New Revised MRP, 100% GST benefit passed P 650 Tablet 10'S
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Introduction About P 650 TABLET
P 650 TABLET contains Paracetamol which belongs to the group of medicines called Analgesics and Antipyretics. It is used to relieve mild to moderate pain (including headaches, backache, toothache, severe nerve pain, sore throat, period pain, low back and leg pain, muscle, connective tissue and joint pain, symptomatic relief of sprains, strain, joint swelling and stiffness). It is also used to lower fever (high body temperature) and relieves the symptoms of cold or flu.
Before taking P 650 TABLET, inform your doctor if you or your child have liver or kidney problems or any allergies. It should be used with caution in patients with liver problems due to alcohol to manage the risk of liver damage.
P 650 TABLET should be used with caution in pregnant women only if clearly advised by the doctor and can be used in breastfeeding women. P 650 TABLET is not recommended for use in children less than 10 years of age and should be used with caution in elderly patients.
Consult your doctor if you experience any side effects or unusual effects during management with P 650 TABLET.
Uses Of P 650 TABLET
- relieves mild to moderate pain (such as headache, toothache, joint pain)
- lowers fever and relieves the symptoms of cold or flu
How P 650 TABLET Works
P 650 TABLET relieves pain by increasing the pain threshold by inhibiting certain enzymes (COX-1 and COX-2) involved in the synthesis of chemicals responsible for inducing pain (prostaglandins). It reduces fever by directly acting on heat-regulating centers in the brain, resulting in vessel relaxation, sweating and loss of body heat.
How to use P 650 TABLET
Take P 650 TABLET as advised by your physician. It can be taken with or without food.
For Tablet, Capsule: Swallow P 650 TABLET with a glass of water. Do not crush or chew the medicine.
For Dispersible Tablet: Disperse the medicine in the specified quantity of water as mentioned in the label. Consume the medicine immediately after reconstitution.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and severity of the condition.
Side Effects Of P 650 TABLET
Rare
- reduced white blood cells (infections are more likely to occur)
Stop taking P 650 TABLET and contact your doctor immediately if you experience any of the following side effects:
- allergic reaction (swelling of the hands, feet, ankles, face, lips or throat which may cause trouble swallowing or breathing, an itchy, lumpy rash or nettle rash, runny nose)
Warning & Precautions
Pregnancy
P 650 TABLET should be used with caution in pregnant women only if considered clearly necessary. Your doctor may use the lowest possible dose to reduce the pain and fever only for a shorter duration in pregnant women. Consult your doctor before taking P 650 TABLET.
Breastfeeding
P 650 TABLET should be used with caution in breastfeeding women. Consult your doctor before taking it.
Driving and Using Machines
P 650 TABLET has no influence on the ability to drive and operate machinery.
Alcohol
P 650 TABLET should be used with caution in patients with chronic alcoholism. Consult your doctor before taking it.
Kidney
P 650 TABLET should be used with caution in patients with severe kidney problems. Consult your doctor before taking it.
Liver
P 650 TABLET should be used with caution in patients with severe liver problems or liver problems due to alcohol. Consult your doctor before taking it.
Allergy
Do not take P 650 TABLET if you are allergic to Paracetamol or any other ingredients of this medicine.
Others
Before taking P 650 TABLET, inform your doctor if you:
- have sepsis (circulation of bacteria and their toxins in the blood leading to organ damage)
- are malnourished
Use in pediatrics:
P 650 TABLET is not recommended for use in children less than 10 years of age. It can be used in children and adolescents aged above 10 and your child’s doctor may adjust the dose based on the child’s age and body weight. Consult your child’s doctor for advice.
Use in geriatrics:
P 650 TABLET should be used with caution in elderly patients. Consult your doctor before taking it.
Interactions
A. Drug - Drug interactions:
Before taking P 650 TABLET, inform your doctor if you are taking any of the following medicines:
- other medicines containing paracetamol
- medicines to manage nausea and vomiting (Ex. metoclopramide, domperidone)
- cholestyramine (used to control blood lipid levels)
- warfarin (used for managing blood clots)
- medicines used to manage bacterial infections (Ex. rifampicin, flucloxacillin, chloramphenicol)
Overdosage:
If you or anyone else accidentally takes too much of P 650 TABLET, consult your doctor immediately or visit the nearby hospital, even if you feel well, as it can cause delayed, serious liver damage.
Synopsis
| Drug | : | Paracetamol |
| Pharmacological Category | : | Para aminophenol derivative |
| Therapeutic Indication | : | Pain, Fever |
| Dosage Forms | : | Tablet, Dispersible tablet, Drops, Syrup, Oral suspension, Liquid, Oral solution, Suppositories, Infusion, Injection |
More Information
- Keep P 650 TABLET out of reach of children
- Store below 25°C
FAQs About P 650 TABLET
Q: What is the use of P 650 TABLET?
A: P 650 TABLET is commonly used to relieve mild to moderate pain and reduce fever. It contains paracetamol (acetaminophen) and is often used for conditions like headaches, muscle aches, toothaches, associated with various illnesses.
