OXRAMET S XR 1000 Tablet 7's

Introduction About OXRAMET S XR TABLET

OXRAMET S XR 1000 Tablet is a combination medicine designed to support blood sugar control. It is recommended to be used alongside diet and physical activity to enhance blood glucose management in adults with type 2 diabetes mellitus. This tablet combines three active ingredients such as Dapagliflozin, Metformin, and Sitagliptin that work together to help the pancreas release more insulin, a hormone essential for processing glucose. By improving the body's ability to regulate blood sugar, OXRAMET S XR 1000 Tablet supports better glucose absorption by body cells.    

OXRAMET S XR 1000 Tablet can be taken with or without food at any time of the day, but it is recommended to take it at the same time every day for consistent blood sugar management. The dosage will be determined by your doctor, so do not stop or change the dose without consulting them. Stopping the medicine abruptly may cause blood sugar levels to rise, increasing the risk of serious complications such as kidney issues and vision problems. This medicine is intended to be used as part of a comprehensive program that includes a healthy diet, regular physical activity, and weight management as advised by your healthcare provider. 

Common side effects of this medicine may include urinary tract infections, nasal congestion, sore throat, upper respiratory tract infections, digestive discomfort, headache, increased urination, nausea, vomiting, diarrhoea, stomach pain, dizziness, and genital fungal infections. Drinking plenty of fluids during management helps reduce the risk of dehydration. Maintaining good personal hygiene can help manage the chance of developing fungal infections in the genital area. If side effects persist or worsen, consult your doctor immediately. 

Before taking OXRAMET S XR 1000 Tablet, inform your doctor if you have any kidney or liver problems or if you are currently experiencing a urinary tract infection. Also, let your doctor know if you are taking water pills (diuretics). Pregnant or breastfeeding women should consult their doctor before using this medicine. It is advised to avoid excessive alcohol consumption while on this medication, as it may increase the chance of certain side effects. Regular monitoring of your blood sugar levels is important to help manage your condition effectively.  

Uses Of OXRAMET S XR TABLET

• Type 2 diabetes mellitus in adults

Benefits of OXRAMET S XR TABLET

1. Supports Blood Sugar Control: Oxramet S XR 1000 Tablet combines Dapagliflozin, Metformin, and Sitagliptin to aid in regulating blood glucose levels effectively in adults with type 2 diabetes.
2. Enhances Insulin Utilization: Metformin in the tablet improves insulin sensitivity, helping the body use insulin more efficiently without raising insulin levels.
3. Promotes Excess Glucose Elimination: Dapagliflozin helps the kidneys remove excess sugar through urine, assisting in lowering blood sugar levels.
4. Supports Glucose Regulation: Sitagliptin increases natural substances that help lower blood sugar when elevated, complementing the overall blood sugar management.
5. Convenient Once-Daily Dosing: The extended-release formulation allows for consistent blood sugar control with just one tablet daily.
6. May Reduce Risk of Diabetes Complications: By maintaining balanced blood sugar levels, this medicine aids in reducing the chance of complications affecting the kidneys, eyes, and heart.

How OXRAMET S XR TABLET Works

How OXRAMET S XR 1000 Tablet Works

OXRAMET S XR 1000 Tablet combines three active ingredients such as Dapagliflozin, Metformin, and Sitagliptin that work together to support blood sugar regulation in adults with type 2 diabetes mellitus.

Mechanism of Action of Active Ingredients

• Dapagliflozin helps the kidneys remove excess glucose through urine by inhibiting the sodium-glucose co-transporter 2 (SGLT2), reducing blood sugar levels without increasing insulin.
• Metformin decreases glucose production in the liver and improves the body's sensitivity to insulin, allowing cells to absorb glucose more effectively.
• Sitagliptin enhances the levels of natural hormones that signal the pancreas to release insulin post meals and reduce glucose production when blood sugar is high.

Combined Action for Better Glucose Regulation

Together, these ingredients promote balanced blood sugar levels by increasing insulin availability, improving glucose uptake, and facilitating glucose elimination. This complementary mechanism helps maintain stable glucose levels throughout the day.

