Oxramet XR 10/500mg Tablet 7'S

Introduction About OXRAMET XR 10/500MG TABLET

Oxramet XR 10/500mg Tablet combines dapagliflozin and metformin, which belongs to the group of medicines called Antidiabetics agents. It is designed for adults with type 2 diabetes who are also following a balanced diet and regular exercise routine. This dual-action medicine helps to manage blood sugar by lowering glucose production in the liver, increasing glucose elimination through urine, and enhancing the body’s response to insulin.

 It can take Oxramet XR 10mg/500mg Tablet with food. Try to take it at the same time each day to help you remember. Your doctor will decide the right dose for you. Do not stop taking this medicine without talking to your doctor, as stopping suddenly may raise your blood sugar and increase the risk of health problems. Remember, this tablet is just one part of your overall management plan, which should also include a healthy diet, regular exercise, and weight management as recommended by your doctor.

Common side effects of this medicine include sore throat, nasal congestion, runny or stuffy nose, headache, weakness, nausea, vomiting, diarrhea, weakness, dizziness, taste changes, and loss of appetite. Drinking plenty of fluids can helps to reduce dehydration while taking it. Some people may experience fungal infections in the genital area, which can be reduced by maintaining good hygiene.

Before starting this medicine, let your doctor know if you have any kidney or liver problems or urinary tract infection, or if you are taking water pills (diuretics).  Pregnant or breastfeeding women should also check with their doctor before taking it. Avoid drinking too much alcohol while on this medicine, as it can increase the chance of side effects like lactic acidosis. Remember to monitor your blood sugar levels regularly during management.

Uses Of OXRAMET XR 10/500MG TABLET

• Type 2 diabetes
• Weight loss (Off lable use)

Benefits of OXRAMET XR 10/500MG TABLET

1) Supports Blood Sugar Management:
Oxramet XR 10/500mg Tablet helps maintain stable blood sugar levels in adults with type 2 diabetes by working through multiple pathways. This dual-action formula combines dapagliflozin and metformin to offer comprehensive glucose regulation, making it a preferred choice for effective diabetes management.

2) Cardiovascular Support:
This tablet is designed to support heart health and may help lower the risk of certain cardiovascular events, such as heart attack and stroke, especially in adults with type 2 diabetes and existing heart conditions. Its unique combination aligns with the latest diabetes care guidelines that recommend SGLT2 inhibitors for cardiovascular benefit.

3) Weight Management: Oxramet XR 10/500mg Tablet may assist with modest weight loss by promoting the excretion of excess glucose and calories through urine. This benefit is especially important for adults aiming to manage both blood sugar and weight as part of their overall diabetes care plan.

4) Blood Pressure Control:
Studies have shown that this medicine can help lower blood pressure, which is beneficial for individuals managing both type 2 diabetes and high blood pressure. Better blood pressure control supports long-term heart and kidney health.

5) Convenient Combination Therapy:
By combining two proven antidiabetic agents in a single extended-release tablet, Oxramet XR 10/500mg simplifies your daily medication routine. This convenience can improve adherence and support better health outcomes.

How OXRAMET XR 10/500MG TABLET Works

Oxramet XR 10/500mg Tablet is a combination of dapagliflozin (an SGLT2 inhibitor) and metformin (a biguanide), designed to help control blood glucose levels in adults with type 2 diabetes mellitus. It works through complementary mechanisms to target both insulin resistance and excess glucose in the bloodstream, supporting overall glycemic control when used alongside diet and exercise.

Mechanism of Action of Oxramet XR 10/500mg Tablet:

The dual-action approach of Oxramet XR combines two effective mechanisms:

• Dapagliflozin lowers blood glucose by promoting the excretion of glucose through urine.
• Metformin works by decreasing hepatic glucose production and improving insulin sensitivity.

Together, they reduce both fasting and postprandial blood sugar levels.

Role of Dapagliflozin in Oxramet XR:

Dapagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor. It works primarily in the kidneys to:

• Block glucose reabsorption in the proximal renal tubules.
• Promote glucose excretion in urine (glucosuria).
• Lower blood glucose levels independently of insulin.
• Provide potential additional benefits such as modest weight loss and blood pressure reduction.

