Ozomet Pg2 Tablet 15'S

Introduction About OZOMET PG2 TABLET

OZOMET PG2 TABLET manages type II diabetes mellitus when diet, exercise and management with single agent does not result in adequate sugar control. It is a combination of Glimepiride, Metformin and Pioglitazone which belongs to the group of medicines called Antidiabetic agents.

Before taking OZOMET PG2 TABLET, inform your doctor if you have any liver, kidney or heart problems, eye problems, hormonal imbalance, alcoholism, or if you are malnourished, starved, on an irregular diet as a precaution. It is strictly not recommended for use in patients with type I diabetes mellitus, bladder cancer, severe heart failure or lactic acidosis.

Follow the diet and lifestyle changes advised by your doctor to achieve better results. Avoid smoking and consumption of alcohol while taking the medicine as it may aggravate the existing condition. Common side effects are low blood sugar levels, nausea, stomach upset, constipation, sore throat, muscle pain, headache, dizziness and weight gain.

Key Composition

• Glimepiride 2 mg
• Metformin 500 mg (extended-release)
• Pioglitazone 15 mg

Uses Of OZOMET PG2 TABLET

• Manages type II diabetes mellitus

Benefits of OZOMET PG2 TABLET

• Triple-Action Blood Sugar Control – Combines three proven anti-diabetic medicines for a broader approach to managing type 2 diabetes.
• Supports Better Insulin Function – Encourages the body to use insulin more effectively and helps regulate sugar levels throughout the day.
• Reduces Sugar Production in the Liver – Metformin helps lower the amount of glucose released into the blood.
• Improves Insulin Sensitivity – Pioglitazone makes muscle, fat, and liver cells respond better to insulin.
• Stimulates Gentle Insulin Release – Glimepiride prompts the pancreas to release insulin when needed.
• Convenient Fixed-Dose Combination – Reduces pill burden by combining three medicines into one tablet.
• Helps Achieve Target HbA1c – When combined with diet and exercise, may help patients reach blood sugar goals.

How OZOMET PG2 TABLET Works

• Glimepiride (Sulfonylurea class)
  Helps the pancreas produce more insulin by gently stimulating its beta cells, supporting better sugar regulation. It acts as a secretagogue of insulin
• Metformin (Biguanide class, Extended-Release)
  Works in multiple ways: it lowers the liver’s glucose production, slows absorption of sugar from food, and improves how body tissues respond to insulin—without causing low blood sugar by itself
• Pioglitazone (Thiazolidinedione class)
  Enhances insulin sensitivity in muscle, liver, and fat cells by activating cellular receptors—making it easier for the body to use insulin and helping control sugar levels

Together, these three components provide a multi-angle approach: encouraging insulin production, reducing sugar production and absorption, and improving insulin response in the body—all in a single tablet

How to use OZOMET PG2 TABLET

General Instructions for Taking Ozomet PG2 Tablet

• Take the tablet exactly as advised by your healthcare provider.
• Follow the dosage schedule and frequency recommended for you.
• Use it as part of a complete diabetes management plan that includes balanced nutrition and regular physical activity.

Best Time to Take Ozomet PG2 Tablet

• Usually taken once daily, preferably in the morning or as directed by your doctor.
• Maintaining the same time each day helps keep your blood sugar levels steady.

Should Ozomet PG2 Be Taken With or Without Food?

• It is generally taken with meals to minimize stomach discomfort and improve absorption.

Swallowing and Handling Instructions

• Swallow the tablet whole with a glass of water.
• Do not crush, chew, or split the tablet, as it may affect how the medicine is released in your body.

What if I forgot to take OZOMET PG2 TABLET

• If you forget to take a dose, take it as soon as you remember.
• If it’s almost time for your next dose, skip the missed one and continue your regular schedule.
• Do not double the dose to make up for a missed tablet.

Overdose

• If you or anyone else accidentally took more OZOMET PG2 TABLET, you may experience the signs of hypoglycemia (such as increased hunger, sweating, headache, feeling clammy, restless or aggressive, shakiness, fast heartbeat and confusion).
• To manage this, consume any sugary food immediately. If the symptom did not improve or worsens contact your doctor immediately.
• Other symptoms of overdosage might include vomiting, stomach pain with muscle cramps, feeling generally unwell with severe tiredness and difficulty in breathing.

Side Effects Of OZOMET PG2 TABLET

Common side effects of OZOMET PG2 TABLET:

• hypoglycemia (low blood sugar levels)
• diarrhea, stomach pain, loss of appetite, flatulence
• changes in taste, metallic taste
• joint pain, back pain, muscle pain

Signs that require prompt medical attention:

• signs of lactic acidosis (cold hands or feet, dizziness or light-headedness, slow or irregular heartbeat, weakness or tiredness, unusual muscle pain, trouble breathing, sleepiness or drowsiness, stomach pains, nausea or vomiting)
• symptoms of heart failure (such as unusual shortness of breath or trouble in breathing, rapid increase in weight or localised swelling (oedema), especially in the ankles or legs, unusual tiredness)
• signs and symptoms of bladder cancer (blood in your urine, pain while urinating or urgent need to pee)
• increased risk of fractures (especially in the bones of hand, upper arm, or foot in women)
• blurred vision due to swelling at the back of the eye or worsening of existing blurred vision
• serious allergic reaction (hives, swelling of the face, lips, tongue or throat causing difficulty in breathing or swallowing)
• signs of liver problems (nausea or vomiting, stomach pain, unusual or unexplained tiredness, loss of appetite, dark urine, yellowing of the skin or the whites of the eyes)

Warning & Precautions

Pregnancy

Consult your doctor

Adequate human data not available to determine the safety of OZOMET PG2 TABLET during pregnancy.

