Oxramet XR 10/1000mg Tablet 7'S

Introduction About OXRAMET XR 10/1000MG TABLET

Oxramet XR 10/1000mg Tablet is a dual-action oral medicine combining dapagliflozin (10 mg) and Metformin Hydrochloride Extended Release (1000 mg). This extended-release combination is often considered in individuals who require additional support to regulate blood sugar levels when diet, physical activity and single-ingredient tablets alone are not sufficient. Its complementary mechanism helps maintain daily glucose balance through both improved insulin sensitivity and the elimination of excess sugar via the kidneys.

This tablet is generally ideal for adults managing long-term glucose elevation who may benefit from once-daily, extended support. It can be particularly suitable for those advised a combination strategy involving Metformin XR and SGLT2 inhibitors like dapagliflozin. Taken with meals preferably in the morning Oxramet XR offers the advantage of smoother blood sugar regulation throughout the day, with reduced chances of gastric discomfort, often associated with immediate-release formulations. Consistency in timing and hydration is important while on this medication.

Patients are advised to swallow the tablet whole with water and avoid crushing or chewing. Regular monitoring of kidney function, hydration status, and glucose levels is recommended while on long-term use. It is also important to watch for symptoms like fatigue, unusual thirst, or stomach upset, which may require timely consultation. In case of missed doses, it’s best to skip the missed one and continue with the next scheduled dose never double up.

Use during pregnancy and breastfeeding must be decided only under medical supervision, as safety data is still evolving in these populations. Common side effects may include increased urination, mild stomach upset, or changes in appetite. Staying well-hydrated and consuming balanced meals can help manage these effects better. Always keep follow-up appointments for health checks while using this combination tablet for glucose support.

Uses Of OXRAMET XR 10/1000MG TABLET

• Used in the management of type II diabetes mellitus

Benefits of OXRAMET XR 10/1000MG TABLET

OXRAMET XR 10/1000 mg Tablet in Type 2 Diabetes Management

OXRAMET XR 10/1000 mg Tablet is indicated for the management of type 2 diabetes mellitus in adults, especially when blood sugar levels are not adequately controlled by diet, exercise, or single antidiabetic medicine alone. It combines dapagliflozin and metformin, two agents that work together to lower blood glucose: dapagliflozin promotes the elimination of excess glucose via urine, while metformin reduces glucose production in the liver and improves insulin sensitivity. This dual mechanism helps achieve better glycemic control without causing weight gain or significant risk of hypoglycemia. Used alongside a healthy lifestyle, OXRAMET XR 10/1000 mg Tablet supports long-term blood sugar management and may be prescribed alone or in combination with other diabetes medications.

OXRAMET XR 10/1000 mg Tablet: Reduces risk of diabetic complications

Consistet use of OXRAMET XR 10/1000 mg Tablet helps reduce the risk of serious complications related to diabetes, such as kidney damage, heart disease, nerve problems, limb loss, and eye damage. By improving overall blood glucose regulation and eliminating excess sugar, it limits the damage high blood sugar can cause to vital organs over time. The medicine is especially beneficial for type 2 diabetic patients with existing heart conditions, as it lowers the risk of heart failure and other cardiovascular complications. Adhering to prescribed treatment—along with a proper diet and exercise—enhances long-term health, reduces hospitalizations, and helps maintain a better quality of life for people living with diabetes

How OXRAMET XR 10/1000MG TABLET Works

How Does Oxramet XR 10/1000 mg Lower Blood Sugar

Oxramet XR 10/1000 mg lowers blood sugar through two complementary actions:

• Metformin works by reducing the amount of sugar released by the liver and improving how the body uses insulin. This makes your body more efficient in handling the sugar already in your bloodstream.
• Dapagliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, removes excess sugar through the urine by stopping the kidneys from reabsorbing it back into the blood.

Together, they help reduce both fasting blood sugar and post-meal glucose spikes, while also minimizing the risk of weight gain and improving metabolic balance.

How does OXRAMET XR 10/1000 mg Tablet help improve insulin sensitivity

OXRAMET XR 10/1000 mg Tablet combines metformin and dapagliflozin to enhance blood sugar control in type 2 diabetes. The key mechanism for improving insulin sensitivity lies in the action of metformin, which reduces glucose production in the liver and makes the body’s cells more responsive to insulin. This leads to better uptake and utilization of glucose by the muscles and tissues, resulting in lower blood sugar levels and improved overall metabolic control. Enhanced insulin sensitivity is crucial for people with type 2 diabetes, as it directly targets insulin resistance—the main problem in the condition. Dapagliflozin complements this by removing excess glucose via urine, but improvement in insulin sensitivity is primarily due to metformin