Role of Metformin in Oxramet XR:

Metformin belongs to the biguanide class of antidiabetic medications and acts primarily in the liver and peripheral tissues. It:

• Reduces hepatic glucose production (gluconeogenesis).
• Increases insulin sensitivity in muscles and fat, enhancing glucose uptake.
• Helps lower fasting blood glucose levels.
• Does not typically cause hypoglycemia or weight gain.

How the Combination Supports Blood Sugar Control:

The combination of dapagliflozin and metformin offers a synergistic effect:

• Dapagliflozin eliminates glucose via urine, addressing excess circulating sugar.
• Metformin reduces the internal production of glucose and boosts insulin effectiveness.
• This dual action helps achieve better overall glycemic control with a reduced risk of hypoglycemia.
• It also addresses both fasting and post-meal blood glucose elevations.

Understanding SGLT2 Inhibition and Glucose Excretion:

SGLT2 inhibitors like dapagliflozin target a key protein in the kidneys responsible for reabsorbing glucose back into the blood.

• By inhibiting SGLT2, dapagliflozin prevents this reabsorption.
• This causes excess glucose to be excreted through urine.
• As a result, blood glucose levels are reduced, and calorie loss may support weight management.

Improving Insulin Sensitivity with Oxramet XR:

Metformin in Oxramet XR helps improve the body's response to insulin by:

• Enhancing insulin receptor activity in muscle and fat cells.
• Increasing glucose uptake in peripheral tissues.
• Lowering insulin resistance, a core issue in type 2 diabetes.
• Supporting more stable blood sugar levels without increasing insulin levels.

How to use OXRAMET XR 10/500MG TABLET

Follow your doctor's instructions regarding the exact dosage. Do not exceed the recommended daily dosage.

Recommended Dosage and Timing:

• Typical Starting Dosage: One tablet of Oxramet XR 10/500mg once a day.
• Adjustments: The dose may be adjusted depending on your blood sugar levels and how well you tolerate the medication.
• Timing: It is usually taken once daily, with or without food, at a consistent time each day.

How to Take Oxramet XR 10/500mg Tablet Safely:

• Swallow the tablet whole: Do not chew, crush, or split the tablet.
• With or without food: You can take the tablet with or without food, but taking it with food may reduce the chances of stomach upset.
• Water: Drink a full glass of water with your dose.

Important Administration Tips:

• Consistency: Take Oxramet XR at the same time each day to help remember.
• Monitor Blood Sugar: Regularly check your blood sugar levels as advised by your healthcare provider to ensure the medication is working effectively.
• Avoid Dehydration: Stay well-hydrated, especially if you are experiencing increased urination due to dapagliflozin.

What if I forgot to take OXRAMET XR 10/500MG TABLET

• If you miss a dose, take it as soon as you remember.
• If it is almost time for your next dose, skip the missed dose, do not take two doses at once.
• Never double up on doses to make up for a missed one.

Overdose

In the event of an overdose:

• Contact your healthcare provider or seek immediate medical attention.
• Symptoms of overdose may include:
  • Severe hypoglycemia (low blood sugar)
  • Lactic acidosis symptoms (in the case of metformin overdose)
  • Dehydration or electrolyte imbalances

Management for an overdose will depend on the severity and the combination of active ingredients involved. Immediate medical attention is critical.

Side Effects Of OXRAMET XR 10/500MG TABLET

Like all medicine, Oxramet XR 10/500mg Tablet may cause certain side effects in some individuals, although not everybody gets them.

Common Side Effects of Oxramet XR 10/500mg Tablet are:

• Sore throat
• Nasal congestion
• Runny or stuffy nose
• Headache
• Weakness
• Nausea, vomiting
• Diarrhea
• Dizziness
• Taste changes
• Loss of appetite

When To Seek Medical Attention?

• Lactic Acidosis symptoms such as vomiting, stomach pain, muscle cramps, severe tiredness, difficulty breathing, feeling very unwell, and low body temperature.
• Diabetic Ketoacidosis symptoms such as rapid weight loss, nausea, vomiting, excessive thirst, deep or rapid breathing, unusual sleepiness or tiredness, sweet-smelling breath, or a metallic taste in the mouth.
• Severe Hypoglycaemia (Low Blood Sugar) symptoms such as confusion, sweating, rapid heartbeat, shakiness, blurred vision, and fainting
• Severe allergic reactions symptoms such as swelling of the face, lips, tongue, or throat, difficulty breathing, or a severe rash.
• Serious Genital or Urinary Tract Infections symptoms such as pain, redness, swelling, fever, or unusual discharge in the genital area, or severe pain and burning during urination

