Pacitane Effect on Nerve Signals and Coordination

Pacitane 2mg influences how nerve signals are transmitted in the brain and spinal cord. By regulating these signals, it helps reduce erratic or uncoordinated muscle responses. As a result, users may notice better movement coordination, balance, and reduced shakiness. This effect can be especially useful in managing symptoms related to neuromuscular imbalances.

How to use PACITANE 2MG TABLET

How to Take Pacitane 2mg

• Take Pacitane 2mg exactly as advised by your doctor.
• Swallow the tablet whole with a glass of water.
• Take it at the same time each day to maintain consistent levels.
• Do not crush or chew the tablet.
• Your dose may start low and increase gradually based on your response.
• Never change your dose without consulting your healthcare provider.

Should Pacitane 2mg Be Taken Before or After Meals?

• Pacitane 2mg may be taken with or without food, based on your doctor’s guidance
• Taking it after food can help reduce the chances of stomach upset
• Maintain a consistent routine preferably around the same time daily
• Avoid alcohol and caffeine as they may interfere with the medicine’s effect
• Stay well-hydrated and follow any specific meal timing suggested by your doctor

What if I forgot to take PACITANE 2MG TABLET

• Take it as soon as you remember, if it's not too close to your next scheduled dose
• Skip the missed dose if it’s almost time for the next one do not double up
• with your regular dosing schedule as advised
• Missing doses regularly may reduce the medicine’s effectiveness
• If you're unsure what to do, speak with your doctor or pharmacist
• To avoid missing future doses, set a daily reminder or alarm

Overdose

If you or anyone else accidentally took more PACITANE 2MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose might include anxiety, depression, and behavioural changes.

Side Effects Of PACITANE 2MG TABLET

Common side effects of PACITANE 2MG TABLET

• dry mouth
• constipation
• dizziness
• blurred vision
• nausea
• nervousness

When to Seek Medical Attention?

Stop taking PACITANE 2MG TABLET and contact your doctor immediately if you experience any of the following side effects:

• feeling restless, agitated, or confused
• delusion (false beliefs), hallucinations (seeing or hearing things that does not exist)
• difficulty in sleeping
• immediate or short-term memory loss
• worsening of myasthenia gravis (muscle pain or weakness)
• eye problems (dilated pupils, eye discomfort and increased sensitivity to light, eye pain)
• fast heartbeat
• fever, skin rash with redness or dryness
• inability to pass urine, feeling thirsty

How To Manage Side Effects

Constipation

• Drink a glass of warm water immediately after waking up in an empty stomach. And it helps to stimulates bowel movement and softens stool.
• Rich in natural fibre will acts as a mild natural laxative.
• Soak 5–6 raisins or 2 dried figs overnight; eat on an empty stomach in the morning.

Dizziness Or Drowsiness

• If dizziness occurs suddenly, lie down in a quiet, dark room and close your eyes.
• Ginger may support circulation and reduce queasy or lightheaded feelings.
• Sip on warm ginger tea or chew a small piece of raw ginger (if comfortable) once or twice a day.

Dry Mouth

• Mix 1 cup of warm water with ½ tsp of salt or baking soda.
• Use as a mouth rinse 2–3 times daily to maintain moisture and reduce oral irritation.
• Sip water frequently throughout the day. Keep a water bottle handy.
• Choose soft, moist meals (e.g., soups, stews, curd rice)

Nausea And Vomiting

• Smelling or sipping lemon juice in warm water can calm the stomach.
• Add honey if needed. Avoid if you have acidity.

Warning & Precautions

Pregnancy

Contraindicated

PACITANE 2MG TABLET is not recommended for use in pregnant women. Therefore, consult your doctor before taking it.

Breastfeeding

Contraindicated

PACITANE 2MG TABLET is not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if you feel dizzy after taking PACITANE 2MG TABLET.

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking PACITANE 2MG TABLET.

Kidney

Use with Caution

PACITANE 2MG TABLET should be used with caution in patients with kidney problems. Therefore, consult your doctor before taking it.

Liver

Use with Caution

PACITANE 2MG TABLET should be used with caution in patients with liver problems. Therefore, consult your doctor before taking it.

