OXRAMET G XR 10/1/500 Tablet 7's

Introduction About OXRAMET G XR 10/1/500 TABLET

OXRAMET G XR 10/1/500 TABLET is a combination of Dapagliflozin, Glimepiride, and Metformin, which belongs to the group of medicines called Antidiabetic agents. It is used as an adjunct to diet and exercise to improve glycemic control among patients with type II diabetes mellitus when management with single agents does not result in adequate response.

Type II diabetes mellitus is a chronic disease characterized by abnormally high levels of glucose in the blood. It is caused by inadequate production of a hormone called insulin (produced by the pancreas to metabolize glucose) in the body or by inadequate sensitivity of body cells to the actions of insulin.

Before taking OXRAMET G XR 10/1/500 TABLET, inform your doctor if you have any liver, kidney, or heart problems. You must also inform your doctor if you have any eye problems, hormonal imbalance, alcoholism, or if you are malnourished or starved on an irregular diet as a precaution.

OXRAMET G XR 10/1/500 TABLET is strictly not recommended for use in patients with type I diabetes mellitus, bladder cancer, severe heart failure or lactic acidosis, severe low blood pressure, or severe dehydration. It is also not suitable for use in pregnant or breastfeeding women.

Along with the management, follow the diet and lifestyle changes advised by your doctor to achieve better results. Avoid smoking and consumption of alcohol while taking OXRAMET G XR 10/1/500 TABLET, as it may aggravate your existing condition. During therapy with OXRAMET G XR 10/1/500 TABLET, your doctor might regularly monitor your blood sugar levels and kidney functions to avoid the risk of unwanted side effects.

The most common side effects of taking OXRAMET G XR 10/1/500 TABLET are low blood sugar levels, nausea, stomach upset, constipation, sore throat, muscle pain, headache, dizziness, genital infections, back pain, and passing more urine. Consult your doctor if any of these side effects worsen.

Uses Of OXRAMET G XR 10/1/500 TABLET

• It is used as an adjunct to diet and exercise to improve glycemic control among patients with type II diabetes mellitus.

How OXRAMET G XR 10/1/500 TABLET Works

OXRAMET G XR 10/1/500 TABLET contains three medicines, namely, metformin, glimepiride, and dapagliflozin. Metformin and glimepiride stimulate the pancreas to secrete more insulin (a hormone involved in glucose metabolism). They also make our body more sensitive to insulin, which helps in digesting the circulating sugars (glucose) in the blood, thereby reducing blood sugar levels. Additionally, metformin can also reduce the glucose produced by the liver and reduce its absorption in the body.

Dapagliflozin is an SGLT-2 inhibitor. It works by blocking the action of a protein called SGLT-2 in the kidneys. This action manages the reabsorption of glucose and sodium ions in the kidneys. As a result, it excretes excess glucose from the body in the form urine.

How to use OXRAMET G XR 10/1/500 TABLET

Take OXRAMET G XR 10/1/500 TABLET preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.

Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight, and disease condition.

Do not stop taking OXRAMET G XR 10/1/500 TABLET unless your doctor advises you to stop.

Overdose

If you or anyone else accidentally took more OXRAMET G XR 10/1/500 TABLET, you may experience the signs of hypoglycemia (such as increased hunger, sweating, headache, feeling clammy, restless or aggressive, shakiness, fast heartbeat, and confusion). To manage this, consume any sugary food immediately. If the symptoms do not improve or worsen, contact your doctor immediately. Other symptoms of overdose might include vomiting, stomach pain with muscle cramps, feeling generally unwell with severe tiredness, and difficulty breathing.

Side Effects Of OXRAMET G XR 10/1/500 TABLET

Common side effects of OXRAMET G XR 10/1/500 TABLET:

• hypoglycemia (low blood sugar levels)
• nausea, vomiting
• diarrhea, stomach pain, loss of appetite, flatulence
• changes in taste, metallic taste
• headache, dizziness
• joint pain, back pain, muscle pain
• impotence
• sinus infection, sore throat
• fungal infections of the genital (thrush) causing itching, irritation, unusual discharge, odour
• passing more urine, increased urine frequency
• skin rash
• changes in blood cholesterol levels
• changes in RBC in blood