How To Manage Side Effects

Warning & Precautions

Other Warnings for OXRAMET XR 10/500MG TABLET

Before taking Oxramet XR 10/500mg Tablet, inform your doctor if you:

• have to undergo intravascular radiocontrast study with iodinated materials for X-ray procedure
• had any surgical procedure
• have acute febrile illness
• are taking reduced intake of food
• had prolonged fasting due to acute illness or post-surgery
• have pancreatic diseases
• have urinary tract infections
• have low blood sugar
• are debilitated, or malnourished
• have adrenal or pituitary insufficiency
• have vitamin B12 deficiency
• have genital mycotic infections
• have or had bladder cancer
• have serious illness
• are on low salt diet
• had stroke

Who should not take [GBNKEYWORD

Oxramet XR 10/500mg Tablet is not recommended for use if you have or had:

• septicemia or severe infection
• diabetic ketoacidosis or type 1 diabetes
• dehydration from diarrhoea, vomiting and excessive heat exposure
• uncontrolled diabetes
• lactic acidosis

Drug - Drug interaction

Inform your physician if you are taking any of the following medications before starting Oxramet XR 10/500mg Tablet:

1. Diuretics (Water Pills) – e.g., Furosemide, Hydrochlorothiazide

• Interaction: May increase the risk of dehydration and low blood pressure when used with Oxramet XR.
• Effects: Higher chance of dizziness, fainting, and kidney problems.
• Management: Your doctor may monitor your hydration status and kidney function closely and adjust your dose if needed.

2. Insulin and Insulin Secretagogues (e.g., Sulphonylureas)

• Interaction: Using these together with Oxramet XR can cause extremely low blood sugar (hypoglycaemia).
• Effects: Symptoms may include sweating, shakiness, confusion, rapid heartbeat, or fainting.
• Management: Blood sugar monitoring is essential; your doctor may lower the dose of insulin or sulphonylureas to reduce the risk.

3. Iodinated Contrast Agents (used in certain X-rays/CT scans)

• Interaction: Increased risk of lactic acidosis when combined with metformin.
• Effects: Serious metabolic complications.
• Management: Oxramet XR may need to be temporarily discontinued before and after imaging procedures. Always inform your doctor in advance.

4. Cimetidine (for stomach acidity)

• Interaction: Can increase metformin levels in the blood.
• Effects: Higher risk of side effects such as lactic acidosis.
• Management: Dose adjustments and close monitoring may be required.

5. Other Medicines

• Rifampicin (for tuberculosis), Simvastatin (for cholesterol), Glucocorticoids (for inflammation), NSAIDs (e.g., ibuprofen), ACE inhibitors (e.g., ramipril), ARBs (e.g., losartan): These may alter the effects of Oxramet XR or increase the risk of side effects.
• Management: Always provide your doctor with a full list of medications, including over-the-counter drugs and supplements, so they can check for potential interactions.

Drug - Food interaction

Before starting Oxramet XR 10/500mg Tablet, it is important to understand how certain foods and beverages may interact with your medication. These interactions can affect how well the medicine works or increase the risk of side effects.

1. Alcohol

• Interaction: Alcohol can increase the risk of lactic acidosis (a rare but serious side effect of metformin) and may also worsen hypoglycaemia (low blood sugar).
• Effects: Symptoms may include muscle pain, trouble breathing, stomach pain, dizziness, or feeling very weak.
• Management: Avoid or strictly limit alcohol consumption while taking Oxramet XR. Discuss any alcohol use with your doctor.

2. High-Fat or High-Calorie Meals

• Interaction: Consuming large, high-fat meals can delay the absorption of the medicine and may increase stomach side effects such as nausea or diarrhoea.
• Effects: More pronounced gastrointestinal discomfort.
• Management: Take Oxramet XR with a normal, balanced meal to reduce stomach upset and improve absorption.

3. Grapefruit and Grapefruit Juice

• Interaction: While not a major interaction for dapagliflozin or metformin, grapefruit can affect the metabolism of some medications. Always check with your doctor before consuming large amounts of grapefruit products.
• Effects: Possible changes in drug levels, though not commonly reported with Oxramet XR.
• Management: Consume grapefruit in moderation and inform your healthcare provider if you regularly eat grapefruit.