Allergy

Contraindicated

Do not take PACITANE 2MG TABLET if you are allergic to PACITANE 2MG TABLET.

Heart Disease

Use with Caution

PACITANE 2MG TABLET should be used with caution in patients with heart problems (such as high blood pressure). Therefore, consult your doctor before taking it.

Use In Pediatrics

Use with Caution

PACITANE 2MG TABLET should be used with caution in children and adolescents (below 18 years). Therefore, consult your doctor before taking it.

Use In Geriatrics

Use with Caution

PACITANE 2MG TABLET should be used with caution in elderly patients (aged 65 years or above). Therefore, consult your doctor before taking it.

Other Warnings for PACITANE 2MG TABLET

Before taking PACITANE 2MG TABLET, inform your doctor if you:

• have glaucoma (increased pressure in the eye)
• have problems in prostate gland
• have difficulty in passing urine
• have stomach ulcer, severe heartburn, acid indigestion or any other digestive disorders
• suffer from myasthenia gravis (muscle weakness)
• have tardive dyskinesia (unusual movements of the face and the tongue)

Safety Advice

• Take only as prescribed do not adjust the dose without medical advice
• Stay hydrated, as the tablet may reduce sweating and raise body temperature
• Inform your doctor if you’re on other neurological or psychiatric medicines
• Regular follow-ups are important to monitor your response and adjust the dose
• Report symptoms like confusion, fast heartbeat, or dry mouth that lasts too long

Diet and Lifestyle Advice

• Stay well-hydrated to reduce dryness in the mouth and maintain overall balance
• Include a fiber-rich diet to help with constipation, a possible side effect
• Eat light, balanced meals avoid heavy or oily foods that may cause stomach upset
• Limit caffeine and alcohol as they may worsen nervous system-related symptoms
• Follow a gentle physical activity routine (like walking or yoga) to support flexibility and movement
• Practice stress-reducing techniques such as breathing exercises or meditation to aid nervous system health
• Avoid prolonged sun exposure wear light clothes and sunglasses, as sweating may reduce on this medicine
• Maintain a consistent sleep routine to help regulate brain function and rest patterns
• If dry mouth persists, suck on sugar-free lozenges or chew gum (as advised by your doctor)

Drug - Drug interaction

1. Antipsychotics (e.g., Haloperidol, Risperidone, Olanzapine)

• Interaction: Pacitane is often co-prescribed with antipsychotics to manage extrapyramidal symptoms, but it may sometimes alter the effects of these medicines.
• Management: Use only under supervision. Dosage adjustments and regular monitoring for both therapeutic and side effects (e.g., confusion, restlessness) are recommended.

2. CNS Depressants (e.g., Benzodiazepines, Sleep Medicines)

• Interaction: May enhance drowsiness, dizziness, or confusion due to additive central nervous system depression.
• Management: Avoid operating heavy machinery. Doctors may lower the dose or adjust timing to minimize overlap.

3. Antihistamines (e.g., Diphenhydramine, Cetirizine)

• Interaction: Increased anticholinergic side effects like dry mouth, blurred vision, or constipation.
• Management: Patients should stay hydrated, monitor for excessive dryness or drowsiness, and consult before combining.

4. Tricyclic Antidepressants (e.g., Amitriptyline, Nortriptyline)

• Interaction: May cause increased risk of heat intolerance, dry mouth, and rapid heartbeat due to combined anticholinergic effects.
• Management: Dose modifications and monitoring are essential. Patients should avoid overheating and drink fluids regularly.

5. Monoamine Oxidase Inhibitors (MAOIs) (e.g., Selegiline)

• Interaction: Risk of increased stimulant-like effects or exaggerated anticholinergic action.
• Management: Close medical supervision advised. Not commonly combined unless clearly justified.

6. Levodopa (Used in Parkinson’s Disease)

• Interaction: Pacitane can complement Levodopa but may also increase the chances of involuntary movements or confusion.
• Management: Dose balancing is crucial. Regular follow-ups recommended to monitor for dyskinesia or mood changes.