Impact on Reducing Diabetes-Related Complications

Consistent use supports better blood sugar control, which may help reduce risks associated with diabetes such as kidney stress, nerve discomfort, and cardiovascular strain. Regular monitoring and adherence to medical guidance are important for optimal management.

How to use OXRAMET S XR TABLET

How to Use OXRAMET S XR 1000 Tablet

• Take OXRAMET S XR 1000 Tablet exactly as prescribed by your doctor.
• Swallow the tablet whole with a glass of water, do not cut, break, or chew it.
• It can be taken with or without food but try to take it at the same time each day to maintain consistent blood sugar control.
• The usual dosage frequency is once or twice daily, as advised by your healthcare provider.

Recommended Dosage and Frequency

Your doctor will decide the right dosage based on your medical condition and response to management. Always follow your doctor's instructions and never exceed the prescribed dose.

Administration Guidelines for OXRAMET S XR 1000

• Take the tablet with meals to reduce the chance of stomach upset.
• Maintain adequate hydration by drinking plenty of fluids throughout the day.
• Do not abruptly stop taking the medicine without consulting your doctor, as this may lead to increased blood sugar levels and raise risks of complications.

Best Practices for Taking OXRAMET S XR 1000

• Take the tablet consistently at the same time every day to help remember your dose and maintain even blood sugar levels.
• Combine medication use with a balanced diet, regular exercise, and weight management as advised by your healthcare provider.

Tips to Avoid Side Effects During Use

• Drinking sufficient water can help reduce the risk of dehydration and urinary tract infections.
• Maintain good personal hygiene to lower the chance of genital fungal infections.
• Report persistent or severe side effects to your doctor promptly.

Important Precautions During Dosage

• Inform your doctor if you have any kidney or liver conditions, are pregnant or breastfeeding, or if you are taking other medications such as diuretics.
• Avoid excessive alcohol intake while using this medicine as it may increase side effect risks.
• Regularly monitor your blood sugar levels as recommended by your healthcare professional.

What if I forgot to take OXRAMET S XR TABLET

• Take the missed dose as soon as you remember unless it is almost time for your next scheduled dose.
• Do not double the dose to make up for a missed one.
• If unsure, consult your doctor for guidance.

Side Effects Of OXRAMET S XR TABLET

Common Side Effects of OXRAMET S XR 1000 TABLET:

• Urinary tract infections
• Nasal congestion
• Sore throat
• Upper respiratory tract infections
• Digestive discomfort
• Headache
• Increased urination
• Nausea
• Vomiting
• Diarrhoea
• Stomach pain
• Dizziness
• Genital fungal infections

When to consult your doctor?

• Signs of lactic acidosis such as nausea, vomiting, stomach pain, muscle cramps, severe tiredness, body pain, difficulty breathing, dizziness, light-headedness, low body temperature, low heartbeat, and low blood pressure.
• Signs of diabetic ketoacidosis such as dehydration, nausea, vomiting, abdominal pain, excessive thirst, generalized weakness, rapid weight loss, fast/deep breathing, confusion, unusual sleepiness, fruity-smelling breath, sweet or metallic taste in mouth, or unusual Odor in urine or sweat.
• Urinary tract infection symptoms such as fever, chills, burning sensation while urinating, back pain, or blood in urine.
• Signs of low blood sugar (hypoglycemia) such as weakness, shaking, sweating, drowsiness, dizziness, anxiety, fast heartbeat, hunger, headache, vision changes, mood changes, confusion, and irritability.
• Allergic reactions symptoms such as rash, itching, swelling.
• Liver problems symptoms such as yellowing of skin or eyes.

How To Manage Side Effects

Dizziness Or Drowsiness

• Sit or Lie Down: If you feel dizzy, sit down, or lie down immediately to reduce falling. Keep your head still and close your eyes if needed.
• Hydrate: Dehydration can cause dizziness, so drink water or electrolyte-replenishing drinks like sports drinks.
• Avoid Sudden Movements: When standing or sitting, do so slowly to avoid triggering dizziness. Take your time when getting up.
• Eat Small, Regular Meals: Low blood sugar can cause dizziness, so eat small meals throughout the day and avoid skipping meals.
• Fresh Air: Sometimes dizziness can be alleviated by taking slow, deep breaths in a well-ventilated area.