4. Caffeine (Coffee, Tea, Energy Drinks)

• Interaction: High caffeine intake may increase blood sugar levels, counteracting the effects of your diabetes medication.
• Effects: Less effective blood sugar control.
• Management: Monitor your caffeine intake and aim for moderation.

5. Foods Affecting Kidney Function

• Interaction: Diets very high in protein or salt can strain the kidneys, which is important for patients taking Oxramet XR, especially those with existing kidney concerns.
• Effects: Increased risk of kidney-related side effects.
• Management: Follow a kidney-friendly, balanced diet as advised by your doctor or dietitian.

Synopsis

Drug	:	Dapagliflozin, Metformin
Pharmacological Category	:	Antidiabetics
Therapeutic Indication	:	Type 2 diabetes mellitus
Dosage Forms	:	Tablet

More Information

1) Why Choose Oxramet XR 10/500mg Tablet?

Dual-Action Blood Sugar Control

Oxramet XR 10/500mg Tablet combines dapagliflozin (an SGLT2 inhibitor) and metformin (a biguanide), offering a powerful approach to managing type 2 diabetes in adults. This combination works by both reducing glucose production in the liver and promoting the removal of excess glucose through urine, resulting in more effective blood sugar control than metformin alone.

Added Cardiovascular Protection

Beyond just lowering blood sugar, Oxramet XR 10/500mg Tablet may help reduce the risk of serious cardiovascular events such as heart attack and heart failure, especially in patients with type 2 diabetes and existing heart disease. This makes it a preferred option for those seeking both glycaemic and heart health benefits.

Weight and Blood Pressure Benefits

The medicine can contribute to modest weight loss by increasing glucose and calorie excretion, and it has also been shown to help lower blood pressure, an important advantage for people managing both diabetes and hypertension.

Convenient Combination Therapy

By combining two effective antidiabetic agents in a single extended-release tablet, Oxramet XR simplifies your daily medication routine, improving adherence and making diabetes management easier.

Comprehensive Diabetes Management

Oxramet XR 10/500mg Tablet is designed to be used alongside a healthy diet and regular exercise, and can be combined with other diabetes medications if needed. It helps lower the risk of complications such as kidney damage, nerve problems, and vision loss when taken as prescribed and as part of a complete diabetes care plan.

Well-Studied Safety Profile

Metformin is known for its low risk of causing hypoglycaemia when used alone, and the combination with dapagliflozin is well-tolerated by most patients. Common side effects are generally mild and manageable, such as nausea or stomach upset.

Conclusion:
Choose Oxramet XR 10/500mg Tablet for its dual-action blood sugar control, added heart protection, support for weight and blood pressure management, and the convenience of combination therapy, all backed by clinical research and recommended as part of a holistic diabetes management plan.

2) Diet and Lifestyle Tips

Aspect	Tips for Diet and Lifestyle Integration with Oxramet XR 10/500mg Tablet
Diet	- Eat a balanced diet rich in fiber, fruits, vegetables, and whole grains. - Include healthy carbohydrates and avoid sugary or fatty foods. - Eat at regular intervals to maintain steady blood sugar levels.
Exercise	- Engage in regular physical activity such as brisk walking, cycling, or swimming as advised by your doctor. - Combine aerobic exercise with strength training for best results. - Monitor your blood sugar before and after exercise.
Hydration	- Drink plenty of water throughout the day to prevent dehydration, especially if you experience vomiting or diarrhea. - Limit sugary drinks and avoid alcohol.
Weight Management	- Aim for gradual weight loss if overweight, as recommended by your doctor - Track your weight regularly and set realistic goals.
Monitoring	- Check your blood sugar levels regularly as advised by your doctor. - Keep a log of your readings and share them during check-ups.
Hygiene	- Maintain good personal hygiene to reduce the risk of infections, especially genital fungal infections.
Other Tips	- Take Oxramet XR with food to reduce stomach upset. - Avoid skipping meals to prevent low blood sugar. - Consult your doctor before starting any new diet or exercise plan.