How OXRAMET XR mechanism reduce diabetes complications

The dual-action mechanism of OXRAMET XR 10/1000 mg Tablet helps reduce the risk of diabetes-related complications by addressing both high blood sugar and insulin resistance. Metformin’s glucose-lowering and insulin-sensitizing effects reduce the risk of long-term damage to organs such as the kidneys, heart, nerves, and eyes. Dapagliflozin, by promoting glucose excretion through urine, adds another layer of glycemic control without increasing the risk of hypoglycemia. This combined approach leads to better blood sugar stability, which has been shown to decrease the risk of serious complications such as diabetic kidney disease, heart disease, and nerve damage. Maintaining recommended blood glucose levels with OXRAMET XR, alongside regular monitoring, diet, and exercise, is essential for effective long-term management and prevention of diabetes complications

How to use OXRAMET XR 10/1000MG TABLET

Oxramet XR 10/1000mg Dosage Instructions

• Take exactly as prescribed by your doctor.
• Take once daily with food to minimize stomach upset.
• Take at the same time every day for best effect.
• Do not stop or alter dose without consulting your doctor

Oxramet XR: With or Without Food

• Oxramet XR should be taken with food, preferably during a meal.
• Taking it with food reduces the chance of stomach upset, especially due to the Metformin XR component.
• A balanced meal also helps improve the tablet’s glucose-lowering support and comfort level.

Avoid skipping meals while on this medicine and try to keep your eating routine regular and well-spaced for best results.

What if I forgot to take OXRAMET XR 10/1000MG TABLET

If you forgot or miss a dose, take it as soon as you remember unless it’s almost time for your next scheduled dose. In that case, skip the missed one and continue your regular schedule

Overdose

If you or anyone else accidentally took too much of this medicine, consult your doctor immediately. Symptoms of overdose are hypoglycaemia and lactic acidosis.

Side Effects Of OXRAMET XR 10/1000MG TABLET

Common side effects of Oxramet XR 10/1000mg Tablet

• diarrhoea
• stomach pain
• loss of appetite
• genital infection (irritation, itching, unusual discharge or odour)
• back pain
• increased urination
• decrease in creatinine clearance
• changes in taste
• constipation

When to Seek Medical Attention?

Stop taking OXRAMET XR 10/1000MG TABLET and contact your physician immediately if you experience any of the following side effects:

• nausea, vomiting, stomach pain, muscle cramps, feeling of not being well with severe tiredness, body pain, increasing somnolence, difficulty in breathing, dizziness, light-headedness, reduced body temperature, heartbeat, and low blood pressure (symptoms of lactic acidosis)
• dehydration, nausea, vomiting, abdominal pain, excessive thirst, generalised weakness, rapid weight loss, fast and deep breathing, confusion, unusual sleepiness or tiredness, fruity smell breath, a sweet or metallic taste in mouth, different odour to your urine or sweat (signs and symptoms of diabetic ketoacidosis)
• fever, chills, burning sensation while passing urine, back pain, or blood in urine (signs of urinary tract infection)
• weakness, shaking, sweating, drowsiness, dizziness, feeling very anxious, fast heartbeat, hunger, headache, change in vision, change in mood or confusion, and irritability (signs of low blood sugar)

How To Manage Side Effects

Constipation

• Drink a glass of warm water immediately after waking up in an empty stomach. And it helps to stimulates bowel movement and softens stool.
• Rich in natural fibre will acts as a mild natural laxative.
• Soak 5–6 raisins or 2 dried figs overnight; eat on an empty stomach in the morning.

Stomach Pain

• Heat relaxes abdominal muscles and improves blood flow, easing cramps and bloating.
• Drink warm water slowly or place a hot water bag on your abdomen for 15–20 minutes.
• Cumin aids digestion and helps relieve gas and bloating.
• Boil 1 tsp cumin seeds in 1 cup of water, cool slightly, and drink after meals.

Warning & Precautions

Pregnancy

Risky

OXRAMET XR 10/1000MG TABLET should be used during pregnancy only if the potential benefit justifies the potential risk to the foetus.  

Breastfeeding

Consult your doctor

It is not known whether OXRAMET XR 10/1000MG TABLET pass through the breast milk, contact your doctor before taking the medicine.

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if you experience symptoms of hypoglycaemia such as weakness, dizziness, increased sweating, fast heartbeat, change in vision, difficulty in concentration, weakness, sleepiness, light-headedness after taking OXRAMET XR 10/1000MG TABLET.

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking OXRAMET XR 10/1000MG TABLET as it increases the risk of lactic acidosis.

Kidney

Consult your doctor

OXRAMET XR 10/1000MG TABLET is not recommended for use in patients with moderate to severe kidney disease. It should be used with caution in patients with acute kidney injury.

Liver

Use with Caution

OXRAMET XR 10/1000MG TABLET should be used with caution in patients with liver disease.