7. Antacids (Containing Magnesium or Aluminium)

• Interaction: May reduce the absorption of Pacitane when taken together.
• Management: Keep a 1–2-hour gap between taking Pacitane and antacid medications.

Drug - Food interaction

1. High-Fat or Greasy Meals

• Interaction: May slow down the absorption of Pacitane, potentially reducing its effectiveness or delaying onset of action.
• Management: Prefer light, balanced meals. If you notice delayed effects, consult your doctor to adjust dosing time relative to meals.

2. Citrus Fruits (Especially Grapefruit)

• Interaction: Grapefruit and grapefruit juice may affect liver enzymes that break down medications, potentially altering Pacitane levels in the blood.
• Management: Avoid grapefruit and its juice while on Pacitane unless advised otherwise by your doctor. Orange juice is generally safe.

3. Caffeinated Beverages (Coffee, Tea, Cola)

• Interaction: May worsen side effects such as dry mouth, restlessness, or difficulty sleeping.
• Management: Reduce intake of caffeine-containing drinks. Drink water or herbal teas to stay hydrated and balance side effects.

4. Low-Fiber Diet

• Interaction: A low-fiber diet can worsen constipation, a known side effect of anticholinergic medicines like Pacitane.
• Management: Include fiber-rich foods (vegetables, fruits, whole grains) in your meals. Stay physically active and drink plenty of water.

Synopsis

Drug: Trihexyphenidyl

Pharmacological Category: Antimuscarinic agents

Therapeutic Indication: Abnormal muscle movements

Dosage Forms: Tablet, Injection

More Information

01)Pacitane 2mg vs Syndopa – Difference in Usage

Main Use:
Pacitane 2mg Tablet helps manage involuntary movements, particularly those caused by certain medications.
Syndopa Tablet is commonly used to manage symptoms associated with Parkinson’s disease.

Active Ingredient:
Pacitane contains Trihexyphenidyl.
Syndopa contains a combination of Levodopa and Carbidopa.

Mechanism of Action:
Pacitane works by balancing acetylcholine levels in the brain to help control muscle activity and reduce stiffness or tremors.
Syndopa works by increasing dopamine levels in the brain, helping improve movement control and reduce Parkinson’s symptoms.

Common Prescription For:
Pacitane is often prescribed for drug-induced tremors, stiffness, and muscle rigidity caused by psychiatric or neurological medicines.
Syndopa is mainly prescribed for Parkinson’s disease, tremors, and muscle rigidity related to dopamine deficiency.

Onset of Action:
Pacitane usually shows gradual improvement, and effects may be noticed over time.
Syndopa often provides noticeable improvement within a few days of starting treatment.

Common Side Effects:
Pacitane may cause dry mouth, dizziness, blurred vision, or mild drowsiness.
Syndopa may cause nausea, sleepiness, or involuntary movements in some patients.

Patient Suitability:
Pacitane is often used alongside psychiatric or neurological medications to control side effects such as tremors or stiffness.
Syndopa is typically used for patients with Parkinson’s disease or related movement disorders.

Dosage Frequency:
Pacitane dosage varies depending on the condition and is usually taken one to three times daily as prescribed.
Syndopa is generally taken two to four times a day based on the patient’s condition and medical advice.

02)Pacitane vs Amantrel – Which Suits Better for Tremors?

Active Ingredient:
Pacitane 2mg Tablet contains Trihexyphenidyl.
Amantrel Tablet contains Amantadine Hydrochloride.

Main Use:
Pacitane is commonly used to help control drug-induced tremors and stiffness.
Amantrel is often recommended for tremors and movement symptoms associated with Parkinson’s disease.

Mechanism of Action:
Pacitane works by blocking acetylcholine activity to reduce involuntary muscle movements and stiffness.
Amantrel helps increase dopamine release in the brain and blocks its reuptake, improving motor control.

Ideal For:
Pacitane is best suited for tremors linked to psychiatric or antipsychotic medication use.
Amantrel is often preferred for tremors in early-stage Parkinson’s disease and related conditions.

Effect on Tremors:
Pacitane may help reduce stiffness and tremors in certain neurological conditions.
Amantrel may ease tremors, improve movement, and reduce fatigue in Parkinson’s care.