3) Product Comparison

Feature/Aspect	Oxramet XR 10/500mg Tablet (Dapagliflozin + Metformin)	Metformin Alone	Sulfonylurea + Metformin (e.g., Glimepiride + Metformin)	SGLT2 Inhibitor Alone (e.g., Dapagliflozin)
Convenience	Single tablet, dual-action, once daily	Single agent, may require higher or more frequent dosing	Two medications, may require multiple tablets per day	Single agent, once daily
Efficacy	Controls blood sugar via multiple pathways: reduces liver glucose, increases urinary glucose excretion, improves insulin sensitivity	Controls blood sugar by reducing liver glucose production	Controls blood sugar by stimulating insulin release and reducing liver glucose	Increases urinary glucose excretion
Weight Impact	May aid modest weight loss due to glucose excretion	Weight-neutral or slight loss	May cause weight gain	May aid modest weight loss
Cardiovascular Benefit	May reduce risk of heart failure and cardiovascular events in high-risk patients	Neutral or possible benefit	Neutral or possible increased risk	May reduce risk of heart failure
Blood Pressure	Can help lower blood pressure	Neutral	Neutral	Can help lower blood pressure
Hypoglycaemia Risk	Low (unless combined with other antidiabetics)	Very low	Higher, especially if meals are skipped	Low
Side Effects	Genital infections, UTI, nausea, diarrhea, headache	GI upset, diarrhea, nausea	Hypoglycaemia, weight gain, GI upset	Genital infections, UTI, dehydration
Kidney Precautions	Not for severe kidney disease; monitor function	Not for severe kidney disease	Use with caution in kidney impairment	Not for severe kidney disease
Alcohol Interaction	Avoid (risk of lactic acidosis)	Avoid (risk of lactic acidosis)	Caution	Caution

Conclusion:
Oxramet XR 10/500mg Tablet offers the convenience of dual-action blood sugar control, potential weight and blood pressure benefits, and cardiovascular protection, all in a single daily dose. Compared to other diabetes medicines, it has a lower risk of hypoglycaemia than sulfonylurea combinations and may support additional health goals for adults with type 2 diabetes. Always consult your doctor to choose the best option for your individual needs.

4) Who Should Consider Oxramet XR 10/500mg Tablet?

Oxramet XR 10/500mg Tablet is specifically designed for certain patient profiles with type 2 diabetes. The following groups are most likely to benefit from this medication:

1. Adults with Type 2 Diabetes Not Controlled by Diet, Exercise, or Metformin Alone

• Ideal for adults whose blood sugar levels remain high despite following a healthy diet, regular exercise, and/or taking metformin alone.
• Especially beneficial when a single medication is not sufficient to achieve target blood glucose levels.

2. Patients Requiring Combination Therapy

• Suitable for adults who need dual therapy to improve blood sugar control, as it combines dapagliflozin (an SGLT2 inhibitor) and metformin (a biguanide) in one tablet.

3. Adults at Increased Risk of Cardiovascular Events

• Recommended for type 2 diabetes patients who have existing heart disease or are at high risk for cardiovascular events, as this combination may help reduce the risk of heart failure, heart attack, and stroke.

4. Overweight or Obese Adults with Type 2 Diabetes

• Metformin, a component of Oxramet XR, is particularly effective and safe in overweight or obese patients, supporting both blood sugar and weight management.

5. Patients Needing a Convenient, Once-Daily Regimen

• Beneficial for adults seeking a simplified medication routine, as Oxramet XR combines two effective agents in a single extended-release tablet.

FAQs About OXRAMET XR 10/500MG TABLET

References

1. K.D. Tripathi. Insulin, oral hypoglycaemic drugs and glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page-278, 275.

2. Clifford J Bailey, Jorge L Gross, Delphine Hennicken, Nayyar Iqbal, Traci A Mansfield, James F List. Uses of metformin and dapagliflozin. Biomed Central (BMC). February 2013. [Accessed on 18th June 2025]

3. AstraZeneca UK Ltd. Electronic Medicines Compendium (EMC). [Revised in May 2021] [Accessed on 18th June 2025] 

4. AstraZeneca Pharmaceuticals. U.S. Food & Drug Administration. [Revised in July 2017] [Accessed on 18th June 2025] 

5. Torrent Pharmaceuticals Ltd. Dapagliflozin and Metformin. [Revised in May 2022] [Accessed on 18th June 2025] 

6. AstraZeneca Pharmaceuticals LP. Dapagliflozin and Metformin. [Revised in April 2022] [Accessed on 18th June 2025] 

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Useful Diagnostic Tests

• Random Blood Sugar (RBS)
• Fasting Blood Sugar (FBS)
• Post Prandial Blood Sugar (PPBS)
• Sugar Risk Package
• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin

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