Allergy

Contraindicated

Do not take OXRAMET XR 10/1000MG TABLET if you are allergic to Dapagliflozin, Metformin or to any other ingredients of this medicine.

Heart Disease

Consult your doctor

OXRAMET XR 10/1000MG TABLET is not recommended for use in patients with recent heart attack or acute myocardial infarction, heart failure, cardiovascular shock. It should be used with caution in patients with hypotension.

Use In Pediatrics

Consult your doctor

It is not known whether OXRAMET XR 10/1000MG TABLET is safe and effective in children and adolescents below 18 years of age.

Use In Geriatrics

Use with Caution

OXRAMET XR 10/1000MG TABLET should be used with caution in elderly patients (aged above 65 years).

Other Warnings for OXRAMET XR 10/1000MG TABLET

Before taking OXRAMET XR 10/1000MG TABLET, inform your doctor if you:

• Have to undergo intravascular radiocontrast study with iodinated materials for X-ray procedure
• had any surgical procedure
• have acute febrile illness
• are taking reduced intake of food
• had prolonged fasting due to acute illness or post-surgery
• have pancreatic diseases
• have urinary tract infections
• have low blood sugar
• are debilitated, or malnourished
• have adrenal or pituitary insufficiency
• have vitamin B12 deficiency
• have genital mycotic infections
• have or had bladder cancer
• have serious illness
• are on low salt diet
• had stroke

Who should not take [GBNKEYWORD

OXRAMET XR 10/1000MG TABLET is not recommended for use if you have or had:

• septicaemia or severe infection
• diabetic ketoacidosis or type 1 diabetes
• dehydration from diarrhoea, vomiting and excessive heat exposure
• uncontrolled diabetes
• lactic acidosis

Safety Advice

• Take the tablet with food to reduce the risk of stomach discomfort associated with metformin
• Swallow the tablet whole with water; do not crush or chew, as it is an extended-release formulation
• Stay well-hydrated, especially during warm weather or physical activity, as dapagliflozin increases urination
• Monitor kidney function regularly, especially if you have pre-existing kidney issues or are on other medications
• Avoid alcohol or use cautiously, as excessive intake may increase the risk of lactic acidosis
• Inform your doctor before surgery or contrast dye imaging; temporary discontinuation may be needed
• Watch for signs of urinary or genital infections (burning, itching, unusual discharge), and report them promptly
• Do not take if you're pregnant or breastfeeding, unless advised and closely monitored by a healthcare provider
• Avoid skipping meals, as it may lead to low blood sugar, especially when paired with exercise or fasting
• Inform your doctor about all medications and supplements you're using to avoid potential interactions
• Check blood sugar levels regularly as recommended to ensure the medicine is working effectively

Diet and Lifestyle Advice

Diet Tips:

• Choose low-glycaemic index (GI) foods like whole grains, legumes, leafy greens, and non-starchy vegetables
• Include lean proteins (tofu, egg whites, chicken breast, fish) to maintain muscle and control appetite
• Limit refined carbs and sugars such as sweets, white bread, sugary drinks, and processed snacks
• Eat smaller, frequent meals to avoid glucose spikes
• Stay hydrated Oxramet contains dapagliflozin, which increases urination, drink adequate water daily
• Avoid alcohol or drink in moderation, as it increases the risk of lactic acidosis with metformin

Lifestyle Habits:

• Exercise regularly Aim for at least 30 minutes of moderate activity (walking, yoga, cycling) 5 days a week
• Monitor your blood sugar levels as advised to track how your body responds to food and activity
• Get adequate sleep, ideally 7–8 hours nightly, as poor sleep can affect glucose levels
• Maintain a healthy weight Even a small weight loss can improve insulin sensitivity
• Avoid dehydration especially during summer or physical exertion, as dapagliflozin may increase fluid loss
• Don’t skip meals, especially while on blood sugar-lowering medicines, to avoid sudden dips in glucose

1. Is Oxramet XR 10/1000mg better than plain Metformin XR for sugar control

2. How does Oxramet XR compare to Janumet XR?

Drug - Drug interaction

1. Diuretics (e.g., Furosemide, Hydrochlorothiazide)

• Interaction: May increase the risk of dehydration, low blood pressure, or imbalance in electrolytes.
• Management: Stay well-hydrated and inform your doctor if you notice dizziness, low energy, or changes in urination. Regular monitoring of kidney function may be needed.

 2. Blood Pressure Medications (e.g., ACE inhibitors, ARBs)

• Interaction: Can intensify the sugar-lowering effect and may lead to a drop in blood pressure or low blood sugar.
• Management: Regular blood pressure and blood sugar checks are advised. Your doctor may adjust the dose or recommend monitoring salt and fluid intake.