Breastfeeding

Consult your doctor

It is not known if OZOMET PG2 TABLET passes into human milk and harm your baby. Talk to your doctor about the best way to control your blood glucose levels while breastfeeding.

Driving and Using Machines

Use with Caution

Do not drive or operate any heavy tools or machines if your ability is affected by OZOMET PG2 TABLET.

Alcohol

Consult your doctor

Avoid alcohol consumption while taking OZOMET PG2 TABLET as it may increase the risk of unwanted side effects.

Kidney

Consult your doctor

OZOMET PG2 TABLET is not advisable for use in patients with severe kidney problems. It should be used cautiously in patients with other kidney problems.

Liver

Consult your doctor

OZOMET PG2 TABLET is not recommended for use in patients with severe liver problems. It should be used cautiously in patients with other liver problems.

Allergy

Contraindicated

Do not take OZOMET PG2 TABLET if you are allergic to Glimepiride, Metformin, Pioglitazone or to any other ingredients of this medicine.

Heart Disease

Consult your doctor

OZOMET PG2 TABLET is not advisable for use in patients with severe heart problems (such as heart failure). It should be used cautiously in patients with other heart problems.  

Use In Pediatrics

Contraindicated

OZOMET PG2 TABLET is not advisable for use in children and in adolescents (aged below 18 years).  

Use In Geriatrics

Use with Caution

OZOMET PG2 TABLET should be used cautiously in elderly patients (aged above 65 years).

Other Warnings for OZOMET PG2 TABLET

Before taking OZOMET PG2 TABLET, inform your doctor if you:

• are recovering from any injury, operation, infections or from any form of stress
• have G6PD deficiency
• are on fating or malnourished, starved, on an irregular diet, or feeling weak
• perform extreme physical exercises without proper carbohydrate intake
• are severely dehydrated
• have hormonal problems
• have edema (swelling of body parts)
• smoke
• have special type of diabetic eye disease called macular oedema  
• have cysts on your ovaries (polycystic ovarian syndrome)
• previously had stroke
• have anemia  
• have any bone problems or at risk of developing bone fractures
• are a premenopausal woman
• have thyroid problems

Who should not take [GBNKEYWORD

It is not recommended for use if you:

• have type I diabetes mellitus (insulin dependent diabetes)
• have lactic acidosis (build-up of lactic acid in the body)
• have diabetic ketoacidosis
• have bladder cancer
• pass bloody urine

Drug - Drug interaction

Commonly Reported Interactions

• Antibiotics (e.g., Rifampicin, Clarithromycin) – may alter blood glucose regulation.
• Heart medications (e.g., Beta-blockers, ACE inhibitors) – can mask low blood sugar symptoms or enhance effects.
• Corticosteroids (e.g., Prednisolone) – may reduce blood sugar control.
• Thyroid medications (e.g., Levothyroxine) – can influence the effectiveness of glucose-lowering agents.
• Antifungal medicines (e.g., Ketoconazole) – may change how the body metabolizes the drug.
• Diuretics (e.g., Furosemide) – may impact kidney function and fluid balance.
• Alcohol – may increase the risk of lactic acidosis (with metformin).

Synopsis

More Information

Comparison of Ozomet PG2 Tablet with Similar Medicines

 Did You Know?

• Ozomet PG2 Tablet combines three different diabetes medicines – Metformin, Glimepiride, and Pioglitazone – to help manage type 2 diabetes through different mechanisms.
• Metformin is one of the most widely prescribed oral antidiabetic medicines globally and has been in use for over 60 years.
• Glimepiride belongs to the sulfonylurea group, which works by stimulating the pancreas to release more insulin.
• Pioglitazone improves insulin sensitivity in the body, making it easier for cells to use glucose effectively.
• The combination approach is often used when single-drug therapy does not provide adequate blood sugar control.
• Maintaining a balanced diet, regular exercise, and lifestyle adjustments can greatly enhance the effectiveness of your prescribed diabetes treatment.
• Regular blood sugar and HbA1c monitoring helps track progress and adjust therapy if needed.

ALTERNATIVES

• Triohale PG2 Tablet
• Glycomet GP 2 Forte P
• Reclimet PG2 Tablet

FAQs About OZOMET PG2 TABLET

References

1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 270, 275 & 277.

2. Jeong Mi Kim, Sang Soo Kim, Jong Ho Kim, Mi Kyung Kim, Tae Nyun Kim, Soon Hee Lee, Chang Won Lee, Ja Young Park, Eun Sook Kim, Kwang Jae Lee, Young Sik Choi, Duk Kyu Kim and In Joo Kim. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. July 2019. [Accessed on 9th August 2025] 

3. Brown & Burk UK Limited. Electronic Medicines Compendium (EMC). [Revised in December 2020] [Accessed on 9th August 2025] 

4. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in June 2020] [Accessed on 9th August 2025] 

5. Rx Farma Limited. Electronic Medicines Compendium (EMC). [Revised in September 2019] [Accessed on 9th August 2025] 

6. Gerard Laboratories. Electronic Medicines Compendium (EMC). [Revised in August 2020] [Accessed on 9th August 2025] 

7. Central Drugs Standard Control Organization. FDC of Glimepiride (1mg/2mg) + Pioglitazone (15mg) + Metformin (500mg E.R) Tablet. August 2005. [Accessed on 9th August 2025] 

Useful Diagnostic Tests

• Random Blood Sugar (RBS)
• Fasting Blood Sugar (FBS)
• Post Prandial Blood Sugar (PPBS)
• Sugar Risk Package
• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 14 Aug 2025 | 09:34 AM(IST)