Stop taking OXRAMET G XR 10/1/500 TABLET and contact your doctor immediately if you experience any of the following side effects:

• signs of diabetic ketoacidosis or lactic acidosis (cold hands or feet, dizziness or lightheadedness, slow or irregular heartbeat, weakness or tiredness, unusual muscle pain, trouble breathing, sleepiness or drowsiness, stomach pains, nausea or vomiting, a sweet smell to breath, a sweet or metallic taste in the mouth or a different odor to urine or sweat, and rapid weight loss)
• symptoms of heart failure (such as unusual shortness of breath or trouble breathing, rapid increase in weight or localized swelling (oedema), especially in the ankles or legs, unusual tiredness)
• blurred vision, urinary tract infections
• pain, swelling, redness, or tenderness of the genitals or the areas between the genitals and the anus accompanied by a high fever or a feeling generally unwell (a sign of necrotizing fasciitis of the perineum)

How To Manage Side Effects

Diarrhea

Hydrate yourself by drinking plenty of fluids, such as water or fruit juices. Consuming ORS can also be beneficial. Do not manage diarrhea on your own. Consult your doctor if your diarrhea becomes uncontrollable.

Dizziness Or Drowsiness

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol. Consult your doctor if your dizziness worsens.

Headache

Rest and relax. Keep yourself hydrated by drinking plenty of fluids, such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.

Hypoglycemia

Have foods rich in sugars, such as fruit juices, glucose drinks, candies, honey, or biscuits. Check your blood sugar after 10 minutes. If you have not gained the optimum level, take another sugary snack or drink and check the blood sugar again. Consult your doctor if there is no improvement in your condition.

Nausea And Vomiting

Take OXRAMET G XR 10/1/500 TABLET with or just after meals. Stick to simple meals. Avoid eating oily or spicy foods. Consult your doctor if your nausea worsens.

Warning & Precautions

Pregnancy

Contraindicated

OXRAMET G XR 10/1/500 TABLET is not recommended for use in pregnant women. Therefore, consult your doctor before taking it.

Breastfeeding

Contraindicated

OXRAMET G XR 10/1/500 TABLET is not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.

Driving and Using Machines

Use with Caution

Do not drive or operate any heavy tools or machines if your ability is affected by OXRAMET G XR 10/1/500 TABLET.

Alcohol

Contraindicated

Avoid consumption of alcohol while taking OXRAMET G XR 10/1/500 TABLET, as it may increase the risk of unwanted side effects.

Kidney

Consult your doctor

OXRAMET G XR 10/1/500 TABLET is not recommended for use in patients with severe kidney problems. It should be used with caution in patients with mild to moderate kidney problems. Therefore, consult your doctor before taking it.

Liver

Consult your doctor

OXRAMET G XR 10/1/500 TABLET is not recommended for use in patients with severe liver problems. It should be used with caution in patients with mild to moderate liver problems. Therefore, consult your doctor before taking it.

Allergy

Contraindicated

Do not take OXRAMET G XR 10/1/500 TABLET if you are allergic to Glimepiride, Metformin, or Dapagliflozin.

Heart Disease

Consult your doctor

OXRAMET G XR 10/1/500 TABLET is not recommended for use in patients with severe heart problems (such as heart failure). It should be used with caution in patients with other heart problems. Therefore, consult your doctor before taking it.

Use In Pediatrics

Contraindicated

OXRAMET G XR 10/1/500 TABLET is not recommended for use in children and in adolescents (aged below 18 years). Therefore, consult your doctor before taking it. 

Use In Geriatrics

Use with Caution

OXRAMET G XR 10/1/500 TABLET should be used with caution in elderly patients (aged above 65 years). Therefore, consult your doctor before taking it.