Headache

• Stay Hydrated: Drink plenty of water throughout the day to help ease headache symptoms.
• Rest in a Quiet Environment: Minimize noise and bright lights by resting in a calm, dark room.
• Use Over-the-Counter Pain Relief: Consult your doctor about using mild pain relievers like acetaminophen to alleviate headaches.
• Avoid Stressful Activities: Limit activities that increase stress or physical exertion when experiencing headaches.
• Seek Medical Advice: Contact your healthcare provider if headaches become severe, persistent, or are accompanied by other symptoms.

Nausea And Vomiting

• Stay Hydrated: Sip fluids slowly, such as water, ginger tea, or clear soups to support hydration and reduce discomfort.
• Eat Small, Bland Meals: Choose light foods like crackers, toast, or plain rice to minimize stomach irritation.
• Avoid Strong Odors and Spicy Foods: These can worsen feelings of nausea and should be limited during symptoms.
• Rest and Relaxation: Rest in a comfortable position and avoid sudden movements to calm the digestive system.
• Seek Medical Advice: Consult a healthcare provider promptly if nausea is severe, persistent, or accompanied by vomiting.

Warning & Precautions

Pregnancy

Consult your doctor

Consult your doctor before taking OXRAMET S XR 1000 Tablet during pregnancy. There are no well-controlled human studies available. Animal studies showed some harmful effects on offspring. Take this medicine during pregnancy only if your doctor considers it clearly necessary.        

Breastfeeding

Consult your doctor

Consult your doctor if you are breastfeeding. It is unknown if OXRAMET S XR 1000 Tablet pass into breast milk. Animal studies reported excretion in milk and effects on nursing offspring. Avoid OXRAMET S XR 1000 Tablet while breastfeeding unless your doctor advises otherwise.

Driving and Using Machines

Use with Caution

Avoid driving or operating machinery if you experience dizziness or drowsiness after taking OXRAMET S XR 1000 Tablet. 

Alcohol

Consult your doctor

Consult your doctor before consuming alcohol. Alcohol intake may increase the risk of lactic acidosis when taking this medicine.

Kidney

Consult your doctor

Consult your doctor before use if you have kidney problems. OXRAMET S XR 1000 Tablet is not recommended for severe kidney disease and should be used cautiously in mild to moderate impairment.

Liver

Contraindicated

OXRAMET S XR TABLET is not recommended for use if you have liver disease. Consult your doctor before taking it.

Allergy

Contraindicated

OXRAMET S XR TABLET is not recommended for use if you are allergic to Dapagliflozin or Metformin or sitagliptin, or any of the other ingredients of this medicine.

Lungs

Contraindicated

OXRAMET S XR TABLET is not recommended for use if you have respiratory failure. Consult your doctor before taking it. 

Heart Disease

Contraindicated

OXRAMET S XR TABLET is not recommended for use if you have heart failure or a recent myocardial infarction. Consult your doctor before taking it. 

Use In Pediatrics

Contraindicated

OXRAMET S XR TABLET is not recommended for use in children and adolescents below 18 years of age as safety and efficacy are not clinically established. Contact your doctor before taking.  

Use In Geriatrics

Use with Caution

OXRAMET S XR TABLET should be used with caution in elderly patients (aged 65 years or older). Contact your doctor before taking.

Other Warnings for OXRAMET S XR TABLET

Before taking OXRAMET S XR TABLET, inform your doctor if you:

• Have a history of pancreatitis
• Have or have had gallstones
• Have very high levels of triglycerides (a form of fat) in blood

Who should not take OXRAMET S XR TABLET

OXRAMET S XR TABLET is not recommended for use if you:

• Have Type 1 diabetes mellitus
• Have acute metabolic acidosis (such as lactic acidosis or diabetic ketoacidosis)
• Have diabetic pre-coma
• Have dehydration
• Have a severe infection
• Have shock
• Are scheduled for a lab test
• Are planned for surgery

Drug - Drug interaction

1. Diuretics (e.g., Furosemide, Hydrochlorothiazide)
Interaction: Using diuretics with OXRAMET S XR 1000 Tablet may increase the risk of dehydration, low blood pressure, and electrolyte imbalance.
Effects: Increased chance of dizziness, fatigue, low blood pressure, and kidney function deterioration.
Management: Stay well-hydrated and have regular kidney function and blood pressure monitoring. Inform your doctor if symptoms like dizziness or reduced urination occur.