Common Side Effects:
Pacitane may cause dry mouth, drowsiness, constipation, or blurred vision.
Amantrel may cause dizziness, swelling, sleep disturbances, or nervousness.

Dosing Frequency:
Pacitane is usually taken one to three times per day based on medical advice.
Amantrel is generally taken once or twice daily depending on the condition.

Special Notes:
Pacitane is often prescribed as part of combination therapy with other neurological or psychiatric medicines.
Amantrel may also help manage fatigue and movement-related symptoms in Parkinson’s treatment plans.

FAQs About PACITANE 2MG TABLET

Q: What is Pacitane 2mg Tablet used for?

A: Pacitane 2mg Tablet is used to treat symptoms of Parkinson’s disease, such as tremors, muscle stiffness and poor muscle control. It is also prescribed to manage movement disorders caused by certain medications, especially antipsychotic drugs.

Q: Can Pacitane cause constipation?

A: Yes, Pacitane can slow down digestion and may cause constipation. Drink plenty of water and eat fiber-rich foods. Ask your doctor for suitable remedies if needed.

Q: What precautions should I take while using Pacitane?

A: Inform your doctor about all health issues, especially glaucoma, urinary problems, or liver issues. Stay hydrated, avoid overheating, and follow up regularly.

Q: Can children use Pacitane 2mg?

A: Pacitane is generally not the first choice for children and is only given if advised by a doctor. It requires careful dose adjustment and close monitoring.

Q: Can Pacitane be used for mental health conditions?

A: Pacitane itself is not a psychiatric medicine but is used to manage movement side effects caused by certain mental health medicines. It supports better tolerance to long-term therapy.

Q: Does Pacitane help with muscle cramps or spasms?

A: Pacitane helps relax muscles in specific neurological conditions, but it is not a general medicine for muscle cramps. Your doctor will decide if it is suitable based on your condition.

Q: Can I take Pacitane with other medicines?

A: Always inform your doctor about any medicines you're taking. Some medicines, especially psychiatric or sleep-related ones, may interact with Pacitane. Your doctor will adjust doses if needed.

Q: Can Pacitane 2mg cause drowsiness?

A: Yes, Pacitane may cause drowsiness or dizziness in some people. Avoid driving or handling heavy machines until you know how the tablet affects you. Take care when combining it with other medicines that cause sleepiness.

Q: Can Pacitane 2mg be taken on an empty stomach?

A: It is better to take Pacitane after food, as this reduces chances of stomach discomfort. Taking it with meals also helps in better absorption and tolerance. If your doctor has advised otherwise, follow their instructions.

Q: How long does it take for Pacitane to show results?

A: You may notice improvement in symptoms within a few days, but full benefits might take 1 to 2 weeks. Consistent use is key for best results. Let your doctor know if you don’t see improvement or experience side effects.

Q: Can Pacitane 2mg affect my vision?

A: Yes, some people may notice blurred vision or difficulty focusing. This usually goes away as your body adjusts. Inform your doctor if it continues or gets worse.

References

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3. Talha N. Jilani; Sarah Sabir; Sandeep Sharma. Trihexyphenidyl. NIH National Library of Medicine, National center for biotechnology information. February 2022 [Accessed on on 23rd July 2025]

4. B D BURNS, D DEJONG, O H SOLIS-QUIROGA. EFFECTS OF TRIHEXYPHENIDYL HYDROCHLORIDE (ARTANE) ON PARKINSON'S DISEASE. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. Jan 1964 [Accessed on on 23rd July 2025]

5. Thomton & Ross Ltd. Electronic medicines compendium (EMC). [Revised in July 2018] [Accessed on on 23rd July 2025]

6. ACTAVIS PHARMA, INC. TRIHEXYPHENIDYL HYDROCHLORIDE tablet. DailyMed. NIH U.S. National Library of Medicine. [Revised in June 2015] [Accessed on on 23rd July 2025]

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Sankara Babu Gorle - MBBS, MD (Pharmacology)

Last updated on 24 Jul 2025 | 12:49 PM(IST)