Q: What happens if I take P 650 TABLET?
A: P 650 TABLET contains a medicine called paracetamol which is an analgesic and antipyretic agent. Following administration, it works by blocking the release of certain chemicals called prostaglandins in the body which is responsible for causing pain and inflammation. Paracetamol also manages the release of such chemicals in the hypothalamus of the brain which helps in controlling fever.
Q: Can I take two doses of P 650 TABLET in a day?
A: The dosage of P 650 TABLET is decided by your physician. However, studies have shown that taking paracetamol once in every 4-6 hours significantly reduced fever and body pains.
Q: Can we use P 650 TABLET for cold?
A: P 650 TABLET could be used in the management of sore throat and body pains that is associated with common cold. It contains a medicine called paracetamol which is commonly used to relieve mild to moderate pain, like headaches, muscle aches, toothaches, and fever associated with various illnesses.
Q. Can I take P 650 TABLET as often as required?
A: The dosage of P 650 TABLET and duration of the therapy would be decided by your doctor. It is usually not recommended to take more than 4 doses of P 650 TABLET in a day. Leave a time gap of 4-6 hours, between each dose.
Q: Is P 650 TABLET a strong medicine?
A: P 650 TABLET is relatively an effective medicine in controlling fever and body pain. It is typically used for mild to moderate pain relief and fever reduction. However, it should be used as directed, and exceeding the recommended dosage can lead to adverse effects.
Q: When would P 650 TABLET start working?
A: It takes around 30 minutes for you to feel better after taking P 650 TABLET.
Q: Can I take P 650 TABLET and ibuprofen together?
A: It is generally advisable to avoid taking P 650 TABLET (paracetamol) and ibuprofen together unless recommended by a healthcare professional. Mixing these medications can increase the risk of side effects and potential harm to the liver and stomach.
Q: When should we discontinue the use of Paracetamol?
A: Discontinue the use of Paracetamol if you experience allergic reactions, severe skin reactions, liver problems, or if you consume alcohol regularly. Always consult a healthcare professional if you have concerns or experience adverse effects.
Q: Is P 650 TABLET an antibiotic?
No. P 650 TABLET is an analgesic and antipyretic medicine. It works by reducing fever and provides pain relief.
Q: What happens if I take more doses of P 650 TABLET than recommended to me?
A: Taking more than the recommended doses of P 650 TABLET may be harmful. Studies have shown that the overdosage of paracetamol may affect your liver and gastrointestinal tract. Symptoms of overdosage might include vomiting, loss of appetite, stomach pain, paleness and nausea.
Q: Can P 650 TABLET be used for a headache?
A: Yes. P 650 TABLET can relieve your headache. It can also symptomatically manage headaches, however, cannot manage the underlying cause. If you experience recurrent headaches, please consult your doctor. In such cases, avoid self-medication with over-the-counter pain killers.
Q: Can P 650 TABLET be used during pregnancy?
A: P 650 TABLET can be used during pregnancy, however not during the last trimester as it could delay the onset of pain sensation. If necessary, you should use the lowest possible dose that reduces your pain and/or your fever and use it for the shortest time possible.
Q: What happens if I take Dolo 650 without fever?
A: Dolo 650 tablet is generally used for managing pain and fever, It can be used without getting a fever in most cases, especially if you have headaches, toothaches, or period cramps.
References
1. Tilo Grosser, Emer Smyth and Garret A. FitzGerald. Anti-inflammatory, Antipyretic and Analgesic agents; Pharmacotherapy of gout. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 693.
2. KD. Tripathi. NSAIDs and Antipyretic-Analgesics. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 206.
3. Ulderico Freo, Chiara Ruocco, Alessandra Valerio, Irene Scagnol and Enzo Nisoli. Paracetamol: A Review of Guideline Recommendations. NIH National Library of Medicine, National center for biotechnology information. PubMed Central. August 2021. [Accessed on 12th August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347233/
4. Ohashi N and Kohno T. Analgesic Effect of Acetaminophen: A Review of Known and Novel Mechanisms of Action. Pharmacology. Frontiers. November 2020. [Accessed on 12th August 2022] https://www.frontiersin.org/articles/10.3389/fphar.2020.580289/full
5. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in April 2022] [Accessed on 12th August 2022] https://www.medicines.org.uk/emc/files/pil.1958.pdf
6. Zentiva Pharma UK Limited. Electronic Medicines Compendium (EMC). [Revised in May 2022] [Accessed on 12th August 2022] https://www.medicines.org.uk/emc/files/pil.4195.pdf
7. GlaxoSmithKline Asia Private Limited. Crocin 500 mg and Crocin 650 mg (Paracetamol). [Accessed on 12th August 2022] https://www.crocin.com/content/dam/cf-consumer-healthcare/panadol/en_in/adult/productshots/pdfs/Crocin-650-mg-Product-Info.pdf
Useful Diagnostic Tests
- Complete blood count
- Liver function test
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