 3. Insulin or Sulfonylureas (e.g., Glimepiride, Gliclazide)

• Interaction: Increased risk of low blood sugar when used together with Oxramet XR.
• Management: Your healthcare provider may lower the insulin or sulfonylurea dose. Always carry a sugar source in case you feel dizzy or weak.

4. Corticosteroids (e.g., Prednisolone)

• Interaction: May reduce the effectiveness of Oxramet XR by increasing blood sugar levels.
• Management: If corticosteroids are necessary, your sugar levels may need closer monitoring, and Oxramet XR dosage might be adjusted accordingly.

 5. Thyroid Medications (e.g., Levothyroxine)

• Interaction: May interfere with how the body processes glucose, affecting the medicine's sugar-lowering effect.
• Management: Ensure blood sugar is checked regularly when starting or changing thyroid medicine doses.

 6. Beta Blockers (e.g., Metoprolol, Atenolol)

• Interaction: Can mask signs of low blood sugar (like fast heartbeat), making it harder to detect.
• Management: Pay attention to other signs of low sugar such as sweating, fatigue, or hunger. Regular self-monitoring is essential.

 7. Iodinated Contrast Agents (used for imaging tests)

• Interaction: Risk of a rare but serious condition called lactic acidosis when combined with Metformin.
• Management: Oxramet XR may need to be temporarily stopped before and after contrast exposure. Always inform your healthcare provider before scans.

8. Rifampicin or Other Antibiotics/Antifungals

• Interaction: May reduce the level of Empagliflozin in the blood, making it less effective.
• Management: Your doctor may monitor sugar levels closely and consider dose adjustments if needed.

 9. Lithium (used for mental health conditions)

• Interaction: May affect lithium levels in the body due to fluid changes caused by Empagliflozin.
• Management: Blood lithium levels should be monitored more frequently. Adjustments may be necessary.

Drug - Food interaction

1. High-Carbohydrate Meals (Sugary or Refined Foods)

• Interaction: Meals high in sugar or refined carbs (like sweets, white bread, sugary drinks) can reduce the effectiveness of Oxramet XR in supporting healthy blood sugar levels.
• Management: Choose complex carbs like whole grains, lentils, or vegetables. Maintain balanced, fibre-rich meals to enhance the tablet’s supportive role.

2. High-Fat Meals

• Interaction: Large, fatty meals can delay the absorption of Metformin XR, potentially causing stomach upset or reducing overall benefit.
• Management: Eat light to moderate fat meals when taking the tablet. Try including lean protein and vegetables.

 3. Alcohol

• Interaction: Alcohol may increase the risk of a rare condition called lactic acidosis (especially with Metformin) and can affect kidney function and hydration.
• Management: Avoid or limit alcohol intake. Stay hydrated and inform your doctor about your drinking habits.

 4. Dairy in Large Quantities (especially full-fat milk or cream)

• Interaction: While not directly harmful, excessive dairy fat may delay the release of Metformin XR and cause gastrointestinal discomfort in some users.
• Management: Moderate dairy intake is usually fine. Choose low-fat or plant-based options if you’re prone to bloating.

5. Caffeine-Containing Drinks (Coffee, Energy Drinks)

• Interaction: High caffeine may affect sugar balance and cause dehydration, which is a concern especially with Empagliflozin.
• Management: Limit caffeine intake. Drink enough water to stay hydrated.

 6. Salty or Processed Foods

• Interaction: These foods may worsen water retention or affect kidney function when combined with certain medications.
• Management: Reduce intake of packaged, salty foods. opt for fresh meals with controlled seasoning.

Synopsis

More Information

FAQs About OXRAMET XR 10/1000MG TABLET

References

1. K.D. Tripathi. Insulin, oral hypoglycaemic drugs and glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page-278, 275.

2. Clifford J Bailey, Jorge L Gross, Delphine Hennicken, Nayyar Iqbal, Traci A Mansfield, James F List. Uses of metformin and dapagliflozin. Biomed Central (BMC). February 2013. [Accessed on 17th July 2025]

3. AstraZeneca Pharmaceuticals. U.S. Food & Drug Administration. [Revised in July 2017] [Accessed on 17th July 2025] 

4. Torrent Pharmaceuticals Ltd. Dapagliflozin and Metformin. [Revised in May 2022] [Accessed on 17th July 2025] 

5. AstraZeneca Pharmaceuticals LP. Dapagliflozin and Metformin. [Revised in April 2022] [Accessed on 17th July 2025] 

User Feedback

Useful Diagnostic Tests

• Random Blood Sugar (RBS)
• Fasting Blood Sugar (FBS)
• Post Prandial Blood Sugar (PPBS)
• Sugar Risk Package
• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 22 Jul 2025 | 11:53 AM(IST)