Other Warnings for OXRAMET G XR 10/1/500 TABLET

Before taking OXRAMET G XR 10/1/500 TABLET, inform your doctor if you:

• are recovering from any injury, operation, infection, or from any form of stress
• have G6PD deficiency
• are on fating or malnourished, starved, on an irregular diet, or feeling weak
• perform extreme physical exercises without proper carbohydrate intake
• are severely dehydrated
• have hormonal problems (Ex. disorders of the pituitary gland, adrenal cortex, or thyroid gland)
• are an alcoholic
• have edema (swelling of body parts)
• have a habit of smoking
• have cysts on your ovaries (polycystic ovarian syndrome)
• previously had stroke
• have anemia (low RBC in blood)
• have diabetes-related kidney problems

Who should not take OXRAMET G XR 10/1/500 TABLET

OXRAMET G XR 10/1/500 TABLET is not recommended for use if you:

• have type I diabetes mellitus (insulin-dependent diabetes)
• have lactic acidosis (buildup of lactic acid in the body)
• have diabetic ketoacidosis (a diabetic complication causing episodes of fatigue, nausea, frequent urination, and muscular stiffness)
• have bladder cancer
• pass bloody urine

Drug - Drug interaction

Before taking OXRAMET G XR 10/1/500 TABLET, inform your doctor if you are taking any of the following medicines:

• Other medicines used to regulate blood sugar levels (such as teneligliptin, rosiglitazone, insulin, and gliclazide)
• Medicines used in pain management (Ex. aspirin, ibuprofen, celecoxib, phenylbutazone, azopropazone, oxyphenbutazone, prednisolone, betamethasone)
• Medicines for managing urinary infections (amikacin, nitrofurantoin, sulfamethoxazole)
• Antibiotics (such as tetracyclines, chloramphenicol, ciprofloxacin, and clarithromycin); antifungals (fluconazole, miconazole, and isuvaconazole)
• medicines used for blood thinning (Ex. warfarin)
• Hormones (Ex. testosterone, estradiol)
• Medicines used in the management of mental illnesses (such as moclobemide, isocarboxazid, phenelzine, tranylcypromine, fluoxetine, chlorpromazine, prochlorperazine, and lithium)
• Antihyperlipidemics (Ex. fenofibrate, nicotinic acid, colesevelam)
• Antihypertensives (Ex. enalapril, lisinopril, ramipril, atenolol, propranolol, telmisartan, olmesartan, clonidine, guanethidine, reserpine, prazosin, doxazosin)
• medicines used to manage gout (Ex. allopurinol, probenecid, sulfinpyrazone)
• medicines used in the management of cancer (Ex. cyclophosphamide, ifosfamide, trofosfamide, vandetanib, crizotinib, and olaparib)
• medicines used in the management of allergic rhinitis (Ex. tritoqualine)
• Water pills (Ex. hydrochlorothiazide)
• Anti-asthmatics (Ex. salbutamol, terbutaline)
• adrenaline (a medicine used for anaphylaxis)
• Medicines used for constipation (Ex. lactulose, liquid paraffin)

Synopsis

More Information

FAQs About OXRAMET G XR 10/1/500 TABLET

References

1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of Medical Pharmacology. Seventh Edition. 2013. Page – 270, 275, 277, 278.

2. Dirk Müller-Wieland, Monika Kellerer, Katarzyna Cypryk, Dasa Skripova, Katja Rohwedder, Eva Johnsson, Ricardo Garcia-Sanchez, Raisa Kurlyandskaya, David Sjöström, Stephan Jacob, Jochen Seufert, Nalina Dronamraju, and Katalin Csomós. Efficacy and safety of dapagliflozin or dapagliflozin plus saxagliptin versus glimepiride as add-on to metformin in patients with type 2 diabetes. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. July 2018. [Accessed on 27th July 2026]

3. Brown & Burk UK Limited. Electronic Medicines Compendium (EMC). [Revised in December 2020] [Accessed on 27th July 2026]

4. AstraZeneca UK Limited. Electronic Medicines Compendium (EMC). [Revised in November 2022] [Accessed on 27th July 2026]

5. CDSCO. Dapagliflozin… 5 mg/5 mg/10 mg/10 mg + Metformin HCL (extended release) …. 500mg/1000mg/500mg/1000mg. October 2017. [Accessed on 27th July 2026]

6. Centuar Pharma. Glimitab-M 1 mg/2 mg Tablets. [Accessed on 27th July 2026]

Useful Diagnostic Tests

• Random Blood Sugar (RBS)
• Fasting Blood Sugar (FBS)
• Post Prandial Blood Sugar (PPBS)
• Sugar Risk Package
• HbA1C, also known as Glycated Haemoglobin, Glycosylated Haemoglobin

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 28 Jul 2026 | 09:52 AM(IST)