2. Blood Pressure Medications (e.g., ACE inhibitors, ARBs)
Interaction: These medications may enhance the blood sugar-lowering effect of OXRAMET S XR 1000 Tablet, possibly causing low blood sugar or blood pressure.
Effects: Risk of hypoglycemia and hypotension, especially in sensitive patients.
Management: Regular blood sugar and blood pressure monitoring is essential. Dosage adjustments may be needed under doctor supervision.

3. Insulin and Sulfonylureas (e.g., Glimepiride, Gliclazide)
Interaction: Combining with OXRAMET S XR 1000 Tablet can increase the risk of low blood sugar (hypoglycemia).
Effects: Symptoms include shakiness, sweating, dizziness, and weakness.
Management: Your doctor may adjust insulin or sulfonylurea dosages. Always carry a quick sugar source and monitor blood sugar frequently.

4. Corticosteroids (e.g., Prednisolone)
Interaction: Corticosteroids may reduce the effectiveness of OXRAMET S XR 1000 Tablet by raising blood sugar levels.
Effects: Poor blood sugar control leading to hyperglycemia.
Management: Closer blood sugar monitoring is necessary, and dosage changes may be considered.

5. Certain Antibiotics and Antifungals (e.g., Clarithromycin, Ketoconazole)
Interaction: These may affect the metabolism of OXRAMET S XR 1000 Tablet, altering its blood sugar-lowering effects.
Effects: Possible increased side effects or reduced efficacy.
Management: Inform your doctor before starting these medications; dosage or monitoring adjustments may be required.

Drug - Food interaction

1. High-Carbohydrate Meals (Sugary or Refined Foods)
Interaction: Meals high in sugar or refined carbohydrates such as sweets, white bread, and sugary beverages may reduce the effectiveness of OXRAMET S XR 1000 in controlling blood sugar levels.
Effects: Reduced blood sugar control leading to higher blood glucose levels.
Management: Prefer complex carbohydrates like whole grains, lentils, and vegetables for better blood sugar management.

2. High-Fat Meals
Interaction: Large, fatty meals can delay the absorption of the Metformin XR component in OXRAMET S XR 1000, potentially causing stomach upset or reducing efficacy.
Effects: Increased gastrointestinal side effects such as nausea or discomfort.
Management: Consume lighter, moderate-fat meals including lean proteins and vegetables while taking this medication.

3. Alcohol
Interaction: Alcohol intake may increase the risk of lactic acidosis and negatively affect kidney function and hydration status during management with OXRAMET S XR 1000.
Effects: Increased risk of severe side effects including lactic acidosis.
Management: Avoid or limit alcohol consumption and maintain good hydration; consult your doctor for advice.

4. Large Quantities of Dairy (Full-Fat Milk or Cream)
Interaction: Excessive dairy fat may delay release of Metformin XR, causing gastrointestinal discomfort in some patients.
Effects: Possible bloating or stomach upset.
Management: Moderate dairy intake, consider low-fat or plant-based alternatives if prone to discomfort.

5. Caffeine-Containing Drinks (Coffee, Energy Drinks)
Interaction: High caffeine intake may affect blood sugar balance and cause dehydration, which can be problematic with OXRAMET S XR 1000.
Effects: Dehydration and potential blood sugar fluctuations.
Management: Limit caffeine consumption and ensure adequate water intake for hydration.

6. Salty or Processed Foods
Interaction: Excess salt and processed foods may worsen water retention and affect kidney function when used with OXRAMET S XR 1000.
Effects: Potential increased risk of kidney strain and fluid imbalance.
Management: Reduce intake of processed and salty foods; opt for fresh, balanced meals.

Synopsis

More Information

01. What are the best tips for combining OXRAMET S XR 1000 tablet with diet, exercise, hydration, and regular monitoring to effectively control blood sugar levels?

FAQs About OXRAMET S XR TABLET

Q: What is OXRAMET S XR 1000 Tablet used for?

A: OXRAMET S XR 1000 Tablet is used to manage blood sugar levels in adults with type 2 diabetes mellitus. It helps control high blood glucose and reduces the risk of diabetes-related complications by improving insulin sensitivity and promoting glucose excretion through urine.

Q: How does OXRAMET S XR 1000 Tablet work?

A: This tablet combines dapagliflozin, sitagliptin, and metformin. Dapagliflozin helps remove excess sugar from the body via urine, metformin reduces glucose production in the liver and enhances the effect of insulin, and sitagliptin improves insulin release and lowers blood sugar levels.

Q: Can I take OXRAMET S XR 1000 Tablet with food?

A: Yes, it is recommended to take OXRAMET S XR 1000 Tablet with meals to reduce gastrointestinal side effects and improve tolerance. Try to take it at the same time every day as advised by your doctor.

Q: Are there any common side effects of OXRAMET S XR 1000 Tablet?

A: Common side effects include urinary tract infections, genital fungal infections, nausea, vomiting, diarrhoea, headache, and nasal congestion. Inform your doctor if any side effects worsen or persist.

Q: Who should avoid taking OXRAMET S XR 1000 Tablet?

A: People with severe kidney or liver disease, type 1 diabetes, or a history of lactic acidosis should avoid this medicine. It is also not recommended for pregnant or breastfeeding women unless advised by a doctor.

Q: Do I need to monitor anything while taking OXRAMET S XR 1000 Tablet?

A: Yes, regular monitoring of blood sugar levels and kidney function is essential. Report symptoms like unusual thirst, frequent urination, or fatigue to your doctor as these may indicate the need for dosage adjustment.

Q: Can OXRAMET S XR 1000 Tablet be used with exercise and diet?

A: Yes, this medication should be used alongside a healthy diet and regular exercise routine to enhance blood sugar control and achieve the best management outcomes.

Q: Can OXRAMET S XR 1000 Tablet be taken with other diabetes medicines?

A: Yes, OXRAMET S XR 1000 Tablet can be taken with other diabetes medicines such as insulin or sulfonylureas. However, combining these may increase the risk of low blood sugar (hypoglycemia). It is important to inform your doctor about all the medications you are taking so the dosage can be adjusted, and you can be monitored closely.

Q: Is fasting blood sugar level monitoring necessary while taking OXRAMET S XR 1000 Tablet?

A: Yes, regular monitoring of fasting blood sugar is necessary to ensure the medication is effectively controlling your blood sugar levels. Frequent testing helps your doctor adjust the dose and manage any potential side effects or complications early.

Q: Are there any dietary considerations while on OXRAMET S XR 1000 Tablet?

A: Yes, it is recommended to maintain a balanced diet with controlled carbohydrate intake to maximize blood sugar control. Avoid excessive sugary foods, refined carbs, and alcohol as they can affect medication effectiveness and increase side effects risk. Taking the tablet with meals can also reduce gastrointestinal discomfort.

Q: How to buy OXRAMET S XR 1000 Tablet online safely from Netmeds?

A: Visit the official Netmeds website, search for OXRAMET S XR 1000 Tablet, upload a valid doctor’s prescription during checkout, choose a secure payment method, and provide an accurate delivery address. Netmeds will verify your prescription before processing the order to ensure you receive genuine medication safely at your doorstep.

References

1. K.D. Tripathi. Insulin, oral hypoglycaemic drugs and glucagon. Essentials of Medical Pharmacology. Seventh Edition. 2013. Page - 278, 275.

2. Clifford J Bailey, Jorge L Gross, Delphine Hennicken, Nayyar Iqbal, Traci A Mansfield, and James F List. Uses of metformin and dapagliflozin. Biomed Central (BMC). February 2013. [Accessed on 7th October 2025]

3. La Renon Healthcare. Dapagliflozin+Metformin+Sitagliptin. [Accessed on 7th October 2025]

Useful Diagnostic Tests

• Fasting Blood Sugar (FBS)
• Post Prandial Blood Sugar (PPBS)
• Random Blood Sugar (RBS)
• HbA1C, also known as Glycated Hemoglobin, Glycosylated Hemoglobin
• Kidney Function Test (KFT)
• Liver Function Test (LFT)
• Lipid & Diabetes Monitoring Test

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 08 Oct 2025 | 09:17 AM(IST)